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Search results 701 to 800 out of 868 for Plk1

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0.028s

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Hits by Strain

Type Details Score
Protein
Q70FJ1
Organism: Mus musculus/domesticus
Length: 3797  
Fragment?: false
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Protein
P30276
Organism: Mus musculus/domesticus
Length: 398  
Fragment?: false
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Protein
P97477
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
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Protein
Q569L8
Organism: Mus musculus/domesticus
Length: 1344  
Fragment?: false
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Protein
Q7TSH4
Organism: Mus musculus/domesticus
Length: 1004  
Fragment?: false
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Protein
Q8K3K8
Organism: Mus musculus/domesticus
Length: 584  
Fragment?: false
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Protein
Q9JMK2
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
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Protein
E9Q8I9
Organism: Mus musculus/domesticus
Length: 3020  
Fragment?: false
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Protein
A0A5F8MPN1
Organism: Mus musculus/domesticus
Length: 3017  
Fragment?: false
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Protein
F8VQ05
Organism: Mus musculus/domesticus
Length: 3007  
Fragment?: false
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Publication
20100802 | J:173149
First Author: Andrysik Z
Year: 2010
Journal: Nucleic Acids Res
Title: The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus.
Volume: 38
Issue: 9
Pages: 2931-43
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Publication
24776885 | J:219399
First Author: Nam HJ
Year: 2014
Journal: Nat Cell Biol
Title: Cyclin B2 and p53 control proper timing of centrosome separation.
Volume: 16
Issue: 6
Pages: 538-49
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Publication
35459234 | J:336919
First Author: He Z
Year: 2022
Journal: Nat Commun
Title: Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation.
Volume: 13
Issue: 1
Pages: 2200
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Publication
34006870 | J:306092
First Author: Carr RM
Year: 2021
Journal: Nat Commun
Title: RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis.
Volume: 12
Issue: 1
Pages: 2901
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Publication
34706236 | J:337687
First Author: Symeonidou V
Year: 2021
Journal: Cell Rep
Title: Defining the fetal origin of MLL-AF4 infant leukemia highlights specific fatty acid requirements.
Volume: 37
Issue: 4
Pages: 109900
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Publication
26406118 | J:227070
 
First Author: Hehnly H
Year: 2015
Journal: Elife
Title: A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells.
Volume: 4
Pages: e09384
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Publication
21241890 | J:173135
First Author: Song MS
Year: 2011
Journal: Cell
Title: Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner.
Volume: 144
Issue: 2
Pages: 187-99
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Publication
15661742 | J:98571
First Author: Kim SA
Year: 2005
Journal: J Biol Chem
Title: Polo-like kinase 1 phosphorylates heat shock transcription factor 1 and mediates its nuclear translocation during heat stress.
Volume: 280
Issue: 13
Pages: 12653-7
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Publication
26147444 | J:224372
 
First Author: Clift D
Year: 2015
Journal: Nat Commun
Title: A three-step MTOC fragmentation mechanism facilitates bipolar spindle assembly in mouse oocytes.
Volume: 6
Pages: 7217
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Publication
28193847 | J:244083
 
First Author: Li Z
Year: 2017
Journal: Mol Cell Biol
Title: DNA Damage Response-Independent Role for MDC1 in Maintaining Genomic Stability.
Volume: 37
Issue: 9
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Publication
30598363 | J:271922
First Author: Liccardi G
Year: 2019
Journal: Mol Cell
Title: RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation.
Volume: 73
Issue: 3
Pages: 413-428.e7
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Protein
Q9CZC6
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: false
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Publication
12769845 | -
First Author: Kitagawa K
Year: 2003
Journal: Mol Cell
Title: Requirement of Skp1-Bub1 interaction for kinetochore-mediated activation of the spindle checkpoint.
Volume: 11
Issue: 5
Pages: 1201-13
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Publication
10395177 | -
First Author: Yamaguchi K
Year: 1999
Journal: Cancer Lett
Title: Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell lines.
Volume: 139
Issue: 2
Pages: 183-7
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Publication
9521327 | -
First Author: Cahill DP
Year: 1998
Journal: Nature
Title: Mutations of mitotic checkpoint genes in human cancers.
Volume: 392
Issue: 6673
Pages: 300-3
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Publication
17369399 | -
First Author: Burton JL
Year: 2007
Journal: Genes Dev
Title: Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.
Volume: 21
Issue: 6
Pages: 655-67
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Publication
16964243 | -
First Author: Beausoleil SA
Year: 2006
Journal: Nat Biotechnol
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Volume: 24
Issue: 10
Pages: 1285-92
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Publication
16977596 | -
First Author: Botta E
Year: 2007
Journal: Hum Mutat
Title: Mutations in the C7orf11 (TTDN1) gene in six nonphotosensitive trichothiodystrophy patients: no obvious genotype-phenotype relationships.
Volume: 28
Issue: 1
Pages: 92-6
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Protein Domain
IPR028265 | TTDN1/SICKLE
Type: Family
Description: This entry includes animal M-phase-specific PLK1-interacting protein (also known as TTDN1) and plant protein SICKLE. M-phase-specific PLK1-interacting protein (also known as TTD non-photosensitive 1 protein, TTDN1) co-localises with Plk1 at the centrosome in mitosis and the midbody during cytokinesis []. TTDN1 is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1 (PLK1) [, ]. It may play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis []. Mutations in the C7orf11 (TTDN1) gene has been linked to Trichothiodystrophy (TTD), a rare autosomal recessive disorder whose defining feature is brittle hair []. Protein SICKLE is required for development and abiotic stress tolerance, and is involved in microRNA biogenesis []and mRNA splicing []. SICKLE, also known as ROTUNDA 3, may contribute to plant development by phosphatase 2A-mediated regulation of auxin transporter recycling [].
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Protein Domain
IPR026618 | MPLKIP-like_vertebrate
Type: Family
Description: This entry represents M-phase-specific PLK1-interacting protein and related uncharacterised sequences from vertebrates.M-phase-specific PLK1-interacting protein (also known as TTD non-photosensitive 1 protein, TTDN1) may play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis []. Its The subcellular location is regulated during cell cycle. During interphase, it is located in the nucleus. During mitosis, it is located at the centrosome and dispersed in the cytoplasm. During telophase, it is located in the midbody. It colocalizes with PLK1 at the centrosome in M phase [, ]. It is phosphorylated during mitosis in the cell cycle probably by CDK1 [, ]. Defects in MPLKIP are a cause of trichothiodystrophy non-photosensitive type 1 (TTDN1); also known as Amish brittle hair brain syndrome (ABHS), hair-brain syndrome and BIDS syndrome. TTDN1 is an autosomal recessive disorder characterised by short stature, intellectual impairment, sulfur-deficient brittle hair and decreased male fertility but not cutaneous photosensitivity [].
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Protein Domain
IPR015661 | Bub1/Mad3
Type: Family
Description: This represents the mitotic checkpoint serine/threonine-protein kinase Bub1. Saccharomyces cerevisiae Bub1 has a paralogue, Mad3, which is also included in this entry. Bub1 forms a complex with Mad1 and Bub3 that is crucial for preventing cell cycle progression into anaphase in the presence of spindle damage [], while Mad3 is a component of the spindle-assembly complex consisting of Mad2, Mad3, Bub3 and Cdc20 []. Mad3 contains a D-box and two KEN- boxes, which function together to mediate Cdc20-Mad3 interaction. Mad3 and an anaphase-promoting complex (APC) substrate, Hsl1, compete for Cdc20 binding in a D-box- and KEN-box-dependent manner [].Similar to its yeast homologues, human Bub1 is a critical component of the mitotic checkpoint that delays the onset of anaphase until all chromosomes have established bipolar attachment to the microtubules. In interphase cells it localises to centrosomes and suppresses centrosome amplification via regulating Plk1 activity []. Mutations in the human Bub1 gene have been linked to cancers [, ].
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Protein
Q9D011
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: false
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Protein
B2RTG9
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: false
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Protein
A0A1Y7VKT3
Organism: Mus musculus/domesticus
Length: 48  
Fragment?: false
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Protein
J3QQ10
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: false
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Publication
17310276 | -
First Author: Zhang Y
Year: 2007
Journal: Cell Mol Life Sci
Title: TTDN1 is a Plk1-interacting protein involved in maintenance of cell cycle integrity.
Volume: 64
Issue: 5
Pages: 632-40
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Publication
15645389 | -
First Author: Nakabayashi K
Year: 2005
Journal: Am J Hum Genet
Title: Identification of C7orf11 (TTDN1) gene mutations and genetic heterogeneity in nonphotosensitive trichothiodystrophy.
Volume: 76
Issue: 3
Pages: 510-6
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Protein Coding Gene
MGI:1923957 | Clasp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109359 | Nek2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107733 | Dctn2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109520 | Pafah1b1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1355272 | Csnk1d
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914453 | Nde1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1858964 | Actr1a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1923036 | Ckap5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:891995 | Mapre1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1859251 | Dctn3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108109 | Ywhag
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107745 | Dctn1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1347085 | Cetn2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
A2AGT5
Organism: Mus musculus/domesticus
Length: 2032  
Fragment?: false
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Protein
P61982
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: false
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Protein
Q9R1K9
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
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Protein
O35942
Organism: Mus musculus/domesticus
Length: 443  
Fragment?: false
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Protein
P63005
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
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Protein
O08788
Organism: Mus musculus/domesticus
Length: 1281  
Fragment?: false
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Protein
Q99KJ8
Organism: Mus musculus/domesticus
Length: 402  
Fragment?: false
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Protein
P61164
Organism: Mus musculus/domesticus
Length: 376  
Fragment?: false
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Protein
Q61166
Organism: Mus musculus/domesticus
Length: 268  
Fragment?: false
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Protein
Q9Z0Y1
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: false
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Protein
Q9DC28
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
Q80TV8
Organism: Mus musculus/domesticus
Length: 1535  
Fragment?: false
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Protein
Q9CZA6
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: false
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Publication
21245385 | J:170612
First Author: de Cárcer G
Year: 2011
Journal: Mol Cell Biol
Title: Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression.
Volume: 31
Issue: 6
Pages: 1225-39
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Publication
12639966 | J:177166
First Author: Walter SA
Year: 2003
Journal: J Biol Chem
Title: Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue.
Volume: 278
Issue: 20
Pages: 18221-8
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Publication
26731471 | J:231166
First Author: Naylor RM
Year: 2016
Journal: J Clin Invest
Title: Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy.
Volume: 126
Issue: 2
Pages: 543-59
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Publication
17079455 | J:114921
First Author: Knock E
Year: 2006
Journal: Cancer Res
Title: Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c.
Volume: 66
Issue: 21
Pages: 10349-56
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Publication
25628462 | J:260326
First Author: Bowman BM
Year: 2015
Journal: Sci Signal
Title: Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer.
Volume: 8
Issue: 361
Pages: ra9
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Publication
22102825 | J:178940
First Author: Lal A
Year: 2011
Journal: PLoS Genet
Title: Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling.
Volume: 7
Issue: 11
Pages: e1002363
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Publication
23610072 | J:198448
First Author: Zhai R
Year: 2013
Journal: Mol Reprod Dev
Title: Bora regulates meiotic spindle assembly and cell cycle during mouse oocyte meiosis.
Volume: 80
Issue: 6
Pages: 474-87
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Publication
20126263 | J:245264
First Author: van Vugt MA
Year: 2010
Journal: PLoS Biol
Title: A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.
Volume: 8
Issue: 1
Pages: e1000287
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Publication
19822658 | J:155123
First Author: Ma HT
Year: 2009
Journal: Mol Cell Biol
Title: Cyclin A2-cyclin-dependent kinase 2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-anaphase-promoting complex/cyclosome axis to promote genome reduplication in the absence of mitosis.
Volume: 29
Issue: 24
Pages: 6500-14
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Publication
22890240 | J:191834
First Author: Liu X
Year: 2012
Journal: Cancer Res
Title: Protein tyrosine phosphatase Shp2 (Ptpn11) plays an important role in maintenance of chromosome stability.
Volume: 72
Issue: 20
Pages: 5296-306
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Publication
22859367 | J:193355
First Author: Pomerantz Y
Year: 2012
Journal: FASEB J
Title: From ubiquitin-proteasomal degradation to CDK1 inactivation: requirements for the first polar body extrusion in mouse oocytes.
Volume: 26
Issue: 11
Pages: 4495-505
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Publication
25740542 | J:222105
First Author: Luo YB
Year: 2015
Journal: Biol Reprod
Title: PLK4 is essential for meiotic resumption in mouse oocytes.
Volume: 92
Issue: 4
Pages: 101
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Publication
26468278 | J:227126
First Author: Ramkumar P
Year: 2015
Journal: J Biol Chem
Title: JNK-associated Leucine Zipper Protein Functions as a Docking Platform for Polo-like Kinase 1 and Regulation of the Associating Transcription Factor Forkhead Box Protein K1.
Volume: 290
Issue: 49
Pages: 29617-28
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Publication
24475924 | J:229357
First Author: Kumeta M
Year: 2014
Journal: Genes Cells
Title: Caprice/MISP is a novel F-actin bundling protein critical for actin-based cytoskeletal reorganizations.
Volume: 19
Issue: 4
Pages: 338-49
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Publication
26802898 | J:251247
First Author: Jeon HJ
Year: 2016
Journal: Biochim Biophys Acta
Title: TCTP regulates spindle microtubule dynamics by stabilizing polar microtubules during mouse oocyte meiosis.
Volume: 1863
Issue: 4
Pages: 630-7
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Publication
31175830 | J:289109
First Author: Ahodantin J
Year: 2020
Journal: Carcinogenesis
Title: Hepatitis B virus X protein enhances the development of liver fibrosis and the expression of genes associated with epithelial-mesenchymal transitions and tumor progenitor cells.
Volume: 41
Issue: 3
Pages: 358-367
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Publication
34343212 | J:314254
First Author: Yu L
Year: 2021
Journal: PLoS Pathog
Title: Mouse papillomavirus type 1 (MmuPV1) DNA is frequently integrated in benign tumors by microhomology-mediated end-joining.
Volume: 17
Issue: 8
Pages: e1009812
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Publication
26466676 | J:315995
First Author: Yamamori T
Year: 2015
Journal: Mol Biol Cell
Title: Inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) impairs mitochondrial fission and mitotic catastrophe after x-irradiation.
Volume: 26
Issue: 25
Pages: 4607-17
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Publication
32562308 | J:329438
First Author: Zhou CJ
Year: 2020
Journal: FEBS J
Title: Protein regulator of cytokinesis 1 regulates chromosome dynamics and cytoplasmic division during mouse oocyte meiotic maturation and early embryonic development.
Volume: 287
Issue: 23
Pages: 5130-5147
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Protein
Q9CS10
Organism: Mus musculus/domesticus
Length: 275  
Fragment?: true
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Protein
Q8C4D0
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: false
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Publication
10704439 | -
First Author: Hardwick KG
Year: 2000
Journal: J Cell Biol
Title: MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p.
Volume: 148
Issue: 5
Pages: 871-82
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Publication
17081983 | -
First Author: Olsen JV
Year: 2006
Journal: Cell
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Volume: 127
Issue: 3
Pages: 635-48
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Publication
23071326 | -
First Author: Zhan X
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Arabidopsis proline-rich protein important for development and abiotic stress tolerance is involved in microRNA biogenesis.
Volume: 109
Issue: 44
Pages: 18198-203
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Publication
26888284 | -
First Author: Karampelias M
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: ROTUNDA3 function in plant development by phosphatase 2A-mediated regulation of auxin transporter recycling.
Volume: 113
Issue: 10
Pages: 2768-73
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Publication
27624757 | -
First Author: Marshall CM
Year: 2016
Journal: Plant Cell
Title: The Arabidopsis sickle Mutant Exhibits Altered Circadian Clock Responses to Cool Temperatures and Temperature-Dependent Alternative Splicing.
Volume: 28
Issue: 10
Pages: 2560-2575
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Publication
22447658 | -
First Author: Luo J
Year: 2012
Journal: Protein Cell
Title: Polo-like kinase 1, on the rise from cell cycle regulation to prostate cancer development.
Volume: 3
Issue: 3
Pages: 182-97
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Publication
21153517 | -
First Author: Liu XS
Year: 2010
Journal: Protein Cell
Title: The substrates of Plk1, beyond the functions in mitosis.
Volume: 1
Issue: 11
Pages: 999-1010
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Publication
20107874 | -
First Author: Schmit TL
Year: 2010
Journal: Pharm Res
Title: Modulating polo-like kinase 1 as a means for cancer chemoprevention.
Volume: 27
Issue: 6
Pages: 989-98
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Publication
17172872 | -
First Author: Martin BT
Year: 2006
Journal: Cell Cycle
Title: Polo-like kinase 1: target and regulator of transcriptional control.
Volume: 5
Issue: 24
Pages: 2881-5
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Publication
16849530 | -
First Author: Eckerdt F
Year: 2006
Journal: Cancer Res
Title: Polo-like kinase 1: target and regulator of anaphase-promoting complex/cyclosome-dependent proteolysis.
Volume: 66
Issue: 14
Pages: 6895-8
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Protein Domain
IPR033702 | PLK1_cat
Type: Domain
Description: Serine/Threonine Kinases (STKs) catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Polo-like kinases (PLKs) are serine/threonine kinases that play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes [].PLK1 functions as a positive regulator of mitosis, meiosis, and cytokinesis. Its localization changes during mitotic progression; associating first with centrosomes in prophase, with kinetochores in prometaphase and metaphase, at the central spindle in anaphase, and in the midbody during telophase [, , ]. It carries multiple functions throughout the cell cycle through interactions with differrent substrates at these specific subcellular locations []. PLK1 is overexpressed in many human cancers and is associated with poor prognosis [, , ].This entry represents the N-terminal catalytic kinase domain of PLK1.
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Protein Coding Gene
MGI:2144023 | Fbxw11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:894689 | Ywhae
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:103147 | Dync1h1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96250 | Hsp90aa1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88302 | Ccnb1
Type: protein_coding_gene
Organism: mouse, laboratory
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