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Search results 701 to 800 out of 851 for Lrp2

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Type Details Score
Publication
32332780 | J:292220
First Author: Seo JA
Year: 2020
Journal: Nat Commun
Title: Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity.
Volume: 11
Issue: 1
Pages: 2024
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Publication
30590522 | J:275641
First Author: Festa BP
Year: 2019
Journal: Hum Mol Genet
Title: OCRL deficiency impairs endolysosomal function in a humanized mouse model for Lowe syndrome and Dent disease.
Volume: 28
Issue: 12
Pages: 1931-1946
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Publication
31483289 | J:280893
First Author: Liu Y
Year: 2019
Journal: J Clin Invest
Title: Lactoferrin-induced myeloid-derived suppressor cell therapy attenuates pathologic inflammatory conditions in newborn mice.
Volume: 129
Issue: 10
Pages: 4261-4275
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Publication
27554085 | J:316650
First Author: Nasrallah R
Year: 2016
Journal: Blood
Title: Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes.
Volume: 128
Issue: 15
Pages: 1928-1939
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Publication
7979249 | -
 
First Author: Krieger M
Year: 1994
Journal: Annu Rev Biochem
Title: Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP).
Volume: 63
Pages: 601-37
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Publication
7548065 | -
First Author: Bieri S
Year: 1995
Journal: Biochemistry
Title: Disulfide bridges of a cysteine-rich repeat of the LDL receptor ligand-binding domain.
Volume: 34
Issue: 40
Pages: 13059-65
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Publication
3283935 | -
First Author: Mahley RW
Year: 1988
Journal: Science
Title: Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.
Volume: 240
Issue: 4852
Pages: 622-30
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Protein Domain
IPR023415 | LDLR_class-A_CS
Type: Conserved_site
Description: Low-density lipoprotein (LDL) receptors are the major cholesterol-carrying lipoproteins of plasma. Seven successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein []. Similar domains have been found (see references in []) in other extracellular and membrane proteins which are listed below: Vertebrate very low density lipoprotein (VLDL) receptor, which binds and transports VLDL. Its extracellular domain is composed of 8 LDLRA domains, 3 EGF-like domains and 6 LDL-receptor class B domains (LDLRB). Vertebrate low-density lipoprotein receptor-related protein 1 (LRP1) (reviewed in []), which may act as a receptor for the endocytosis of extracellular ligands. LRP1 contains 31 LDLRA domains and 22 EGF-like domains. Vertebrate low-density lipoprotein receptor-related protein 2 (LRP2) (also known as gp330 or megalin). LRP2 contains 36 LDLRA domains and 17 EGF-like domains. A LRP-homologue from Caenorhabditis elegans, which contains 35 LDLRA domains and 17 EGF-like domains. Drosophila putative vitellogenin receptor, with 13 copies of LDLRA domains and 17 EGF-like repeats. Complement factor I, which is responsible for cleaving the alpha-chains of C4b and C3b. It consists of a FIMAC domain (Factor I/MAC proteins C6/C7), a scavenger receptor-like domain, 2 copies of LDLRA and a C-terminal serine protease domain. Complement components C6, C7, C8 and C9. They contain each one LDLRA domain. Perlecan, a large multidomain basement membrane heparan sulphate proteoglycan composed of 4 LDLRA domains, 3 LamB domains, 12 laminin EGF- like domains, 14-21 IG-like domains, 3 LamG domains, and 4 EGF-like domains. A similar but shorter proteoglycan (UNC52) is found in Caenorhabditis elegans which has 3 repeats of LDLRA. Invertebrate giant extracellular hemoglobin linker chains, which allow heme-containing chains to construct giant hemoglobin (1 LDLRA domain). G-protein coupled receptor Grl101 of the snail Lymnaea stagnalis, which might directly transduce signals carried by large extracellular proteins. Vertebrate enterokinase (EC 3.4.21.9), a type II membrane protein of the intestinal brush border, which activates trypsinogen. It consists at least of a catalytic light chain and a multidomain heavy chain which has 2 LDLRA, a MAM domain (see ), a SRCR domain (see ) and a CUB domain (see ).Human autosomal dominant polycystic kidney disease protein 1 (PKD1), which is involved in adhesive protein-protein and protein-carbohydrate interactions. The potential calcium-binding site of its single LDLRA domain is missing. Vertebrate integral membrane protein DGCR2/IDD, a potential adhesion receptor with 1 LDLRA domain, a C-type lectin and a VWFC domain (see ).Drosophila serine protease nudel (EC 3.4.21.-), which is involved in the induction of dorsoventral polarity of the embryo. It has 11 LDLRA domains, 3 of which miss the first disulphide bond (C1-C3). Avian subgroup A rous sarcoma virus receptor (1 copy of LDLRA). Bovine Sco-spondin, which is secreted by the subcommissural organ in embryos and is involved in the modulation of neuronal aggregation. It contains at least 2 EGF-like domains and 3 LDLRA domains. The LDL-receptor class A domain contains 6 disulphide-bound cysteines []and a highly conserved cluster of negatively charged amino acids, of which many are clustered on one face of the module []. A schematic representation of this domain is shown here: +---------------------+ +--------------------------------+| | | |-CxxxxxxxxxxxxCxxxxxxxxCxxxxxxxxCxxxxxxxxxxCxxxxxxxxxxxxxxxxxxxxxC-|*******************************************| |+----------------------------+'C': conserved cysteine involved in a disulphide bond.'x': any residue.'*': position of the pattern.In LDL-receptors the class A domains form the binding site for LDL []and calcium. The acidic residues between the fourth and sixth cysteines are important for high-affinity binding of positively charged sequences in LDLR's ligands []. The repeat has been shown []to consist of a β-hairpin structure followed by a series of β-turns. The binding of calcium seems to induce no significant conformational change.
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Protein
Q9Z1P5
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: false
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Protein
A2AR95
Organism: Mus musculus/domesticus
Length: 345  
Fragment?: false
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Protein
Q8BWJ4
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: false
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Protein
J3QNN2
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
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Protein
A0A068BES0
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: false
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Protein
F6UAC8
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: true
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Protein
S4R2B5
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: false
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Protein
E9Q643
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: true
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Protein
B7ZND2
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: false
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Protein
A0A068BD29
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: false
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Protein
A0A087WPW4
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: false
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Protein
Q6P220
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: false
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Protein
B2RR20
Organism: Mus musculus/domesticus
Length: 345  
Fragment?: false
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Protein
Q4VAH9
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: false
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Protein
Q3V346
Organism: Mus musculus/domesticus
Length: 426  
Fragment?: false
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Protein
A2AJA7
Organism: Mus musculus/domesticus
Length: 1228  
Fragment?: false
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Protein
Q8BNJ6
Organism: Mus musculus/domesticus
Length: 525  
Fragment?: false
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Protein
Q8R4I7
Organism: Mus musculus/domesticus
Length: 533  
Fragment?: false
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Protein
Q7TQH7
Organism: Mus musculus/domesticus
Length: 713  
Fragment?: false
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Protein
Q8CB67
Organism: Mus musculus/domesticus
Length: 483  
Fragment?: false
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Protein
Q8BUJ9
Organism: Mus musculus/domesticus
Length: 858  
Fragment?: false
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Protein
Q8K480
Organism: Mus musculus/domesticus
Length: 584  
Fragment?: false
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Protein
Q91VN0
Organism: Mus musculus/domesticus
Length: 1614  
Fragment?: false
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Protein
A2AJX4
Organism: Mus musculus/domesticus
Length: 2123  
Fragment?: false
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Protein
P98154
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: false
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Protein
Q9R097
Organism: Mus musculus/domesticus
Length: 507  
Fragment?: false
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Protein
O88572
Organism: Mus musculus/domesticus
Length: 1613  
Fragment?: false
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Protein
Q8BRY4
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: true
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Protein
Q6P5A9
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: false
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Protein
Q8C2R4
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: false
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Protein
Q3US54
Organism: Mus musculus/domesticus
Length: 682  
Fragment?: true
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Protein
Q3TD85
Organism: Mus musculus/domesticus
Length: 713  
Fragment?: false
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Protein
D3Z5M3
Organism: Mus musculus/domesticus
Length: 285  
Fragment?: false
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Protein
A0A0R4J1M6
Organism: Mus musculus/domesticus
Length: 546  
Fragment?: false
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Protein
D3Z2B1
Organism: Mus musculus/domesticus
Length: 438  
Fragment?: false
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Protein
Q6ZQH9
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: true
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Protein
Q3TQ62
Organism: Mus musculus/domesticus
Length: 546  
Fragment?: false
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Protein
Q3TS86
Organism: Mus musculus/domesticus
Length: 619  
Fragment?: true
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Protein
A0A0N4SVX0
Organism: Mus musculus/domesticus
Length: 781  
Fragment?: true
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Protein
E9Q711
Organism: Mus musculus/domesticus
Length: 769  
Fragment?: false
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Protein
D3YY20
Organism: Mus musculus/domesticus
Length: 1232  
Fragment?: false
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Protein
E9Q548
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
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Protein
Q3V1Z1
Organism: Mus musculus/domesticus
Length: 713  
Fragment?: false
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Protein
Q3UI55
Organism: Mus musculus/domesticus
Length: 1614  
Fragment?: false
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Protein
E0CXS1
Organism: Mus musculus/domesticus
Length: 324  
Fragment?: false
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Protein
Q3UV32
Organism: Mus musculus/domesticus
Length: 1037  
Fragment?: true
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Protein
Q571K3
Organism: Mus musculus/domesticus
Length: 1639  
Fragment?: true
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Protein
A0A0U1RNR7
Organism: Mus musculus/domesticus
Length: 584  
Fragment?: false
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Protein
Q3U454
Organism: Mus musculus/domesticus
Length: 1457  
Fragment?: true
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Protein
Q3UEU3
Organism: Mus musculus/domesticus
Length: 638  
Fragment?: false
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Protein
Q3UEV4
Organism: Mus musculus/domesticus
Length: 770  
Fragment?: true
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Protein
F8WIN7
Organism: Mus musculus/domesticus
Length: 498  
Fragment?: false
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Protein
F6QNH6
Organism: Mus musculus/domesticus
Length: 1130  
Fragment?: true
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Protein
A0A0R4J0A9
Organism: Mus musculus/domesticus
Length: 1613  
Fragment?: false
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Protein
E9Q1T6
Organism: Mus musculus/domesticus
Length: 790  
Fragment?: false
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Protein
D3Z3A7
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: true
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Protein
E9QNU3
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: false
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Protein
Q8CB23
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
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Protein
Q9D3K4
Organism: Mus musculus/domesticus
Length: 507  
Fragment?: false
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Protein
B2RXQ6
Organism: Mus musculus/domesticus
Length: 518  
Fragment?: false
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Protein
Q3U5J2
Organism: Mus musculus/domesticus
Length: 743  
Fragment?: false
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Publication
6091915 | -
First Author: Yamamoto T
Year: 1984
Journal: Cell
Title: The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA.
Volume: 39
Issue: 1
Pages: 27-38
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Publication
7603991 | -
First Author: Daly NL
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Three-dimensional structure of a cysteine-rich repeat from the low-density lipoprotein receptor.
Volume: 92
Issue: 14
Pages: 6334-8
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Protein
Q61129
Organism: Mus musculus/domesticus
Length: 603  
Fragment?: false
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Protein
P35951
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
Q924X6
Organism: Mus musculus/domesticus
Length: 996  
Fragment?: false
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Protein
Q9JI18
Organism: Mus musculus/domesticus
Length: 4599  
Fragment?: false
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Protein
Q8VI56
Organism: Mus musculus/domesticus
Length: 1905  
Fragment?: false
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Protein
Q91ZX7
Organism: Mus musculus/domesticus
Length: 4545  
Fragment?: false
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Protein
Q9Z319
Organism: Mus musculus/domesticus
Length: 1113  
Fragment?: false
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Protein
P06683
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: false
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Protein
Q8BH35
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
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Protein
Q8K182
Organism: Mus musculus/domesticus
Length: 587  
Fragment?: false
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Protein
Q8CG65
Organism: Mus musculus/domesticus
Length: 4998  
Fragment?: false
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Protein
Q9JIQ8
Organism: Mus musculus/domesticus
Length: 490  
Fragment?: false
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Protein
Q6R6I7
Organism: Mus musculus/domesticus
Length: 758  
Fragment?: false
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Protein
Q91ZZ5
Organism: Mus musculus/domesticus
Length: 737  
Fragment?: false
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Protein
Q8K1T0
Organism: Mus musculus/domesticus
Length: 453  
Fragment?: false
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Protein
P98156
Organism: Mus musculus/domesticus
Length: 873  
Fragment?: false
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Protein
O88307
Organism: Mus musculus/domesticus
Length: 2215  
Fragment?: false
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Protein
A2ARV4
Organism: Mus musculus/domesticus
Length: 4660  
Fragment?: false
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Protein
E9Q0U9
Organism: Mus musculus/domesticus
Length: 713  
Fragment?: false
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Protein
A2A997
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
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Protein
Q2M1G4
Organism: Mus musculus/domesticus
Length: 453  
Fragment?: false
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Protein
Q91ZJ1
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
Q3TZ06
Organism: Mus musculus/domesticus
Length: 475  
Fragment?: false
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Protein
B1AXJ5
Organism: Mus musculus/domesticus
Length: 896  
Fragment?: false
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Protein
Q9QXT7
Organism: Mus musculus/domesticus
Length: 769  
Fragment?: false
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Protein
B7ZMU6
Organism: Mus musculus/domesticus
Length: 727  
Fragment?: false
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Protein
A0A140LJC7
Organism: Mus musculus/domesticus
Length: 2098  
Fragment?: false
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Protein
Q3TDD1
Organism: Mus musculus/domesticus
Length: 810  
Fragment?: false
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Protein
B1AXJ3
Organism: Mus musculus/domesticus
Length: 832  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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Cambridge CB2 3EH, United Kingdom