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Search results 701 to 800 out of 1772 for Parkinson

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Type Details Score
Publication
12417149 | -
First Author: Deeks MJ
Year: 2002
Journal: Trends Plant Sci
Title: Formins: intermediates in signal-transduction cascades that affect cytoskeletal reorganization.
Volume: 7
Issue: 11
Pages: 492-8
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Publication
11104517 | -
First Author: Cvrcková F
Year: 2000
Journal: Genome Biol
Title: Are plant formins integral membrane proteins?
Volume: 1
Issue: 1
Pages: RESEARCH001
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Publication
16495927 | -
First Author: Kim RH
Year: 2006
Journal: Br J Cancer
Title: Tumours and tremors: how PTEN regulation underlies both.
Volume: 94
Issue: 5
Pages: 620-4
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Publication
21576361 | -
First Author: Dobrikov M
Year: 2011
Journal: Mol Cell Biol
Title: Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.
Volume: 31
Issue: 14
Pages: 2947-59
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Publication
11606767 | -
First Author: Ventoso I
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: HIV-1 protease cleaves eukaryotic initiation factor 4G and inhibits cap-dependent translation.
Volume: 98
Issue: 23
Pages: 12966-71
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Publication
12791690 | -
First Author: Foeger N
Year: 2003
Journal: J Biol Chem
Title: Human rhinovirus 2 2Apro recognition of eukaryotic initiation factor 4GI. Involvement of an exosite.
Volume: 278
Issue: 35
Pages: 33200-7
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Publication
29062139 | -
First Author: Adjibade P
Year: 2017
Journal: Sci Rep
Title: DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression.
Volume: 7
Issue: 1
Pages: 13832
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Protein Domain
IPR044978 | GRV2/DNAJC13
Type: Family
Description: This entry represents a group of DnaJ homologue subfamily C proteins, including GRV2 from Arabidopsis and DNAJC13 (also known as RME-8) from humans. They are involved in endocytosis. GRV2 functions in vesicle trafficking from the multivesicular body/pre-vacuolar compartment to the lytic vacuole []. In Arabidopsis grv2 mutants display enlarged aggregated endosomes, defective vacuole biogenesis and embryogenesis, and reduced gravitropic responses [, , ]. DNAJC13 plays a role in the endosomal transport machinery, in which it coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation [].DNAJC13 has been linked to Parkinson disease []. In humans, DNAJC13 localizes to early endosomal compartments via an N-terminal PI(3)P targeting motif and binds the co-chaperone Heat shock cognate-70 (Hsc70) through the central J domain, whereas the remainder interacts with the BAR-domain containing sorting nexin 1 (SNX1) protein and the FAM21 subunit of the WASH complex[].
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Protein Domain
IPR027643 | Formin-like_plant
Type: Family
Description: Formins (formin homology proteins) proteins play a crucial role in the reorganisation of the actin cytoskeleton and associate with the fast-growing end (barbed end) of actin filaments [, ]. This entry represents the formin homologues from plants. Seed plants have two formin clades with numerous paralogues []. They can be classified as class I and class II formins. Class I formins includes a N-terminal membrane insertion signal, a predicted extracytoplasmic Pro-rich stretch, a transmembrane region, and C-terminal FH1 and FH2 domains []. Though class II formins usually contain a N-terminal PTEN domain related to the human PTEN protein (implied in pathogenesis of the Parkinson disease) [], the N-termini of type-II plant formins do not contain any recognisable domain that can provide a clue to their biological function.
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Protein Domain
IPR037584 | EIF4G1
Type: Family
Description: This entry represents eukaryotic translation initiation factor 4 gamma 1 (EIF4G1), which is a component of the eIF4F complex. The eIF4F complex is required for recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Mitogen-activated protein kinases control translation by post-translational modification of translation initiation factors, and eIF4G1 is a substrate for protein kinase C []. As part of the eIF4F complex, EIF4G1 mediates endoplasmic reticulum stress-induced ATF4 (a master stress-induced transcription factor) mRNA translation []. Mutations in the EIF4G1 gene cause Parkinson disease 18, which is a neurodegenerative disorder with the following symptoms: bradykinesia, resting tremor, muscular rigidity and postural instability, and loss of dopaminergic neurons from the substantia nigra []. Viral infection can lead to the shutdown of translation by cleavage of EIF4G1, for example, by HIV-1 retropepsin [], rhinovirus picornain 2A []and foot-and-mouth disease virus L-peptidase [].
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Strain
MGI:5568204 | B6.Cg-Snca<tm1Rosl> Tg(SNCA*A30P)192Rwm/J
Attribute String: transgenic, targeted mutation, mutant strain, congenic
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Publication
31267130 | J:277774
First Author: Zhang XM
Year: 2019
Journal: Hum Mol Genet
Title: The A30P α-synuclein mutation decreases subventricular zone proliferation.
Volume: 28
Issue: 14
Pages: 2283-2294
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Publication
24121116 | J:201961
 
First Author: Taylor TN
Year: 2014
Journal: Neurobiol Dis
Title: Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse.
Volume: 62
Pages: 193-207
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Publication
26099047 | J:224864
First Author: Bachhuber T
Year: 2015
Journal: Nat Med
Title: Inhibition of amyloid-β plaque formation by α-synuclein.
Volume: 21
Issue: 7
Pages: 802-7
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Strain
MGI:3784588 | C57BL/6J-Tg(Th-SNCA*A30P*A53T)39Eric/J
Attribute String: transgenic, coisogenic
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Publication
38351057 | J:352009
 
First Author: Keomanivong C
Year: 2024
Journal: eNeuro
Title: Mice Expressing A53T/A30P Mutant Alpha-Synuclein in Dopamine Neurons Do Not Display Behavioral Deficits.
Volume: 11
Issue: 2
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Publication
33805843 | J:310935
 
First Author: Pavia-Collado R
Year: 2021
Journal: Int J Mol Sci
Title: Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice.
Volume: 22
Issue: 6
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Publication
36351818 | J:332059
 
First Author: Paul S
Year: 2022
Journal: eNeuro
Title: Cyclin-Dependent Kinase 5 Regulates cPLA2 Activity and Neuroinflammation in Parkinson's Disease.
Volume: 9
Issue: 6
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Publication
28476570 | J:249386
 
First Author: Jiao F
Year: 2017
Journal: Behav Brain Res
Title: Expression signatures of long non-coding RNA in the substantia nigra of pre-symptomatic mouse model of Parkinson's disease.
Volume: 331
Pages: 123-130
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Publication
36497031 | J:346174
 
First Author: Tiwari S
Year: 2022
Journal: Cells
Title: UBA52 Is Crucial in HSP90 Ubiquitylation and Neurodegenerative Signaling during Early Phase of Parkinson's Disease.
Volume: 11
Issue: 23
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Publication
28771510 | J:248076
First Author: Yan J
Year: 2017
Journal: PLoS One
Title: Quantitative proteomics in A30P*A53T α-synuclein transgenic mice reveals upregulation of Sel1l.
Volume: 12
Issue: 8
Pages: e0182092
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Publication
26317511 | J:243019
First Author: Su X
Year: 2015
Journal: PLoS One
Title: PGC-1α Promoter Methylation in Parkinson's Disease.
Volume: 10
Issue: 8
Pages: e0134087
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Strain
MGI:3846798 | FVB/NJ-Tg(Slc6a3-PARK2*Q311X)AXwy
Attribute String: transgenic, coisogenic
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Strain
MGI:3849849 | FVB/NJ-Tg(Slc6a3-PARK2*Q311X)AXwy/J
Attribute String: transgenic, coisogenic
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Publication
25316086 | J:244967
 
First Author: Maraschi A
Year: 2014
Journal: Nat Commun
Title: Parkin regulates kainate receptors by interacting with the GluK2 subunit.
Volume: 5
Pages: 5182
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Strain
MGI:3846796 | FVB/NJ-Tg(Slc6a3-PARK2*Q311X)DXwy
Attribute String: coisogenic, transgenic
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Genotype
Genotype
Symbol: Tg(Th-SNCA*A30P*A53T)39Eric/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Slc6a3-PARK2*Q311X)AXwy/?
Background: FVB/NJ-Tg(Slc6a3-PARK2*Q311X)AXwy
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Slc6a3-PARK2*Q311X)DXwy/?
Background: FVB/NJ-Tg(Slc6a3-PARK2*Q311X)DXwy
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Snca/Snca Tg(SNCA*A30P)192Rwm/?
Background: B6.Cg-Snca Tg(SNCA*A30P)#Rwm
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Th-SNCA*A30P*A53T)39Eric/?
Background: involves: C57BL/6 * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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HT Experiment
E-GEOD-15336 | Eyeless: Pitx3 mutant mouse line, Expression profiling of liver
Series Id: GSE15336
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
38117656 | J:355509
First Author: Xiang J
Year: 2024
Journal: STAR Protoc
Title: Protocol for screening α-synuclein PET tracer candidates in vitro and ex vivo.
Volume: 5
Issue: 1
Pages: 102788
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Publication
27770614 | J:238740
First Author: Sato S
Year: 2016
Journal: Am J Pathol
Title: Lysosomal Storage of Subunit c of Mitochondrial ATP Synthase in Brain-Specific Atp13a2-Deficient Mice.
Volume: 186
Issue: 12
Pages: 3074-3082
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Publication
9371841 | J:44602
First Author: Smidt MP
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons.
Volume: 94
Issue: 24
Pages: 13305-10
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Publication
15474350 | J:93097
First Author: Fernagut PO
Year: 2004
Journal: Neurobiol Dis
Title: Alpha-synuclein and transgenic mouse models.
Volume: 17
Issue: 2
Pages: 123-30
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Publication
20733075 | J:164384
First Author: KĂ©ri S
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: {alpha}-Synuclein gene duplication impairs reward learning.
Volume: 107
Issue: 36
Pages: 15992-4
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Genotype
Genotype
Symbol: Chchd2/Chchd2
Background: C57BL/6-Chchd2
Zygosity: hm
Has Mutant Allele: true
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Publication
28650483 | J:256607
First Author: Meehan TF
Year: 2017
Journal: Nat Genet
Title: Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.
Volume: 49
Issue: 8
Pages: 1231-1238
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Publication
29348434 | J:256608
First Author: Rozman J
Year: 2018
Journal: Nat Commun
Title: Identification of genetic elements in metabolism by high-throughput mouse phenotyping.
Volume: 9
Issue: 1
Pages: 288
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Publication
30588515 | J:267633
 
First Author: Moore BA
Year: 2018
Journal: Commun Biol
Title: Identification of genes required for eye development by high-throughput screening of mouse knockouts.
Volume: 1
Pages: 236
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Publication
33370286 | J:301500
First Author: Swan AL
Year: 2020
Journal: PLoS Genet
Title: Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density.
Volume: 16
Issue: 12
Pages: e1009190
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Protein
Q8BNL1
Organism: Mus musculus/domesticus
Length: 715  
Fragment?: true
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Protein
Q3TNE7
Organism: Mus musculus/domesticus
Length: 479  
Fragment?: true
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Publication
17971043 | -
First Author: Silady RA
Year: 2008
Journal: Plant J
Title: The GRV2/RME-8 protein of Arabidopsis functions in the late endocytic pathway and is required for vacuolar membrane flow.
Volume: 53
Issue: 1
Pages: 29-41
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Publication
25393719 | -
First Author: Gustavsson EK
Year: 2015
Journal: Mov Disord
Title: DNAJC13 genetic variants in parkinsonism.
Volume: 30
Issue: 2
Pages: 273-8
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Publication
31082451 | J:282550
 
First Author: Follett J
Year: 2019
Journal: Neurosci Lett
Title: DNAJC13 p.Asn855Ser, implicated in familial parkinsonism, alters membrane dynamics of sorting nexin 1.
Volume: 706
Pages: 114-122
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Publication
17259264 | -
First Author: Tamura K
Year: 2007
Journal: Plant Cell
Title: Arabidopsis KAM2/GRV2 is required for proper endosome formation and functions in vacuolar sorting and determination of the embryo growth axis.
Volume: 19
Issue: 1
Pages: 320-32
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Publication
31628169 | -
First Author: Rodriguez-Furlan C
Year: 2019
Journal: Plant Cell
Title: Remove, Recycle, Degrade: Regulating Plasma Membrane Protein Accumulation.
Volume: 31
Issue: 12
Pages: 2833-2854
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Publication
15466218 | -
First Author: Silady RA
Year: 2004
Journal: Plant Physiol
Title: The gravitropism defective 2 mutants of Arabidopsis are deficient in a protein implicated in endocytosis in Caenorhabditis elegans.
Volume: 136
Issue: 2
Pages: 3095-103; discussion 3002
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Publication
32400277 | J:313050
First Author: Ko MS
Year: 2021
Journal: Autophagy
Title: Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice.
Volume: 17
Issue: 5
Pages: 1205-1221
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Protein Coding Gene
MGI:1261428 | Chchd2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
A0A0J9YTV0
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: true
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Protein
A0A338P758
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: true
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Protein
Q8BUW8
Organism: Mus musculus/domesticus
Length: 471  
Fragment?: true
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Protein
D3YWC6
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: true
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Protein
D3Z439
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: true
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Protein
A0A0J9YUL1
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: true
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Protein
A0A0J9YU44
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Protein
D3YWY7
Organism: Mus musculus/domesticus
Length: 170  
Fragment?: true
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Protein
D6RCH1
Organism: Mus musculus/domesticus
Length: 79  
Fragment?: false
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Protein
A0A338P7C5
Organism: Mus musculus/domesticus
Length: 61  
Fragment?: true
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Protein
D3YWM1
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: true
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Protein
Q6EVH9
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: true
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Publication
26134565 | -
First Author: Xhabija B
Year: 2015
Journal: J Biol Chem
Title: Receptor-mediated Endocytosis 8 Utilizes an N-terminal Phosphoinositide-binding Motif to Regulate Endosomal Clathrin Dynamics.
Volume: 290
Issue: 35
Pages: 21676-89
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Protein Domain
IPR045802 | GRV2/DNAJC13_N
Type: Domain
Description: This is the N-terminal domain of DNAJC13/GVR2, which is required for membrane association and interaction with FAM21 tail domain []. It contains critical residues mediating phosphatidylinositol 3-phosphate (PI(3)P) binding, required for its association with endosomes [].This entry represents a group of DnaJ homologue subfamily C proteins, including GRV2 from Arabidopsis and DNAJC13 (also known as RME-8) from humans. They are involved in endocytosis. GRV2 functions in vesicle trafficking from the multivesicular body/pre-vacuolar compartment to the lytic vacuole []. In Arabidopsis grv2 mutants display enlarged aggregated endosomes, defective vacuole biogenesis and embryogenesis, and reduced gravitropic responses [, , ]. DNAJC13 plays a role in the endosomal transport machinery, in which it coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation [].DNAJC13 has been linked to Parkinson disease []. In humans, DNAJC13 localizes to early endosomal compartments via an N-terminal PI(3)P targeting motif and binds the co-chaperone Heat shock cognate-70 (Hsc70) through the central J domain, whereas the remainder interacts with the BAR-domain containing sorting nexin 1 (SNX1) protein and the FAM21 subunit of the WASH complex[].
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Publication
27058446 | J:231965
First Author: Diggle CP
Year: 2016
Journal: Am J Hum Genet
Title: Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy.
Volume: 98
Issue: 4
Pages: 735-43
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Publication
16380713 | J:105231
First Author: Gilbert SL
Year: 2006
Journal: Nat Genet
Title: Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice.
Volume: 38
Issue: 2
Pages: 245-50
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Publication
19004816 | J:147239
First Author: Inglis KJ
Year: 2009
Journal: J Biol Chem
Title: Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system.
Volume: 284
Issue: 5
Pages: 2598-602
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Publication
11479594 | J:78668
First Author: Zhou B
Year: 2001
Journal: Nat Genet
Title: A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome.
Volume: 28
Issue: 4
Pages: 345-9
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Publication
17296554 | J:136786
First Author: Ihara M
Year: 2007
Journal: Neuron
Title: Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity.
Volume: 53
Issue: 4
Pages: 519-33
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Publication
30485814 | J:270755
First Author: Lassot I
Year: 2018
Journal: Cell Rep
Title: The E3 Ubiquitin Ligases TRIM17 and TRIM41 Modulate α-Synuclein Expression by Regulating ZSCAN21.
Volume: 25
Issue: 9
Pages: 2484-2496.e9
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Publication
16116427 | J:100860
First Author: Zhao L
Year: 2005
Journal: Nat Genet
Title: Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP.
Volume: 37
Issue: 9
Pages: 974-9
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Publication
30146491 | J:308689
First Author: Gyllborg D
Year: 2018
Journal: Stem Cell Reports
Title: The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation.
Volume: 11
Issue: 3
Pages: 651-664
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Publication
17394578 | J:121540
First Author: Sharma R
Year: 2007
Journal: J Neurochem
Title: Minimal role for caspase 12 in the unfolded protein response in oligodendrocytes in vivo.
Volume: 101
Issue: 4
Pages: 889-97
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Publication
29397366 | J:277454
First Author: Zlatic SA
Year: 2018
Journal: Cell Syst
Title: Rare Disease Mechanisms Identified by Genealogical Proteomics of Copper Homeostasis Mutant Pedigrees.
Volume: 6
Issue: 3
Pages: 368-380.e6
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Publication
16299504 | J:104072
First Author: Liss B
Year: 2005
Journal: Nat Neurosci
Title: K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons.
Volume: 8
Issue: 12
Pages: 1742-51
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Publication
21187382 | J:170567
First Author: Ding Y
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Enhanced striatal cholinergic neuronal activity mediates L-DOPA-induced dyskinesia in parkinsonian mice.
Volume: 108
Issue: 2
Pages: 840-5
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Publication
26411690 | J:265990
First Author: Rekaik H
Year: 2015
Journal: Cell Rep
Title: Engrailed Homeoprotein Protects Mesencephalic Dopaminergic Neurons from Oxidative Stress.
Volume: 13
Issue: 2
Pages: 242-50
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Publication
18076286 | J:130846
First Author: Kittappa R
Year: 2007
Journal: PLoS Biol
Title: The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age.
Volume: 5
Issue: 12
Pages: e325
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Publication
27246266 | J:253782
 
First Author: Hedlund E
Year: 2016
Journal: Sci Rep
Title: Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors.
Volume: 6
Pages: 26448
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Publication
21768369 | J:176022
First Author: Sterky FH
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo.
Volume: 108
Issue: 31
Pages: 12937-42
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Publication
16257223 | J:108007
First Author: Andrews ZB
Year: 2006
Journal: Neurobiol Dis
Title: Transforming growth factor beta2 haploinsufficient mice develop age-related nigrostriatal dopamine deficits.
Volume: 21
Issue: 3
Pages: 568-75
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Publication
28621812 | J:357986
 
First Author: González-Barbosa E
Year: 2017
Journal: J Biochem Mol Toxicol
Title: TCDD induces UbcH7 expression and synphilin-1 protein degradation in the mouse ventral midbrain.
Volume: 31
Issue: 10
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Publication
15199190 | J:91836
First Author: Orb S
Year: 2004
Journal: Physiol Genomics
Title: Knockin mice with Leu9'Ser alpha4-nicotinic receptors: substantia nigra dopaminergic neurons are hypersensitive to agonist and lost postnatally.
Volume: 18
Issue: 3
Pages: 299-307
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Publication
20962279 | J:167081
First Author: Mistry PK
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage.
Volume: 107
Issue: 45
Pages: 19473-8
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Publication
20133810 | J:157536
First Author: Jang SW
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone.
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