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Search results 701 to 800 out of 972 for Srf

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Type Details Score
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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HT Experiment
GSE243678 | SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination (snRNA-Seq)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
27867007 | J:252206
First Author: Gualdrini F
Year: 2016
Journal: Mol Cell
Title: SRF Co-factors Control the Balance between Cell Proliferation and Contractility.
Volume: 64
Issue: 6
Pages: 1048-1061
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HT Experiment
E-GEOD-44406 | Srf is essential for mesodermal cell migration during elongation of the embryonic body axis
Series Id: GSE44406
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
19098903 | J:187572
First Author: Bell RD
Year: 2009
Journal: Nat Cell Biol
Title: SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells.
Volume: 11
Issue: 2
Pages: 143-53
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Publication
17588931 | J:265632
First Author: Vartiainen MK
Year: 2007
Journal: Science
Title: Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL.
Volume: 316
Issue: 5832
Pages: 1749-52
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Publication
31882856 | J:307194
First Author: Nagashima S
Year: 2019
Journal: Sci Rep
Title: Critical role of CRAG, a splicing variant of centaurin-γ3/AGAP3, in ELK1-dependent SRF activation at PML bodies.
Volume: 9
Issue: 1
Pages: 20107
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Publication
17415416 | J:122040
First Author: Kuwahara K
Year: 2007
Journal: J Clin Invest
Title: Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity.
Volume: 117
Issue: 5
Pages: 1324-34
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Publication
30874621 | J:275712
First Author: Kim MS
Year: 2019
Journal: Sci Rep
Title: Methylmercury induces the expression of chemokine CCL4 via SRF activation in C17.2 mouse neural stem cells.
Volume: 9
Issue: 1
Pages: 4631
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GXD Expression
GXD Expression
   
Probe: MGI:6444158
Assay Type: RT-PCR
Annotation Date: 2020-07-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:6444170
Age: embryonic day 8.75-9.0
Image: 4
Specimen Label: Srf flex1/flex1; T(s)::Cre
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6444159
Assay Type: RT-PCR
Annotation Date: 2020-07-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:6444171
Age: embryonic day 8.75-9.0
Image: 4
Specimen Label: Srf flex1/flex1; T(s)::Cre
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6444160
Assay Type: RT-PCR
Annotation Date: 2020-07-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:6444172
Age: embryonic day 8.75-9.0
Image: 4
Specimen Label: Srf flex1/flex1; T(s)::Cre
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6444161
Assay Type: RT-PCR
Annotation Date: 2020-07-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:6444173
Age: embryonic day 8.75-9.0
Image: 4
Specimen Label: Srf flex1/flex1; T(s)::Cre
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6444162
Assay Type: RT-PCR
Annotation Date: 2020-07-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:6444174
Age: embryonic day 8.75-9.0
Image: 4
Specimen Label: Srf flex1/flex1; T(s)::Cre
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6444163
Assay Type: RT-PCR
Annotation Date: 2020-07-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:6444175
Age: embryonic day 8.75-9.0
Image: 4
Specimen Label: Srf flex1/flex1; T(s)::Cre
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6444164
Assay Type: RT-PCR
Annotation Date: 2020-07-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:6444176
Age: embryonic day 8.75-9.0
Image: 4
Specimen Label: Srf flex1/flex1; T(s)::Cre
Detected: true
Specimen Num: 2
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Publication
23318675 | J:194394
First Author: Herndon CA
Year: 2013
Journal: Exp Cell Res
Title: Neuregulin1 signaling targets SRF and CREB and activates the muscle spindle-specific gene Egr3 through a composite SRF-CREB-binding site.
Volume: 319
Issue: 5
Pages: 718-30
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Publication
16945101 | J:112588
First Author: Shiota J
Year: 2006
Journal: J Neurochem
Title: Developmental expression of the SRF co-activator MAL in brain: role in regulating dendritic morphology.
Volume: 98
Issue: 6
Pages: 1778-88
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Publication
25585691 | J:219731
 
First Author: Rajakylä EK
Year: 2015
Journal: Nat Commun
Title: RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1.
Volume: 6
Pages: 5978
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Publication
26554816 | J:260201
First Author: Kircher P
Year: 2015
Journal: Sci Signal
Title: Filamin A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and cell migration.
Volume: 8
Issue: 402
Pages: ra112
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Publication
12802082 | J:209201
First Author: L'honore A
Year: 2003
Journal: Mol Biol Cell
Title: MyoD distal regulatory region contains an SRF binding CArG element required for MyoD expression in skeletal myoblasts and during muscle regeneration.
Volume: 14
Issue: 5
Pages: 2151-62
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Protein Coding Gene
MGI:2137495 | Myocd
Type: protein_coding_gene
Organism: mouse, laboratory
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Interaction Experiment
Nagashima S (2019)
Description: Critical role of CRAG, a splicing variant of centaurin-?3/AGAP3, in ELK1-dependent SRF activation at PML bodies.
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Publication
24440334 | -
First Author: Lundquist MR
Year: 2014
Journal: Cell
Title: Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.
Volume: 156
Issue: 3
Pages: 563-76
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Protein
Q8VIM5
Organism: Mus musculus/domesticus
Length: 935  
Fragment?: false
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Protein
P41158
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
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GXD Expression
GXD Expression
Probe: MGI:1314968
Assay Type: Immunohistochemistry
Annotation Date: 2024-10-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1626720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:7750937
Age: embryonic day 12.5
Image: 3A
Note: Acta2 was used to monitor Srf status in mesoderm due to antibody incompatibility between anti-Srf and anti-Itga5 antibodies.
Specimen Label: 3A
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:7750930
Assay Type: Immunohistochemistry
Annotation Date: 2024-10-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1626720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:7750939
Age: embryonic day 12.5
Image: 4B
Note: Expression was moderately disrupted in the mutant compared to the wild-type. Disturbance was correlated with loss of Srf protein.
Specimen Label: 4B
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3624000
Assay Type: Immunohistochemistry
Annotation Date: 2023-08-07
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7514933
Age: postnatal adult
Note: In livers with extensive loss of Srf expression, the number of Casp3-expressing cells increased 19-fold compared with control.
Specimen Label: 5F
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:3624000
Assay Type: Immunohistochemistry
Annotation Date: 2023-08-07
Strength: Trace
Sex: Not Specified
Emaps: EMAPS:1684628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7514933
Age: postnatal adult
Note: In livers with mosaic loss of Srf expression, the number of Casp3-expressing cells increased only slightly compared to control.
Specimen Label: 5I
Detected: true
Specimen Num: 5
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Protein
Q8VIM5-5
Organism: Mus musculus/domesticus
Length: 856  
Fragment?: false
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Protein
Q8VIM5-4
Organism: Mus musculus/domesticus
Length: 904  
Fragment?: false
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Protein
Q8VIM5-3
Organism: Mus musculus/domesticus
Length: 983  
Fragment?: false
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GXD Expression
GXD Expression
Probe: MGI:1314968
Assay Type: Immunohistochemistry
Annotation Date: 2024-10-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1626720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:7750937
Age: embryonic day 12.5
Image: 2A
Note: Used as a marker dependent on Srf for expression and was not used as a marker for the presence of smooth muscle cells.
Specimen Label: 2A
Detected: true
Specimen Num: 1
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Protein
Q8VIM5-2
Organism: Mus musculus/domesticus
Length: 855  
Fragment?: false
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HT Experiment
E-GEOD-13333 | Transcription profiling of mouse Serum response factor (Srf) conditional knockout in the mouse liver
Series Id: GSE13333
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE186770 | Differential regulation of cranial and cardiac neural crest by Serum Response Factor
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
34376651 | J:308983
First Author: Farmer DT
Year: 2021
Journal: Nat Commun
Title: The developing mouse coronal suture at single-cell resolution.
Volume: 12
Issue: 1
Pages: 4797
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Publication
37175668 | J:357335
 
First Author: Vogiatzi A
Year: 2023
Journal: Int J Mol Sci
Title: Development of Erf-Mediated Craniosynostosis and Pharmacological Amelioration.
Volume: 24
Issue: 9
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Publication
33436522 | J:322658
First Author: Calpena E
Year: 2022
Journal: J Med Genet
Title: Unexpected role of SIX1 variants in craniosynostosis: expanding the phenotype of SIX1-related disorders.
Volume: 59
Issue: 2
Pages: 165-169
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Publication
31067316 | J:285570
     
First Author: Goos JAC
Year: 2019
Journal: Hum Mol Genet
Title: A de novo substitution in BCL11B leads to loss of interaction with transcriptional complexes and craniosynostosis.
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Allele
Srf<tm1.1Wtp> | MGI:5606035
Name: serum response factor; targeted mutation 1.1, William T Pu
Allele Type: Targeted
Attribute String: Inserted expressed sequence
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Publication
29016847 | J:250314
First Author: Davies B
Year: 2017
Journal: Hum Mol Genet
Title: A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability.
Volume: 26
Issue: 20
Pages: 3869-3882
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Allele
Mrtfb<tm2.1Eno> | MGI:4818683
Name: myocardin related transcription factor B; targeted mutation 2.1, Eric N Olson
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Cnn1<em1Mork> | MGI:7797876
Name: calponin 1; endonuclease-mediated mutation 1, Kathleen G Morgan
Allele Type: Endonuclease-mediated
Attribute String: Hypomorph
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Genotype
Genotype
Symbol: Srf/Srf
Background: involves: 129S4/SvJae * C57BL/6 * SJL * Swiss Webster
Zygosity: hm
Has Mutant Allele: true
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Publication
27385017 | J:235718
First Author: Cenik BK
Year: 2016
Journal: Development
Title: Myocardin-related transcription factors are required for skeletal muscle development.
Volume: 143
Issue: 15
Pages: 2853-61
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Protein
A0A0N4SUW0
Organism: Mus musculus/domesticus
Length: 88  
Fragment?: true
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Protein
A0A0N4SVJ6
Organism: Mus musculus/domesticus
Length: 490  
Fragment?: false
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Protein
Q8C4E7
Organism: Mus musculus/domesticus
Length: 528  
Fragment?: true
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Protein
Q3TQB4
Organism: Mus musculus/domesticus
Length: 396  
Fragment?: false
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Protein Domain
IPR022709 | SCAI
Type: Family
Description: SCAI is a transcriptional cofactor and tumour suppressor that suppresses MKL1-induced SRF transcriptional activity. It may function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1 [].
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Protein
Q8C8N2
Organism: Mus musculus/domesticus
Length: 606  
Fragment?: false
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Publication
38147352 | J:360267
First Author: Kajuluri LP
Year: 2024
Journal: J Cell Mol Med
Title: Calponin 1 inhibits agonist-induced ERK activation and decreases calcium sensitization in vascular smooth muscle.
Volume: 28
Issue: 1
Pages: e18025
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Publication
26386146 | J:226394
First Author: Mokalled MH
Year: 2015
Journal: Dev Biol
Title: Myocardin-related transcription factors are required for cardiac development and function.
Volume: 406
Issue: 2
Pages: 109-16
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Publication
12640126 | J:82506
First Author: Du KL
Year: 2003
Journal: Mol Cell Biol
Title: Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation.
Volume: 23
Issue: 7
Pages: 2425-37
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Allele
Gt(ROSA)26Sor<tm1(SRF/VP16)Antu> | MGI:4838411
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Alfred Nordheim
Allele Type: Targeted
Attribute String: Conditional ready, Constitutively active, Humanized sequence, Inserted expressed sequence
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Protein Domain
IPR016607 | SCAI_metazoan/Viridiplantae
Type: Family
Description: This entry represents protein SCAI from metazoans and plants. SCAI is a transcriptional cofactor and tumour suppressor that suppresses MKL1-induced SRF transcriptional activity. It may function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1 [].
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Publication
- | J:170074
     
First Author: Sandstrom J
Year: 2011
Journal: MGI Direct Data Submission
Title: Submission in advance of publication in Molecular Vision
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mrtfa/Mrtfa Mrtfb/Mrtfb
Background: involves: 129 * 129S/SvEv * C57BL/6 * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Publication
20093627 | J:170871
First Author: Seeger TS
Year: 2010
Journal: Circ Res
Title: Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo.
Volume: 106
Issue: 5
Pages: 880-90
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Publication
18849881 | -
First Author: Roginski RS
Year: 2008
Journal: Neuroreport
Title: GRINL1A colocalizes with N-methyl D-aspartate receptor NR1 subunit and reduces N-methyl D-aspartate toxicity.
Volume: 19
Issue: 17
Pages: 1721-6
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Protein
Q3UIJ9
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein
E9PWY8
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
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Protein
E9Q4R0
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: true
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Protein
E9Q565
Organism: Mus musculus/domesticus
Length: 438  
Fragment?: false
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Publication
10835359 | -
First Author: Huang K
Year: 2000
Journal: EMBO J
Title: Solution structure of the MEF2A-DNA complex: structural basis for the modulation of DNA bending and specificity by MADS-box transcription factors.
Volume: 19
Issue: 11
Pages: 2615-28
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Protein Domain
IPR029992 | MRTF-A
Type: Family
Description: Myocardin-related transcription factor A (MRTFA, also known MKL1) is an actin-binding transcriptional coactivator whose localisation is regulated by its interaction with monomeric actin (G-actin) []. Its N-terminal domain consists of three tandem RPEL repeats, where the G-actin binding site and the nuclear localisation signal can be found [, ]. In the nucleus MAL associates with SRF (serum response factor) and activates transcription of SRF:MAL-dependent target genes []. It has been implicated in human diseases, such as acute megakaryocytic leukemia []and other cancers [].
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Protein Domain
IPR028273 | Myozap
Type: Family
Description: Myocardial zonula adherens protein (Myozap) plays a role in cellular signaling via Rho-related GTP-binding proteins and activation of transcription factor SRF []. It localises to the intercalated disk in cardiomyocytes and colocalises with GRIN1 in postsynaptic neurites [, ]. It also colocalises with cortical actin at the intercalated disc in the cardiomyocytes []. In cortical neurons, it may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 [].
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Protein Domain
IPR033896 | MADS_MEF2-like
Type: Domain
Description: This entry represents the MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor)) box family of eukaryotic transcriptional regulators []. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface []. Important in homeotic regulation in plants and in immediate-early development in animals []. Also found in fungi [].
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Publication
10330504 | J:54210
First Author: Vogel AM
Year: 1999
Journal: Mech Dev
Title: A zebrafish homolog of the serum response factor gene is highly expressed in differentiating embryonic myocytes.
Volume: 81
Issue: 1-2
Pages: 217-21
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Publication
21673315 | -
First Author: Mouilleron S
Year: 2011
Journal: Sci Signal
Title: Structure of a pentavalent G-actin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator.
Volume: 4
Issue: 177
Pages: ra40
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Publication
21964294 | -
First Author: Hirano H
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Sensing actin dynamics: structural basis for G-actin-sensitive nuclear import of MAL.
Volume: 414
Issue: 2
Pages: 373-8
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Publication
20818336 | J:165431
First Author: Pawłowski R
Year: 2010
Journal: EMBO J
Title: An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A.
Volume: 29
Issue: 20
Pages: 3448-58
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Publication
11344311 | -
First Author: Mercher T
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia.
Volume: 98
Issue: 10
Pages: 5776-9
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Strain
MGI:5607151 | STOCK Gt(ROSA)26Sor<tm1.1(birA)Mejr> Srf<tm1.1Wtp>/Mmjax
Attribute String: mutant stock, targeted mutation
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Publication
37289107 | J:343806
First Author: Yamamura Y
Year: 2023
Journal: FASEB J
Title: Myocardin-related transcription factor contributes to renal fibrosis through the regulation of extracellular microenvironment surrounding fibroblasts.
Volume: 37
Issue: 7
Pages: e23005
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Genotype
Genotype
Symbol: Mrtfb/Mrtfb Tg(GFAP-cre)25Mes/?
Background: involves: 129S/SvEv * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mrtfa/Mrtfa Mrtfb/Mrtfb Tg(ACTA1-cre)79Jme/?
Background: involves: 129 * 129S/SvEv * C57BL/6J * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mrtfa/Mrtfa Mrtfb/Mrtfb Tg(Myh6-cre)2182Mds/?
Background: involves: 129 * 129S/SvEv * FVB/N * ICR
Zygosity: cn
Has Mutant Allele: true
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Protein
A0A5F8MPG5
Organism: Mus musculus/domesticus
Length: 124  
Fragment?: false
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Protein
A0A5F8MPI2
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
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Protein
A0A668KL76
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: true
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Protein
Q3TLK1
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: false
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Publication
15620697 | -
First Author: Favot L
Year: 2005
Journal: FEBS Lett
Title: Overexpression of a family of RPEL proteins modifies cell shape.
Volume: 579
Issue: 1
Pages: 100-4
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Protein Domain
IPR004018 | RPEL_repeat
Type: Repeat
Description: RPEL repeat (RPxxxEL) containing proteins are found in a wide range ofmetazoan organisms. RPEL repeats have been shown to be required forunpolymerised actin binding and proteins containing RPEL repeats are able tomodify cell shape and/or are important in the regulation of gene expression bythe actin cytoskeleton. RPEL repeats can be found in association with the SAPmotif, which could be involved in DNA binding [, ].Some proteins known to containRPEL repeats are listed below:Mammalian myocardin, heart-specific serum response factor (SRF) co-activator.Vertebrate myocardin-related transcription factor A (MRTF-A or MAL), asignal-regulated SRF co-activator.Vertebrate myocardin-related transcription factor B (MRTF-B).Mammalian phosphatase and actin regulator 1 to 3.
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HT Experiment
GSE69726 | Myocardin-related transcription factors are required for cardiac development and function
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-84063 | Myocardin-related Transcription Factors Are Required for Skeletal Muscle Development
Series Id: GSE84063
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein
F6TBX6
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: true
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Protein
Q3US93
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: true
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Protein
Q8R2L3
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: false
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Publication
24025544 | -
First Author: Long X
Year: 2013
Journal: Arterioscler Thromb Vasc Biol
Title: Myocardin: new therapeutic agent in vascular disease?
Volume: 33
Issue: 10
Pages: 2284-5
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Publication
24567363 | -
First Author: Morita T
Year: 2014
Journal: J Cell Biol
Title: Arp5 is a key regulator of myocardin in smooth muscle cells.
Volume: 204
Issue: 5
Pages: 683-96
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Publication
14565952 | -
First Author: Selvaraj A
Year: 2003
Journal: J Biol Chem
Title: Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation.
Volume: 278
Issue: 43
Pages: 41977-87
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Protein Domain
IPR043451 | Myocardin-like
Type: Family
Description: Myocardin (Myocd) is a coactivator of serum response factor (SRF), which is a key regulator of the expression of smooth and cardiac muscle genes. Myocardin plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) [, ]. It contains the RPEL repeats, which are monomeric globular actin (G-actin) binding elements. However, it binds to actin-related protein 5 (Arp5) instead of conventional actin, resulting in a significant suppression of Myocd activity [].Myocardin-related transcription factor A (MRTFA, also known MKL1) is an actin-binding transcriptional coactivator whose localisation is regulated by its interaction with monomeric actin (G-actin) []. Its N-terminal domain consists of three tandem RPEL repeats, where the G-actin binding site and the nuclear localisation signal can be found [, ]. In the nucleus MAL associates with SRF (serum response factor) and activates transcription of SRF:MAL-dependent target genes []. It has been implicated in human diseases, such as acute megakaryocytic leukemia []and other cancers [].MKL2 binds to and activates SRF (serum response factor) similar to myocardin and MKL1 [].This entry includes Myocardin and MKL/myocardin-like protein 1/2 (MKL1/2).
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Publication
7744019 | J:25287
First Author: Shore P
Year: 1995
Journal: Eur J Biochem
Title: The MADS-box family of transcription factors.
Volume: 229
Issue: 1
Pages: 1-13
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