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Search results 701 to 800 out of 919 for Nfatc1

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Type Details Score
Publication
33605542 | J:329409
First Author: Shalev M
Year: 2021
Journal: FEBS J
Title: PTPRJ promotes osteoclast maturation and activity by inhibiting Cbl-mediated ubiquitination of NFATc1 in late osteoclastogenesis.
Volume: 288
Issue: 15
Pages: 4702-4723
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Publication
26141367 | J:289048
First Author: Zhou C
Year: 2016
Journal: Ann Rheum Dis
Title: Deficiency of sorting nexin 10 prevents bone erosion in collagen-induced mouse arthritis through promoting NFATc1 degradation.
Volume: 75
Issue: 6
Pages: 1211-8
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Publication
23044922 | J:190380
First Author: Li YJ
Year: 2012
Journal: Lab Invest
Title: Nordihydroguaiaretic acid inhibition of NFATc1 suppresses osteoclastogenesis and arthritis bone destruction in rats.
Volume: 92
Issue: 12
Pages: 1777-87
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Publication
25123438 | J:218467
First Author: Dou C
Year: 2014
Journal: Biochim Biophys Acta
Title: MiR-7b directly targets DC-STAMP causing suppression of NFATc1 and c-Fos signaling during osteoclast fusion and differentiation.
Volume: 1839
Issue: 11
Pages: 1084-96
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Publication
34906330 | J:321277
First Author: Suthon S
Year: 2022
Journal: Am J Hum Genet
Title: Estrogen receptor alpha and NFATc1 bind to a bone mineral density-associated SNP to repress WNT5B in osteoblasts.
Volume: 109
Issue: 1
Pages: 97-115
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GXD Expression
GXD Expression
Probe: MGI:5660388
Assay Type: Immunohistochemistry
Annotation Date: 2015-09-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1635419
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5660552
Age: embryonic day 11.5
Image: 2A
Note: Expressed in endothelial cells. Coexpressed with Nfatc1 and Flt4.
Specimen Label: 2A
Detected: true
Specimen Num: 8
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Interaction Experiment
Karpurapu M (2008)
Description: NFATc1 targets cyclin A in the regulation of vascular smooth muscle cell multiplication during restenosis.
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Interaction Experiment
Chiou WF (2014)
Description: (+)-Vitisin A Inhibits Osteoclast Differentiation by Preventing TRAF6 Ubiquitination and TRAF6-TAK1 Formation to Suppress NFATc1 Activation.
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GXD Expression
GXD Expression
Probe: MGI:5660388
Assay Type: Immunohistochemistry
Annotation Date: 2015-09-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1824819
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5660552
Age: embryonic day 11.5
Image: 2A
Note: Expressed in lymphatic endothelial cells sprouting from the cardinal vein. Coexpressed with Nfatc1 and Flt4.
Specimen Label: 2A
Detected: true
Specimen Num: 8
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HT Experiment
GSE80964 | Regulation of cardiac cushion endocardial cells by KLF2
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein
O88942
Organism: Mus musculus/domesticus
Length: 717  
Fragment?: false
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Protein
O88942-3
Organism: Mus musculus/domesticus
Length: 681  
Fragment?: false
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Protein
O88942-2
Organism: Mus musculus/domesticus
Length: 703  
Fragment?: false
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Allele
Rr345<em1Serf> | MGI:7428886
Name: regulatory region 345; endonuclease-mediated mutation 1, Edgar Serfling
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, Modified regulatory region, No functional change
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Publication
16498455 | -
First Author: Huang H
Year: 2006
Journal: Cell Death Differ
Title: Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-kappaB transactivation by RANKL.
Volume: 13
Issue: 11
Pages: 1879-91
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Publication
18667424 | -
First Author: Karpurapu M
Year: 2008
Journal: J Biol Chem
Title: NFATc1 targets cyclin A in the regulation of vascular smooth muscle cell multiplication during restenosis.
Volume: 283
Issue: 39
Pages: 26577-90
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Publication
24558484 | -
First Author: Chiou WF
Year: 2014
Journal: PLoS One
Title: (+)-Vitisin A inhibits osteoclast differentiation by preventing TRAF6 ubiquitination and TRAF6-TAK1 formation to suppress NFATc1 activation.
Volume: 9
Issue: 2
Pages: e89159
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GXD Expression
GXD Expression
Probe: MGI:5660388
Assay Type: Immunohistochemistry
Annotation Date: 2015-09-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1635417
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5660553
Age: embryonic day 10.5
Image: 1A
Note: Expressed in the cardinal vein endothelial cells and lymphatic endothelial cells sprouting from the cardinal vein. Nfatc1 and Prox1 were colocalized only in the regions of active lymphatic sprouting.
Specimen Label: 1A
Detected: true
Specimen Num: 1
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GO Term
GO:0051525 | NFAT protein binding
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Allele
Nfatc1<em2(GFP/cre)Bzsh> | MGI:5804181
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; endonuclease-mediated mutation 2, Bin Zhou
Allele Type: Endonuclease-mediated
Attribute String: Recombinase, Reporter
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Allele
Nfatc1<em3(dre)Bzsh> | MGI:5804102
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; endonuclease-mediated mutation 3, Bin Zhou
Allele Type: Endonuclease-mediated
Attribute String: Recombinase
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Allele
Tg(tetO-Nfatct1*)1Grc | MGI:3820649
Name: transgene insertion 1, Gerald R Crabtree
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
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Allele
Tg(Nfat1c-cre)1Bz | MGI:5430637
Name: transgene insertion 1, Bin Zhou
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Nfatc1<tm1.1(cre)Bz> | MGI:5471107
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; targeted mutation 1.1, Bin Zhou
Allele Type: Targeted
Attribute String: Recombinase
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Allele
Nfatc1<tm1(cre)Bz> | MGI:5699715
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; targeted mutation 1, Bin Zhou
Allele Type: Targeted
Attribute String: Recombinase
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Allele
Nfatc1<em1(cre/ERT2)Bzsh> | MGI:5804178
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; endonuclease-mediated mutation 1, Bin Zhou
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
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Genotype
Genotype
Symbol: Nfatc1/Nfatc1<+>
Background: involves: C57BL/6 * ICR
Zygosity: ht
Has Mutant Allele: true
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Protein
A0A1B0GT86
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: true
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Publication
12015988 | -
First Author: Launay P
Year: 2002
Journal: Cell
Title: TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization.
Volume: 109
Issue: 3
Pages: 397-407
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Publication
24756717 | -
 
First Author: Mathar I
Year: 2014
Journal: Handb Exp Pharmacol
Title: TRPM4.
Volume: 222
Pages: 461-87
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Publication
24721656 | -
 
First Author: Kruse M
Year: 2014
Journal: Curr Opin Pharmacol
Title: TRPM4 channels in the cardiovascular system.
Volume: 15
Pages: 68-73
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Publication
15472118 | -
First Author: Earley S
Year: 2004
Journal: Circ Res
Title: Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries.
Volume: 95
Issue: 9
Pages: 922-9
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Publication
20656926 | -
First Author: Weber KS
Year: 2010
Journal: J Immunol
Title: Trpm4 differentially regulates Th1 and Th2 function by altering calcium signaling and NFAT localization.
Volume: 185
Issue: 5
Pages: 2836-46
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Protein Domain
IPR029581 | TRPM4
Type: Family
Description: The TRPM subfamily of mammalian TRP channels includes TRPM4, which is a Ca2+-activated nonselective cation channel that mediates cell membrane depolarisation []. Unlike TRPM5, its closest relative in the transient receptor potential family, TRPM4 proteins are widely expressed in the body []. They are abundant expressed in cardiac cells and are involved in several aspects of cardiac rhythmicity, including cardiac conduction, pace making and action-potential repolarisation []. They are also expressed in cerebral arteries, where they play a role in myogenic vasoconstriction []. TRPM4 proteins also affect T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signalling and NFATC1 localisation [].
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Publication
23624921 | J:212364
First Author: Tripathi P
Year: 2014
Journal: Oncogene
Title: Activation of NFAT signaling establishes a tumorigenic microenvironment through cell autonomous and non-cell autonomous mechanisms.
Volume: 33
Issue: 14
Pages: 1840-9
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Genotype
Genotype
Symbol: Krit1/Krit1 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ift88/Ift88 Nfatc1/Nfatc1<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ift88/Ift88<+> Nfatc1/Nfatc1<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Allele
Tg(Nfatc1-rtTA)96Bz | MGI:5471110
Name: transgene insertion 96, Bin Zhou
Allele Type: Transgenic
Attribute String: Transactivator
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Genotype
Genotype
Symbol: Kdr/Kdr Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ccm2/Ccm2 Nfatc1/Nfatc1<+>
Background: involves: 129 * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Adgrg6/Adgrg6 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nfatc1/Nfatc1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * ICR
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dhh/Dhh Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dhh/Dhh<+> Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Jag1/Jag1 Nfatc1/Nfatc1<+>
Background: involves: 129 * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
GSE159187 | Transcriptomic analysis of myocardium-specific Creld1 knockout mice at E13.5 and P3
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
26634652 | J:246377
First Author: Huk DJ
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: Valve Endothelial Cell-Derived Tgfβ1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification.
Volume: 36
Issue: 2
Pages: 328-38
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Genotype
Genotype
Symbol: Tbx20/Tbx20 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nfatc1/Nfatc1<+> Smarca4/Smarca4
Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Smarca4/Smarca4 Tg(Nfat1c-cre)1Bz/?
Background: involves: 129S2/SvPas
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pdcd10/Pdcd10 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nfatc1/Nfatc1<+> Sema6d/Sema6d
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/Sv * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dzip1/Dzip1 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Krit1/Krit1 Map3k3/Map3k3<+> Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl * C57BL/6NTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dzip1/Dzip1<+> Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crk/Crk Crkl/Crkl Nfatc1/Nfatc1<+>
Background: B6J.Cg-Crk Crkl Nfatc1
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nfatc1/Nfatc1<+> Npr3/Npr3<+>
Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * ICR
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dll4/Dll4 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Notch1/Notch1 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Efnb2/Efnb2 Nfatc1/Nfatc1<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nfatc1/Nfatc1<+> Tek/Tek
Background: involves: 129 * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sox17/Sox17 Tg(Nfat1c-cre)1Bz/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Publication
18775427 | J:139657
First Author: Hayashi H
Year: 2008
Journal: FEBS Lett
Title: The role of Mac-1 (CD11b/CD18) in osteoclast differentiation induced by receptor activator of nuclear factor-kappaB ligand.
Volume: 582
Issue: 21-22
Pages: 3243-8
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Publication
23183242 | J:193136
First Author: Okamura H
Year: 2013
Journal: FEBS Lett
Title: Protein phosphatase 2A Cα is involved in osteoclastogenesis by regulating RANKL and OPG expression in osteoblasts.
Volume: 587
Issue: 1
Pages: 48-53
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Protein
Q7TN37
Organism: Mus musculus/domesticus
Length: 1213  
Fragment?: false
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Protein
A0A1B0GS49
Organism: Mus musculus/domesticus
Length: 1066  
Fragment?: false
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Publication
29787136 | J:299670
       
First Author: Qu X
Year: 2016
Title: A Novel Role for Endocardium in Perinatal Valve Development: Lessons Learned from Tissue-Specific Gene Deletion of the Tie1 Receptor Tyrosine Kinase
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Genotype
Genotype
Symbol: Sox7/Sox7 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rag2/Rag2 Tg(EmuSR-tTa)83Bop/? Tg(tetO-Nfatct1*)1Grc/?
Background: involves: 129S/SvEv * C57BL/6J * CBA/J * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nfatc1/Nfatc1<+> Smarca4/Smarca4
Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Map3k3/Map3k3 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bmp2/Bmp2 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crk/Crk Crkl/Crkl Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nfatc1/Nfatc1<+>
Background: involves: 129S6/SvEvTac * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Klf2/Klf2 Tg(Nfat1c-cre)1Bz/?
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Publication
18691762 | J:139569
First Author: Wang D
Year: 2008
Journal: Mol Immunol
Title: The interleukin-1 receptor associated kinase 1 contributes to the regulation of NFAT.
Volume: 45
Issue: 15
Pages: 3902-8
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Publication
18710934 | J:140561
First Author: Fukushima H
Year: 2008
Journal: Mol Cell Biol
Title: The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis.
Volume: 28
Issue: 20
Pages: 6402-12
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Publication
29382851 | J:260013
First Author: Patterson AR
Year: 2018
Journal: Nat Commun
Title: Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology.
Volume: 9
Issue: 1
Pages: 430
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Publication
16890539 | J:129733
First Author: Zhao C
Year: 2006
Journal: Cell Metab
Title: Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis.
Volume: 4
Issue: 2
Pages: 111-21
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Publication
24087791 | J:215146
First Author: D'Arcy CE
Year: 2014
Journal: Hum Mol Genet
Title: Identification of FHL1 as a therapeutic target for Duchenne muscular dystrophy.
Volume: 23
Issue: 3
Pages: 618-36
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Publication
30271915 | J:278110
 
First Author: Huynh H
Year: 2018
Journal: Commun Biol
Title: mTORC1 impedes osteoclast differentiation via calcineurin and NFATc1.
Volume: 1
Pages: 29
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Publication
26912704 | J:229528
First Author: Wang L
Year: 2016
Journal: Science
Title: Foxc1 reinforces quiescence in self-renewing hair follicle stem cells.
Volume: 351
Issue: 6273
Pages: 613-7
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Publication
12524538 | J:126980
First Author: Bour-Jordan H
Year: 2003
Journal: Nat Immunol
Title: CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment.
Volume: 4
Issue: 2
Pages: 182-8
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Publication
26456333 | J:299578
First Author: Wang X
Year: 2015
Journal: Cell Metab
Title: A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption.
Volume: 22
Issue: 5
Pages: 811-24
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Publication
35045301 | J:327027
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