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Search results 701 to 800 out of 1142 for Ptn

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Allele
Tg(PDGFB-Ptn)2Rau | MGI:6153152
Name: transgene insertion 2, Heikki Rauvala
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:6429446 | C57BL/6JSmoc-Ptn<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6145845 | 129;FVB-Tg(PDGFB-Ptn)2Rau/RauRbrc
Attribute String: mutant stock, transgenic
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Allele
Ptn<tm1(cre/ERT2)Zjh> | MGI:7438130
Name: pleiotrophin; targeted mutation 1, Z Josh Huang
Allele Type: Targeted
Attribute String: Inducible, Recombinase
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Strain
MGI:3762816 | B6;D2-Tg(BGLAP-PTN)1Thg/ThgRbrc
Attribute String: transgenic, mutant stock
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Strain
MGI:3053393 | B6;D2-Tg(BGLAP-PTN)1Thg
Attribute String: mutant stock, transgenic
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Publication
23284618 | J:195641
First Author: Albi E
Year: 2012
Journal: PLoS One
Title: Loss of parafollicular cells during gravitational changes (microgravity, hypergravity) and the secret effect of pleiotrophin.
Volume: 7
Issue: 12
Pages: e48518
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Publication
15108072 | J:189413
First Author: Hashimoto-Gotoh T
Year: 2004
Journal: J Bone Miner Metab
Title: Bone mass increase specific to the female in a line of transgenic mice overexpressing human osteoblast stimulating factor-1.
Volume: 22
Issue: 3
Pages: 278-82
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Publication
22558148 | J:187284
First Author: Masini MA
Year: 2012
Journal: PLoS One
Title: The impact of long-term exposure to space environment on adult mammalian organisms: a study on mouse thyroid and testis.
Volume: 7
Issue: 4
Pages: e35418
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Genotype
Genotype
Symbol: Tg(BGLAP-PTN)1Thg/Tg(BGLAP-PTN)1Thg
Background: involves: C57BL/6 * DBA/1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(BGLAP-PTN)1Thg/?
Background: involves: C57BL/6 * DBA/1
Zygosity: ot
Has Mutant Allele: true
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Protein Coding Gene
MGI:97816 | Ptprz1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
B9EKR1
Organism: Mus musculus/domesticus
Length: 2312  
Fragment?: false
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Allele
Tg(Ptn-EGFP)HJ32Gsat | MGI:4847351
Name: transgene insertion HJ32, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:5003742 | STOCK Tg(Ptn-EGFP)HJ32Gsat/Mmucd
Attribute String: mutant stock, transgenic
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HT Experiment
E-SMDB-3845 | Transcription profiling of mouse adult and juvenile dura mater (bone) to explore the reossification of large calvarial defects during development
 
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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Publication
7824199 | J:20923
First Author: Matsumoto K
Year: 1994
Journal: Neurosci Lett
Title: Localization of pleiotrophin and midkine in the postnatal developing cerebellum.
Volume: 178
Issue: 2
Pages: 216-20
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ptn/Ptn<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Publication
31235908 | J:281538
First Author: Nikolakopoulou AM
Year: 2019
Journal: Nat Neurosci
Title: Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss.
Volume: 22
Issue: 7
Pages: 1089-1098
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Publication
37542032 | J:347045
First Author: Takeo M
Year: 2023
Journal: Nat Commun
Title: Cyclical dermal micro-niche switching governs the morphological infradian rhythm of mouse zigzag hair.
Volume: 14
Issue: 1
Pages: 4478
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Publication
14727142 | J:87797
First Author: Hornum L
Year: 2004
Journal: Mamm Genome
Title: Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6.
Volume: 15
Issue: 1
Pages: 53-61
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Publication
24727451 | J:219461
First Author: Fan JB
Year: 2014
Journal: Biochem Biophys Res Commun
Title: EGFR trans-activation mediates pleiotrophin-induced activation of Akt and Erk in cultured osteoblasts.
Volume: 447
Issue: 3
Pages: 425-30
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Publication
15226403 | -
First Author: Motegi A
Year: 2004
Journal: J Cell Sci
Title: ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.
Volume: 117
Issue: Pt 15
Pages: 3319-29
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Publication
11121404 | -
First Author: Souttou B
Year: 2001
Journal: J Biol Chem
Title: Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway.
Volume: 276
Issue: 12
Pages: 9526-31
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Publication
17274988 | -
First Author: Degoutin J
Year: 2007
Journal: FEBS Lett
Title: ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation.
Volume: 581
Issue: 4
Pages: 727-34
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Publication
12107166 | -
First Author: Bowden ET
Year: 2002
Journal: J Biol Chem
Title: Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase.
Volume: 277
Issue: 39
Pages: 35862-8
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Publication
11278720 | -
First Author: Stoica GE
Year: 2001
Journal: J Biol Chem
Title: Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin.
Volume: 276
Issue: 20
Pages: 16772-9
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Publication
12122009 | -
First Author: Stoica GE
Year: 2002
Journal: J Biol Chem
Title: Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types.
Volume: 277
Issue: 39
Pages: 35990-8
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Protein Domain
IPR026830 | ALK
Type: Family
Description: ALK tyrosine kinase receptor (also known as anaplastic lymphoma kinase, ALK) is a neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system [].ALK transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1 [, , ]. ALK acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation [, ]. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction [].
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Publication
20200993 | J:233132
First Author: Neunaber C
Year: 2010
Journal: J Bone Miner Res
Title: Increased trabecular bone formation in mice lacking the growth factor midkine.
Volume: 25
Issue: 8
Pages: 1724-35
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Publication
32168373 | J:286597
 
First Author: Xi G
Year: 2020
Journal: Endocrinology
Title: Estrogen Stimulation of Pleiotrophin Enhances Osteoblast Differentiation and Maintains Bone Mass in IGFBP-2 Null Mice.
Volume: 161
Issue: 4
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Publication
37260355 | J:338798
First Author: Kastana P
Year: 2023
Journal: Int J Cancer
Title: Genetic deletion or tyrosine phosphatase inhibition of PTPRZ1 activates c-Met to up-regulate angiogenesis and lung adenocarcinoma growth.
Volume: 153
Issue: 5
Pages: 1051-1066
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Publication
31416834 | J:282779
First Author: Fujikawa A
Year: 2019
Journal: J Biol Chem
Title: A head-to-toe dimerization has physiological relevance for ligand-induced inactivation of protein tyrosine receptor type Z.
Volume: 294
Issue: 41
Pages: 14953-14965
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Publication
35143418 | J:336213
 
First Author: Liu Z
Year: 2022
Journal: J Clin Invest
Title: Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling.
Volume: 132
Issue: 7
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Publication
17578909 | J:122589
First Author: Chang Y
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Secretion of pleiotrophin stimulates breast cancer progression through remodeling of the tumor microenvironment.
Volume: 104
Issue: 26
Pages: 10888-93
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Publication
28965856 | J:248912
 
First Author: Marino S
Year: 2017
Journal: Cancer Lett
Title: Pharmacological evidence for the bone-autonomous contribution of the NFκB/β-catenin axis to breast cancer related osteolysis.
Volume: 410
Pages: 180-190
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Publication
16980845 | J:356728
First Author: Wan DC
Year: 2006
Journal: Plast Reconstr Surg
Title: Differential gene expression between juvenile and adult dura mater: a window into what genes play a role in the regeneration of membranous bone.
Volume: 118
Issue: 4
Pages: 851-61
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Publication
15226297 | J:92392
First Author: Deepa SS
Year: 2004
Journal: J Biol Chem
Title: Chondroitin sulfate chains on syndecan-1 and syndecan-4 from normal murine mammary gland epithelial cells are structurally and functionally distinct and cooperate with heparan sulfate chains to bind growth factors. A novel function to control binding of midkine, pleiotrophin, and basic fibroblast growth factor.
Volume: 279
Issue: 36
Pages: 37368-76
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Publication
15880136 | J:101133
First Author: Mäkitie AA
Year: 2005
Journal: Lab Invest
Title: Molecular characterization of salivary gland malignancy using the Smgb-Tag transgenic mouse model.
Volume: 85
Issue: 8
Pages: 947-61
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Publication
26338327 | J:226163
First Author: Kuboyama K
Year: 2015
Journal: J Neurosci
Title: Inactivation of Protein Tyrosine Phosphatase Receptor Type Z by Pleiotrophin Promotes Remyelination through Activation of Differentiation of Oligodendrocyte Precursor Cells.
Volume: 35
Issue: 35
Pages: 12162-71
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Protein
A0A076N402
Organism: Mus musculus/domesticus
Length: 688  
Fragment?: true
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Protein
Q52KP9
Organism: Mus musculus/domesticus
Length: 679  
Fragment?: true
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Protein
A0A076N9K6
Organism: Mus musculus/domesticus
Length: 650  
Fragment?: true
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Protein
A0A076N8A1
Organism: Mus musculus/domesticus
Length: 718  
Fragment?: true
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Protein
A0A076NBC4
Organism: Mus musculus/domesticus
Length: 699  
Fragment?: true
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Protein
A0A076N1C3
Organism: Mus musculus/domesticus
Length: 661  
Fragment?: true
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Protein
A0A076N9K1
Organism: Mus musculus/domesticus
Length: 729  
Fragment?: true
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Protein
D3YV54
Organism: Mus musculus/domesticus
Length: 34  
Fragment?: true
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Protein
A0A5F8MPI0
Organism: Mus musculus/domesticus
Length: 95  
Fragment?: true
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Protein
D3Z418
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: true
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Protein
A0A1Y7VJA6
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: true
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Publication
14704859 | -
First Author: Rothhammer T
Year: 2004
Journal: Cell Mol Life Sci
Title: The Ets-1 transcription factor is involved in the development and invasion of malignant melanoma.
Volume: 61
Issue: 1
Pages: 118-28
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Publication
9031109 | -
First Author: Wlodarska I
Year: 1996
Journal: Leuk Lymphoma
Title: ETV6 gene rearrangements in hematopoietic malignant disorders.
Volume: 23
Issue: 3-4
Pages: 287-95
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Publication
12577325 | J:135865
First Author: Coonan JR
Year: 2003
Journal: J Comp Neurol
Title: Role of EphA4 in defining the position of a motoneuron pool within the spinal cord.
Volume: 458
Issue: 1
Pages: 98-111
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Publication
12389031 | -
First Author: Irie F
Year: 2002
Journal: Nat Neurosci
Title: EphB receptors regulate dendritic spine development via intersectin, Cdc42 and N-WASP.
Volume: 5
Issue: 11
Pages: 1117-8
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Publication
14659698 | J:87527
First Author: Melino G
Year: 2003
Journal: Trends Biochem Sci
Title: Functional regulation of p73 and p63: development and cancer.
Volume: 28
Issue: 12
Pages: 663-70
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Publication
14499651 | -
First Author: Bloyer S
Year: 2003
Journal: Dev Biol
Title: Identification and characterization of polyhomeotic PREs and TREs.
Volume: 261
Issue: 2
Pages: 426-42
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Protein Domain
IPR013761 | SAM/pointed_sf
Type: Homologous_superfamily
Description: Sterile alpha motif (SAM) domains are known to be involved in diverse protein-protein interactions, associating with both SAM-containing and non-SAM-containing proteins pathway []. SAM domains exhibit a conserved structure, consisting of a 4-5-helical bundle of two orthogonally packed alpha-hairpins. However SAM domains display a diversity of function, being involved in interactions with proteins, DNA and RNA []. The name sterile alpha motif arose from its presence in proteins that are essential for yeast sexual differentiation. The SAM domain has had various names, including SPM, PTN (pointed), SEP (yeast sterility, Ets-related, PcG proteins), NCR (N-terminal conserved region) and HLH (helix-loop-helix) domain, all of which are related and can be classified as SAM domains.SAM domains occur in eukaryotic and in some bacterial proteins. Structures have been determined for several proteins that contain SAM domains, including Ets-1 transcription factor, which plays a role in the development and invasion of tumour cells by regulating the expression of matrix-degrading proteases []; Etv6 transcription factor, gene rearrangements of which have been demonstrated in several malignancies []; EphA4 receptor tyrosine kinase, which is believed to be important for the correct localization of a motoneuron pool to a specific position in the spinal cord []; EphB2 receptor, which is involved in spine morphogenesis via intersectin, Cdc42 and N-Wasp []; p73, a p53 homologue involved in neuronal development []; and polyhomeotic, which is a member of the Polycomb group of genes (Pc-G) required for the maintenance of the spatial expression pattern of homeotic genes [].
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Protein
Q8R3Y5
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
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Protein
Q5SXE1
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
A0A087WPA4
Organism: Mus musculus/domesticus
Length: 190  
Fragment?: true
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Protein
D2JZZ5
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
G5E8E3
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
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Protein
A0A0R4J2B5
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: false
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Protein
A0A087WRI8
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: false
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Protein
Q5SXE2
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: true
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Protein
Q6PAJ3
Organism: Mus musculus/domesticus
Length: 880  
Fragment?: false
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Protein
Q3UFT3
Organism: Mus musculus/domesticus
Length: 876  
Fragment?: false
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Protein
E9QAJ7
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: true
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Protein
Q6TDG7
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
Q8CC79
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: true
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Protein
A0A3B2WCY8
Organism: Mus musculus/domesticus
Length: 282  
Fragment?: true
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Protein
D3Z292
Organism: Mus musculus/domesticus
Length: 66  
Fragment?: true
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Publication
12858164 | -
First Author: Aviv T
Year: 2003
Journal: Nat Struct Biol
Title: The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators.
Volume: 10
Issue: 8
Pages: 614-21
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Protein
Q61127
Organism: Mus musculus/domesticus
Length: 525  
Fragment?: false
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Protein
Q8K070
Organism: Mus musculus/domesticus
Length: 417  
Fragment?: false
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Protein
F6XZJ7
Organism: Mus musculus/domesticus
Length: 620  
Fragment?: false
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Protein
D3YXK1
Organism: Mus musculus/domesticus
Length: 519  
Fragment?: false
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Protein
Q60710
Organism: Mus musculus/domesticus
Length: 658  
Fragment?: false
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Protein
Q8VCQ6
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
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Protein
Q8C8Y5
Organism: Mus musculus/domesticus
Length: 445  
Fragment?: false
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Protein
Q69Z37
Organism: Mus musculus/domesticus
Length: 1561  
Fragment?: false
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Protein
Q8C4H2
Organism: Mus musculus/domesticus
Length: 520  
Fragment?: false
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Protein
Q9DA37
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: false
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Protein
Q7TST3
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: false
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Protein
Q1RNF8
Organism: Mus musculus/domesticus
Length: 542  
Fragment?: false
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Protein
Q0VE29
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: false
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Protein
D3YUG0
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: false
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Protein
Q3V1H9
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: false
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Protein
Q6NZC7
Organism: Mus musculus/domesticus
Length: 998  
Fragment?: false
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Protein
Q9ERA0
Organism: Mus musculus/domesticus
Length: 502  
Fragment?: false
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Protein
Q3UNW5
Organism: Mus musculus/domesticus
Length: 479  
Fragment?: false
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Protein
Q80VG1
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: false
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Protein
Q811S7
Organism: Mus musculus/domesticus
Length: 540  
Fragment?: false
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Protein
Q3UH82
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
Q3U247
Organism: Mus musculus/domesticus
Length: 342  
Fragment?: false
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Protein
Q8C5C0
Organism: Mus musculus/domesticus
Length: 551  
Fragment?: false
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Protein
E9Q3G4
Organism: Mus musculus/domesticus
Length: 514  
Fragment?: false
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Protein
Q3TYF1
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Protein
Q14AQ4
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom