| Type |
Details |
Score |
| Pseudogene |
| Type: |
pseudogene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion, Barbara B Kahn |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shepherd PR |
| Year: |
1993 |
| Journal: |
J Biol Chem |
| Title: |
Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. |
| Volume: |
268 |
| Issue: |
30 |
| Pages: |
22243-6 |
|
•
•
•
•
•
|
| Allele |
| Name: |
solute carrier family 2 (facilitated glucose transporter), member 4; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 15, John A Hanover |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
77
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Budding yeast Bud22 is required for rRNA maturation and ribosomal subunit biogenesis [, ]. Serum response factor-binding protein 1 (SRFB1) is Bud22 homologue in animals. SRFB1 may be involved in regulating transcriptional activation of cardiac genes during the aging process and may play a role in biosynthesis and/or processing of SLC2A4 in adipose cells [, ]. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang X |
| Year: |
2004 |
| Journal: |
J Biol Chem |
| Title: |
Identification of a novel serum response factor cofactor in cardiac gene regulation. |
| Volume: |
279 |
| Issue: |
53 |
| Pages: |
55626-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lisinski I |
| Year: |
2006 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Identification and characterization of p49/STRAP as a novel GLUT4-binding protein. |
| Volume: |
344 |
| Issue: |
4 |
| Pages: |
1179-85 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
441
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li Z |
| Year: |
2009 |
| Journal: |
PLoS Biol |
| Title: |
Rational extension of the ribosome biogenesis pathway using network-guided genetics. |
| Volume: |
7 |
| Issue: |
10 |
| Pages: |
e1000213 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dakshinamurthy A |
| Year: |
2010 |
| Journal: |
Genetics |
| Title: |
BUD22 affects Ty1 retrotransposition and ribosome biogenesis in Saccharomyces cerevisiae. |
| Volume: |
185 |
| Issue: |
4 |
| Pages: |
1193-205 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents a domain found in the fungal Bud22 protein and the animal SRFB1 (serum response factor-binding protein 1) protein. Budding yeast Bud22 is required for rRNA maturation and ribosomal subunit biogenesis [, ]. SRFB1 may be involved in regulating transcriptional activation of cardiac genes during the aging process and may play a role in biosynthesis and/or processing of SLC2A4 in adipose cells [, ]. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yore MM |
| Year: |
2014 |
| Journal: |
Cell |
| Title: |
Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. |
| Volume: |
159 |
| Issue: |
2 |
| Pages: |
318-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McClain DA |
| Year: |
2002 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia. |
| Volume: |
99 |
| Issue: |
16 |
| Pages: |
10695-9 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(SLC2A4-OGT)15Jaha/? |
| Background: |
involves: C57BL/6 |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Samuel Cushman |
| Allele Type: |
Transgenic |
| Attribute String: |
Humanized sequence, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 546, Domenico Accili |
| Allele Type: |
Transgenic |
| Attribute String: |
Recombinase |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
transgenic, mutant strain, congenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Geiser A |
| Year: |
2024 |
| Journal: |
J Cell Sci |
| Title: |
A novel 3D imaging approach for quantification of GLUT4 levels across the intact myocardium. |
| Volume: |
137 |
| Issue: |
20 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fatima LA |
| Year: |
2019 |
| Journal: |
Mol Cell Endocrinol |
| Title: |
Estradiol stimulates adipogenesis and Slc2a4/GLUT4 expression via ESR1-mediated activation of CEBPA. |
| Volume: |
498 |
|
| Pages: |
110447 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Moreira D |
| Year: |
2015 |
| Journal: |
PLoS Pathog |
| Title: |
Leishmania infantum modulates host macrophage mitochondrial metabolism by hijacking the SIRT1-AMPK axis. |
| Volume: |
11 |
| Issue: |
3 |
| Pages: |
e1004684 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Actis Dato V |
| Year: |
2023 |
| Journal: |
Sci Rep |
| Title: |
Transcriptional analysis reveals that the intracellular lipid accumulation impairs gene expression profiles involved in insulin response-associated cardiac functionality. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
8761 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rios-Morales M |
| Year: |
2022 |
| Journal: |
Biochim Biophys Acta Mol Basis Dis |
| Title: |
Butyrate oxidation attenuates the butyrate-induced improvement of insulin sensitivity in myotubes. |
| Volume: |
1868 |
| Issue: |
11 |
| Pages: |
166476 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Patel R |
| Year: |
2022 |
| Journal: |
Nature |
| Title: |
ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids. |
| Volume: |
606 |
| Issue: |
7916 |
| Pages: |
968-975 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Insr/Insr Tg(Slc2a4-cre)546Dac/? |
| Background: |
involves: 129S4/SvJaeSor * C57BL/6 * FVB |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lin HV |
| Year: |
2011 |
| Journal: |
J Biol Chem |
| Title: |
Reconstitution of insulin action in muscle, white adipose tissue, and brain of insulin receptor knock-out mice fails to rescue diabetes. |
| Volume: |
286 |
| Issue: |
11 |
| Pages: |
9797-804 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ren H |
| Year: |
2019 |
| Journal: |
Endocrinology |
| Title: |
Altered Central Nutrient Sensing in Male Mice Lacking Insulin Receptors in Glut4-Expressing Neurons. |
| Volume: |
160 |
| Issue: |
9 |
| Pages: |
2038-2048 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sanchez-Gurmaches J |
| Year: |
2018 |
| Journal: |
Cell Metab |
| Title: |
Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis. |
| Volume: |
27 |
| Issue: |
1 |
| Pages: |
195-209.e6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics and VEGA Genome Database Project |
| Year: |
2006 |
| Journal: |
Database Release |
| Title: |
Collaboration to Associate VEGA (Vertebrate Genome Annotation) Mouse Gene Models with MGI Markers |
|
|
|
|
•
•
•
•
•
|