|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 701 to 800 out of 803 for Rptor

0.032s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap EUCE0258h12, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap EUCE0196a06, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap EUCE0195c09, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap EUCE0273c05, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap EUCJ0153b01, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap EUCJ0020c05, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap EUCJ0092a03, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap S1-7C1, Philippe Soriano
Allele Type: Gene trapped
Allele
Name: RPTOR independent companion of MTOR, complex 2; targeted mutation 1.1, Kun-Liang Guan
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Allele
Name: RPTOR independent companion of MTOR, complex 2; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele
Name: RPTOR independent companion of MTOR, complex 2; endonuclease-mediated mutation 8, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: RPTOR independent companion of MTOR, complex 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele
Name: RPTOR independent companion of MTOR, complex 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: RPTOR independent companion of MTOR, complex 2; endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Publication
First Author: Signer RA
Year: 2014
Journal: Nature
Title: Haematopoietic stem cells require a highly regulated protein synthesis rate.
Volume: 509
Issue: 7498
Pages: 49-54
Publication  
First Author: Byles V
Year: 2013
Journal: Nat Commun
Title: The TSC-mTOR pathway regulates macrophage polarization.
Volume: 4
Pages: 2834
Publication
First Author: Lee D
Year: 2014
Journal: Stem Cell Reports
Title: Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors.
Volume: 3
Issue: 5
Pages: 832-40
Publication
First Author: Van de Velde LA
Year: 2017
Journal: J Biol Chem
Title: T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions.
Volume: 292
Issue: 1
Pages: 15-30
Publication
First Author: Sato R
Year: 2018
Journal: Nat Immunol
Title: Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis.
Volume: 19
Issue: 10
Pages: 1071-1082
Publication
First Author: Parker SJ
Year: 2018
Journal: Am J Physiol Heart Circ Physiol
Title: Proteomics reveals Rictor as a noncanonical TGF-β signaling target during aneurysm progression in Marfan mice.
Volume: 315
Issue: 5
Pages: H1112-H1126
Publication
First Author: Hagan GN
Year: 2008
Journal: Mol Cell Biol
Title: A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes.
Volume: 28
Issue: 13
Pages: 4215-26
Publication
First Author: Jung SM
Year: 2019
Journal: Mol Cell
Title: Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1.
Volume: 75
Issue: 4
Pages: 807-822.e8
Publication
First Author: Charbonnier LM
Year: 2015
Journal: Nat Immunol
Title: Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling.
Volume: 16
Issue: 11
Pages: 1162-73
Publication
First Author: Martinez Calejman C
Year: 2020
Journal: Nat Commun
Title: mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis.
Volume: 11
Issue: 1
Pages: 575
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Publication
First Author: Yilmaz ÖH
Year: 2012
Journal: Nature
Title: mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.
Volume: 486
Issue: 7404
Pages: 490-5
Publication  
First Author: Raynor JL
Year: 2020
Journal: J Exp Med
Title: Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions.
Volume: 217
Issue: 6
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Strain
Attribute String: congenic, mutant strain, targeted mutation
Strain
Attribute String: congenic, mutant strain, targeted mutation
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap IST10543A6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap IST12128E12, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap IST10543A11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap IST14219G9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap IST14743F3, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap IST14888F4, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: RPTOR independent companion of MTOR, complex 2; gene trap IST15070E11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Genotype
Symbol: Rictor/Rictor
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Rictor/Rictor
Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Rictor/Rictor
Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Rictor/Rictor
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Rictor/Rictor
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Rictor/Rictor
Background: involves: 129S6/SvEvTac * C57BL/6 * DBA
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Rictor/Rictor
Background: B6.Cg-Rictor Tg(Fabp4-cre)1Rev
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Liu C
Year: 2021
Journal: Sci Adv
Title: Glycogen synthase kinase 3 drives thymocyte egress by suppressing β-catenin activation of Akt.
Volume: 7
Issue: 41
Pages: eabg6262
Publication
First Author: Li M
Year: 2024
Journal: Cell Res
Title: AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine.
Volume: 34
Issue: 10
Pages: 683-706
Publication
First Author: McGuire VA
Year: 2013
Journal: Mol Cell Biol
Title: Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling.
Volume: 33
Issue: 21
Pages: 4152-65
Publication
First Author: Hresko RC
Year: 2005
Journal: J Biol Chem
Title: mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.
Volume: 280
Issue: 49
Pages: 40406-16
Publication
First Author: Jacinto E
Year: 2006
Journal: Cell
Title: SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.
Volume: 127
Issue: 1
Pages: 125-37
Publication
First Author: Tao R
Year: 2015
Journal: Diabetes
Title: Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling.
Volume: 64
Issue: 4
Pages: 1211-23
Publication
First Author: Julien LA
Year: 2010
Journal: Mol Cell Biol
Title: mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.
Volume: 30
Issue: 4
Pages: 908-21
Publication
First Author: Zhang C
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling.
Volume: 109
Issue: 5
Pages: 1667-72
Publication
First Author: Gao D
Year: 2010
Journal: Mol Cell
Title: Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.
Volume: 39
Issue: 5
Pages: 797-808
Publication
First Author: Ou YH
Year: 2011
Journal: Mol Cell
Title: TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation.
Volume: 41
Issue: 4
Pages: 458-70
Publication
First Author: Betz C
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Feature Article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology.
Volume: 110
Issue: 31
Pages: 12526-34
Publication
First Author: Akgül S
Year: 2018
Journal: Cell Rep
Title: Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma.
Volume: 24
Issue: 2
Pages: 463-478.e5
Publication
First Author: Zhu Y
Year: 2019
Journal: Cell Death Differ
Title: Superhero Rictor promotes cellular differentiation of mouse embryonic stem cells.
Volume: 26
Issue: 5
Pages: 958-968
Publication
First Author: Inomata M
Year: 2021
Journal: Exp Cell Res
Title: Rictor-targeting exosomal microRNA-16 ameliorates lung fibrosis by inhibiting the mTORC2-SPARC axis.
Volume: 398
Issue: 2
Pages: 112416
Publication  
First Author: Chen WY
Year: 2017
Journal: Sci Rep
Title: Heterogeneous nuclear ribonucleoprotein M associates with mTORC2 and regulates muscle differentiation.
Volume: 7
Pages: 41159
Publication
First Author: Zhang Z
Year: 2012
Journal: Mol Cell Biochem
Title: mTOR-rictor is the Ser473 kinase for AKT1 in mouse one-cell stage embryos.
Volume: 361
Issue: 1-2
Pages: 249-57
Publication
First Author: Shiota C
Year: 2006
Journal: Dev Cell
Title: Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability.
Volume: 11
Issue: 4
Pages: 583-9
Strain
Attribute String: congenic, mutant strain, targeted mutation, transgenic
Strain
Attribute String: congenic, targeted mutation, transgenic
Genotype
Symbol: Rictor/Rictor Tg(ACTA1-cre)1Mll/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Rictor/Rictor Tg(Fabp4-cre)1Rev/?
Background: B6.Cg-Rictor Tg(Fabp4-cre)1Rev
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Rictor/Rictor Tg(Ins2-cre)25Mgn/?
Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Rictor/Rictor Tg(Mx1-cre)1Cgn/?
Background: B6.Cg-Rictor Tg(Mx1-cre)1Cgn
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Rictor/Rictor<+>
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
Publication    
First Author: Porter SN
Year: 2016
Journal: Elife
Title: Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations.
Volume: 5
Publication
First Author: Zhang C
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTOR and rictor.
Volume: 307
Issue: 3
Pages: E305-15
Publication
First Author: Micevic G
Year: 2016
Journal: Cell Rep
Title: DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR.
Volume: 14
Issue: 9
Pages: 2180-2192
Publication  
First Author: Baffi TR
Year: 2021
Journal: Sci Signal
Title: mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif.
Volume: 14
Issue: 678
Publication
First Author: Lamouille S
Year: 2012
Journal: J Cell Sci
Title: TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion.
Volume: 125
Issue: Pt 5
Pages: 1259-73
Strain
Attribute String: mutant stock, targeted mutation, variant allele
Genotype
Symbol: Rictor/Rictor
Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Pten/Pten Rictor/Rictor
Background: involves: 129S4/SvJae * 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Pten/Pten Rictor/Rictor Tg(Ins2-cre)25Mgn/?
Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Singh BK
Year: 2016
Journal: J Biol Chem
Title: Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition.
Volume: 291
Issue: 1
Pages: 198-214
Publication
First Author: Liu P
Year: 2014
Journal: Nature
Title: Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.
Volume: 508
Issue: 7497
Pages: 541-5
Publication
First Author: García-Martínez JM
Year: 2008
Journal: Biochem J
Title: mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).
Volume: 416
Issue: 3
Pages: 375-85
Publication
First Author: Kaur S
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses.
Volume: 109
Issue: 20
Pages: 7723-8
Publication
First Author: Kroczynska B
Year: 2016
Journal: J Biol Chem
Title: Interferon γ (IFNγ) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses.
Volume: 291
Issue: 5
Pages: 2389-96
Genotype
Symbol: Rictor/Rictor Meox2/Meox2<+>
Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Rictor/Rictor Rptor/Rptor Tg(ACTA1-cre)1Mll/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Pten/Pten<+> Rictor/Rictor<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Rictor/Rictor Speer6-ps1/Speer6-ps1<+>
Background: involves: 129S6/SvEvTac * C57BL/6 * DBA
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Sarbassov DD
Year: 2004
Journal: Curr Biol
Title: Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
Volume: 14
Issue: 14
Pages: 1296-302
Publication
First Author: Facchinetti V
Year: 2008
Journal: EMBO J
Title: The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C.
Volume: 27
Issue: 14
Pages: 1932-43
Publication
First Author: Gan X
Year: 2012
Journal: Nat Cell Biol
Title: PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12.
Volume: 14
Issue: 7
Pages: 686-96
Publication
First Author: Green RM
Year: 2017
Journal: Nat Commun
Title: Developmental nonlinearity drives phenotypic robustness.
Volume: 8
Issue: 1
Pages: 1970
Publication
First Author: Pearce LR
Year: 2011
Journal: Biochem J
Title: Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney.
Volume: 436
Issue: 1
Pages: 169-79
Publication
First Author: Wan S
Year: 2022
Journal: Cell Death Dis
Title: mTORC1 signaling pathway integrates estrogen and growth factor to coordinate vaginal epithelial cells proliferation and differentiation.
Volume: 13
Issue: 10
Pages: 862
Publication
First Author: Nord C
Year: 2024
Journal: Dev Dyn
Title: Reduced mTORC1-signaling in progenitor cells leads to retinal lamination deficits.
Volume: 253
Issue: 10
Pages: 922-939
Publication  
First Author: Mazier W
Year: 2019
Journal: Mol Metab
Title: mTORC1 and CB1 receptor signaling regulate excitatory glutamatergic inputs onto the hypothalamic paraventricular nucleus in response to energy availability.
Volume: 28
Pages: 151-159
Publication
First Author: Silva J
Year: 2022
Journal: Nat Commun
Title: Ribosome impairment regulates intestinal stem cell identity via ZAKÉ‘ activation.
Volume: 13
Issue: 1
Pages: 4492
Publication    
First Author: Roy A
Year: 2015
Journal: Elife
Title: Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy.
Volume: 4
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt