|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 701 to 800 out of 878 for Sf1

<< First    < Previous  |  Next >    Last >>
0.03s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein
Q5NC05
Organism: Mus musculus/domesticus
Length: 1138  
Fragment?: false
•
•
•
•
•
Protein
H3BJK2
Organism: Mus musculus/domesticus
Length: 1525  
Fragment?: false
•
•
•
•
•
Protein
J3QP94
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
•
•
•
•
•
Protein
Q3U1I9
Organism: Mus musculus/domesticus
Length: 733  
Fragment?: false
•
•
•
•
•
Protein
Q3TMV6
Organism: Mus musculus/domesticus
Length: 789  
Fragment?: false
•
•
•
•
•
Protein
Q80XB7
Organism: Mus musculus/domesticus
Length: 2544  
Fragment?: false
•
•
•
•
•
Protein
H3BLH0
Organism: Mus musculus/domesticus
Length: 1601  
Fragment?: false
•
•
•
•
•
Protein
A2A5R5
Organism: Mus musculus/domesticus
Length: 869  
Fragment?: true
•
•
•
•
•
Protein
Q91YT4
Organism: Mus musculus/domesticus
Length: 725  
Fragment?: true
•
•
•
•
•
Protein
Q8R0K1
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: true
•
•
•
•
•
Protein
D2CGM4
Organism: Mus musculus/domesticus
Length: 1025  
Fragment?: false
•
•
•
•
•
Protein
Q9CU66
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: true
•
•
•
•
•
Protein
A2A5R4
Organism: Mus musculus/domesticus
Length: 840  
Fragment?: true
•
•
•
•
•
Protein
Q05CC6
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: true
•
•
•
•
•
Protein
A0A0R4J170
Organism: Mus musculus/domesticus
Length: 1617  
Fragment?: false
•
•
•
•
•
Protein
A2AP29
Organism: Mus musculus/domesticus
Length: 707  
Fragment?: true
•
•
•
•
•
Protein
G3UYS5
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: true
•
•
•
•
•
Protein
G3X8T0
Organism: Mus musculus/domesticus
Length: 1187  
Fragment?: false
•
•
•
•
•
Protein
A3KMF3
Organism: Mus musculus/domesticus
Length: 1214  
Fragment?: true
•
•
•
•
•
Protein
Q3UQQ4
Organism: Mus musculus/domesticus
Length: 1244  
Fragment?: false
•
•
•
•
•
Protein
Q3KQQ7
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: true
•
•
•
•
•
Protein
F2Z4A9
Organism: Mus musculus/domesticus
Length: 1583  
Fragment?: false
•
•
•
•
•
Protein
F2YMC1
Organism: Mus musculus/domesticus
Length: 1239  
Fragment?: false
•
•
•
•
•
Protein
Q05AH2
Organism: Mus musculus/domesticus
Length: 1165  
Fragment?: false
•
•
•
•
•
Protein
B2RX10
Organism: Mus musculus/domesticus
Length: 2021  
Fragment?: false
•
•
•
•
•
Protein
Q9D5K6
Organism: Mus musculus/domesticus
Length: 473  
Fragment?: false
•
•
•
•
•
Protein
A0A0R4J0J3
Organism: Mus musculus/domesticus
Length: 1216  
Fragment?: false
•
•
•
•
•
Protein
A2A4N9
Organism: Mus musculus/domesticus
Length: 1174  
Fragment?: true
•
•
•
•
•
Protein
Q3UI73
Organism: Mus musculus/domesticus
Length: 806  
Fragment?: true
•
•
•
•
•
Protein
Q3U606
Organism: Mus musculus/domesticus
Length: 672  
Fragment?: false
•
•
•
•
•
Protein
A0A087WPL5
Organism: Mus musculus/domesticus
Length: 1383  
Fragment?: false
•
•
•
•
•
Protein
E9QNN1
Organism: Mus musculus/domesticus
Length: 1384  
Fragment?: false
•
•
•
•
•
Protein
A0ZVB6
Organism: Mus musculus/domesticus
Length: 1848  
Fragment?: false
•
•
•
•
•
Protein
E9QAE3
Organism: Mus musculus/domesticus
Length: 1848  
Fragment?: false
•
•
•
•
•
Protein
Q5DTN5
Organism: Mus musculus/domesticus
Length: 1264  
Fragment?: true
•
•
•
•
•
Protein
E9QAB8
Organism: Mus musculus/domesticus
Length: 1510  
Fragment?: false
•
•
•
•
•
Protein
Q3TB25
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: true
•
•
•
•
•
Protein
Q52KH4
Organism: Mus musculus/domesticus
Length: 990  
Fragment?: true
•
•
•
•
•
Protein
G8JL31
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: true
•
•
•
•
•
Protein
Q9CSD9
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: true
•
•
•
•
•
Protein
A0A2R8W710
Organism: Mus musculus/domesticus
Length: 1173  
Fragment?: false
•
•
•
•
•
Protein
Q7TND4
Organism: Mus musculus/domesticus
Length: 978  
Fragment?: true
•
•
•
•
•
Protein
Q3UHL2
Organism: Mus musculus/domesticus
Length: 1510  
Fragment?: false
•
•
•
•
•
Protein
D2CGM5
Organism: Mus musculus/domesticus
Length: 1025  
Fragment?: false
•
•
•
•
•
Protein
Q3UR42
Organism: Mus musculus/domesticus
Length: 735  
Fragment?: true
•
•
•
•
•
Protein
D3YWG8
Organism: Mus musculus/domesticus
Length: 1239  
Fragment?: false
•
•
•
•
•
Publication
15538360 | -
First Author: Singleton MR
Year: 2004
Journal: Nature
Title: Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks.
Volume: 432
Issue: 7014
Pages: 187-93
•
•
•
•
•
Publication
12535527 | -
First Author: Tanner NK
Year: 2003
Journal: Mol Cell
Title: The Q motif: a newly identified motif in DEAD box helicases may regulate ATP binding and hydrolysis.
Volume: 11
Issue: 1
Pages: 127-38
•
•
•
•
•
Publication
21071401 | -
First Author: Yeeles JT
Year: 2011
Journal: Nucleic Acids Res
Title: The AddAB helicase-nuclease catalyses rapid and processive DNA unwinding using a single Superfamily 1A motor domain.
Volume: 39
Issue: 6
Pages: 2271-85
•
•
•
•
•
Protein Domain
IPR014016 | UvrD-like_ATP-bd
Type: Domain
Description: Helicases have been classified in 5 superfamilies (SF1-SF5). All of theproteins bind ATP and, consequently, all of them carry the classical Walker A(phosphate-binding loop or P-loop) and Walker B(Mg2+-binding aspartic acid) motifs. For the two largest groups, commonlyreferred to as SF1 and SF2, a total of seven characteristic motifs have beenidentified []which are distributed over two structural domains, anN-terminal ATP-binding domain and a C-terminal domain. UvrD-like DNA helicasesbelong toSF1, but they differ from classical SF1/SF2 by alarge insertion in each domain. UvrD-like DNA helicases unwind DNA with a3'-5' polarity [].Crystal structures of several uvrD-like DNA helicases have been solved [, , ]. They are monomeric enzymes consisting of twodomains with a common α-β RecA-like core. The ATP-binding site issituated in a cleft between the N terminus of the ATP-binding domain and thebeginning of the C-terminal domain. The enzyme crystallizes in two differentconformations (open and closed). The conformational difference between the twoforms comprises a large rotation of the end of the C-terminal domain byapproximately 130 degrees. This "domain swiveling"was proposed to be an importantaspect of the mechanism of the enzyme [].Some proteins that belong to the UvrD-like DNA helicase family are listedbelow:Bacterial UvrD helicase. It is involved in the post-incision events ofnucleotide excision repair and methyl-directed mismatch repair. It unwindsDNA duplexes with 3'-5' polarity with respect to the bound strand andinitiates unwinding most effectively when a single-stranded region ispresent.Gram-positive bacterial pcrA helicase, an essential enzyme involved in DNArepair and rolling circle replication. The Staphylococcus aureus pcrAhelicase has both 5'-3' and 3'-5' helicase activities.Bacterial rep proteins, a single-stranded DNA-dependent ATPase involved inDNA replication which can initiate unwinding at a nick in the DNA. It bindsto the single-stranded DNA and acts in a progressive fashion along the DNAin the 3' to 5' direction.Bacterial helicase IV (helD gene product). It catalyzes the unwinding ofduplex DNA in the 3'-5' direction.Bacterial recB protein. RecBCD is a multi-functional enzyme complex thatprocesses DNA ends resulting from a double-strand break. RecB is a helicasewith a 3'-5' directionality.Fungal srs2 proteins, an ATP-dependent DNA helicase involved in DNA repair. The polarity of the helicase activity was determined to be 3'-5'.This domain is also found bacterial helicase-nuclease complex AddAB, both in subunit AddA and AddB. The AddA subunit is responsable for the helicase activity. AddB also harbors a putative ATP-binding domain which does not play a role as a secondary DNA motor, but that it may instead facilitate the recognition of the recombination hotspot sequences [].This entry represents the ATP-binding domain found in AddA, AddB and UvrD-like helicases.
•
•
•
•
•
Protein Domain
IPR014017 | DNA_helicase_UvrD-like_C
Type: Domain
Description: Helicases have been classified in 5 superfamilies (SF1-SF5) []. All of the proteins bind ATP and, consequently, all of them carry the classical Walker A (phosphate-binding loop or P-loop), and Walker B (Mg2+-binding aspartic acid) motifs []. For the two largest groups, commonly referred to as SF1 and SF2, a total of seven characteristic motifs have been identified []which are distributed over two structural domains, an N-terminal ATP-binding domain and a C-terminal domain.This entry represents the C-terminal domain.UvrD-like DNA helicases belong to SF1, but they differ from classical SF1/SF2 by a large insertion in each domain. UvrD-like DNA helicases unwind DNA with a 3'-5' polarity []. Crystal structures of several uvrD-like DNA helicases have been solved [, , ]. They are monomeric enzymes consisting of two domains with a common α-β RecA-like core. The ATP-binding site is situated in a cleft between the N terminus of the ATP-binding domain and the beginning of the C-terminal domain. The enzyme crystallizes in two different conformations (open and closed). The conformational difference between the two forms comprises a large rotation of the end of the C-terminal domain by approximately 130 degrees. This "domain swiveling"was proposed to be an important aspect of the mechanism of the enzyme [].Some proteins that belong to the uvrD-like DNA helicase family are listed below:Bacterial UvrD helicase. It is involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair. It unwinds DNA duplexes with 3'-5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present.Gram-positive bacterial pcrA helicase, an essential enzyme involved in DNA repair and rolling circle replication. The Staphylococcus aureus pcrA helicase has both 5'-3' and 3'-5' helicase activities. Bacterial rep proteins, a single-stranded DNA-dependent ATPase involved in DNA replication which can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.Bacterial helicase IV (helD gene product). It catalyzes the unwinding of duplex DNA in the 3'-5' direction.Bacterial recB protein. RecBCD is a multi-functional enzyme complex that processes DNA ends resulting from a double-strand break. RecB is a helicase with a 3'-5' directionality.Fungal srs2 proteins, an ATP-dependent DNA helicase involved in DNA repair. The polarity of the helicase activity was determined to be 3'-5'.
•
•
•
•
•
Protein
Q6ZQJ5
Organism: Mus musculus/domesticus
Length: 1062  
Fragment?: false
•
•
•
•
•
Protein
Q0VGT4
Organism: Mus musculus/domesticus
Length: 1863  
Fragment?: false
•
•
•
•
•
Protein
Q9EPU0
Organism: Mus musculus/domesticus
Length: 1124  
Fragment?: false
•
•
•
•
•
Protein
Q69ZA7
Organism: Mus musculus/domesticus
Length: 1622  
Fragment?: true
•
•
•
•
•
Protein
I3PQW4
Organism: Mus musculus/domesticus
Length: 1843  
Fragment?: false
•
•
•
•
•
Publication
9288744 | -
First Author: Korolev S
Year: 1997
Journal: Cell
Title: Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP.
Volume: 90
Issue: 4
Pages: 635-47
•
•
•
•
•
Publication
1552844 | J:23311
First Author: Schmid SR
Year: 1992
Journal: Mol Microbiol
Title: D-E-A-D protein family of putative RNA helicases.
Volume: 6
Issue: 3
Pages: 283-91
•
•
•
•
•
Publication
10199404 | -
First Author: Velankar SS
Year: 1999
Journal: Cell
Title: Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism.
Volume: 97
Issue: 1
Pages: 75-84
•
•
•
•
•
Publication
10679457 | -
First Author: Soultanas P
Year: 2000
Journal: Curr Opin Struct Biol
Title: DNA helicases: 'inching forward'.
Volume: 10
Issue: 1
Pages: 124-8
•
•
•
•
•
Publication
28651017 | -
First Author: Hao W
Year: 2017
Journal: PLoS Pathog
Title: Crystal structure of Middle East respiratory syndrome coronavirus helicase.
Volume: 13
Issue: 6
Pages: e1006474
•
•
•
•
•
Protein
Q91VR5
Organism: Mus musculus/domesticus
Length: 740  
Fragment?: false
•
•
•
•
•
Protein
D3Z6P9
Organism: Mus musculus/domesticus
Length: 646  
Fragment?: false
•
•
•
•
•
Protein
Q3V1Z7
Organism: Mus musculus/domesticus
Length: 740  
Fragment?: false
•
•
•
•
•
Protein
Q922B8
Organism: Mus musculus/domesticus
Length: 740  
Fragment?: false
•
•
•
•
•
Protein
Q8BIM5
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: false
•
•
•
•
•
Protein
Q8BUB9
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: true
•
•
•
•
•
Protein
D3Z700
Organism: Mus musculus/domesticus
Length: 508  
Fragment?: false
•
•
•
•
•
Protein
A3KFM7
Organism: Mus musculus/domesticus
Length: 2711  
Fragment?: false
•
•
•
•
•
Protein
P40201
Organism: Mus musculus/domesticus
Length: 1711  
Fragment?: false
•
•
•
•
•
Protein
Q8R418
Organism: Mus musculus/domesticus
Length: 1916  
Fragment?: false
•
•
•
•
•
Protein
Q61687
Organism: Mus musculus/domesticus
Length: 2476  
Fragment?: false
•
•
•
•
•
Protein
E9PZJ8
Organism: Mus musculus/domesticus
Length: 2198  
Fragment?: false
•
•
•
•
•
Protein
Q6Q899
Organism: Mus musculus/domesticus
Length: 926  
Fragment?: false
•
•
•
•
•
Protein
Q6PCN7
Organism: Mus musculus/domesticus
Length: 1003  
Fragment?: false
•
•
•
•
•
Protein
E9PZM4
Organism: Mus musculus/domesticus
Length: 1827  
Fragment?: false
•
•
•
•
•
Protein
Q8BYH8
Organism: Mus musculus/domesticus
Length: 2885  
Fragment?: false
•
•
•
•
•
Protein
O88700
Organism: Mus musculus/domesticus
Length: 1416  
Fragment?: false
•
•
•
•
•
Protein
Q09XV5
Organism: Mus musculus/domesticus
Length: 2582  
Fragment?: false
•
•
•
•
•
Protein
Q9CXF7
Organism: Mus musculus/domesticus
Length: 900  
Fragment?: false
•
•
•
•
•
Protein
A2AJK6
Organism: Mus musculus/domesticus
Length: 2986  
Fragment?: false
•
•
•
•
•
Protein
Q6P5D3
Organism: Mus musculus/domesticus
Length: 1388  
Fragment?: false
•
•
•
•
•
Protein
Q91ZW3
Organism: Mus musculus/domesticus
Length: 1051  
Fragment?: false
•
•
•
•
•
Protein
O09053
Organism: Mus musculus/domesticus
Length: 1401  
Fragment?: false
•
•
•
•
•
Protein
Q6P4T2
Organism: Mus musculus/domesticus
Length: 2136  
Fragment?: false
•
•
•
•
•
Protein
Q80YD1
Organism: Mus musculus/domesticus
Length: 779  
Fragment?: false
•
•
•
•
•
Protein
Q3B807
Organism: Mus musculus/domesticus
Length: 590  
Fragment?: false
•
•
•
•
•
Protein
Q6PGB8
Organism: Mus musculus/domesticus
Length: 1046  
Fragment?: false
•
•
•
•
•
Protein
Q8CGF7
Organism: Mus musculus/domesticus
Length: 1100  
Fragment?: false
•
•
•
•
•
Protein
B2RR83
Organism: Mus musculus/domesticus
Length: 1445  
Fragment?: false
•
•
•
•
•
Protein
Q3TH57
Organism: Mus musculus/domesticus
Length: 1100  
Fragment?: false
•
•
•
•
•
Protein
A0A0G2JE88
Organism: Mus musculus/domesticus
Length: 139  
Fragment?: false
•
•
•
•
•
Protein
A0A8F5XVB9
Organism: Mus musculus/domesticus
Length: 1692  
Fragment?: false
•
•
•
•
•
Protein
D6RJ11
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: false
•
•
•
•
•
Protein
Q8K2P5
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: true
•
•
•
•
•
Protein
Q05DE7
Organism: Mus musculus/domesticus
Length: 1032  
Fragment?: true
•
•
•
•
•
Protein
Q3USG6
Organism: Mus musculus/domesticus
Length: 924  
Fragment?: true
•
•
•
•
•
Protein
D3Z5P5
Organism: Mus musculus/domesticus
Length: 885  
Fragment?: false
•
•
•
•
•
Protein
Q8BKG1
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: true
•
•
•
•
•
Protein
O35662
Organism: Mus musculus/domesticus
Length: 169  
Fragment?: true
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom