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Search results 701 to 773 out of 773 for Traf3

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Type Details Score
Protein Domain
IPR040468 | TRAF3IP1_N
Type: Domain
Description: TRAF3-interacting protein 1 (TRAF3IP1) recruits TRAF3 (tumour necrosis factor receptor-associated factor 3) and DISC1 (Disrupted-In-Schizophrenia 1) to the microtubules and is conserved from worms to humans []. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3. The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved []. In humans, it plays an inhibitory role on IL13 signaling by binding to IL13RA1. It is involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding [, ].This entry represents the N-terminal domain of TRAF3-interacting protein 1.
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Publication
24721909 | J:209956
 
First Author: Liakath-Ali K
Year: 2014
Journal: Nat Commun
Title: Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.
Volume: 5
Pages: 3540
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Publication
18663224 | J:139293
First Author: Sasaki Y
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells.
Volume: 105
Issue: 31
Pages: 10883-8
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Publication
19917778 | J:155688
First Author: Tusche MW
Year: 2009
Journal: J Exp Med
Title: Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets.
Volume: 206
Issue: 12
Pages: 2671-83
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Publication
21896778 | J:178327
First Author: Ganeff C
Year: 2011
Journal: Mol Cell Biol
Title: Induction of the alternative NF-κB pathway by lymphotoxin αβ (LTαβ) relies on internalization of LTβ receptor.
Volume: 31
Issue: 21
Pages: 4319-34
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Publication
29150602 | J:256313
First Author: Saitoh SI
Year: 2017
Journal: Nat Commun
Title: TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells.
Volume: 8
Issue: 1
Pages: 1592
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Publication
28846086 | J:271836
First Author: Zheng Q
Year: 2017
Journal: Nat Immunol
Title: The RNA helicase DDX46 inhibits innate immunity by entrapping m6A-demethylated antiviral transcripts in the nucleus.
Volume: 18
Issue: 10
Pages: 1094-1103
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Publication
29734366 | J:324167
First Author: Zhang L
Year: 2018
Journal: PLoS Pathog
Title: Induction of OTUD1 by RNA viruses potently inhibits innate immune responses by promoting degradation of the MAVS/TRAF3/TRAF6 signalosome.
Volume: 14
Issue: 5
Pages: e1007067
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Publication
38127621 | J:351131
First Author: Cai X
Year: 2024
Journal: Cell Rep
Title: Factor inhibiting HIF negatively regulates antiviral innate immunity via hydroxylation of IKKϵ.
Volume: 43
Issue: 1
Pages: 113606
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Publication
17327220 | J:121134
First Author: Guo B
Year: 2007
Journal: J Biol Chem
Title: Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK.
Volume: 282
Issue: 16
Pages: 11817-26
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Publication
27195665 | -
First Author: Han D
Year: 2016
Journal: PLoS One
Title: Ubiquitylation of Rad51d Mediated by E3 Ligase Rnf138 Promotes the Homologous Recombination Repair Pathway.
Volume: 11
Issue: 5
Pages: e0155476
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Protein Domain
IPR034734 | ZF_C2HC_RNF
Type: Domain
Description: This entry includes the C2HC RNF-type zinc finger.Ubiquitination is a post-translational modification that mediates the covalent attachment of ubiquitin (Ub), a small, highly conserved, cytoplasmic protein of 76 amino acid residues, to target proteins. This conjugation is catalyzed by the sequential action of three enzymes: Ub-activating (E1) enzyme, Ub-conjugating (E2) enzyme and Ub ligase (E3). A large number of RING finger (RNF) proteins are present in eukaryotic cells and the majority of them are believed to act as E3 ubiquitin ligases. The closely related proteins RNF125/TRAC-1, RNF114 (also known as Zpf313), RNF138 (or NARF) and RNF166 contain, apart from the RING domain, a C2HC (Cys2-His-Cys)- and two C2H2 (Cys2-His2)-type zinc fingers, as well as an ubiquitin interacting motif (UIM) [, , , ].Some proteins known to contain a C2HC RNF-type zinc finger are listed below:Mammalian RNF125/T-cell RING protein in activation 1 (TRAC-1)/, a positive regulator of T-cell activation. It negatively regulates RIG-1 mediated antiviral activity via conjugating ubiquitin chains to RIG-1 and MDA5, leading to their degradation by the proteasome.Vertebrate RNF114, acts as negative regulator of NF-kappaB-dependent transcription. It interacts with A20 in T cells and modulates A20 ubiquitylation.Vertebrate RNF138, likely involved in regulating homologous recombination repair pathway.Vertebrate RNF166, potentiates the RNA virus-induced production of IFN-beta via enhancing the ubiquitination of TRAF3 and TRAF6.
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Publication
10187771 | J:54313
First Author: Thome M
Year: 1999
Journal: J Biol Chem
Title: Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase.
Volume: 274
Issue: 15
Pages: 9962-8
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Publication
8790348 | J:36889
First Author: Ishida TK
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling.
Volume: 93
Issue: 18
Pages: 9437-42
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Publication
9488716 | J:46205
First Author: Kawamata S
Year: 1998
Journal: J Biol Chem
Title: Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation.
Volume: 273
Issue: 10
Pages: 5808-14
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Publication
36633157 | J:355570
First Author: Khaw YM
Year: 2023
Journal: EMBO Rep
Title: Estrogen receptor alpha signaling in dendritic cells modulates autoimmune disease phenotype in mice.
Volume: 24
Issue: 3
Pages: e54228
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Publication
22860133 | J:189670
First Author: Arcipowski KM
Year: 2012
Journal: PLoS One
Title: Roles of the kinase TAK1 in TRAF6-dependent signaling by CD40 and its oncogenic viral mimic, LMP1.
Volume: 7
Issue: 7
Pages: e42478
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Publication
29717061 | J:282112
 
First Author: Hayashi K
Year: 2018
Journal: Sci Signal
Title: The interaction between IKKα and LC3 promotes type I interferon production through the TLR9-containing LAPosome.
Volume: 11
Issue: 528
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Publication
34255829 | J:335034
First Author: Li Y
Year: 2021
Journal: Blood
Title: DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis.
Volume: 138
Issue: 23
Pages: 2360-2371
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Publication
30018073 | J:266034
First Author: Huang T
Year: 2018
Journal: J Exp Med
Title: CRL4DCAF2 negatively regulates IL-23 production in dendritic cells and limits the development of psoriasis.
Volume: 215
Issue: 8
Pages: 1999-2017
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Publication
21151480 | J:167281
First Author: Yang C
Year: 2010
Journal: PLoS One
Title: NIK stabilization in osteoclasts results in osteoporosis and enhanced inflammatory osteolysis.
Volume: 5
Issue: 11
Pages: e15383
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Publication
21266470 | J:182877
First Author: Kim JY
Year: 2011
Journal: J Cell Sci
Title: TNFα induced noncanonical NF-κB activation is attenuated by RIP1 through stabilization of TRAF2.
Volume: 124
Issue: Pt 4
Pages: 647-56
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Publication
36631487 | J:352075
First Author: Li J
Year: 2023
Journal: Nat Commun
Title: TGFβ1(+)CCR5(+) neutrophil subset increases in bone marrow and causes age-related osteoporosis in male mice.
Volume: 14
Issue: 1
Pages: 159
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Publication
22570473 | J:188379
First Author: McPherson AJ
Year: 2012
Journal: J Biol Chem
Title: Opposing roles for TRAF1 in the alternative versus classical NF-κB pathway in T cells.
Volume: 287
Issue: 27
Pages: 23010-9
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Publication
21115691 | J:176865
First Author: González-Navajas JM
Year: 2010
Journal: J Exp Med
Title: Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.
Volume: 207
Issue: 13
Pages: 2799-807
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Publication
20360684 | J:159293
First Author: Chattopadhyay S
Year: 2010
Journal: EMBO J
Title: Viral apoptosis is induced by IRF-3-mediated activation of Bax.
Volume: 29
Issue: 10
Pages: 1762-73
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Publication
34292968 | J:308065
First Author: Davis JL
Year: 2021
Journal: PLoS One
Title: Constitutive activation of NF-κB inducing kinase (NIK) in the mesenchymal lineage using Osterix (Sp7)- or Fibroblast-specific protein 1 (S100a4)-Cre drives spontaneous soft tissue sarcoma.
Volume: 16
Issue: 7
Pages: e0254426
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Publication
18439848 | J:136289
First Author: Michallet MC
Year: 2008
Journal: Immunity
Title: TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
Volume: 28
Issue: 5
Pages: 651-61
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Publication
16148124 | J:116726
First Author: Moore CR
Year: 2005
Journal: J Immunol
Title: Differential regulation of CD40-mediated TNF receptor-associated factor degradation in B lymphocytes.
Volume: 175
Issue: 6
Pages: 3780-9
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Publication
16897814 | J:116746
First Author: Benson RJ
Year: 2006
Journal: Eur J Immunol
Title: Rapid CD40-mediated rescue from CD95-induced apoptosis requires TNFR-associated factor-6 and PI3K.
Volume: 36
Issue: 9
Pages: 2535-43
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Publication
16622006 | J:131656
First Author: Xie P
Year: 2006
Journal: J Immunol
Title: Cooperation between TNF receptor-associated factors 1 and 2 in CD40 signaling.
Volume: 176
Issue: 9
Pages: 5388-400
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Publication
18573890 | J:139741
First Author: Ikeda O
Year: 2008
Journal: Mol Cell Biol
Title: STAP-2 negatively regulates both canonical and noncanonical NF-kappaB activation induced by Epstein-Barr virus-derived latent membrane protein 1.
Volume: 28
Issue: 16
Pages: 5027-42
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Publication
22685329 | J:198887
First Author: Hupalowska A
Year: 2012
Journal: J Cell Sci
Title: APPL1 regulates basal NF-κB activity by stabilizing NIK.
Volume: 125
Issue: Pt 17
Pages: 4090-102
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Publication
22936176 | J:318949
First Author: Liu XQ
Year: 2012
Journal: Eur J Immunol
Title: Malaria infection alters the expression of B-cell activating factor resulting in diminished memory antibody responses and survival.
Volume: 42
Issue: 12
Pages: 3291-301
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Publication
17990982 | -
First Author: Giannini AL
Year: 2008
Journal: Biochem J
Title: T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain.
Volume: 410
Issue: 1
Pages: 101-11
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Publication
25165885 | -
 
First Author: Rodriguez MS
Year: 2014
Journal: Cell Death Dis
Title: The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-κB activity and T-cell activation.
Volume: 5
Pages: e1399
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Publication
11275257 | J:68102
First Author: Grech A
Year: 2000
Journal: Mol Immunol
Title: Complete structural characterisation of the mammalian and Drosophila TRAF genes: implications for TRAF evolution and the role of RING finger splice variants.
Volume: 37
Issue: 12-13
Pages: 721-34
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Publication
22536156 | J:195390
First Author: Vrazo AC
Year: 2012
Journal: PLoS Pathog
Title: Epstein-Barr virus LMP2A reduces hyperactivation induced by LMP1 to restore normal B cell phenotype in transgenic mice.
Volume: 8
Issue: 4
Pages: e1002662
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Publication
36177892 | J:340946
 
First Author: Chang W
Year: 2022
Journal: Mol Med Rep
Title: Downregulation of deubiquitinating enzyme USP25 promotes the development of allergic rhinitis by enhancing TSLP signaling in the nasal epithelium.
Volume: 26
Issue: 5
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Publication
37679334 | J:340285
First Author: Vashisht M
Year: 2023
Journal: Cell Death Dis
Title: TRAF2/3 deficient B cells resist DNA damage-induced apoptosis via NF-κB2/XIAP/cIAP2 axis and IAP antagonist sensitizes mutant lymphomas to chemotherapeutic drugs.
Volume: 14
Issue: 9
Pages: 599
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Protein
Q9CSA3
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: true
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Protein
Q3UC35
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: true
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Protein
A0A3Q4EHU1
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: true
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Protein
Q9CQE0
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
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Protein
Q9D9M9
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: false
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Protein
Q9D9R0
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
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Protein
Q3U9F6
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: false
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Protein
Q8C521
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: false
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Protein
A4PBT3
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
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Protein
A2RS02
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: false
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Publication
- | J:175295
     
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
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Protein
Q9ET26
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: false
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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