Type |
Details |
Score |
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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•
•
•
•
•
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
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•
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
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•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
•
•
•
•
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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•
•
•
•
•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
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•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
•
•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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|
Allele |
Name: |
nuclear receptor subfamily 1, group H, member 4; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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•
•
•
•
•
|
Allele |
Name: |
nuclear receptor subfamily 1, group H, member 4; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
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•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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•
•
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•
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Publication |
First Author: |
Modica S |
Year: |
2010 |
Journal: |
Nucl Recept Signal |
Title: |
Deciphering the nuclear bile acid receptor FXR paradigm. |
Volume: |
8 |
|
Pages: |
e005 |
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•
•
•
•
•
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Publication |
First Author: |
Hollman DA |
Year: |
2012 |
Journal: |
Biochim Biophys Acta |
Title: |
Anti-inflammatory and metabolic actions of FXR: insights into molecular mechanisms. |
Volume: |
1821 |
Issue: |
11 |
Pages: |
1443-52 |
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•
•
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•
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Publication |
First Author: |
Bijsmans IT |
Year: |
2015 |
Journal: |
Sci Rep |
Title: |
The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression. |
Volume: |
5 |
|
Pages: |
14086 |
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the ligand binding domain found in bile acid receptor NR1H4 (also known as farnesoid X-activated receptor, FXR). NR1H4 is a ligand-activated transcription factor belonging to the nuclear receptor (NR) superfamily. It regulates bile salt, glucose and cholesterol homeostasis by binding to DNA response elements, thereby activating gene expression []. It is a receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA) []. It also inhibits the immune response via tethering to NF-kappaB []. |
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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•
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Allele |
Name: |
nuclear receptor subfamily 1, group H, member 4; targeted mutation 1, Frank Gonzalez |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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•
•
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Publication |
First Author: |
Leclerc D |
Year: |
2013 |
Journal: |
Cancer Prev Res (Phila) |
Title: |
Genes with aberrant expression in murine preneoplastic intestine show epigenetic and expression changes in normal mucosa of colon cancer patients. |
Volume: |
6 |
Issue: |
11 |
Pages: |
1171-81 |
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•
•
•
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•
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Publication |
First Author: |
Aboudehen K |
Year: |
2017 |
Journal: |
J Am Soc Nephrol |
Title: |
Hepatocyte Nuclear Factor-1β Regulates Urinary Concentration and Response to Hypertonicity. |
Volume: |
28 |
Issue: |
10 |
Pages: |
2887-2900 |
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•
•
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•
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Publication |
First Author: |
Zummo FP |
Year: |
2023 |
Journal: |
J Mol Endocrinol |
Title: |
A time- and space-resolved nuclear receptor atlas in mouse liver. |
Volume: |
71 |
Issue: |
1 |
|
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•
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•
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•
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Strain |
Attribute String: |
targeted mutation, mutant stock |
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•
•
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•
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Strain |
Attribute String: |
targeted mutation, mutant strain, congenic |
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•
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Strain |
Attribute String: |
targeted mutation, congenic |
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•
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Genotype |
Symbol: |
Nr1h4/Nr1h4 |
Background: |
involves: 129X1/SvJ * C57BL/6N |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nr1h4/Nr1h4 |
Background: |
involves: 129 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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•
•
•
•
•
|
Genotype |
Symbol: |
Nr1h4/Nr1h4 |
Background: |
involves: 129X1/SvJ |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nr1h4/Nr1h4 |
Background: |
STOCK Nr1h4/J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nr1h4/Nr1h4 |
Background: |
involves: 129X1/SvJ * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nr1h4/Nr1h4 |
Background: |
B6.129(FVB)-Nr1h4 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nr1h4/Nr1h4 Xbp1/Xbp1 |
Background: |
involves: 129 * C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Trenteseaux C |
Year: |
2017 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Perinatal Hypercholesterolemia Exacerbates Atherosclerosis Lesions in Offspring by Altering Metabolism of Trimethylamine-N-Oxide and Bile Acids. |
Volume: |
37 |
Issue: |
11 |
Pages: |
2053-2063 |
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•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nr0b2/Nr0b2 Nr1h4/Nr1h4 |
Background: |
B6.129(FVB)-Nr0b2 Nr1h4 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nr1h4/Nr1h4 Speer6-ps1/Speer6-ps1<+> Xbp1/Xbp1 |
Background: |
involves: 129 * C57BL/6J * DBA |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
488
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
497
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
484
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
497
 |
Fragment?: |
false |
|
•
•
•
•
•
|