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Search results 701 to 716 out of 716 for Sorl1

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0.014s

Type

Details

Score

Publication

21385844 | -

First Author:	Klinger SC
Year:	2011
Journal:	J Cell Sci
Title:	SorLA regulates the activity of lipoprotein lipase by intracellular trafficking.
Volume:	124
Issue:	Pt 7
Pages:	1095-105

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Publication

23486467 | -

First Author:	Nishii K
Year:	2013
Journal:	J Biol Chem
Title:	The soluble form of LR11 protein is a regulator of hypoxia-induced, urokinase-type plasminogen activator receptor (uPAR)-mediated adhesion of immature hematological cells.
Volume:	288
Issue:	17
Pages:	11877-86

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Publication

26858303 | -

First Author:	Larsen JV
Year:	2016
Journal:	Mol Cell Biol
Title:	Cytokine-Like Factor 1, an Essential Facilitator of Cardiotrophin-Like Cytokine:Ciliary Neurotrophic Factor Receptor ? Signaling and sorLA-Mediated Turnover.
Volume:	36
Issue:	8
Pages:	1272-86

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Publication

32355037 | -

First Author:	Vilstrup J
Year:	2020
Journal:	Acta Crystallogr D Struct Biol
Title:	Crystal and solution structures of fragments of the human leucocyte common antigen-related protein.
Volume:	76
Issue:	Pt 5
Pages:	406-417

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Publication

17855360 | -

First Author:	Schmidt V
Year:	2007
Journal:	J Biol Chem
Title:	SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1.
Volume:	282
Issue:	45
Pages:	32956-64

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Publication

18603531 | -

First Author:	Nilsson SK
Year:	2008
Journal:	J Biol Chem
Title:	Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS10p domain receptor families.
Volume:	283
Issue:	38
Pages:	25920-7

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Publication

31138794 | J:279083

First Author:	Pietil? M
Year:	2019
Journal:	Nat Commun
Title:	SORLA regulates endosomal trafficking and oncogenic fitness of HER2.
Volume:	10
Issue:	1
Pages:	2340

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Protein Domain

IPR057841 | FN3_SORL1

Type:

Domain

Description:

This Fn3 domain is found towards the C-terminal of human Sortilin-related receptor (SORL1).SORL1 is a multifunctional sorting receptor involved in the intracellular trafficking and localisation of various protein cargoes. It cooperates with the AP-1 complex in Golgi-endosome sorting pathways []and regulates the trafficking of amyloid precursor protein (APP), retaining it in the trans-Golgi network to prevent its processing into amyloidogenic peptides Abeta40 and Abeta42 in late endosomes [, , , ]. It may also facilitate lysosomal degradation of newly formed amyloid-beta peptides []but does not influence APP transport between the endoplasmic reticulum and Golgi compartments []. SORL1 acts as a sorting receptor for several other key proteins, including the BDNF receptor NTRK2/TRKB, promoting its intracellular redistribution and enhancing BDNF signalling []; GDNF and its receptor GFRA1, directing GDNF for lysosomal degradation while recycling GFRA1 and mediating RETendocytosis [, ]; ERBB2/HER2, regulating its recycling to the plasma membrane to sustain PI3K-dependent signalling and support proliferation in ERBB2-driven cancers []; lipoprotein lipase (LPL), targeting it for lysosomal degradation []; APOA5, inducing its internalisation and sorting to both lysosomes and the trans-Golgi network []; and the insulin receptor (INSR), promoting its recycling to the cell surface and enhancing insulin responsiveness in adipose tissue without affecting its internalisation []. SORL1 also plays roles in renal ion homeostasis through the intracellular sorting of STK39 and PPP3CB, and its N-terminal ectodomain promotes proliferation and migration of smooth muscle cells via uPAR/PLAUR, contributing to extracellular matrix remodelling and intimal thickening following vascular injury []. It further supports monocyte adhesion []and may enhance monocyte/macrophage proliferation and migration, contributing to foam cell formation and atherosclerosis. In haematopoietic stem and progenitor cells, SORL1 mediates hypoxia-enhanced adhesion to bone marrow stroma via PLAUR []. Additionally, it functions as a metabolic regulator that limits adipose tissue energy expenditure by inhibiting the BMP/Smad pathway, and may modulate signalling of the CLCF1-CRLF1-CNTFR complex and IL6 by promoting lysosomal degradation and shifting the balance between cis and trans IL6 signalling [, ].

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Publication

32941599 | J:299276

First Author:	Liu T
Year:	2020
Journal:	J Exp Med
Title:	Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE.
Volume:	217
Issue:	12

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Publication

34965419 | J:328738

First Author:	Simoes S
Year:	2021
Journal:	Cell Rep
Title:	Alzheimer's vulnerable brain region relies on a distinct retromer core dedicated to endosomal recycling.
Volume:	37
Issue:	13
Pages:	110182

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Genotype

Symbol:	Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(APPV717F)109Ili/?
Background:	Not Specified
Zygosity:	cx
Has Mutant Allele:	true

•

Publication

25385546 | -

First Author:	Coles CH
Year:	2014
Journal:	Nat Commun
Title:	Structural basis for extracellular cis and trans RPTP? signal competition in synaptogenesis.
Volume:	5

Pages:	5209

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Publication

25908590 | J:222796

First Author:	Yamagata A
Year:	2015
Journal:	Nat Commun
Title:	Mechanisms of splicing-dependent trans-synaptic adhesion by PTP?-IL1RAPL1/IL-1RAcP for synaptic differentiation.
Volume:	6

Pages:	6926

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Publication

39902677 | J:361771

First Author:	Fu X
Year:	2025
Journal:	J Neurochem
Title:	FOXP1 is a Transcription Factor for the Alzheimer's Disease Risk Gene SORL1.
Volume:	169
Issue:	2
Pages:	e70011

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Protein

Q8C2R1

Organism:	Mus musculus/domesticus
Length:	469
Fragment?:	true

•

Protein

O88307

Organism:	Mus musculus/domesticus
Length:	2215
Fragment?:	false

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