Type |
Details |
Score |
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
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•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Tae H |
Year: |
2011 |
Journal: |
Channels (Austin) |
Title: |
The elusive role of the SPRY2 domain in RyR1. |
Volume: |
5 |
Issue: |
2 |
Pages: |
148-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sugiura K |
Year: |
2009 |
Journal: |
Biol Reprod |
Title: |
Fibroblast growth factors and epidermal growth factor cooperate with oocyte-derived members of the TGFbeta superfamily to regulate Spry2 mRNA levels in mouse cumulus cells. |
Volume: |
81 |
Issue: |
5 |
Pages: |
833-41 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling. |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 69, Timothy P O'Brien |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 2, Timothy P O'Brien |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Gail R Martin |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, deletion, mutant strain, radiation induced mutation, transgenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
transgenic, radiation induced mutation, mutant strain, deletion, congenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ednrb/Ednrb Tg(Spry2)2Tpo/? |
Background: |
B6.Cg-Ednrb Tg(Spry2)2Tpo |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ednrb/Ednrb Tg(Spry2)69Tpo/? |
Background: |
B6.Cg-Ednrb Tg(Spry2)69Tpo |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Pax3/Pax3<+> Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/? |
Background: |
Not Specified |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Tae HS |
Year: |
2009 |
Journal: |
Clin Exp Pharmacol Physiol |
Title: |
Molecular recognition of the disordered dihydropyridine receptor II-III loop by a conserved spry domain of the type 1 ryanodine receptor. |
Volume: |
36 |
Issue: |
3 |
Pages: |
346-9 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This SPRY domain (SPRY2) is the second of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, The SPRY2 domain has been shown to bind to the dihydropryidine receptor (DHPR) II-III loop and the ASI region of RyR1 [, ]. |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mesp1/Mesp1<+> Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/? |
Background: |
involves: C57BL/6NCrlj * CBA/JNCrlj |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Pten/Pten Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/? Tg(Osr1-cre)4Mrt/? |
Background: |
involves: 129P2/OlaHsd * 129S1/Sv * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee J |
Year: |
2018 |
Journal: |
Endocrinology |
Title: |
A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission. |
Volume: |
159 |
Issue: |
9 |
Pages: |
3321-3330 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shin EH |
Year: |
2015 |
Journal: |
Dev Biol |
Title: |
Sprouty gain of function disrupts lens cellular processes and growth by restricting RTK signaling. |
Volume: |
406 |
Issue: |
2 |
Pages: |
129-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Calmont A |
Year: |
2006 |
Journal: |
Dev Cell |
Title: |
An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cells. |
Volume: |
11 |
Issue: |
3 |
Pages: |
339-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yousaf R |
Year: |
2018 |
Journal: |
J Clin Invest |
Title: |
Modifier variant of METTL13 suppresses human GAB1-associated profound deafness. |
Volume: |
128 |
Issue: |
4 |
Pages: |
1509-1522 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao YT |
Year: |
2017 |
Journal: |
Cardiovasc Res |
Title: |
Sensitized signalling between L-type Ca2+ channels and ryanodine receptors in the absence or inhibition of FKBP12.6 in cardiomyocytes. |
Volume: |
113 |
Issue: |
3 |
Pages: |
332-342 |
|
•
•
•
•
•
|
Publication |
First Author: |
Davidson BP |
Year: |
2000 |
Journal: |
Dev Biol |
Title: |
Exogenous FGF-4 can suppress anterior development in the mouse embryo during neurulation and early organogenesis. |
Volume: |
221 |
Issue: |
1 |
Pages: |
41-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chi L |
Year: |
2004 |
Journal: |
Development |
Title: |
Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development. |
Volume: |
131 |
Issue: |
14 |
Pages: |
3345-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee SA |
Year: |
2008 |
Journal: |
Hepatology |
Title: |
Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer. |
Volume: |
47 |
Issue: |
4 |
Pages: |
1200-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okur MN |
Year: |
2014 |
Journal: |
Mol Cell Biol |
Title: |
Receptor tyrosine kinase ubiquitylation involves the dynamic regulation of Cbl-Spry2 by intersectin 1 and the Shp2 tyrosine phosphatase. |
Volume: |
34 |
Issue: |
2 |
Pages: |
271-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alvarado FJ |
Year: |
2019 |
Journal: |
JCI Insight |
Title: |
Cardiac hypertrophy and arrhythmia in mice induced by a mutation in ryanodine receptor 2. |
Volume: |
5 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Park EJ |
Year: |
2008 |
Journal: |
Development |
Title: |
An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart. |
Volume: |
135 |
Issue: |
21 |
Pages: |
3599-610 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
5035
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
4966
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
4863
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
4868
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
4966
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
5033
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
4858
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
5061
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
4888
 |
Fragment?: |
false |
|
•
•
•
•
•
|