Type |
Details |
Score |
Allele |
Name: |
transgene insertion KH6, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Allele |
Name: |
frizzled class receptor 3; targeted mutation 2.1, Jeremy Nathans |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant stock |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Fzd3/Fzd3 |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
526
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Phillips HM |
Year: |
2005 |
Journal: |
Circ Res |
Title: |
Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract. |
Volume: |
96 |
Issue: |
3 |
Pages: |
292-9 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
521
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
253
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
575
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
102
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
393
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
130
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
137
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
561
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
476
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Hatakeyama J |
Year: |
2014 |
Journal: |
Endocr Relat Cancer |
Title: |
Vangl1 and Vangl2: planar cell polarity components with a developing role in cancer. |
Volume: |
21 |
Issue: |
5 |
Pages: |
R345-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Leung V |
Year: |
2016 |
Journal: |
Dev Neurobiol |
Title: |
The planar cell polarity protein Vangl2 is required for retinal axon guidance. |
Volume: |
76 |
Issue: |
2 |
Pages: |
150-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yates LL |
Year: |
2010 |
Journal: |
Hum Mol Genet |
Title: |
The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. |
Volume: |
19 |
Issue: |
23 |
Pages: |
4663-76 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
VANGL proteins play important roles in the establishment of planar cell polarity (PCP) []. Vangl2 is required for retinal axon guidance [], kidney-branching morphogenesis and glomerular maturation []. It also plays a role in the orientation of stereociliary bundles in the cochlea and is required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process []. It is required for cell surface localization of FZD3 and FZD6 in the inner ear []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Elliott KL |
Year: |
2023 |
Journal: |
Neurosci Lett |
Title: |
Ptf1a expression is necessary for correct targeting of spiral ganglion neurons within the cochlear nuclei. |
Volume: |
806 |
|
Pages: |
137244 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao Y |
Year: |
2020 |
Journal: |
Aging (Albany NY) |
Title: |
NEAT1 regulates microtubule stabilization via FZD3/GSK3β/P-tau pathway in SH-SY5Y cells and APP/PS1 mice. |
Volume: |
12 |
Issue: |
22 |
Pages: |
23233-23250 |
|
•
•
•
•
•
|
Publication |
First Author: |
Endo Y |
Year: |
2008 |
Journal: |
Mol Cell Biol |
Title: |
Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism. |
Volume: |
28 |
Issue: |
7 |
Pages: |
2368-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schafer ST |
Year: |
2015 |
Journal: |
J Neurosci |
Title: |
The Wnt adaptor protein ATP6AP2 regulates multiple stages of adult hippocampal neurogenesis. |
Volume: |
35 |
Issue: |
12 |
Pages: |
4983-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Simonetti M |
Year: |
2014 |
Journal: |
Neuron |
Title: |
Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways. |
Volume: |
83 |
Issue: |
1 |
Pages: |
104-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
|
|
|
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•
•
•
•
•
|