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Search results 701 to 800 out of 1340 for Tlr9

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Type Details Score
Publication
First Author: Gratz N
Year: 2008
Journal: J Biol Chem
Title: Group A streptococcus activates type I interferon production and MyD88-dependent signaling without involvement of TLR2, TLR4, and TLR9.
Volume: 283
Issue: 29
Pages: 19879-87
Publication
First Author: Boonstra A
Year: 2006
Journal: J Immunol
Title: Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals.
Volume: 177
Issue: 11
Pages: 7551-8
Publication
First Author: Bagchi A
Year: 2007
Journal: J Immunol
Title: MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists.
Volume: 178
Issue: 2
Pages: 1164-71
Publication
First Author: Yang M
Year: 2011
Journal: J Exp Med
Title: E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKC{zeta}.
Volume: 208
Issue: 10
Pages: 2099-112
Publication
First Author: Huang LR
Year: 2013
Journal: Nat Immunol
Title: Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection.
Volume: 14
Issue: 6
Pages: 574-83
Publication
First Author: Tang X
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways.
Volume: 103
Issue: 37
Pages: 13777-82
Publication
First Author: Kato H
Year: 2005
Journal: Immunity
Title: Cell type-specific involvement of RIG-I in antiviral response.
Volume: 23
Issue: 1
Pages: 19-28
Publication
First Author: Heil F
Year: 2004
Journal: Science
Title: Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.
Volume: 303
Issue: 5663
Pages: 1526-9
Publication
First Author: Tezuka H
Year: 2007
Journal: Nature
Title: Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells.
Volume: 448
Issue: 7156
Pages: 929-33
Publication
First Author: Young GR
Year: 2012
Journal: Nature
Title: Resurrection of endogenous retroviruses in antibody-deficient mice.
Volume: 491
Issue: 7426
Pages: 774-8
Publication
First Author: Yi AK
Year: 2006
Journal: J Biol Chem
Title: CpG DNA-mediated induction of acute liver injury in D-galactosamine-sensitized mice: the mitochondrial apoptotic pathway-dependent death of hepatocytes.
Volume: 281
Issue: 21
Pages: 15001-12
Publication
First Author: Biswas S
Year: 2016
Journal: Blood
Title: Novel phosphatidylethanolamine derivatives accumulate in circulation in hyperlipidemic ApoE-/- mice and activate platelets via TLR2.
Volume: 127
Issue: 21
Pages: 2618-29
Publication
First Author: Sabatel C
Year: 2017
Journal: Immunity
Title: Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages.
Volume: 46
Issue: 3
Pages: 457-473
Publication
First Author: Zhang X
Year: 2009
Journal: Immunity
Title: Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils.
Volume: 31
Issue: 5
Pages: 761-71
Publication
First Author: Tchaptchet S
Year: 2012
Journal: PLoS One
Title: TLR9-dependent and independent pathways drive activation of the immune system by Propionibacterium acnes.
Volume: 7
Issue: 6
Pages: e39155
Publication
First Author: Kirkland D
Year: 2012
Journal: Immunity
Title: B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage.
Volume: 36
Issue: 2
Pages: 228-38
Publication
First Author: Kawane K
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation.
Volume: 107
Issue: 45
Pages: 19432-7
Publication
First Author: Jeon SG
Year: 2012
Journal: PLoS Pathog
Title: Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon.
Volume: 8
Issue: 5
Pages: e1002714
Publication
First Author: Lindsay RW
Year: 2010
Journal: J Immunol
Title: CD8+ T cell responses following replication-defective adenovirus serotype 5 immunization are dependent on CD11c+ dendritic cells but show redundancy in their requirement of TLR and nucleotide-binding oligomerization domain-like receptor signaling.
Volume: 185
Issue: 3
Pages: 1513-21
Publication
First Author: Kerur N
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy.
Volume: 54
Issue: 12
Pages: 7395-401
Publication
First Author: Morrissey SM
Year: 2021
Journal: Cell Metab
Title: Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming.
Volume: 33
Issue: 10
Pages: 2040-2058.e10
Publication
First Author: Xia X
Year: 2015
Journal: Cell Rep
Title: Porous silicon microparticle potentiates anti-tumor immunity by enhancing cross-presentation and inducing type I interferon response.
Volume: 11
Issue: 6
Pages: 957-966
Publication
First Author: Mayer-Barber KD
Year: 2010
Journal: J Immunol
Title: Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo.
Volume: 184
Issue: 7
Pages: 3326-30
Publication
First Author: Hasegawa M
Year: 2010
Journal: Infect Immun
Title: Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development.
Volume: 78
Issue: 2
Pages: 639-50
Publication
First Author: Hoshino K
Year: 2010
Journal: J Immunol
Title: Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells.
Volume: 184
Issue: 7
Pages: 3341-5
Publication
First Author: Mascarenhas DP
Year: 2015
Journal: J Infect Dis
Title: Interleukin 1 receptor-driven neutrophil recruitment accounts to MyD88-dependent pulmonary clearance of legionella pneumophila infection in vivo.
Volume: 211
Issue: 2
Pages: 322-30
Publication
First Author: Wang H
Year: 2016
Journal: PLoS Pathog
Title: MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase.
Volume: 12
Issue: 8
Pages: e1005787
Publication
First Author: Price AE
Year: 2018
Journal: Immunity
Title: A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns.
Volume: 49
Issue: 3
Pages: 560-575.e6
Publication
First Author: Jiang D
Year: 2005
Journal: Nat Med
Title: Regulation of lung injury and repair by Toll-like receptors and hyaluronan.
Volume: 11
Issue: 11
Pages: 1173-9
Publication
First Author: de Almeida LA
Year: 2011
Journal: PLoS One
Title: MyD88 and STING signaling pathways are required for IRF3-mediated IFN-β induction in response to Brucella abortus infection.
Volume: 6
Issue: 8
Pages: e23135
Publication
First Author: Seehawer M
Year: 2018
Journal: Nature
Title: Necroptosis microenvironment directs lineage commitment in liver cancer.
Volume: 562
Issue: 7725
Pages: 69-75
Publication
First Author: Andoniou CE
Year: 2005
Journal: Nat Immunol
Title: Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity.
Volume: 6
Issue: 10
Pages: 1011-9
Publication
First Author: Medina EA
Year: 2010
Journal: J Immunol
Title: Phosphatidylinositol 3-kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain.
Volume: 185
Issue: 12
Pages: 7562-72
Publication
First Author: Deshmukh SD
Year: 2012
Journal: J Immunol
Title: NO is a macrophage autonomous modifier of the cytokine response to streptococcal single-stranded RNA.
Volume: 188
Issue: 2
Pages: 774-80
Publication
First Author: Jung A
Year: 2008
Journal: J Virol
Title: Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88.
Volume: 82
Issue: 1
Pages: 196-206
Publication
First Author: Costa A
Year: 2012
Journal: J Immunol
Title: Activation of the NLRP3 inflammasome by group B streptococci.
Volume: 188
Issue: 4
Pages: 1953-60
Publication
First Author: Hou J
Year: 2009
Journal: J Immunol
Title: MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2.
Volume: 183
Issue: 3
Pages: 2150-8
Publication
First Author: Coban C
Year: 2007
Journal: Int Immunol
Title: Pathological role of Toll-like receptor signaling in cerebral malaria.
Volume: 19
Issue: 1
Pages: 67-79
Publication
First Author: Yarovinsky F
Year: 2005
Journal: Science
Title: TLR11 activation of dendritic cells by a protozoan profilin-like protein.
Volume: 308
Issue: 5728
Pages: 1626-9
Publication
First Author: Conrad ML
Year: 2009
Journal: J Exp Med
Title: Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78.
Volume: 206
Issue: 13
Pages: 2869-77
Publication
First Author: Gaya M
Year: 2015
Journal: Science
Title: Host response. Inflammation-induced disruption of SCS macrophages impairs B cell responses to secondary infection.
Volume: 347
Issue: 6222
Pages: 667-72
Publication
First Author: Zhang K
Year: 2014
Journal: PLoS Pathog
Title: Age-dependent enterocyte invasion and microcolony formation by Salmonella.
Volume: 10
Issue: 9
Pages: e1004385
Publication  
First Author: Pradhan P
Year: 2021
Journal: Sci Adv
Title: TRAF6-IRF5 kinetics, TRIF, and biophysical factors drive synergistic innate responses to particle-mediated MPLA-CpG co-presentation.
Volume: 7
Issue: 3
Publication  
First Author: Querrey M
Year: 2022
Journal: J Clin Invest
Title: CD11b suppresses TLR activation of nonclassical monocytes to reduce primary graft dysfunction after lung transplantation.
Volume: 132
Issue: 14
Publication
First Author: Xu J
Year: 2014
Journal: J Leukoc Biol
Title: TLR ligands up-regulate Trex1 expression in murine conventional dendritic cells through type I Interferon and NF-κB-dependent signaling pathways.
Volume: 96
Issue: 1
Pages: 93-103
Publication
First Author: Shi C
Year: 2011
Journal: Immunity
Title: Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands.
Volume: 34
Issue: 4
Pages: 590-601
Publication
First Author: Van Prooyen N
Year: 2016
Journal: PLoS Pathog
Title: CD103+ Conventional Dendritic Cells Are Critical for TLR7/9-Dependent Host Defense against Histoplasma capsulatum, an Endemic Fungal Pathogen of Humans.
Volume: 12
Issue: 7
Pages: e1005749
Publication  
First Author: Acharya M
Year: 2016
Journal: Nat Commun
Title: αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells.
Volume: 7
Pages: 10917
Publication
First Author: Festuccia WT
Year: 2014
Journal: PLoS One
Title: Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide.
Volume: 9
Issue: 4
Pages: e95432
Publication
First Author: Craxton A
Year: 2007
Journal: Eur J Immunol
Title: Bim regulates BCR-induced entry of B cells into the cell cycle.
Volume: 37
Issue: 10
Pages: 2715-22
Publication
First Author: Iversen MB
Year: 2016
Journal: Nat Immunol
Title: An innate antiviral pathway acting before interferons at epithelial surfaces.
Volume: 17
Issue: 2
Pages: 150-8
Publication  
First Author: Famà A
Year: 2020
Journal: mBio
Title: Nucleic Acid-Sensing Toll-Like Receptors Play a Dominant Role in Innate Immune Recognition of Pneumococci.
Volume: 11
Issue: 2
Publication
First Author: Ishii KJ
Year: 2008
Journal: Nature
Title: TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.
Volume: 451
Issue: 7179
Pages: 725-9
Publication
First Author: Sanjuan MA
Year: 2007
Journal: Nature
Title: Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis.
Volume: 450
Issue: 7173
Pages: 1253-7
Publication  
First Author: Velasco WV
Year: 2023
Journal: Front Immunol
Title: Toll-like receptors 2, 4, and 9 modulate promoting effect of COPD-like airway inflammation on K-ras-driven lung cancer through activation of the MyD88/NF-ĸB pathway in the airway epithelium.
Volume: 14
Pages: 1118721
Publication
First Author: Qian C
Year: 2007
Journal: Blood
Title: TLR agonists induce regulatory dendritic cells to recruit Th1 cells via preferential IP-10 secretion and inhibit Th1 proliferation.
Volume: 109
Issue: 8
Pages: 3308-15
Publication
First Author: Suzuki N
Year: 2002
Journal: Nature
Title: Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4.
Volume: 416
Issue: 6882
Pages: 750-6
Publication
First Author: Spörri R
Year: 2006
Journal: J Immunol
Title: MyD88-dependent IFN-gamma production by NK cells is key for control of Legionella pneumophila infection.
Volume: 176
Issue: 10
Pages: 6162-71
Publication
First Author: Frazer LC
Year: 2013
Journal: J Immunol
Title: CD4+ T cell expression of MyD88 is essential for normal resolution of Chlamydia muridarum genital tract infection.
Volume: 191
Issue: 8
Pages: 4269-79
Publication
First Author: Kim S
Year: 2009
Journal: Nature
Title: Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis.
Volume: 457
Issue: 7225
Pages: 102-6
Publication
First Author: Imai Y
Year: 2008
Journal: Cell
Title: Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.
Volume: 133
Issue: 2
Pages: 235-49
Publication
First Author: Naik S
Year: 2012
Journal: Science
Title: Compartmentalized control of skin immunity by resident commensals.
Volume: 337
Issue: 6098
Pages: 1115-9
Publication
First Author: Schwandt T
Year: 2012
Journal: EMBO J
Title: Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis.
Volume: 31
Issue: 1
Pages: 201-13
Publication
First Author: Biondo C
Year: 2012
Journal: Eur J Immunol
Title: Recognition of fungal RNA by TLR7 has a nonredundant role in host defense against experimental candidiasis.
Volume: 42
Issue: 10
Pages: 2632-43
Publication
First Author: Bourgeois C
Year: 2011
Journal: J Immunol
Title: Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-β signaling.
Volume: 186
Issue: 5
Pages: 3104-12
Publication  
First Author: Auger JP
Year: 2017
Journal: Front Immunol
Title: Type I Interferon Induced by Streptococcus suis Serotype 2 is Strain-Dependent and May Be Beneficial for Host Survival.
Volume: 8
Pages: 1039
Publication
First Author: Weiss G
Year: 2012
Journal: J Immunol
Title: MyD88 drives the IFN-β response to Lactobacillus acidophilus in dendritic cells through a mechanism involving IRF1, IRF3, and IRF7.
Volume: 189
Issue: 6
Pages: 2860-8
Publication
First Author: Moroishi T
Year: 2016
Journal: Cell
Title: The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.
Volume: 167
Issue: 6
Pages: 1525-1539.e17
Publication
First Author: Benmerzoug S
Year: 2018
Journal: Nat Commun
Title: STING-dependent sensing of self-DNA drives silica-induced lung inflammation.
Volume: 9
Issue: 1
Pages: 5226
Publication
First Author: Gasse P
Year: 2007
Journal: J Clin Invest
Title: IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice.
Volume: 117
Issue: 12
Pages: 3786-99
Publication
First Author: Couillin I
Year: 2009
Journal: J Immunol
Title: IL-1R1/MyD88 signaling is critical for elastase-induced lung inflammation and emphysema.
Volume: 183
Issue: 12
Pages: 8195-202
Publication  
First Author: Takemura N
Year: 2014
Journal: Nat Commun
Title: Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome.
Volume: 5
Pages: 3492
Publication
First Author: Grivennikov SI
Year: 2012
Journal: Nature
Title: Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.
Volume: 491
Issue: 7423
Pages: 254-8
Publication  
First Author: Martino MM
Year: 2016
Journal: Nat Commun
Title: Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration.
Volume: 7
Pages: 11051
Publication
First Author: Zhang C
Year: 2018
Journal: Cell Mol Immunol
Title: Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity.
Volume: 15
Issue: 11
Pages: 973-982
Publication
First Author: Anzai A
Year: 2017
Journal: J Exp Med
Title: The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes.
Volume: 214
Issue: 11
Pages: 3293-3310
Publication
First Author: Chen CJ
Year: 2007
Journal: Nat Med
Title: Identification of a key pathway required for the sterile inflammatory response triggered by dying cells.
Volume: 13
Issue: 7
Pages: 851-6
Publication
First Author: Tang H
Year: 2010
Journal: Nat Immunol
Title: The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling.
Volume: 11
Issue: 7
Pages: 608-17
Publication
First Author: Enoksson M
Year: 2011
Journal: J Immunol
Title: Mast cells as sensors of cell injury through IL-33 recognition.
Volume: 186
Issue: 4
Pages: 2523-8
Publication
First Author: Togbe D
Year: 2007
Journal: Am J Pathol
Title: Murine cerebral malaria development is independent of toll-like receptor signaling.
Volume: 170
Issue: 5
Pages: 1640-8
Publication
First Author: Cousin C
Year: 2019
Journal: Cell Rep
Title: Persistence of Integrase-Deficient Lentiviral Vectors Correlates with the Induction of STING-Independent CD8+ T Cell Responses.
Volume: 26
Issue: 5
Pages: 1242-1257.e7
Publication
First Author: Eigenbrod T
Year: 2012
Journal: J Immunol
Title: Bacterial RNA mediates activation of caspase-1 and IL-1β release independently of TLRs 3, 7, 9 and TRIF but is dependent on UNC93B.
Volume: 189
Issue: 1
Pages: 328-36
Publication
First Author: Lacroix-Lamandé S
Year: 2012
Journal: J Immunol
Title: Downregulation of the Na/K-ATPase pump by leptospiral glycolipoprotein activates the NLRP3 inflammasome.
Volume: 188
Issue: 6
Pages: 2805-14
Publication    
First Author: Kim EH
Year: 2020
Journal: Elife
Title: Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway.
Volume: 9
Publication
First Author: de Queiroz NMGP
Year: 2021
Journal: Sci Rep
Title: MyD88-dependent BCG immunotherapy reduces tumor and regulates tumor microenvironment in bladder cancer murine model.
Volume: 11
Issue: 1
Pages: 15648
Publication
First Author: Winkler ES
Year: 2020
Journal: Cell
Title: The Intestinal Microbiome Restricts Alphavirus Infection and Dissemination through a Bile Acid-Type I IFN Signaling Axis.
Volume: 182
Issue: 4
Pages: 901-918.e18
Publication
First Author: Rai P
Year: 2021
Journal: Nat Immunol
Title: IRGM1 links mitochondrial quality control to autoimmunity.
Volume: 22
Issue: 3
Pages: 312-321
Publication
First Author: Abe T
Year: 2009
Journal: J Virol
Title: Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner.
Volume: 83
Issue: 15
Pages: 7629-40
Publication
First Author: Marichal T
Year: 2011
Journal: Nat Med
Title: DNA released from dying host cells mediates aluminum adjuvant activity.
Volume: 17
Issue: 8
Pages: 996-1002
Publication
First Author: Lentini G
Year: 2020
Journal: J Immunol
Title: Neutrophils Enhance Their Own Influx to Sites of Bacterial Infection via Endosomal TLR-Dependent Cxcl2 Production.
Volume: 204
Issue: 3
Pages: 660-670
Publication
First Author: Dai P
Year: 2014
Journal: PLoS Pathog
Title: Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway.
Volume: 10
Issue: 4
Pages: e1003989
Publication
First Author: Pimentel-Coelho PM
Year: 2013
Journal: J Neurosci
Title: Evidence for a gender-specific protective role of innate immune receptors in a model of perinatal brain injury.
Volume: 33
Issue: 28
Pages: 11556-72
Publication
First Author: Won S
Year: 2012
Journal: J Virol
Title: Increased susceptibility to DNA virus infection in mice with a GCN2 mutation.
Volume: 86
Issue: 3
Pages: 1802-8
Publication
First Author: Kumar H
Year: 2009
Journal: Biochem J
Title: Pathogen recognition in the innate immune response.
Volume: 420
Issue: 1
Pages: 1-16
Publication  
First Author: Sweere JM
Year: 2019
Journal: Science
Title: Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection.
Volume: 363
Issue: 6434
Publication
First Author: Wang Y
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.
Volume: 113
Issue: 7
Pages: E884-93
Publication
First Author: Hoebe K
Year: 2003
Journal: J Endotoxin Res
Title: Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening.
Volume: 9
Issue: 4
Pages: 250-5
Publication
First Author: Kuo CC
Year: 2007
Journal: J Immunol
Title: Involvement of heat shock protein (Hsp)90 beta but not Hsp90 alpha in antiapoptotic effect of CpG-B oligodeoxynucleotide.
Volume: 178
Issue: 10
Pages: 6100-8
Publication
First Author: Kim YI
Year: 2008
Journal: J Biol Chem
Title: CpG DNA prevents liver injury and shock-mediated death by modulating expression of interleukin-1 receptor-associated kinases.
Volume: 283
Issue: 22
Pages: 15258-70
Strain
Attribute String: congenic, mutant strain, targeted mutation