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Search results 701 to 800 out of 12470 for Impact

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Type Details Score
Publication
First Author: Hingorani DV
Year: 2018
Journal: PLoS One
Title: Impact of MMP-2 and MMP-9 enzyme activity on wound healing, tumor growth and RACPP cleavage.
Volume: 13
Issue: 9
Pages: e0198464
Publication
First Author: Cakarova L
Year: 2009
Journal: Am J Respir Crit Care Med
Title: Macrophage tumor necrosis factor-alpha induces epithelial expression of granulocyte-macrophage colony-stimulating factor: impact on alveolar epithelial repair.
Volume: 180
Issue: 6
Pages: 521-32
Publication
First Author: Chourbaji S
Year: 2011
Journal: PLoS One
Title: Differences in mouse maternal care behavior - is there a genetic impact of the glucocorticoid receptor?
Volume: 6
Issue: 4
Pages: e19218
Publication
First Author: Clarke JR
Year: 2015
Journal: EMBO Mol Med
Title: Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation.
Volume: 7
Issue: 2
Pages: 190-210
Publication
First Author: Kernbauer E
Year: 2013
Journal: PLoS One
Title: Route of Infection Determines the Impact of Type I Interferons on Innate Immunity to Listeria monocytogenes.
Volume: 8
Issue: 6
Pages: e65007
Publication
First Author: Winokur OC
Year: 2020
Journal: PLoS Negl Trop Dis
Title: Impact of temperature on the extrinsic incubation period of Zika virus in Aedes aegypti.
Volume: 14
Issue: 3
Pages: e0008047
Publication
First Author: Jeong JW
Year: 2006
Journal: Mol Endocrinol
Title: The genomic analysis of the impact of steroid receptor coactivators ablation on hepatic metabolism.
Volume: 20
Issue: 5
Pages: 1138-52
Publication
First Author: Wyburn K
Year: 2006
Journal: Am J Transplant
Title: Interleukin-18 affects local cytokine expression but does not impact on the development of kidney allograft rejection.
Volume: 6
Issue: 11
Pages: 2612-21
Publication
First Author: Nelson ED
Year: 2011
Journal: J Neurophysiol
Title: Selective impact of MeCP2 and associated histone deacetylases on the dynamics of evoked excitatory neurotransmission.
Volume: 106
Issue: 1
Pages: 193-201
Publication
First Author: Shao Y
Year: 2021
Journal: Genes Dev
Title: Identification and characterization of conserved noncoding cis-regulatory elements that impact Mecp2 expression and neurological functions.
Volume: 35
Issue: 7-8
Pages: 489-494
Publication
First Author: Dalloz C
Year: 2003
Journal: Hum Mol Genet
Title: Targeted inactivation of dystrophin gene product Dp71: phenotypic impact in mouse retina.
Volume: 12
Issue: 13
Pages: 1543-54
Publication  
First Author: Ovlund T
Year: 2021
Journal: Front Endocrinol (Lausanne)
Title: Impact of Incretin Hormone Receptors on Insulin-Independent Glucose Disposal in Model Experiments in Mice.
Volume: 12
Pages: 680153
Publication
First Author: Boele HJ
Year: 2018
Journal: Sci Adv
Title: Impact of parallel fiber to Purkinje cell long-term depression is unmasked in absence of inhibitory input.
Volume: 4
Issue: 10
Pages: eaas9426
Publication
First Author: Terauchi Y
Year: 2003
Journal: J Biol Chem
Title: Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice.
Volume: 278
Issue: 16
Pages: 14284-90
Publication
First Author: Tata BK
Year: 2012
Journal: Biol Reprod
Title: Fibroblast growth factor signaling deficiencies impact female reproduction and kisspeptin neurons in mice.
Volume: 86
Issue: 4
Pages: 119
Publication
First Author: Irsik DL
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: Renoprotective impact of estrogen receptor-α and its splice variants in female mice with type 1 diabetes.
Volume: 315
Issue: 3
Pages: F512-F520
Publication
First Author: Kobayashi D
Year: 2008
Journal: Neurobiol Aging
Title: BACE1 gene deletion: impact on behavioral function in a model of Alzheimer's disease.
Volume: 29
Issue: 6
Pages: 861-73
Publication
First Author: McColl SR
Year: 2006
Journal: FASEB J
Title: Immunomodulatory impact of the A2A adenosine receptor on the profile of chemokines produced by neutrophils.
Volume: 20
Issue: 1
Pages: 187-9
Publication
First Author: Avila G
Year: 2000
Journal: J Gen Physiol
Title: Functional impact of the ryanodine receptor on the skeletal muscle L-type Ca(2+) channel.
Volume: 115
Issue: 4
Pages: 467-80
Publication
First Author: Pang KC
Year: 2006
Journal: J Immunol
Title: Immunoproteasome subunit deficiencies impact differentially on two immunodominant influenza virus-specific CD8+ T cell responses.
Volume: 177
Issue: 11
Pages: 7680-8
Publication
First Author: Stahl JS
Year: 2004
Journal: J Neurophysiol
Title: Eye movements of the murine P/Q calcium channel mutant rocker, and the impact of aging.
Volume: 91
Issue: 5
Pages: 2066-78
Publication
First Author: Robertson KM
Year: 2002
Journal: Endocrinology
Title: The phenotype of the aromatase knockout mouse reveals dietary phytoestrogens impact significantly on testis function.
Volume: 143
Issue: 8
Pages: 2913-21
Publication
First Author: Stolt CC
Year: 2005
Journal: Dev Biol
Title: Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord.
Volume: 281
Issue: 2
Pages: 309-17
Publication
First Author: Burcham GN
Year: 2014
Journal: Am J Pathol
Title: Impact of prostate inflammation on lesion development in the POET3(+)Pten(+/-) mouse model of prostate carcinogenesis.
Volume: 184
Issue: 12
Pages: 3176-91
Publication
First Author: Delano MJ
Year: 2011
Journal: J Immunol
Title: Sepsis induces early alterations in innate immunity that impact mortality to secondary infection.
Volume: 186
Issue: 1
Pages: 195-202
Publication  
First Author: Klueh U
Year: 2016
Journal: Biosens Bioelectron
Title: Impact of CCL2 and CCR2 chemokine/receptor deficiencies on macrophage recruitment and continuous glucose monitoring in vivo.
Volume: 86
Pages: 262-269
Publication
First Author: Kharazi S
Year: 2011
Journal: Blood
Title: Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.
Volume: 118
Issue: 13
Pages: 3613-21
Publication
First Author: McElroy GS
Year: 2022
Journal: Sci Rep
Title: Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice.
Volume: 12
Issue: 1
Pages: 5196
Publication      
First Author: Smith A
Year: 2023
Journal: G3 (Bethesda)
Title: Cardiac muscle-restricted partial loss of Nos1ap expression has limited but significant impact on electrocardiographic features.
Publication
First Author: Ke F
Year: 2012
Journal: Cell Death Differ
Title: BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice.
Volume: 19
Issue: 6
Pages: 915-25
Publication
First Author: Cochran BJ
Year: 2016
Journal: Diabetes
Title: Impact of Perturbed Pancreatic β-Cell Cholesterol Homeostasis on Adipose Tissue and Skeletal Muscle Metabolism.
Volume: 65
Issue: 12
Pages: 3610-3620
Publication  
First Author: Bond ST
Year: 2021
Journal: Mol Metab
Title: Tissue-specific expression of Cas9 has no impact on whole-body metabolism in four transgenic mouse lines.
Volume: 53
Pages: 101292
Publication
First Author: Von Schulze A
Year: 2018
Journal: J Physiol
Title: Hepatic mitochondrial adaptations to physical activity: impact of sexual dimorphism, PGC1α and BNIP3-mediated mitophagy.
Volume: 596
Issue: 24
Pages: 6157-6171
Publication
First Author: Kühnisch J
Year: 2014
Journal: PLoS One
Title: Multiscale, converging defects of macro-porosity, microstructure and matrix mineralization impact long bone fragility in NF1.
Volume: 9
Issue: 1
Pages: e86115
Publication
First Author: Lange J
Year: 2018
Journal: Acta Neuropathol Commun
Title: Compromised astrocyte function and survival negatively impact neurons in infantile neuronal ceroid lipofuscinosis.
Volume: 6
Issue: 1
Pages: 74
Publication
First Author: Rooney GE
Year: 2016
Journal: J Neurosci
Title: Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome.
Volume: 36
Issue: 1
Pages: 142-52
Publication
First Author: Mishra AP
Year: 2023
Journal: Cell Death Dis
Title: Characterization of BRCA2 R3052Q variant in mice supports its functional impact as a low-risk variant.
Volume: 14
Issue: 11
Pages: 753
Publication
First Author: Sudarov A
Year: 2013
Journal: EMBO Mol Med
Title: Lis1 controls dynamics of neuronal filopodia and spines to impact synaptogenesis and social behaviour.
Volume: 5
Issue: 4
Pages: 591-607
Publication
First Author: Luque RM
Year: 2011
Journal: PLoS One
Title: Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropes.
Volume: 6
Issue: 1
Pages: e15767
Publication  
First Author: Katayama A
Year: 2015
Journal: Sci Rep
Title: Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis.
Volume: 5
Pages: 16920
Publication
First Author: Narayanan V
Year: 2011
Journal: PLoS One
Title: Social defeat: impact on fear extinction and amygdala-prefrontal cortical theta synchrony in 5-HTT deficient mice.
Volume: 6
Issue: 7
Pages: e22600
Publication  
First Author: Bearer EL
Year: 2018
Journal: Neurobiol Aging
Title: Alterations of functional circuitry in aging brain and the impact of mutated APP expression.
Volume: 70
Pages: 276-290
Publication
First Author: Yanada M
Year: 2002
Journal: Blood
Title: Impact of antithrombin deficiency in thrombogenesis: lipopolysaccharide and stress-induced thrombus formation in heterozygous antithrombin-deficient mice.
Volume: 99
Issue: 7
Pages: 2455-8
Publication
First Author: O'Tuathaigh CM
Year: 2010
Journal: Neuropsychopharmacology
Title: Chronic adolescent exposure to Δ-9-tetrahydrocannabinol in COMT mutant mice: impact on psychosis-related and other phenotypes.
Volume: 35
Issue: 11
Pages: 2262-73
Publication
First Author: Wallraff A
Year: 2006
Journal: J Neurosci
Title: The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus.
Volume: 26
Issue: 20
Pages: 5438-47
Publication
First Author: Toda K
Year: 2012
Journal: Endocrinology
Title: Impact of ovarian sex steroids on ovulation and ovulatory gene induction in aromatase-null mice.
Volume: 153
Issue: 1
Pages: 386-94
Publication
First Author: Jones KB
Year: 2016
Journal: Oncogene
Title: The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis.
Volume: 35
Issue: 38
Pages: 5021-32
Publication
First Author: Montavon T
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Impact of copy number variations (CNVs) on long-range gene regulation at the HoxD locus.
Volume: 109
Issue: 50
Pages: 20204-11
Publication
First Author: Hermiston ML
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses.
Volume: 106
Issue: 2
Pages: 546-51
Publication
First Author: Kofuji P
Year: 2000
Journal: J Neurosci
Title: Genetic inactivation of an inwardly rectifying potassium channel (Kir4.1 subunit) in mice: phenotypic impact in retina.
Volume: 20
Issue: 15
Pages: 5733-40
Publication
First Author: Hedrich J
Year: 2020
Journal: J Comp Neurol
Title: Cell type specific impact of cannabinoid receptor signaling in somatosensory barrel map formation in mice.
Volume: 528
Issue: 1
Pages: 3-13
Publication
First Author: Qiu L
Year: 2008
Journal: J Biol Chem
Title: Aldose reductase regulates hepatic peroxisome proliferator-activated receptor alpha phosphorylation and activity to impact lipid homeostasis.
Volume: 283
Issue: 25
Pages: 17175-83
Publication
First Author: Welsh J
Year: 2002
Journal: J Steroid Biochem Mol Biol
Title: Impact of the Vitamin D3 receptor on growth-regulatory pathways in mammary gland and breast cancer.
Volume: 83
Issue: 1-5
Pages: 85-92
Publication  
First Author: Nagy JA
Year: 2022
Journal: Front Neurol
Title: Assessing the therapeutic impact of resveratrol in ALS SOD1-G93A mice with electrical impedance myography.
Volume: 13
Pages: 1059743
Publication  
First Author: Setter DO
Year: 2018
Journal: Brain Behav Immun
Title: Impact of peripheral immune status on central molecular responses to facial nerve axotomy.
Volume: 68
Pages: 98-110
Publication  
First Author: Arnold W
Year: 2016
Journal: Neurobiol Dis
Title: The neuromuscular impact of symptomatic SMN restoration in a mouse model of spinal muscular atrophy.
Volume: 87
Pages: 116-23
Publication
First Author: Ruetten H
Year: 2019
Journal: Am J Physiol Renal Physiol
Title: Impact of sex, androgens, and prostate size on C57BL/6J mouse urinary physiology: functional assessment.
Volume: 317
Issue: 4
Pages: F996-F1009
Publication
First Author: Wells JE
Year: 2005
Journal: Eur J Neurosci
Title: Matrix metalloproteinase (MMP)-12 expression has a negative impact on sensorimotor function following intracerebral haemorrhage in mice.
Volume: 21
Issue: 1
Pages: 187-96
Publication
First Author: Zhu M
Year: 2010
Journal: Am J Respir Cell Mol Biol
Title: Impact of adiponectin deficiency on pulmonary responses to acute ozone exposure in mice.
Volume: 43
Issue: 4
Pages: 487-97
Publication
First Author: Amiri M
Year: 2024
Journal: Cell Rep
Title: Impact of eIF2α phosphorylation on the translational landscape of mouse embryonic stem cells.
Volume: 43
Issue: 1
Pages: 113615
Publication
First Author: Venken K
Year: 2007
Journal: J Bone Miner Res
Title: Impact of androgens, growth hormone, and IGF-I on bone and muscle in male mice during puberty.
Volume: 22
Issue: 1
Pages: 72-82
Publication
First Author: Oyama K
Year: 2018
Journal: Epigenetics Chromatin
Title: Deletion of HP1γ in cardiac myocytes affects H4K20me3 levels but does not impact cardiac growth.
Volume: 11
Issue: 1
Pages: 18
Publication  
First Author: Massana Muñoz X
Year: 2020
Journal: JCI Insight
Title: Physiological impact and disease reversion for the severe form of centronuclear myopathy linked to dynamin.
Volume: 5
Issue: 18
Publication
First Author: Ingvarsen S
Year: 2013
Journal: J Biol Chem
Title: Targeting a single function of the multifunctional matrix metalloprotease MT1-MMP: impact on lymphangiogenesis.
Volume: 288
Issue: 15
Pages: 10195-204
Publication  
First Author: Marazuela P
Year: 2022
Journal: Int J Mol Sci
Title: Impact of Cerebral Amyloid Angiopathy in Two Transgenic Mouse Models of Cerebral β-Amyloidosis: A Neuropathological Study.
Volume: 23
Issue: 9
Publication  
First Author: Sansbury BE
Year: 2014
Journal: Front Physiol
Title: Impact of nutrient excess and endothelial nitric oxide synthase on the plasma metabolite profile in mice.
Volume: 5
Pages: 453
Publication
First Author: Repa JJ
Year: 2004
Journal: Hepatology
Title: ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis.
Volume: 40
Issue: 5
Pages: 1088-97
Publication
First Author: Hall JD
Year: 2009
Journal: Clin Exp Immunol
Title: The impact of chemokine receptor CX3CR1 deficiency during respiratory infections with Mycobacterium tuberculosis or Francisella tularensis.
Volume: 156
Issue: 2
Pages: 278-84
Publication
First Author: Shyamala G
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Impact of progesterone receptor on cell-fate decisions during mammary gland development.
Volume: 97
Issue: 7
Pages: 3044-9
Publication
First Author: Pargmann D
Year: 2007
Journal: Eur J Immunol
Title: Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphocyte function.
Volume: 37
Issue: 12
Pages: 3551-63
Publication
First Author: Huang Y
Year: 2009
Journal: J Exp Med
Title: Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability.
Volume: 206
Issue: 4
Pages: 893-908
Publication
First Author: Gellner AK
Year: 2021
Journal: Brain Stimul
Title: Electrified microglia: Impact of direct current stimulation on diverse properties of the most versatile brain cell.
Volume: 14
Issue: 5
Pages: 1248-1258
Publication
First Author: Yu Q
Year: 2004
Journal: J Exp Med
Title: IL-7 receptor signals inhibit expression of transcription factors TCF-1, LEF-1, and RORgammat: impact on thymocyte development.
Volume: 200
Issue: 6
Pages: 797-803
Publication
First Author: Boesteanu A
Year: 2006
Journal: Int Immunol
Title: Impact of effector cell differentiation on CD4+ T cells that evade negative selection by a self-peptide.
Volume: 18
Issue: 7
Pages: 1017-27
Publication
First Author: Chen CCW
Year: 2018
Journal: Am J Physiol Endocrinol Metab
Title: Parkin is required for exercise-induced mitophagy in muscle: impact of aging.
Volume: 315
Issue: 3
Pages: E404-E415
Publication
First Author: Clifford S
Year: 2011
Journal: Addict Biol
Title: Impact of food restriction and cocaine on locomotion in ghrelin- and ghrelin-receptor knockout mice.
Volume: 16
Issue: 3
Pages: 386-92
Publication
First Author: Lund D
Year: 2010
Journal: Neuroscience
Title: Motor neuron-specific overexpression of the presynaptic choline transporter: impact on motor endurance and evoked muscle activity.
Volume: 171
Issue: 4
Pages: 1041-53
Publication
First Author: Calandreau L
Year: 2010
Journal: Genes Brain Behav
Title: Differential impact of polysialyltransferase ST8SiaII and ST8SiaIV knockout on social interaction and aggression.
Volume: 9
Issue: 8
Pages: 958-67
Publication
First Author: Alcoléa S
Year: 2004
Journal: Circ Res
Title: Replacement of connexin40 by connexin45 in the mouse: impact on cardiac electrical conduction.
Volume: 94
Issue: 1
Pages: 100-9
Publication
First Author: Chevalier NR
Year: 2024
Journal: Commun Biol
Title: Calcium wave dynamics in the embryonic mouse gut mesenchyme: impact on smooth muscle differentiation.
Volume: 7
Issue: 1
Pages: 1277
Publication  
First Author: Kobold S
Year: 2015
Journal: J Natl Cancer Inst
Title: Impact of a New Fusion Receptor on PD-1-Mediated Immunosuppression in Adoptive T Cell Therapy.
Volume: 107
Issue: 8
Publication  
First Author: Schott M
Year: 2022
Journal: Int J Mol Med
Title: Impact of CYLD on chromatin structure and histone methylation in malignant melanoma.
Volume: 49
Issue: 5
Publication  
First Author: Thuy AV
Year: 2022
Journal: Int J Mol Sci
Title: The Impact of Sphingosine Kinases on Inflammation-Induced Cytokine Release and Vascular Endothelial Barrier Integrity.
Volume: 23
Issue: 21
Publication
First Author: Martinic MM
Year: 2007
Journal: Diabetes
Title: Minimal impact of a de novo-expressed beta-cell autoantigen on spontaneous diabetes development in NOD mice.
Volume: 56
Issue: 4
Pages: 1059-68
Publication
First Author: Valdearcos M
Year: 2014
Journal: Cell Rep
Title: Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function.
Volume: 9
Issue: 6
Pages: 2124-38
Publication
First Author: Allen SJ
Year: 2011
Journal: J Virol
Title: Adaptive and innate transforming growth factor beta signaling impact herpes simplex virus 1 latency and reactivation.
Volume: 85
Issue: 21
Pages: 11448-56
Publication
First Author: Mayerl S
Year: 2012
Journal: Endocrinology
Title: Impact of Oatp1c1 deficiency on thyroid hormone metabolism and action in the mouse brain.
Volume: 153
Issue: 3
Pages: 1528-37
Publication  
First Author: Dorsett C
Year: 2021
Journal: eNeuro
Title: The Impact of SST and PV Interneurons on Nonlinear Synaptic Integration in the Neocortex.
Volume: 8
Issue: 5
Publication
First Author: Olah SS
Year: 2023
Journal: Cell Rep
Title: Acute reorganization of postsynaptic GABA(A) receptors reveals the functional impact of molecular nanoarchitecture at inhibitory synapses.
Volume: 42
Issue: 11
Pages: 113331
Publication
First Author: Rodríguez-Carballo E
Year: 2019
Journal: BMC Biol
Title: Impact of genome architecture on the functional activation and repression of Hox regulatory landscapes.
Volume: 17
Issue: 1
Pages: 55
Publication
First Author: Simonetti M
Year: 2021
Journal: Mol Psychiatry
Title: The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology.
Volume: 26
Issue: 4
Pages: 1376-1398
Publication
First Author: Li B
Year: 1999
Journal: Circ Res
Title: Insulin-like growth factor-1 attenuates the detrimental impact of nonocclusive coronary artery constriction on the heart.
Volume: 84
Issue: 9
Pages: 1007-19
Publication  
First Author: Valeri F
Year: 2021
Journal: Microorganisms
Title: Impact of the Age of Cecal Material Transfer Donors on Alzheimer's Disease Pathology in 5xFAD Mice.
Volume: 9
Issue: 12
Publication
First Author: Agrawal S
Year: 2022
Journal: Cell Mol Life Sci
Title: Impact of IL-21-associated peripheral and brain crosstalk on the Alzheimer's disease neuropathology.
Volume: 79
Issue: 6
Pages: 331
Publication  
First Author: Dos Santos Guilherme M
Year: 2020
Journal: Front Microbiol
Title: Impact of Acute and Chronic Amyloid-β Peptide Exposure on Gut Microbial Commensals in the Mouse.
Volume: 11
Pages: 1008
Publication  
First Author: Merz KE
Year: 2022
Journal: Front Endocrinol (Lausanne)
Title: Changes in Skeletal Muscle PAK1 Levels Regulate Tissue Crosstalk to Impact Whole Body Glucose Homeostasis.
Volume: 13
Pages: 821849
Publication
First Author: Rodrigues DC
Year: 2020
Journal: Cell Rep
Title: Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome.
Volume: 30
Issue: 12
Pages: 4179-4196.e11
Publication
First Author: Sawa M
Year: 2022
Journal: Alzheimers Dement
Title: Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model.
Volume: 18
Issue: 6
Pages: 1203-1234
Publication  
First Author: George RM
Year: 2023
Journal: Development
Title: Single cell evaluation of endocardial Hand2 gene regulatory networks reveals HAND2-dependent pathways that impact cardiac morphogenesis.
Volume: 150
Issue: 3
Publication  
First Author: Herold MJ
Year: 2014
Journal: Cell Death Dis
Title: Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice.
Volume: 5
Pages: e1446