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Search results 701 to 800 out of 1091 for Pth

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0.034s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein
A0A3B2WCV5
Organism: Mus musculus/domesticus
Length: 66  
Fragment?: false
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Protein
A0A494BBF3
Organism: Mus musculus/domesticus
Length: 90  
Fragment?: false
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Protein
A0A3B2W7Z9
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: false
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Protein
A0A3B2WAN2
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: false
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Protein
A0A338P698
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: false
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Protein
A0A338P6A4
Organism: Mus musculus/domesticus
Length: 183  
Fragment?: false
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Protein
A0A3B2WBM5
Organism: Mus musculus/domesticus
Length: 66  
Fragment?: false
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Protein
A0A3Q4EGQ0
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: false
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Protein
A0A3Q4EC64
Organism: Mus musculus/domesticus
Length: 69  
Fragment?: false
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Protein
A0A338P747
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: false
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Protein
A0A3Q4EIK7
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: false
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Protein
A0A3B2WAY7
Organism: Mus musculus/domesticus
Length: 65  
Fragment?: false
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Protein
A0A3B2W4H2
Organism: Mus musculus/domesticus
Length: 100  
Fragment?: false
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Protein
A0A3B2WAV1
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: false
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Protein
A0A338P772
Organism: Mus musculus/domesticus
Length: 74  
Fragment?: false
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Protein
A0A3Q4EGR6
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: false
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Protein
A0A3Q4EHI3
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: false
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Protein
A0A3B2WD78
Organism: Mus musculus/domesticus
Length: 69  
Fragment?: false
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Protein
A0A3B2WD95
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: false
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Protein
A0A3B2WBE4
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: false
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Protein
A0A3B2W3M4
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: false
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Protein
A0A3B2WCP3
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: false
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Protein
A0A3Q4EI99
Organism: Mus musculus/domesticus
Length: 66  
Fragment?: false
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Publication
9298824 | -
First Author: Ward BK
Year: 1997
Journal: Hum Mutat
Title: A novel mutation (L174R) in the Ca2+-sensing receptor gene associated with familial hypocalciuric hypercalcemia.
Volume: 10
Issue: 3
Pages: 233-5
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Publication
8675635 | -
First Author: Pearce SH
Year: 1995
Journal: J Clin Invest
Title: Calcium-sensing receptor mutations in familial benign hypercalcemia and neonatal hyperparathyroidism.
Volume: 96
Issue: 6
Pages: 2683-92
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Publication
7874174 | -
First Author: Pollak MR
Year: 1994
Journal: Nat Genet
Title: Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutation.
Volume: 8
Issue: 3
Pages: 303-7
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Protein Domain
IPR000068 | GPCR_3_Ca_sens_rcpt-rel
Type: Family
Description: G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists ofapproximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+intracellular signalling pathway [, , , ]. At least eight sub-types of metabotropic receptor (GRM1-8) have been identified in cloning studies. The sub-types differ in their agonist pharmacology and signal transduction pathways.The calcium-sensing receptor (CaSR) is an integral membrane protein thatsenses changes in the extracellular concentration of calcium ions. Theactivity of the receptor is mediated by a G-protein that activates aphosphatidyl-inositol-calcium second messenger system. The sequences of thereceptors show a high degree of similarity to the TM signature thatcharacterises the metabotropic glutamate receptors. In addition, thesequences contain a large extracellular domain that includes clusters ofacidic amino acid residues, which may be involved in calcium binding [].Defects in CaSR that result in reduced activity of the receptor causefamilial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT), inherited conditions characterised by altered calciumhomeostasis [, ]. FHH-affected individuals exhibit mild or modest hypercalcemia, relative hypocalciuria and inappropriately normal PTH levels. Bycontrast, NSHPT is a rare autosomal recessive life-threatening disordercharacterised by high serum calcium concentrations, skeletal demineralisation and parathyroid hyperplasia. In addition, defects resulting fromreceptor activation at subnormal Ca2+levels cause autosomal dominanthypocalcemia [].This entry represents the extracellular calcium-sensing receptors and related proteins in GPCR family 3, such as the taste receptors.
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Publication
33440155 | J:304310
First Author: Marneros AG
Year: 2021
Journal: Cell Rep
Title: Magnesium and Calcium Homeostasis Depend on KCTD1 Function in the Distal Nephron.
Volume: 34
Issue: 2
Pages: 108616
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Publication
10605626 | J:59793
First Author: Eisman JA
Year: 1999
Journal: Endocr Rev
Title: Genetics of osteoporosis.
Volume: 20
Issue: 6
Pages: 788-804
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Protein
P41593
Organism: Mus musculus/domesticus
Length: 591  
Fragment?: false
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Protein
Q3U0H1
Organism: Mus musculus/domesticus
Length: 307  
Fragment?: false
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Protein
O88982
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: true
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Protein
A0A3B2W3Q7
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: false
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Protein
O35203
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: false
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Protein
Q91WV4
Organism: Mus musculus/domesticus
Length: 591  
Fragment?: false
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Protein
A0A3B2W3Z9
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: false
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Protein
A0A3B2WDB7
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: false
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Protein
A0A3B2W7N2
Organism: Mus musculus/domesticus
Length: 167  
Fragment?: false
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Protein
O35200
Organism: Mus musculus/domesticus
Length: 311  
Fragment?: false
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Protein
A0A3B2W4E6
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Protein
E9PXC1
Organism: Mus musculus/domesticus
Length: 469  
Fragment?: false
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Protein
A0A3B2WCR1
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: false
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Protein
A0A3B2WDC6
Organism: Mus musculus/domesticus
Length: 182  
Fragment?: false
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Protein
A0A3B2WD02
Organism: Mus musculus/domesticus
Length: 512  
Fragment?: false
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Protein
A0A3B2WCI4
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: false
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Protein
A0A3B2WAT0
Organism: Mus musculus/domesticus
Length: 497  
Fragment?: false
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Protein
A0A3B2WCJ3
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: false
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Protein
A0A3B2WD15
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: false
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Protein
A0A3B2W7B9
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: false
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Protein
A0A3B2WCP5
Organism: Mus musculus/domesticus
Length: 500  
Fragment?: false
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Protein
A0A3B2WDC3
Organism: Mus musculus/domesticus
Length: 529  
Fragment?: false
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Protein
A0A3Q4L333
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
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Protein
A0A3B2WDA0
Organism: Mus musculus/domesticus
Length: 500  
Fragment?: false
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Protein
A0A1B0GSD7
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
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Protein
A0A3B2WCN3
Organism: Mus musculus/domesticus
Length: 567  
Fragment?: false
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Protein
A0A3B2WD32
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: false
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Protein
A0A3B2WD89
Organism: Mus musculus/domesticus
Length: 442  
Fragment?: false
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Protein
A0A3B2WCS9
Organism: Mus musculus/domesticus
Length: 470  
Fragment?: false
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Protein
A0A3B2WAY9
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
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Protein
A0A3B2WBG5
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: false
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Protein
A0A3Q4L2R4
Organism: Mus musculus/domesticus
Length: 376  
Fragment?: false
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Protein
Q8C0M6
Organism: Mus musculus/domesticus
Length: 476  
Fragment?: false
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Protein
A0A3Q4L339
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: false
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Protein
A0A3B2WB78
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: false
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Protein
A0A3B2WDE6
Organism: Mus musculus/domesticus
Length: 445  
Fragment?: false
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Protein
A0A3B2WDB2
Organism: Mus musculus/domesticus
Length: 255  
Fragment?: false
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Protein
A0A3B2W8B1
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: false
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Protein
A0A3B2W7Y7
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: false
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Protein
A0A3B2W3I1
Organism: Mus musculus/domesticus
Length: 470  
Fragment?: false
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Protein
A0A3B2WAR2
Organism: Mus musculus/domesticus
Length: 475  
Fragment?: false
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Protein
A0A3Q4L389
Organism: Mus musculus/domesticus
Length: 550  
Fragment?: false
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Protein
Q3LHH5
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: true
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Protein
A0A3B2WD03
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: false
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Protein
A0A3Q4EBX4
Organism: Mus musculus/domesticus
Length: 577  
Fragment?: false
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Protein
A0A3Q4EIB3
Organism: Mus musculus/domesticus
Length: 514  
Fragment?: false
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Protein
O35199
Organism: Mus musculus/domesticus
Length: 507  
Fragment?: false
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Protein
O35198
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
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Protein
Q4VAH6
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: false
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Protein
A0A1B0GRA1
Organism: Mus musculus/domesticus
Length: 106  
Fragment?: false
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Protein
O35363
Organism: Mus musculus/domesticus
Length: 311  
Fragment?: true
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Protein
A0A3Q4EHY5
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
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Protein
A0A3Q4EGR4
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
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Protein
A0A1B0GRQ2
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: false
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Protein
A0A338P793
Organism: Mus musculus/domesticus
Length: 469  
Fragment?: false
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Protein
O35201
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: true
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Protein
A0A3B2WB57
Organism: Mus musculus/domesticus
Length: 595  
Fragment?: false
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Protein
A0A3Q4EGU0
Organism: Mus musculus/domesticus
Length: 520  
Fragment?: false
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Protein
A0A3B2WCZ5
Organism: Mus musculus/domesticus
Length: 496  
Fragment?: false
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Protein
A0A3Q4EGX1
Organism: Mus musculus/domesticus
Length: 561  
Fragment?: false
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Protein
A0A3B2W4J1
Organism: Mus musculus/domesticus
Length: 476  
Fragment?: false
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Protein
Q8BJ74
Organism: Mus musculus/domesticus
Length: 101  
Fragment?: false
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Protein
A0A3B2WCD4
Organism: Mus musculus/domesticus
Length: 530  
Fragment?: false
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Protein
A0A3B2WBK0
Organism: Mus musculus/domesticus
Length: 563  
Fragment?: false
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Protein
A0A3B2WB20
Organism: Mus musculus/domesticus
Length: 533  
Fragment?: false
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Protein
A0A3B2WCA7
Organism: Mus musculus/domesticus
Length: 577  
Fragment?: false
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Protein
Q3LHH6
Organism: Mus musculus/domesticus
Length: 222  
Fragment?: true
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Protein
A0A3B2W896
Organism: Mus musculus/domesticus
Length: 338  
Fragment?: false
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Protein
A0A3B2W3L2
Organism: Mus musculus/domesticus
Length: 557  
Fragment?: false
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Protein
A0A3B2W802
Organism: Mus musculus/domesticus
Length: 544  
Fragment?: false
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Protein
A0A3B2W855
Organism: Mus musculus/domesticus
Length: 511  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom