|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 701 to 800 out of 913 for Tlr7

0.031s
Type Details Score
Publication
First Author: Crespo MI
Year: 2013
Journal: J Immunol
Title: TLR7 triggering with polyuridylic acid promotes cross-presentation in CD8α+ conventional dendritic cells by enhancing antigen preservation and MHC class I antigen permanence on the dendritic cell surface.
Volume: 190
Issue: 3
Pages: 948-60
Publication  
First Author: Thomalla M
Year: 2022
Journal: Int J Mol Sci
Title: Toll-like Receptor 7 (TLR7) Is Expressed in Adipocytes and the Pharmacological TLR7 Agonist Imiquimod and Adipocyte-Derived Cell-Free Nucleic Acids (cfDNA) Regulate Adipocyte Function.
Volume: 23
Issue: 15
Strain
Attribute String: coisogenic, mutant strain, targeted mutation
GO Term
GO Term
GO Term
Publication  
First Author: Merkenschlager J
Year: 2016
Journal: Nat Commun
Title: Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response.
Volume: 7
Pages: 10281
Publication
First Author: Mavrommatis B
Year: 2016
Journal: J Immunol
Title: Dichotomy between T Cell and B Cell Tolerance to Neonatal Retroviral Infection Permits T Cell Therapy.
Volume: 197
Issue: 9
Pages: 3628-3638
Publication
First Author: Young GR
Year: 2012
Journal: PLoS Pathog
Title: Negative selection by an endogenous retrovirus promotes a higher-avidity CD4+ T cell response to retroviral infection.
Volume: 8
Issue: 5
Pages: e1002709
Publication
First Author: Turcotte K
Year: 2005
Journal: J Exp Med
Title: A mutation in the Icsbp1 gene causes susceptibility to infection and a chronic myeloid leukemia-like syndrome in BXH-2 mice.
Volume: 201
Issue: 6
Pages: 881-90
Other Genome Feature
Type: endogenous_retroviral_sequence
Organism: mouse, laboratory
Publication
First Author: Kirchgessner TG
Year: 1989
Journal: J Biol Chem
Title: Genetic and developmental regulation of the lipoprotein lipase gene: loci both distal and proximal to the lipoprotein lipase structural gene control enzyme expression.
Volume: 264
Issue: 3
Pages: 1473-82
Publication
First Author: Ihle JN
Year: 1978
Journal: Virology
Title: Genetic analysis of the endogenous C3H murine leukemia virus genome: evidence for one locus unlinked to the endogenous murine leukemia virus genome of C57BL/6 mice.
Volume: 87
Issue: 2
Pages: 298-306
Publication
First Author: McCubrey J
Year: 1982
Journal: J Exp Med
Title: Allelism and linkage studies of murine leukemia virus activation genes in low leukemic strains of mice.
Volume: 155
Issue: 4
Pages: 1233-8
Publication
First Author: McCubrey J
Year: 1982
Journal: Cell
Title: Genetic interactions in induction of endogenous murine leukemia virus from low leukemic mice.
Volume: 28
Issue: 4
Pages: 881-8
Publication
First Author: McCubrey J
Year: 1982
Journal: J Exp Med
Title: Genetic interactions in the spontaneous production of endogenous murine leukemia virus in low leukemic mouse strains.
Volume: 156
Issue: 2
Pages: 337-49
Publication
First Author: Horowitz JM
Year: 1982
Journal: J Virol
Title: A locus that enhances the induction of endogenous ecotropic murine leukemia viruses is distinct from genome-length ecotropic proviruses.
Volume: 44
Issue: 3
Pages: 950-7
Publication
First Author: Mattano SS
Year: 1988
Journal: J Hered
Title: Linkage of Nat and Es-1 in the mouse and development of strains congenic for N-acetyltransferase.
Volume: 79
Issue: 6
Pages: 430-3
Publication
First Author: Ceci JD
Year: 1990
Journal: Genomics
Title: An interspecific backcross linkage map of mouse chromosome 8.
Volume: 6
Issue: 1
Pages: 72-9
Publication
First Author: Abonia JP
Year: 1993
Journal: Mamm Genome
Title: Linkage of Agt and Actsk-1 to distal mouse chromosome 8 loci: a new conserved linkage.
Volume: 4
Issue: 1
Pages: 25-32
Publication
First Author: Frankel WN
Year: 1994
Journal: Mamm Genome
Title: Endogenous nonecotropic proviruses mapped with oligonucleotide probes from the long terminal repeat region.
Volume: 5
Issue: 5
Pages: 275-81
Publication
First Author: Taylor BA
Year: 1999
Journal: Mamm Genome
Title: Genotyping new BXD recombinant inbred mouse strains and comparison of BXD and consensus maps.
Volume: 10
Issue: 4
Pages: 335-48
Allele
Name: toll-like receptor 7; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: toll-like receptor 7; targeted mutation 3, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: toll-like receptor 8; targeted mutation 3, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Publication
First Author: Majer O
Year: 2019
Journal: Nature
Title: Release from UNC93B1 reinforces the compartmentalized activation of select TLRs.
Volume: 575
Issue: 7782
Pages: 371-374
Publication
First Author: Melchjorsen J
Year: 2005
Journal: J Virol
Title: Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner.
Volume: 79
Issue: 20
Pages: 12944-51
Publication
First Author: Kozak CA
Year: 1982
Journal: J Exp Med
Title: Genetic mapping of ecotropic murine leukemia virus-inducing loci in six inbred strains.
Volume: 155
Issue: 2
Pages: 524-34
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Publication
First Author: Jenkins NA
Year: 1982
Journal: J Virol
Title: Ecotropic murine leukemia virus DNA content of normal and lymphomatous tissues of BXH-2 recombinant inbred mice.
Volume: 42
Issue: 2
Pages: 379-88
Publication
First Author: Taylor BA
Year: 1989
Journal: Genomics
Title: A mouse linkage testing stock possessing multiple copies of the endogenous ecotropic murine leukemia virus genome.
Volume: 5
Issue: 2
Pages: 221-32
Publication
First Author: Pilz A
Year: 1992
Journal: Mamm Genome
Title: Mapping of the structural gene for S-adenosyl homocysteine hydrolase to mouse chromosome 2, and related sequences to chromosomes 8 and X.
Volume: 3
Issue: 11
Pages: 633-6
Publication
First Author: Taylor BA
Year: 1993
Journal: Genomics
Title: The MEV mouse linkage testing stock: mapping 30 novel proviral insertions and establishment of an improved stock.
Volume: 16
Issue: 2
Pages: 380-94
Protein
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: true
Publication
First Author: Pohar J
Year: 2013
Journal: J Biol Chem
Title: The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists.
Volume: 288
Issue: 1
Pages: 442-54
Publication
First Author: Sasai M
Year: 2011
Journal: Immunity
Title: Love triangle between Unc93B1, TLR7, and TLR9 prevents fatal attraction.
Volume: 35
Issue: 1
Pages: 3-5
Protein Domain
Type: Family
Description: UNC93B1 is a multi-transmembrane domain-containing protein that plays an essential role in signalling by the nucleotide-sensing Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9 [, ]. UNC93B1 delivers the nucleotide-sensing receptors TLR7 and TLR9 from the ER to endolysosomes []. It has been shown to recruit Syntenin-1 and dampen TLR7 signalling and prevent autoimmunity []. It also binds TLR9, and the release of TLR9 from UNC93B1 is required for TLR9 to function []. Mutations in the UNC93B1 gene that result in aberrant TLR trafficking can lead to autoimmune disease [].
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Taylor BA
Year: 1985
Journal: J Virol
Title: Chromosomal assignment of two endogenous ecotropic murine leukemia virus proviruses of the AKR/J mouse strain.
Volume: 56
Issue: 1
Pages: 172-5
Allele
Name: transgene insertion 1, Silvia Bolland
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 6, Silvia Bolland
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Publication  
First Author: Botía-Sánchez M
Year: 2023
Journal: Front Immunol
Title: Gut epithelial barrier dysfunction in lupus triggers a differential humoral response against gut commensals.
Volume: 14
Pages: 1200769
Genotype
Symbol: Tg(Tlr7)1Boll/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Tlr7)6Boll/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Jenkins NA
Year: 1982
Journal: J Virol
Title: Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus.
Volume: 43
Issue: 1
Pages: 26-36
Protein
Organism: Mus musculus/domesticus
Length: 598  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 422  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 619  
Fragment?: false
Publication
First Author: Chen W
Year: 2008
Journal: Nat Struct Mol Biol
Title: Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5.
Volume: 15
Issue: 11
Pages: 1213-20
Publication
First Author: Barnes BJ
Year: 2001
Journal: J Biol Chem
Title: Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes.
Volume: 276
Issue: 26
Pages: 23382-90
Publication
First Author: Dideberg V
Year: 2007
Journal: Hum Mol Genet
Title: An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases.
Volume: 16
Issue: 24
Pages: 3008-16
Publication
First Author: Sigurdsson S
Year: 2005
Journal: Am J Hum Genet
Title: Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.
Volume: 76
Issue: 3
Pages: 528-37
Publication
First Author: Schoenemeyer A
Year: 2005
Journal: J Biol Chem
Title: The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.
Volume: 280
Issue: 17
Pages: 17005-12
Protein Domain
Type: Family
Description: Interferon regulatory factor 5 (IRF5) is a transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection []. It is activated by TLR7 or TLR8 signalling []. Its structure has been revealed []. Variations of the IRF5 gene affects the susceptibility of a few diseases, such as inflammatory bowel disease 14 (IBD14) [], systemic lupus erythematosus 10 (SLEB10) []and Rheumatoid arthritis (RA).
Publication
First Author: Wang JQ
Year: 2016
Journal: Blood
Title: Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88L265P plasmablasts in vivo.
Volume: 128
Issue: 12
Pages: 1604-8
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
HT Experiment
Series Id: GSE9287
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication
First Author: Sisirak V
Year: 2014
Journal: J Exp Med
Title: Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus.
Volume: 211
Issue: 10
Pages: 1969-76
Publication
First Author: Tun-Kyi A
Year: 2011
Journal: Nat Immunol
Title: Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity.
Volume: 12
Issue: 8
Pages: 733-41
Protein
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: false
Publication
First Author: de la Cruz IP
Year: 2003
Journal: J Neurosci
Title: sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans.
Volume: 23
Issue: 27
Pages: 9133-45
Publication
First Author: Perland E
Year: 2016
Journal: PLoS One
Title: The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis.
Volume: 11
Issue: 6
Pages: e0156912
Publication
First Author: Li S
Year: 2012
Journal: Medchemcomm
Title: Comparative analysis of the biosynthetic systems for fungal bicyclo[2.2.2]diazaoctane indole alkaloids: the (+)/(-)-notoamide, paraherquamide and malbrancheamide pathways.
Volume: 3
Issue: 8
Pages: 987-996
Protein Domain
Type: Family
Description: The proteins in this family are represented by UNC-93 from Caenorhabditis elegans and also includes protein unc-93 homologue A (UNC93A), protein unc-93 homologue B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET). UNC-93 colocalizes with SUP-10 and SUP-9 within muscle cells. UNC-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans []. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signalling cascades []. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons [].This group of proteins also includes Notoamide biosynthesis cluster protein O' from Aspergillus versicolor, which is involved in the biosynthesis of notoamide, a fungal indole alkaloid that belongs to a family of natural products containing a characteristic bicyclo[2.2.2]diazaoctane core [].
Publication        
First Author: International Committee on Standardized Genetic Nomenclature for Mice
Year: 1993
Title: Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols
Publication
First Author: Ishida H
Year: 2021
Journal: Nat Struct Mol Biol
Title: Cryo-EM structures of Toll-like receptors in complex with UNC93B1.
Volume: 28
Issue: 2
Pages: 173-180
Publication
First Author: Ewald SE
Year: 2011
Journal: J Exp Med
Title: Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase.
Volume: 208
Issue: 4
Pages: 643-51
Publication
First Author: Tilstra JS
Year: 2020
Journal: J Clin Invest
Title: B cell-intrinsic TLR9 expression is protective in murine lupus.
Volume: 130
Issue: 6
Pages: 3172-3187
Publication
First Author: Nickerson KM
Year: 2013
Journal: J Immunol
Title: Exacerbated autoimmunity in the absence of TLR9 in MRL.Fas(lpr) mice depends on Ifnar1.
Volume: 190
Issue: 8
Pages: 3889-94
Publication
First Author: Mouchess ML
Year: 2011
Journal: Immunity
Title: Transmembrane mutations in Toll-like receptor 9 bypass the requirement for ectodomain proteolysis and induce fatal inflammation.
Volume: 35
Issue: 5
Pages: 721-32
Publication
First Author: Marshall-Clarke S
Year: 2006
Journal: Eur J Immunol
Title: Influenza H2 haemagglutinin activates B cells via a MyD88-dependent pathway.
Volume: 36
Issue: 1
Pages: 95-106
Publication
First Author: Carlin LM
Year: 2013
Journal: Cell
Title: Nr4a1-dependent Ly6C(low) monocytes monitor endothelial cells and orchestrate their disposal.
Volume: 153
Issue: 2
Pages: 362-75
Publication  
First Author: Singh TP
Year: 2016
Journal: Nat Commun
Title: Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation.
Volume: 7
Pages: 13581
Publication
First Author: Das A
Year: 2017
Journal: Immunity
Title: Follicular Dendritic Cell Activation by TLR Ligands Promotes Autoreactive B Cell Responses.
Volume: 46
Issue: 1
Pages: 106-119
Publication  
First Author: Babcock RL
Year: 2022
Journal: Mol Immunol
Title: Regulation and function of Id2 in plasmacytoid dendritic cells.
Volume: 148
Pages: 6-17
Publication
First Author: Bonnardel J
Year: 2015
Journal: Cell Rep
Title: Innate and adaptive immune functions of peyer's patch monocyte-derived cells.
Volume: 11
Issue: 5
Pages: 770-84
Publication
First Author: Barchet W
Year: 2005
Journal: Eur J Immunol
Title: Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways.
Volume: 35
Issue: 1
Pages: 236-42
Publication
First Author: Hamilton JA
Year: 2017
Journal: J Immunol
Title: Cutting Edge: Endogenous IFN-β Regulates Survival and Development of Transitional B Cells.
Volume: 199
Issue: 8
Pages: 2618-2623
Publication
First Author: Cheung MB
Year: 2021
Journal: J Immunol
Title: Cutting Edge: Myosin 18A Is a Novel Checkpoint Regulator in B Cell Differentiation and Antibody-Mediated Immunity.
Volume: 206
Issue: 11
Pages: 2521-2526
Publication    
First Author: Stebegg M
Year: 2020
Journal: Elife
Title: Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination.
Volume: 9
Publication
First Author: Ohto U
Year: 2018
Journal: Immunity
Title: Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation.
Volume: 48
Issue: 4
Pages: 649-658.e4
Publication  
First Author: Pohar J
Year: 2017
Journal: Nat Commun
Title: Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9.
Volume: 8
Pages: 15363
Publication
First Author: Xiao N
Year: 2009
Journal: J Immunol
Title: The Tpl2 mutation Sluggish impairs type I IFN production and increases susceptibility to group B streptococcal disease.
Volume: 183
Issue: 12
Pages: 7975-83
Publication
First Author: Edgar LJ
Year: 2019
Journal: Cell Chem Biol
Title: Targeted Delivery of Antigen to Activated CD169+ Macrophages Induces Bias for Expansion of CD8+ T Cells.
Volume: 26
Issue: 1
Pages: 131-136.e4
Publication  
First Author: Alrefai H
Year: 2016
Journal: Nat Commun
Title: NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.
Volume: 7
Pages: 11724
Publication
First Author: Callahan JA
Year: 2013
Journal: J Immunol
Title: Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells.
Volume: 191
Issue: 2
Pages: 535-9
Publication
First Author: Honda K
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling.
Volume: 101
Issue: 43
Pages: 15416-21
Publication
First Author: Barton GM
Year: 2006
Journal: Nat Immunol
Title: Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.
Volume: 7
Issue: 1
Pages: 49-56
Publication
First Author: Gorden KK
Year: 2006
Journal: J Immunol
Title: Cutting edge: activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides.
Volume: 177
Issue: 10
Pages: 6584-7
Publication
First Author: Lopez-Pelaez M
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells.
Volume: 111
Issue: 49
Pages: 17432-7
Publication
First Author: Miyake K
Year: 2018
Journal: Int Immunol
Title: Mechanisms controlling nucleic acid-sensing Toll-like receptors.
Volume: 30
Issue: 2
Pages: 43-51
Publication
First Author: Soni C
Year: 2023
Journal: J Immunol
Title: Cutting Edge: TLR2 Signaling in B Cells Promotes Autoreactivity to DNA via IL-6 Secretion.
Volume: 211
Issue: 10
Pages: 1475-1480
Publication
First Author: Li G
Year: 2020
Journal: iScience
Title: Spermidine Suppresses Inflammatory DC Function by Activating the FOXO3 Pathway and Counteracts Autoimmunity.
Volume: 23
Issue: 1
Pages: 100807
Publication
First Author: Zhu L
Year: 2023
Journal: Cell Rep
Title: SLC38A5 aggravates DC-mediated psoriasiform skin inflammation via potentiating lysosomal acidification.
Volume: 42
Issue: 8
Pages: 112910
Publication
First Author: Medhavy A
Year: 2024
Journal: Nat Immunol
Title: A TNIP1-driven systemic autoimmune disorder with elevated IgG4.
Volume: 25
Issue: 9
Pages: 1678-1691
Protein
Organism: Mus musculus/domesticus
Length: 449  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: false