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Search results 701 to 800 out of 851 for Hras

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Type Details Score
Publication  
First Author: Usui T
Year: 2001
Journal: Toxicol Pathol
Title: CB6F1-rasH2 mouse: overview of available data.
Volume: 29 Suppl
Pages: 90-108
Publication
First Author: Okamura M
Year: 2006
Journal: Toxicology
Title: Gene expression analysis of urethane-induced lung tumors in ras H2 mice.
Volume: 217
Issue: 2-3
Pages: 129-38
Publication
First Author: Morton D
Year: 2004
Journal: Toxicol Pathol
Title: Effect of oral gavage dosing regimens in female Tg rasH2 transgenic mice.
Volume: 32
Issue: 4
Pages: 413-7
Publication
First Author: Maruyama C
Year: 2001
Journal: Oncol Rep
Title: Overexpression of human H-ras transgene is responsible for tumors induced by chemical carcinogens in mice.
Volume: 8
Issue: 2
Pages: 233-7
Publication
First Author: Toyosawa K
Year: 2001
Journal: Toxicol Pathol
Title: Di(2-ethylhexyl)phthalate induces hepatocellular adenoma in transgenic mice carrying a human prototype c-Ha-ras gene in a 26-week carcinogenicity study.
Volume: 29
Issue: 4
Pages: 458-66
Publication
First Author: Imai T
Year: 2002
Journal: Cancer Lett
Title: Inhibitory effects of cinnamaldehyde on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung carcinogenesis in rasH2 mice.
Volume: 175
Issue: 1
Pages: 9-16
Publication
First Author: Tsunematsu S
Year: 1994
Journal: Int J Cancer
Title: Hepatic tumors induced by carbon tetrachloride in transgenic mice carrying a human c-H-ras proto-oncogene without mutations.
Volume: 59
Issue: 4
Pages: 554-9
Publication
First Author: Koujitani T
Year: 2001
Journal: J Toxicol Sci
Title: Lack of modifying effects of eugenol on development of lung proliferative lesions induced by urethane in transgenic mice carrying the human prototype c-Ha-ras gene.
Volume: 26
Issue: 3
Pages: 129-39
Publication
First Author: Tomisawa M
Year: 2003
Journal: Toxicol Lett
Title: Mutation analysis of vinyl carbamate or urethane induced lung tumors in rasH2 transgenic mice.
Volume: 142
Issue: 1-2
Pages: 111-7
Publication
First Author: Okamura M
Year: 2007
Journal: Cancer Lett
Title: The possible mechanism of enhanced carcinogenesis induced by genotoxic carcinogens in rasH2 mice.
Volume: 245
Issue: 1-2
Pages: 321-30
Publication
First Author: Mori I
Year: 2001
Journal: J Vet Med Sci
Title: Aberrant expression of cyclin D1 in pulmonary proliferative lesions induced by high doses of urethane in transgenic mice carrying the human prototype c-H-ras gene.
Volume: 63
Issue: 3
Pages: 261-8
Publication
First Author: Tsuchiya T
Year: 2005
Journal: J Vet Med Sci
Title: Histopathological characterization of the skeletal myopathy in rasH2 mice carrying human prototype c-Ha-ras gene.
Volume: 67
Issue: 5
Pages: 481-9
Publication
First Author: Muto S
Year: 2006
Journal: Cancer Sci
Title: Rapid induction of skin tumors in human but not mouse c-Ha-ras proto-oncogene transgenic mice by chemical carcinogenesis.
Volume: 97
Issue: 9
Pages: 842-7
Publication
First Author: Umemura T
Year: 2002
Journal: Jpn J Cancer Res
Title: The mouse rasH2/BHT model as an in vivo rapid assay for lung carcinogens.
Volume: 93
Issue: 8
Pages: 861-6
Publication
First Author: Watanabe T
Year: 2003
Journal: Toxicol Pathol
Title: Inhibition by ethinylestradiol of N-ethyl-N-nitrosourea-initiated uterine carcinogenesis in transgenic mice carrying a human prototype C-Ha-ras gene (rasH2 mice).
Volume: 31
Issue: 5
Pages: 496-505
Publication
First Author: Toyosawa K
Year: 2003
Journal: Toxicol Pathol
Title: Mutation and overexpression of the transgene in ethylnitrosourea-induced tumors in mice carrying a human prototype c-Ha-ras gene.
Volume: 31
Issue: 5
Pages: 491-5
Publication
First Author: Mitsumori K
Year: 1997
Journal: Mol Carcinog
Title: Susceptibility of transgenic mice carrying human prototype c-Ha-ras gene in a short-term carcinogenicity study of vinyl carbamate and ras gene analyses of the induced tumors.
Volume: 20
Issue: 3
Pages: 298-307
Publication
First Author: Watanabe T
Year: 2002
Journal: Cancer Lett
Title: Rapid induction of uterine endometrial proliferative lesions in transgenic mice carrying a human prototype c-Ha-ras gene (rasH2 mice) given a single intraperitoneal injection of N-ethyl-N-nitrosourea.
Volume: 188
Issue: 1-2
Pages: 39-46
Publication
First Author: Umemura T
Year: 2001
Journal: J Cancer Res Clin Oncol
Title: Butylhydroxytoluene (BHT) increases susceptibility of transgenic rasH2 mice to lung carcinogenesis.
Volume: 127
Issue: 10
Pages: 583-90
Publication
First Author: Tsunematsu S
Year: 1997
Journal: Biochem Mol Biol Int
Title: Role of H-ras gene in chronic liver damage in mice. By using transgenic mice carrying a human C-H-ras proto-oncogene without mutations.
Volume: 42
Issue: 2
Pages: 371-9
Publication
First Author: Doi ST
Year: 1994
Journal: Jpn J Cancer Res
Title: Site-specific mutation of the human c-Ha-ras transgene induced by dimethylbenzanthracene causes tissue-specific tumors in mice.
Volume: 85
Issue: 8
Pages: 801-7
Publication
First Author: Nesfield SR
Year: 2005
Journal: Int J Toxicol
Title: Evaluation of the carcinogenic potential of clofibrate in the rasH2 mouse.
Volume: 24
Issue: 5
Pages: 301-11
Publication
First Author: Ogawa K
Year: 1996
Journal: Carcinogenesis
Title: Chemically induced lung and forestomach neoplasias in transgenic mice carry mutant forms of the human c-Ha-ras transgene.
Volume: 17
Issue: 2
Pages: 341-5
Publication
First Author: Ando K
Year: 1992
Journal: Cancer Res
Title: Chemically induced forestomach papillomas in transgenic mice carry mutant human c-Ha-ras transgenes.
Volume: 52
Issue: 4
Pages: 978-82
Publication
First Author: Sehata S
Year: 2002
Journal: Toxicol Pathol
Title: Twenty-six-Week carcinogenicity study of chloroform in CB6F1 rasH2-transgenic mice.
Volume: 30
Issue: 3
Pages: 328-38
Publication
First Author: Umemura T
Year: 2006
Journal: Cancer Lett
Title: Nine-week detection of six genotoxic lung carcinogens using the rasH2/BHT mouse model.
Volume: 231
Issue: 2
Pages: 314-8
Publication
First Author: Imaoka M
Year: 2002
Journal: J Vet Med Sci
Title: Tumor promoting effect of phenolphthalein on development of lung tumors induced by N-ethyl-N-nitrosourea in transgenic mice carrying human prototype c-Ha-ras gene.
Volume: 64
Issue: 6
Pages: 489-93
Publication
First Author: Mori I
Year: 2000
Journal: Cancer Lett
Title: Carcinogen dose-dependent variation in the transgene mutation spectrum in urethane-induced lung tumors in transgenic mice carrying the human prototype c-Ha-ras gene.
Volume: 153
Issue: 1-2
Pages: 199-209
Publication
First Author: Mitsumori K
Year: 2003
Journal: J Toxicol Sci
Title: Possible mechanism on enhanced carcinogenesis of genotoxic carcinogens and unsolved mechanisms on lesser carcinogenic susceptibility to some carcinogens in rasH2 mice.
Volume: 28
Issue: 5
Pages: 371-83
Publication
First Author: Maronpot RR
Year: 2000
Journal: Toxicology
Title: Interlaboratory comparison of the CB6F1-Tg rasH2 rapid carcinogenicity testing model.
Volume: 146
Issue: 2-3
Pages: 149-59
Publication
First Author: Takaoka M
Year: 2003
Journal: Toxicol Pathol
Title: Interlaboratory comparison of short-term carcinogenicity studies using CB6F1-rasH2 transgenic mice.
Volume: 31
Issue: 2
Pages: 191-9
Publication
First Author: Koujitani T
Year: 2000
Journal: Cancer Lett
Title: Lack of susceptibility of transgenic mice carrying the human c-Ha-ras proto-oncogene (rasH2 mice) to phenolphthalein in a 6-month carcinogenicity study.
Volume: 152
Issue: 2
Pages: 211-6
Publication
First Author: Miyamoto S
Year: 2008
Journal: Carcinogenesis
Title: A novel rasH2 mouse carcinogenesis model that is highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis is useful for preclinical chemoprevention studies.
Volume: 29
Issue: 2
Pages: 418-26
Publication
First Author: Goto Y
Year: 2023
Journal: Sci Rep
Title: Carcinogenicity and testicular toxicity of 2-bromopropane in a 26-week inhalation study using the rasH2 mouse model.
Volume: 13
Issue: 1
Pages: 1782
Publication
First Author: Byrd RA
Year: 2015
Journal: Endocrinology
Title: Chronic Toxicity and Carcinogenicity Studies of the Long-Acting GLP-1 Receptor Agonist Dulaglutide in Rodents.
Volume: 156
Issue: 7
Pages: 2417-28
Publication
First Author: Kobayashi K
Year: 2000
Journal: Toxicol Pathol
Title: Glomerulonephritis with fibrillary deposition in a transgenic mouse carrying the human prototype c-Ha-ras gene (rasH2 mouse).
Volume: 28
Issue: 2
Pages: 359-62
Publication
First Author: Sin SH
Year: 2024
Journal: Cell Host Microbe
Title: The complete Kaposi sarcoma-associated herpesvirus genome induces early-onset, metastatic angiosarcoma in transgenic mice.
Volume: 32
Issue: 5
Pages: 755-767.e4
Publication
First Author: Takegawa K
Year: 2000
Journal: Toxicol Pathol
Title: A mechanistic study of ovarian carcinogenesis induced by nitrofurazone using rasH2 mice.
Volume: 28
Issue: 5
Pages: 649-55
Publication
First Author: Okamura M
Year: 2006
Journal: Toxicol Pathol
Title: A 26-week carcinogenicity study of 2-amino-3-methylimidazo[4,5-f]quinoline in rasH2 mice.
Volume: 34
Issue: 2
Pages: 199-205
Publication
First Author: Morton D
Year: 2002
Journal: Toxicol Pathol
Title: The Tg rasH2 mouse in cancer hazard identification.
Volume: 30
Issue: 1
Pages: 139-46
Publication
First Author: Adachi T
Year: 2002
Journal: J Toxicol Sci
Title: Twenty-six week carcinogenicity study of ampicillin in CB6F1-TgrasH2 mice.
Volume: 27
Issue: 3
Pages: 147-63
Publication
First Author: Tsuchiya T
Year: 2002
Journal: Toxicol Pathol
Title: Skeletal myopathy in transgenic mice carrying human prototype c-Ha-ras gene.
Volume: 30
Issue: 4
Pages: 501-6
Publication
First Author: Urano K
Year: 2007
Journal: J Toxicol Sci
Title: Examination of percutaneous application in a 26-week carcinogenicity test in CB6F1-TG rasH2 mice.
Volume: 32
Issue: 4
Pages: 367-75
Publication
First Author: Okamura M
Year: 2004
Journal: Toxicol Pathol
Title: Carcinogenic susceptibility to N-bis(2-hydroxypropyl)nitrosamine (DHPN) in rasH2 mice.
Volume: 32
Issue: 4
Pages: 474-81
Publication
First Author: Torii M
Year: 2001
Journal: J Toxicol Sci
Title: Twenty-six-week carcinogenicity study of sulfamethoxazole in CB6F1-Tg-rasH2 mice.
Volume: 26
Issue: 2
Pages: 61-73
Publication
First Author: Kuroda H
Year: 2018
Journal: J Toxicol Pathol
Title: Progression process and safety assessment adaptation of endometrial lesions in ENU-induced 2-stage uterine carcinogenicity in a Tg-rasH2 mouse model.
Volume: 31
Issue: 1
Pages: 35-41
Allele
Name: transgene insertion 12, Xue-Ru Wu
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 5, Xue-ru Wu
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Genotype
Symbol: Kras/Kras Tg(HRAS)7Mok/?
Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(HRAS)2Jic/?
Background: involves: BALB/c * C57BL/6
Zygosity: ot
Has Mutant Allele: true
Strain
Attribute String: mutant strain, congenic, transgenic, spontaneous mutation
Publication
First Author: Tang Y
Year: 2005
Journal: Cancer Res
Title: In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time magnetic resonance imaging.
Volume: 65
Issue: 18
Pages: 8324-30
Publication
First Author: Saitoh A
Year: 1990
Journal: Oncogene
Title: Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes.
Volume: 5
Issue: 8
Pages: 1195-200
Publication
First Author: Maruyama T
Year: 2020
Journal: iScience
Title: ZAK Inhibitor PLX4720 Promotes Extrusion of Transformed Cells via Cell Competition.
Volume: 23
Issue: 7
Pages: 101327
Allele
Name: transgene insertion, Arizona Cancer Center
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
Genotype
Symbol: Irf1/Irf1 Tg(HRAS)2Jic/?
Background: involves: 129S2/SvPas * BALB/c * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(Upk2-HRAS*Q61L)12Xrw/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Upk2-HRAS*Q61L)5Xrw/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Milagre C
Year: 2010
Journal: Cancer Res
Title: A mouse model of melanoma driven by oncogenic KRAS.
Volume: 70
Issue: 13
Pages: 5549-57
Publication
First Author: Nozawa H
Year: 1999
Journal: Genes Dev
Title: Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53.
Volume: 13
Issue: 10
Pages: 1240-5
Publication
First Author: Gao J
Year: 2004
Journal: Oncogene
Title: p53 deficiency provokes urothelial proliferation and synergizes with activated Ha-ras in promoting urothelial tumorigenesis.
Volume: 23
Issue: 3
Pages: 687-96
Publication
First Author: Chin L
Year: 1999
Journal: Nature
Title: Essential role for oncogenic Ras in tumour maintenance.
Volume: 400
Issue: 6743
Pages: 468-72
Publication
First Author: Oshimori N
Year: 2015
Journal: Cell
Title: TGF-β promotes heterogeneity and drug resistance in squamous cell carcinoma.
Volume: 160
Issue: 5
Pages: 963-76
Strain
Attribute String: congenic, mutant strain, targeted mutation, transgenic
Allele
Name: transgene insertion 23, Axel Kahn
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
Allele
Name: transgene insertion 21, Axel Kahn
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
Allele
Name: transgene insertion 290, Biomodels Austria
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
Publication
First Author: Powell MB
Year: 1995
Journal: Mol Carcinog
Title: Hyperpigmentation and melanocytic hyperplasia in transgenic mice expressing the human T24 Ha-ras gene regulated by a mouse tyrosinase promoter.
Volume: 12
Issue: 2
Pages: 82-90
Publication
First Author: Broome Powell M
Year: 1999
Journal: Carcinogenesis
Title: Induction of melanoma in TPras transgenic mice.
Volume: 20
Issue: 9
Pages: 1747-53
Genotype
Symbol: Hras/Hras Nras/Nras Tg(HRAS)2Jic/?
Background: involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Kras/Kras<+> Nras/Nras Tg(HRAS)2Jic/?
Background: involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(Tyr-HRAS*G12V)#Acc/?
Background: involves: C3H/HeN * C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Tyr-HRAS*G12V)#Acc/Tg(Tyr-HRAS*G12V)#Acc
Background: involves: C3H/HeN * C57BL/6 * SJL
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Nonaka T
Year: 2016
Journal: J Clin Invest
Title: Involvement of activation-induced cytidine deaminase in skin cancer development.
Volume: 126
Issue: 4
Pages: 1367-82
Publication  
First Author: Huang W
Year: 2017
Journal: Nat Commun
Title: ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells.
Volume: 8
Pages: 15871
Publication
First Author: Mayes DA
Year: 2013
Journal: Cell Rep
Title: Nf1 loss and Ras hyperactivation in oligodendrocytes induce NOS-driven defects in myelin and vasculature.
Volume: 4
Issue: 6
Pages: 1197-212
Publication  
First Author: Huang L
Year: 2014
Journal: Nat Commun
Title: Decreased tumorigenesis in mice with a Kras point mutation at C118.
Volume: 5
Pages: 5410
Publication
First Author: Johnson CW
Year: 2019
Journal: Cell Rep
Title: Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D.
Volume: 28
Issue: 6
Pages: 1538-1550.e7
Publication
First Author: To MD
Year: 2008
Journal: Nat Genet
Title: Kras regulatory elements and exon 4A determine mutation specificity in lung cancer.
Volume: 40
Issue: 10
Pages: 1240-4
Publication
First Author: Modi BG
Year: 2012
Journal: Science
Title: Langerhans cells facilitate epithelial DNA damage and squamous cell carcinoma.
Volume: 335
Issue: 6064
Pages: 104-8
Publication
First Author: Reeves MQ
Year: 2018
Journal: Nat Cell Biol
Title: Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis.
Volume: 20
Issue: 6
Pages: 699-709
Publication
First Author: Zhu B
Year: 2012
Journal: Mol Cell Biol
Title: Peroxisome proliferator-activated receptor β/δ cross talks with E2F and attenuates mitosis in HRAS-expressing cells.
Volume: 32
Issue: 11
Pages: 2065-82
Publication
First Author: Kang HC
Year: 2013
Journal: J Invest Dermatol
Title: Ptch1 overexpression drives skin carcinogenesis and developmental defects in K14Ptch(FVB) mice.
Volume: 133
Issue: 5
Pages: 1311-20
Publication
First Author: Keeton AB
Year: 2017
Journal: Cancer Res
Title: The RAS-Effector Interaction as a Drug Target.
Volume: 77
Issue: 2
Pages: 221-226
Publication
First Author: Pineda CM
Year: 2019
Journal: J Cell Biol
Title: Hair follicle regeneration suppresses Ras-driven oncogenic growth.
Volume: 218
Issue: 10
Pages: 3212-3222
Publication
First Author: Xia Y
Year: 2021
Journal: Nat Commun
Title: Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis.
Volume: 12
Issue: 1
Pages: 2047
Publication
First Author: Mitsumori K
Year: 1998
Journal: Cancer Lett
Title: Pulmonary fibrosis caused by N-methyl-N-nitrosourethane inhibits lung tumorigenesis by urethane in transgenic mice carrying the human prototype c-Ha-ras gene.
Volume: 129
Issue: 2
Pages: 181-90
Publication
First Author: Gulezian D
Year: 2000
Journal: Toxicol Pathol
Title: Use of transgenic animals for carcinogenicity testing: considerations and implications for risk assessment.
Volume: 28
Issue: 3
Pages: 482-99
Publication
First Author: Zhou H
Year: 2012
Journal: Carcinogenesis
Title: Urothelial tumor initiation requires deregulation of multiple signaling pathways: implications in target-based therapies.
Volume: 33
Issue: 4
Pages: 770-80
Publication
First Author: Zhang ZT
Year: 2001
Journal: Oncogene
Title: Role of Ha-ras activation in superficial papillary pathway of urothelial tumor formation.
Volume: 20
Issue: 16
Pages: 1973-80
Allele
Name: transgene insertion 1, Roberto Di Lauro
Allele Type: Transgenic
Attribute String: Conditional ready, Inducible, Inserted expressed sequence
Strain
Attribute String: congenic, mutant strain, transgenic
Genotype
Symbol: Hras/Hras Kras/Kras Nras/Nras Tg(HRAS)7Mok/?
Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Flt4/Flt4<+> Tg(HRAS)2Jic/?
Background: involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Hras/Hras Kras/Kras<+> Nras/Nras<+> Tg(HRAS)2Jic/?
Background: involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(Pklr-HRAS*G12V)23Ak/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Pklr-HRAS*G12V)21Ak/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Ugdh/Ugdh H2az2/H2az2<+> Tg(Pax6-HRAS*G12V)2044Ove/?
Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Tg(RasE)290Biat/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(RasE)290Biat/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true