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Search results 701 to 800 out of 8636 for Pml

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Type Details Score
Publication
First Author: Chin KT
Year: 2007
Journal: Cancer Res
Title: Human T-cell leukemia virus oncoprotein tax represses nuclear receptor-dependent transcription by targeting coactivator TAX1BP1.
Volume: 67
Issue: 3
Pages: 1072-81
Publication
First Author: Yin S
Year: 2022
Journal: Stem Cell Reports
Title: TIN2 deficiency leads to ALT-associated phenotypes and differentiation defects in embryonic stem cells.
Volume: 17
Issue: 5
Pages: 1183-1197
Publication
First Author: Pandolfi PP
Year: 2001
Journal: Hum Mol Genet
Title: Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia.
Volume: 10
Issue: 7
Pages: 769-75
Publication
First Author: Wang YA
Year: 2005
Journal: Mol Carcinog
Title: Induction of murine leukemia and lymphoma by dominant negative retinoic acid receptor alpha.
Volume: 44
Issue: 4
Pages: 252-61
Publication
First Author: Giovannoni F
Year: 2020
Journal: Nat Neurosci
Title: AHR is a Zika virus host factor and a candidate target for antiviral therapy.
Volume: 23
Issue: 8
Pages: 939-951
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Strain
Attribute String: mutant stock, transgenic
Strain
Attribute String: transgenic, mutant stock
Allele
Name: transgene insertion 21, Hugues de The
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: transgene insertion 14, Hugues de The
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Protein
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 324  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 124  
Fragment?: true
Publication
First Author: Gupta P
Year: 2009
Journal: PLoS One
Title: HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase activity-independent function of HDAC3.
Volume: 4
Issue: 2
Pages: e4363
Protein
Organism: Mus musculus/domesticus
Length: 219  
Fragment?: false
Publication
First Author: Kim K
Year: 2009
Journal: BMB Rep
Title: Species-specific variation of RPA-interacting protein (RIP) splice isoforms.
Volume: 42
Issue: 1
Pages: 22-7
Protein
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 219  
Fragment?: false
Publication
First Author: Hollenbach AD
Year: 2002
Journal: J Cell Sci
Title: Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
Volume: 115
Issue: Pt 16
Pages: 3319-30
Publication
First Author: Behlke-Steinert S
Year: 2009
Journal: Cell Cycle
Title: SMC5 and MMS21 are required for chromosome cohesion and mitotic progression.
Volume: 8
Issue: 14
Pages: 2211-8
Publication
First Author: Jullien D
Year: 1999
Journal: EMBO J
Title: Nuclear import of RPA in Xenopus egg extracts requires a novel protein XRIPalpha but not importin alpha.
Volume: 18
Issue: 15
Pages: 4348-58
Protein Domain
Type: Family
Description: Daxx is a ubiquitously expressed protein that functions, in part, as a transcriptional co-repressor through its interaction with a growing numberof nuclear, DNA-associated proteins. Human Daxx contains four structural domains commonly found in transcriptional regulatory proteins: two predicted paired amphipathic helices, an acid-rich domain and a Ser/Pro/Thr (SPT)-rich domain. The post-translational modification status of the SPT-domain of hDaxx regulates its association with transcription factors such as Pax3 and ETS-1, effectively bringing hDaxx to sites of active transcription.Through its presence at the site of active transcription, hDaxx could then be able to associate with acetylated histones present in the nucleosomes andDek that is associated with chromatin. Through its association with the SPT-domain of hDaxx, histone deacetylases may also be brought to the site of active transcription. As a consequence, nucleosomes in the vicinity of the site of active transcription will have the histone tails deacetylated, allowing the deactylated tail to bind to DNA, thereby leading to an inactive chromatin structure and transcriptional repression []. The Daxx protein (also known as the Fas-binding protein or death domain-associated protein 6) is thought to play a role in apoptosis as a component of nuclear promyelocytic leukemia protein (PML) oncogenic domains (PODS). Daxx associates with PODs through a direct interaction withPML, a critical component of PODs. The interaction is a dynamic, cell cycle regulated event and is dependent on the post-translational modification of PML by the small ubiquitin-related modifier SUMO-1.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Cao T
Year: 1996
Journal: Dev Genet
Title: Mouse ret finger protein (rfp) proto-oncogene is expressed at specific stages of mouse spermatogenesis.
Volume: 19
Issue: 4
Pages: 309-20
Publication
First Author: Assier E
Year: 1999
Journal: Gene
Title: Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat.
Volume: 230
Issue: 2
Pages: 145-54
Publication
First Author: Weichenhan D
Year: 1997
Journal: Genomics
Title: Structure and expression of the murine Sp100 nuclear dot gene.
Volume: 43
Issue: 3
Pages: 298-306
Publication
First Author: Seeler JS
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment.
Volume: 95
Issue: 13
Pages: 7316-21
Publication
First Author: Kondo Y
Year: 2014
Journal: J Clin Invest
Title: Human glial chimeric mice reveal astrocytic dependence of JC virus infection.
Volume: 124
Issue: 12
Pages: 5323-36
Publication    
First Author: Lauver MD
Year: 2022
Journal: Elife
Title: T cell deficiency precipitates antibody evasion and emergence of neurovirulent polyomavirus.
Volume: 11
Publication
First Author: Konietzko U
Year: 2010
Journal: Neurobiol Aging
Title: Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories.
Volume: 31
Issue: 1
Pages: 58-73
Publication  
First Author: Rosenblum LT
Year: 2017
Journal: Exp Neurol
Title: Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS.
Volume: 292
Pages: 145-153
Publication
First Author: Welch JS
Year: 2011
Journal: Blood
Title: Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.
Volume: 117
Issue: 8
Pages: 2460-8
Publication
First Author: Janer A
Year: 2010
Journal: Hum Mol Genet
Title: SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7.
Volume: 19
Issue: 1
Pages: 181-95
Publication
First Author: Hansen LA
Year: 2003
Journal: Cancer Res
Title: A PMLRARA transgene results in a retinoid-deficient phenotype associated with enhanced susceptibility to skin tumorigenesis.
Volume: 63
Issue: 17
Pages: 5257-65
Publication
First Author: Esnault C
Year: 2019
Journal: Blood
Title: FLT3-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias.
Volume: 133
Issue: 13
Pages: 1495-1506
Publication
First Author: Singh R
Year: 2014
Journal: J Biol Chem
Title: Calpain 5 is highly expressed in the central nervous system (CNS), carries dual nuclear localization signals, and is associated with nuclear promyelocytic leukemia protein bodies.
Volume: 289
Issue: 28
Pages: 19383-94
Publication  
First Author: Zhang M
Year: 2023
Journal: Cancers (Basel)
Title: Regulation of EZH2 Expression by INPP4B in Normal Prostate and Primary Prostate Cancer.
Volume: 15
Issue: 22
Publication
First Author: Engelhardt OG
Year: 2001
Journal: Exp Cell Res
Title: Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies.
Volume: 271
Issue: 2
Pages: 286-95
Publication
First Author: Rego EM
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins.
Volume: 97
Issue: 18
Pages: 10173-8
Publication
First Author: Tse WT
Year: 2001
Journal: J Biol Chem
Title: A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix.
Volume: 276
Issue: 26
Pages: 23974-85
Publication
First Author: He LZ
Year: 2001
Journal: J Clin Invest
Title: Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia.
Volume: 108
Issue: 9
Pages: 1321-30
Publication
First Author: Khan MM
Year: 2001
Journal: J Biol Chem
Title: PML-RARalpha alleviates the transcriptional repression mediated by tumor suppressor Rb.
Volume: 276
Issue: 47
Pages: 43491-4
Publication
First Author: Topisirovic I
Year: 2002
Journal: Mol Cell Biol
Title: Gamma interferon and cadmium treatments modulate eukaryotic initiation factor 4E-dependent mRNA transport of cyclin D1 in a PML-dependent manner.
Volume: 22
Issue: 17
Pages: 6183-98
Publication
First Author: Matsushita H
Year: 2006
Journal: J Exp Med
Title: In vivo analysis of the role of aberrant histone deacetylase recruitment and RAR alpha blockade in the pathogenesis of acute promyelocytic leukemia.
Volume: 203
Issue: 4
Pages: 821-8
Publication
First Author: Liang J
Year: 2008
Journal: Nat Cell Biol
Title: Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells.
Volume: 10
Issue: 6
Pages: 731-9
Publication
First Author: De Vos WH
Year: 2011
Journal: Hum Mol Genet
Title: Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies.
Volume: 20
Issue: 21
Pages: 4175-86
Publication
First Author: Ji L
Year: 2020
Journal: Biochim Biophys Acta Gene Regul Mech
Title: TOPORS, a tumor suppressor protein, contributes to the maintenance of higher-order chromatin architecture.
Volume: 1863
Issue: 5
Pages: 194518
Strain
Attribute String: mutant strain, transgenic, congenic
Strain
Attribute String: mutant stock, transgenic
Protein
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: true
Publication
First Author: Aapola U
Year: 2000
Journal: Genomics
Title: Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family.
Volume: 65
Issue: 3
Pages: 293-8
Protein Domain
Type: Domain
Description: One of the largest protein families in the human genome is the zinc fingerfamily that contains members involved in the regulation of transcriptionprocesses. The zinc finger domains have been classified based on the order ofcysteine (C) and histidine (H) residues. Zinc fingers are thought to mediateprotein-DNA and protein-protein interactions. The ADD (ATRX, DNMT3, DNMT3L)domain is a cysteine-rich region that consists of a C2C2-type zinc finger anda closely located domain of an imperfect PHD-type zinc finger with C4C4. The region between the two subdomains has a constant length, andit contains identical and conserved amino acids [, ]. The ADD domain binds to the histone H3 tail that is unmethylated at lysine 4 [, ].The ADD domain is present in chromatin-associated proteins that play a role inestablishing and/or maintaining a normal pattern of DNA methylation:DNMT3A, DNMT3B, DNA methyltransferases.DNMT3L, a DNMT3-like enzymatically inactive regulatory factor.ATRX, a large nuclear protein predominantly localized to heterochromatinand nuclear PML bodies. At the C terminus is a helicase/ATPase domain, which characterises ATRX as a member of the SNF2 (SWI/SNF) family of chromatin-associated proteins. The ADD domain is composed of three clearly distinguishable modules that packtogether through extensive hydrophobic interactions to form a single globulardomain. Packed against this GATA-like finger is a second subdomain,which binds two zinc ions and closely resembles the structure reported forseveral PHD fingers. Finally, there is a long C-terminal α-helix that runsout from the PHD finger and makes extensive hydrophobic contacts with the N-terminal GATA finger, bringing the N- and C-termini of the ADD domain closetogether. This combination of fused GATA-like and PHD fingers within a singledomain is thus far unique [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Wang D
Year: 1996
Journal: Cancer Lett
Title: Expression of a specific mouse germ cell nuclear antigen (GCNA1) by early embryonic testicular teratoma cells in 129/Sv-Sl/+ mice.
Volume: 100
Issue: 1-2
Pages: 31-6
GXD Expression    
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2005-04-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3575137
Age: postnatal
Image: 1
Specimen Label: SM
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2005-04-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:3575137
Age: postnatal
Image: 1
Specimen Label: SK
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2005-04-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3283428
Stage: TS28
Assay Id: MGI:3575137
Age: postnatal
Image: 1
Specimen Label: IN
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2005-04-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3575137
Age: postnatal
Image: 1
Specimen Label: KD
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2005-04-22
Strength: Absent
Sex: Male
Emaps: EMAPS:1929028
Stage: TS28
Assay Id: MGI:3575137
Age: postnatal
Image: 1
Specimen Label: EP
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2005-04-22
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3575137
Age: postnatal
Image: 1
Specimen Label: TT
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2005-04-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3575137
Age: postnatal
Image: 1
Specimen Label: BR
Detected: false
Specimen Num: 7
GXD Expression    
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2005-04-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3575137
Age: postnatal
Image: 1
Specimen Label: SE
Detected: false
Specimen Num: 8
GXD Expression    
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2005-04-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3575137
Age: postnatal
Image: 1
Specimen Label: HT
Detected: false
Specimen Num: 9
GXD Expression    
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2005-04-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3575137
Age: postnatal
Image: 1
Specimen Label: LG
Detected: false
Specimen Num: 10
GXD Expression    
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2005-04-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1929028
Stage: TS28
Assay Id: MGI:3575313
Age: postnatal
Image: 3
Specimen Label: EP
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2005-04-25
Strength: Present
Sex: Male
Emaps: EMAPS:3147628
Stage: TS28
Assay Id: MGI:3575313
Age: postnatal adult
Image: 3
Specimen Label: ST
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2005-04-25
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3575313
Age: postnatal day 6
Image: 3
Specimen Label: 6T
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2005-04-25
Strength: Absent
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3575313
Age: postnatal adult
Image: 3
Specimen Label: OV
Detected: false
Specimen Num: 7
GXD Expression    
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2005-04-25
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3575402
Age: postnatal day 6
Image: 2
Specimen Label: 6T
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2005-04-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1929028
Stage: TS28
Assay Id: MGI:3575402
Age: postnatal
Image: 2
Specimen Label: EP
Detected: false
Specimen Num: 8
GXD Expression    
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2005-04-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3575402
Age: postnatal
Image: 2
Specimen Label: LV
Detected: false
Specimen Num: 9
GXD Expression      
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2022-07-25
Strength: Present
Sex: Female
Emaps: EMAPS:1796222
Stage: TS22
Assay Id: MGI:7314917
Age: embryonic day 14.5
Specimen Label: 14.5 XX
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2022-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1796222
Stage: TS22
Assay Id: MGI:7314917
Age: embryonic day 14.5
Specimen Label: 14.5 XY
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2022-07-25
Strength: Present
Sex: Female
Emaps: EMAPS:1796225
Stage: TS25
Assay Id: MGI:7314917
Age: embryonic day 17.5
Specimen Label: 17.5 XX
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2022-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1796225
Stage: TS25
Assay Id: MGI:7314917
Age: embryonic day 17.5
Specimen Label: 17.5 XY
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3574441
Assay Type: Western blot
Annotation Date: 2022-07-25
Strength: Present
Sex: Female
Emaps: EMAPS:1796227
Stage: TS27
Assay Id: MGI:7314917
Age: postnatal newborn
Specimen Label: 20.5 dpc XX
Detected: true
Specimen Num: 5