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Search results 701 to 800 out of 893 for Lyn

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Hits by Strain

Type Details Score
Strain
MGI:7836883 | C57BL/6N-Lyn<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Hcls1/Hcls1
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hcls1/Hcls1
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: involves: 129S4/SvJae
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: involves: 129S1/Sv
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: B6.129S4-Lyn
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: involves: 129S4/SvJaeSor
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: involves: 129S4/SvJaeSor * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: C57BL/6JAnu-Lyn
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: C57B/6JAnu-Lyn/AnuApb
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hcls1/Hcls1
Background: C57BL/6NCrl-Hcls1/Ccpcz
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: C57BL/6N-Lyn/H
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: involves: 129S4/SvJaeSor * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Allele
Gt(ROSA)26Sor<tm8Sia> | MGI:5308572
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 8, Shinichi Aizawa
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Cd22/Cd22<+> Lyn/Lyn<+> Tg(IghelMD4)4Ccg/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Il5ra/Il5ra Lyn/Lyn
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hcls1/Hcls1 Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn Mpl/Mpl
Background: B6.129S1-Mpl
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd19/Cd19 Lyn/Lyn
Background: involves: 129S4/SvJaeSor * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn Tg(Itgax-cre)1-1Reiz/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn<+>
Background: C57BL/6J-Lyn
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn<+>
Background: C57BL/6J-Lyn
Zygosity: ht
Has Mutant Allele: true
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Protein Domain
IPR003110 | Phos_immunorcpt_sig_ITAM
Type: Repeat
Description: Phosphorylated immunoreceptor signalling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases []. Motif may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.
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Genotype
Genotype
Symbol: Lyn/Lyn<+> Ptpn6/Ptpn6<+> Tg(IghelMD4)4Ccg/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
16684964 | -
First Author: Heiss E
Year: 2006
Journal: Blood
Title: Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2.
Volume: 108
Issue: 5
Pages: 1542-50
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Publication
9469421 | -
First Author: Malbec O
Year: 1998
Journal: J Immunol
Title: Fc epsilon receptor I-associated lyn-dependent phosphorylation of Fc gamma receptor IIB during negative regulation of mast cell activation.
Volume: 160
Issue: 4
Pages: 1647-58
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Allele
Gt(ROSA)26Sor<tm8.1Sia> | MGI:5308579
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 8.1, Shinichi Aizawa
Allele Type: Targeted
Attribute String: Reporter
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22<+> Lyn/Lyn<+> Ptpn6/Ptpn6<+> Tg(IghelMD4)4Ccg/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Igh/Igh Lyn/Lyn
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Igh/Igh Lyn/Lyn
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn<+>
Background: C57BL/6N-Lyn/H
Zygosity: ht
Has Mutant Allele: true
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Publication
9126384 | J:51726
First Author: Yamabhai M
Year: 1997
Journal: Anal Biochem
Title: Examining the specificity of Src homology 3 domain--ligand interactions with alkaline phosphatase fusion proteins.
Volume: 247
Issue: 1
Pages: 143-51
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:3785472 | B6.Cg-Hck<tm1Hev> Fgr<tm1Hev> Lyn<tm1Sor>
Attribute String: congenic, targeted mutation
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Genotype
Genotype
Symbol: Fgr/Fgr Hck/Hck Lyn/Lyn
Background: B6.Cg-Hck Fgr Lyn
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn Myd88/Myd88 Tg(Itgax-cre)1-1Reiz/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Publication
7687428 | -
First Author: Roifman CM
Year: 1993
Journal: Biochem Biophys Res Commun
Title: CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells.
Volume: 194
Issue: 1
Pages: 222-5
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Protein Domain
IPR035852 | Lyn_SH2
Type: Domain
Description: Lyn is a member of the Src non-receptor type tyrosine kinase family. It plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance [, ]. It also mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils [, , ]. Lyn plays an essential role in the transmission of signals through phosphorylation of tyrosine residues within the immunoreceptor tyrosine-based inhibitory motifs (ITIM) in regulatory proteins [, ].This entry represents the SH2 domain of Lyn.The Src non-receptor type tyrosine kinase (SFK) family members have an unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail. The SH2 domain of SFKs is involved in kinase autoinhibition and T-cell receptor signaling. The binding SH2 domains to phosphotyrosine (pY) sites is critical for the autoinhibition and substrate recognition of the SFKs [].
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Publication
17127394 | -
 
First Author: Sampson M
Year: 2007
Journal: Front Biosci
Title: Src kinases in G-CSF receptor signaling.
Volume: 12
Pages: 1463-74
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Protein Domain
IPR035748 | Lyn_SH3
Type: Domain
Description: Lyn is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lyn is expressed in B lymphocytes and myeloid cells. It exhibits both positive and negative regulatory roles in B cell receptor (BCR) signaling. Lyn, as well as Fyn and Blk, promotes B cell activation by phosphorylating ITAMs (immunoreceptor tyr activation motifs) in CD19 and in Ig components of BCR []. It negatively regulates signaling by its unique ability to phosphorylate ITIMs (immunoreceptor tyr inhibition motifs) in cell surface receptors like CD22 and CD5 []. Lyn also plays an important role in G-CSF receptor signaling by phosphorylating a variety of adaptor molecules []. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction [, ].
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Publication
9630982 | J:35786
First Author: Sparks AB
Year: 1996
Journal: Nat Biotechnol
Title: Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins.
Volume: 14
Issue: 6
Pages: 741-4
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Publication
24056697 | J:207426
First Author: Okamoto M
Year: 2013
Journal: Nat Neurosci
Title: TAG-1-assisted progenitor elongation streamlines nuclear migration to optimize subapical crowding.
Volume: 16
Issue: 11
Pages: 1556-66
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Publication
34189385 | J:310632
First Author: Yoshioka H
Year: 2021
Journal: JBMR Plus
Title: Single-Cell RNA-Sequencing Reveals the Breadth of Osteoblast Heterogeneity.
Volume: 5
Issue: 6
Pages: e10496
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Publication
25810396 | -
First Author: Ainsua-Enrich E
Year: 2015
Journal: J Immunol
Title: The adaptor 3BP2 is required for KIT receptor expression and human mast cell survival.
Volume: 194
Issue: 9
Pages: 4309-18
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Publication
18336269 | -
First Author: Hatani T
Year: 2008
Journal: Curr Med Chem
Title: Adaptor protein 3BP2 and cherubism.
Volume: 15
Issue: 6
Pages: 549-54
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Publication
22153076 | J:178917
First Author: Levaot N
Year: 2011
Journal: Cell
Title: Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism.
Volume: 147
Issue: 6
Pages: 1324-39
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Publication
15751964 | -
First Author: Qu X
Year: 2005
Journal: Biochemistry
Title: Tyrosine phosphorylation of adaptor protein 3BP2 induces T cell receptor-mediated activation of transcription factor.
Volume: 44
Issue: 10
Pages: 3891-8
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Protein
D3Z107
Organism: Mus musculus/domesticus
Length: 45  
Fragment?: true
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Protein Domain
IPR035847 | SH3BP2_SH2
Type: Domain
Description: The adaptor protein 3BP2/SH3BP2 is a cytoplasmic adaptor that contributes to the regulation of immune responses []. The protein-tyrosine kinase Syk phosphorylates 3BP2 which results in the activation of Rac1 through the interaction with the SH2 domain of Vav1 and induces the binding to the SH2 domain of the upstream protein-tyrosine kinase Lyn and enhances its kinase activity []. 3BP2 has a positive regulatory role in IgE-mediated mast cell activation []. In lymphocytes, engagement of T cell or B cell receptors triggers tyrosine phosphorylation of 3BP2 []. 3BP2 is required for the proliferation of B cells and B cell receptor signaling. Mutations in the 3BP2 gene are responsible for cherubism resulting in excessive bone resorption in the jaw [].This entry represents the SH2 domain of SH3BP2.
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Protein Domain
IPR035848 | SH3BP2
Type: Family
Description: The adaptor protein 3BP2/SH3BP2 is a cytoplasmic adaptor that contributes to the regulation of immune responses []. The protein-tyrosine kinase Syk phosphorylates 3BP2 which results in the activation of Rac1 through the interaction with the SH2 domain of Vav1 and induces the binding to the SH2 domain of the upstream protein-tyrosine kinase Lyn and enhances its kinase activity []. 3BP2 has a positive regulatory role in IgE-mediated mast cell activation []. In lymphocytes, engagement of T cell or B cell receptors triggers tyrosine phosphorylation of 3BP2 []. 3BP2 is required for the proliferation of B cells and B cell receptor signaling. Mutations in the 3BP2 gene are responsible for cherubism resulting in excessive bone resorption in the jaw [].
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Publication
9670936 | J:48581
First Author: Takemoto Y
Year: 1998
Journal: J Immunol
Title: Growth factor receptor-bound protein 2 (Grb2) association with hemopoietic specific protein 1: linkage between Lck and Grb2.
Volume: 161
Issue: 2
Pages: 625-30
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Publication
26195767 | J:226061
First Author: De S
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Erlotinib protects against LPS-induced endotoxicity because TLR4 needs EGFR to signal.
Volume: 112
Issue: 31
Pages: 9680-5
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Publication
17905674 | -
First Author: Ingley E
Year: 2008
Journal: Biochim Biophys Acta
Title: Src family kinases: regulation of their activities, levels and identification of new pathways.
Volume: 1784
Issue: 1
Pages: 56-65
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Publication
18563293 | -
First Author: Engen JR
Year: 2008
Journal: Cell Mol Life Sci
Title: Structure and dynamic regulation of Src-family kinases.
Volume: 65
Issue: 19
Pages: 3058-73
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Publication
11961256 | -
First Author: Lynch DT
Year: 2002
Journal: J Gen Virol
Title: Epstein-Barr virus latent membrane protein 2B (LMP2B) co-localizes with LMP2A in perinuclear regions in transiently transfected cells.
Volume: 83
Issue: Pt 5
Pages: 1025-35
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Publication
17035319 | -
First Author: Rovedo M
Year: 2007
Journal: J Virol
Title: Epstein-barr virus latent membrane protein 2B (LMP2B) modulates LMP2A activity.
Volume: 81
Issue: 1
Pages: 84-94
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Publication
26067064 | -
First Author: Rancan C
Year: 2015
Journal: PLoS Pathog
Title: Latent Membrane Protein LMP2A Impairs Recognition of EBV-Infected Cells by CD8+ T Cells.
Volume: 11
Issue: 6
Pages: e1004906
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Publication
12502882 | -
First Author: Geimonen E
Year: 2003
Journal: J Virol
Title: Hantavirus pulmonary syndrome-associated hantaviruses contain conserved and functional ITAM signaling elements.
Volume: 77
Issue: 2
Pages: 1638-43
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Protein Domain
IPR012316 | ITAM_motif_hantavir-typ
Type: Domain
Description: Signal transduction by T and B cell antigen receptors and certain receptorsfor Ig Fc regions involves a conserved sequence motif, termed animmunoreceptor tyrosine-based activation motif (ITAM). It is also found in thecytoplasmic domain of the apoptosis receptor. Phosphorylation of the two ITAMtyrosines is a critical event in signal transduction. All (p)2ITAMs, but nottheir nonphosphorylated counterparts, induced extensive protein tyrosinephosphorylation in permeabilised cells. After binding of the ligand via an SH2domain, phosphorylation of the two conserved tyrosines of ITAM creates binding sites for downstream signalling molecules and thus enables the initiation of signalling events. This phosphorylation was found to reflect activation of the src family kinases Lyn and Syk. Different ITAMs may preferentially activate distinct signalling pathways as a consequence of distinct SH2 effector binding preference [, ]. Furthermore, in viruses, ITAMs may play key roles in viral pathogenesis by regulating viral clearance, immune cell activation, immune cell recruitment through binding of cellular kinases and thereby down regulate their function [].This motif can be found in one to three copies and in association with the Ig-like domain. Proteins currently known to contain an ITAM motif are:Mammalian alpha and beta immunoglobulin proteins, TCR gamma receptors, FCR gamma receptors subunits, CD3 chains receptors and NFAT activation molecule.Hantavirus cytoplasmic elements.
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Protein Domain
IPR010881 | Herpes_LMP2
Type: Family
Description: This family consists of several Gammaherpesvirus latent membrane protein (LMP2) proteins. Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4) is a human gammaherpesvirus that infects and establishes latency in B lymphocytes in vivo. The latent membrane protein 2 (LMP2) gene is expressed in latently infected B cells and encodes two protein isoforms, LMP2A and LMP2B, that are identical except for an additional N-terminal 119 aa cytoplasmic domain which is present in the LMP2A isoform. LMP2A is thought to play a key role in either the establishment or the maintenance of latency and/or the reactivation of productive infection from the latent state. It modulates B-cell receptor signal transduction through its association with the cellular tyrosine kinases Lyn and Syk via specific motifs at the N-terminal tail domain. LMP2A also modulates the immune system reducing infected B cells recognition by EBV-specific CD8+ T cells []. The significance of LMP2B and its role in pathogenesis remain unclear. It is suggested that it may be a negative regulator of LMP2A [, ].
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Publication
8125254 | J:16994
First Author: Lowell CA
Year: 1994
Journal: Genes Dev
Title: Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity.
Volume: 8
Issue: 4
Pages: 387-98
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Publication
11514602 | J:71100
First Author: Kraus M
Year: 2001
Journal: J Exp Med
Title: Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail.
Volume: 194
Issue: 4
Pages: 455-69
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Publication
27992403 | J:259481
First Author: Cheng D
Year: 2017
Journal: Nat Immunol
Title: Themis2 lowers the threshold for B cell activation during positive selection.
Volume: 18
Issue: 2
Pages: 205-213
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Publication
17254966 | J:120363
First Author: Grimmler M
Year: 2007
Journal: Cell
Title: Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.
Volume: 128
Issue: 2
Pages: 269-80
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Publication
16950138 | J:129743
First Author: Rahaman SO
Year: 2006
Journal: Cell Metab
Title: A CD36-dependent signaling cascade is necessary for macrophage foam cell formation.
Volume: 4
Issue: 3
Pages: 211-21
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Publication
33083760 | J:305934
First Author: Thim-Uam A
Year: 2020
Journal: iScience
Title: STING Mediates Lupus via the Activation of Conventional Dendritic Cell Maturation and Plasmacytoid Dendritic Cell Differentiation.
Volume: 23
Issue: 9
Pages: 101530
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Publication
17641017 | J:149951
First Author: Kin NW
Year: 2007
Journal: J Immunol
Title: CD86 regulates IgG1 production via a CD19-dependent mechanism.
Volume: 179
Issue: 3
Pages: 1516-23
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Publication
18362175 | J:133999
First Author: Weber M
Year: 2008
Journal: J Exp Med
Title: Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen.
Volume: 205
Issue: 4
Pages: 853-68
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Publication
29187734 | J:256286
First Author: Wu JL
Year: 2017
Journal: Nat Commun
Title: O-GlcNAcylation is required for B cell homeostasis and antibody responses.
Volume: 8
Issue: 1
Pages: 1854
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Publication
32958780 | J:298168
First Author: Hao JW
Year: 2020
Journal: Nat Commun
Title: CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis.
Volume: 11
Issue: 1
Pages: 4765
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Publication
9442388 | J:45252
First Author: Heyer J
Year: 1997
Journal: Immunobiology
Title: Inefficient termination of antigen responses in NF-ATp-deficient mice.
Volume: 198
Issue: 1-3
Pages: 162-9
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Publication
36072548 | J:328242
First Author: Zhang J
Year: 2022
Journal: iScience
Title: Na/K-ATPase suppresses LPS-induced pro-inflammatory signaling through Lyn.
Volume: 25
Issue: 9
Pages: 104963
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Publication
17045207 | J:114975
First Author: Yang J
Year: 2006
Journal: Cancer Cell
Title: Targeting beta2-microglobulin for induction of tumor apoptosis in human hematological malignancies.
Volume: 10
Issue: 4
Pages: 295-307
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Publication
9768760 | J:129571
First Author: Caldwell RG
Year: 1998
Journal: Immunity
Title: Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals.
Volume: 9
Issue: 3
Pages: 405-11
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Publication
15637135 | J:98413
First Author: Kitaura J
Year: 2005
Journal: Blood
Title: IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion.
Volume: 105
Issue: 8
Pages: 3222-9
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Publication
10933394 | J:112423
First Author: Fujimoto M
Year: 2000
Journal: Immunity
Title: CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification.
Volume: 13
Issue: 1
Pages: 47-57
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Publication
17631277 | J:123490
First Author: Yu J
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Synthetic glycan ligand excludes CD22 from antigen receptor-containing lipid rafts.
Volume: 360
Issue: 4
Pages: 759-64
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Publication
19198591 | J:146475
First Author: Rub A
Year: 2009
Journal: Nat Immunol
Title: Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function.
Volume: 10
Issue: 3
Pages: 273-80
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Publication
29757188 | J:277878
First Author: Wu R
Year: 2018
Journal: J Clin Invest
Title: MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.
Volume: 128
Issue: 6
Pages: 2551-2568
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Publication
25199687 | J:244222
First Author: Hayashi S
Year: 2014
Journal: Dev Cell
Title: Protocadherin-17 mediates collective axon extension by recruiting actin regulator complexes to interaxonal contacts.
Volume: 30
Issue: 6
Pages: 673-87
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Protein
P20491
Organism: Mus musculus/domesticus
Length: 86  
Fragment?: false
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Protein
P24161
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: false
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Protein
Q3UU54
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: false
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Protein
J3QMU3
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Protein
A2MZG6
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: false
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Publication
34687271 | J:320899
First Author: Kishi K
Year: 2021
Journal: Genesis
Title: Repetitive short-pulsed illumination efficiently activates photoactivatable-Cre as continuous illumination in embryonic stem cells and pre-implantation embryos of transgenic mouse.
Volume: 59
Issue: 12
Pages: e23457
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Publication
10587346 | J:124758
First Author: Cheng PC
Year: 1999
Journal: J Exp Med
Title: A role for lipid rafts in B cell antigen receptor signaling and antigen targeting.
Volume: 190
Issue: 11
Pages: 1549-60
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Publication
11238609 | J:124754
First Author: Cheng PC
Year: 2001
Journal: J Immunol
Title: Translocation of the B cell antigen receptor into lipid rafts reveals a novel step in signaling.
Volume: 166
Issue: 6
Pages: 3693-701
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Publication
21930792 | J:178776
First Author: Draber P
Year: 2011
Journal: Mol Cell Biol
Title: SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling.
Volume: 31
Issue: 22
Pages: 4550-62
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Publication
19508371 | J:155066
First Author: Akimoto M
Year: 2009
Journal: Scand J Immunol
Title: Protein tyrosine phosphatase epsilon is a negative regulator of FcepsilonRI-mediated mast cell responses.
Volume: 69
Issue: 5
Pages: 401-11
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Publication
19923443 | J:158032
First Author: Wang D
Year: 2010
Journal: FASEB J
Title: Enhanced adaptive immunity in mice lacking the immunoinhibitory adaptor Hacs1.
Volume: 24
Issue: 3
Pages: 947-56
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Publication
12054674 | J:77381
First Author: Wang L
Year: 2002
Journal: Biochem Biophys Res Commun
Title: Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms.
Volume: 293
Issue: 5
Pages: 1426-30
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Publication
12538589 | J:82577
First Author: Xu H
Year: 2003
Journal: J Biol Chem
Title: Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress.
Volume: 278
Issue: 13
Pages: 11520-7
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Publication
23840825 | J:204321
First Author: Mao H
Year: 2013
Journal: PLoS One
Title: Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen.
Volume: 8
Issue: 6
Pages: e68143
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Publication
18832724 | J:140755
First Author: Watanabe M
Year: 2008
Journal: J Immunol
Title: Overproduction of IgE induces macrophage-derived chemokine (CCL22) secretion from basophils.
Volume: 181
Issue: 8
Pages: 5653-9
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Publication
20861192 | J:166081
First Author: Hochgräfe F
Year: 2010
Journal: Cancer Res
Title: Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells.
Volume: 70
Issue: 22
Pages: 9391-401
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Publication
37257722 | J:341028
 
First Author: Huang J
Year: 2023
Journal: Biochem Pharmacol
Title: Macrophage scavenger receptor A1 antagonizes abdominal aortic aneurysm via upregulating IRG1.
Volume: 213
Pages: 115631
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Publication
34019873 | J:306285
   
First Author: Matsubara T
Year: 2021
Journal: J Biol Chem
Title: Characterization of unique functionalities in c-Src domains required for osteoclast podosome belt formation.
Pages: 100790
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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