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Search results 701 to 773 out of 773 for Wfs1

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Type Details Score
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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DO Term
DOID:0110629 | Wolfram syndrome 1
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HT Experiment
E-GEOD-15293 | Gene expression profiling of temporal lobes of wfs1 deficient mice in two different genetic background
Series Id: GSE15293
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
25447309 | J:218780
First Author: Odisho T
Year: 2015
Journal: Exp Cell Res
Title: ATF6β regulates the Wfs1 gene and has a cell survival role in the ER stress response in pancreatic β-cells.
Volume: 330
Issue: 1
Pages: 111-22
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Publication
16989814 | -
First Author: Takei D
Year: 2006
Journal: FEBS Lett
Title: WFS1 protein modulates the free Ca(2+) concentration in the endoplasmic reticulum.
Volume: 580
Issue: 24
Pages: 5635-40
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Allele
Wfs1<em1Smoc> | MGI:7293257
Name: wolframin ER transmembrane glycoprotein; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
16648378 | -
First Author: Eiberg H
Year: 2006
Journal: J Med Genet
Title: Autosomal dominant optic atrophy associated with hearing impairment and impaired glucose regulation caused by a missense mutation in the WFS1 gene.
Volume: 43
Issue: 5
Pages: 435-40
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Strain
MGI:6476618 | C57BL/6JSmoc-Wfs1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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DO Term
DOID:0110241 | cataract 41
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Allele
Wfs1<tm1Yoka> | MGI:3044175
Name: wolframin ER transmembrane glycoprotein; targeted mutation 1, Yoshitomo Oka
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Wfs1<tm1Perm> | MGI:3613056
Name: wolframin ER transmembrane glycoprotein; targeted mutation 1, M A Permutt
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Wfs1<tm1.1Bedel> | MGI:7571399
Name: wolframin ER transmembrane glycoprotein; targeted mutation 1.1, Benjamin Delprat
Allele Type: Targeted
Attribute String: Humanized sequence
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DO Term
DOID:0110584 | autosomal dominant nonsyndromic deafness 6
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Allele
Tg(Wfs1-EGFP)IJ128Gsat | MGI:4847536
Name: transgene insertion IJ128, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Tg(Wfs1-cre)5Utr | MGI:5563913
Name: transgene insertion 5, Ken-ichi Yagami
Allele Type: Transgenic
Attribute String: Recombinase
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Genotype
Genotype
Symbol: Wfs1/Wfs1
Background: involves: 129/Sv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Wfs1/Wfs1
Background: B6.Cg-Wfs1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Wfs1/Wfs1 Tg(Ins2-cre)23Herr/?
Background: involves: 129X1/SvJ * C57BL/6J * CBA/J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Wfs1/Wfs1
Background: involves: C57BL/6N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Wfs1/Wfs1
Background: 129S6/SvEvTac-Wfs1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Wfs1/Wfs1
Background: B6J.129-Wfs1
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0080584 | autosomal dominant Wolfram syndrome
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HT Experiment
E-GEOD-65929 | Reduced insulin secretion in WFS1-deficient mice may be related to downregulation of Trpm5
Series Id: GSE65929
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Allele
Wfs1<tm1Koks> | MGI:3835761
Name: wolframin ER transmembrane glycoprotein; targeted mutation 1, Sulev Koks
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Strain
MGI:5004013 | STOCK Tg(Wfs1-EGFP)IJ128Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Publication
24457215 | J:207487
First Author: Kitamura T
Year: 2014
Journal: Science
Title: Island cells control temporal association memory.
Volume: 343
Issue: 6173
Pages: 896-901
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Publication
34400533 | J:347586
First Author: Yokose J
Year: 2021
Journal: Learn Mem
Title: Entorhinal cortical Island cells regulate temporal association learning with long trace period.
Volume: 28
Issue: 9
Pages: 319-328
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Publication
26170279 | J:225981
First Author: Sun C
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Distinct speed dependence of entorhinal island and ocean cells, including respective grid cells.
Volume: 112
Issue: 30
Pages: 9466-71
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Protein Domain
IPR026208 | Wolframin
Type: Family
Description: Wolframin, a multi-pass membrane protein found in the endoplasmic reticulum, is expressed by the Wolfram syndrome 1 gene (WFS1) []. The detailed molecular function of the protein is not known, but it is believed to participate, at least in part, in the regulation of cellular calcium homeostasis by modulating the filling state of the endoplasmic reticulum calcium store.Defects in WFS1 cause Wolfram Syndrome (WFS), also referred to as DIDMOAD []- this syndrome is characterised by diabetes insipidus, childhood-onset diabetes mellitus, gradual loss of vision owing to optic atrophy, and deafness []. It is a rare autosomal recessive disorder, and may give rise to other complications affecting the bladder and nervous system.
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Publication
26402611 | J:262251
First Author: Kitamura T
Year: 2015
Journal: Neuron
Title: Entorhinal Cortical Ocean Cells Encode Specific Contexts and Drive Context-Specific Fear Memory.
Volume: 87
Issue: 6
Pages: 1317-1331
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Protein Domain
IPR026209 | Wolframin_fam
Type: Family
Description: Wolframin, a multi-pass membrane protein found in the endoplasmic reticulum, is expressed by the Wolfram syndrome 1 gene (WFS1) []. The detailed molecular function of the protein is not known, but it is believed to participate, at least in part, in the regulation of cellular calcium homeostasis by modulating the filling state of the endoplasmic reticulum calcium store.Defects in WFS1 cause Wolfram Syndrome (WFS), also referred to as DIDMOAD []- this syndrome is characterised by diabetes insipidus, childhood-onset diabetes mellitus, gradual loss of vision owing to optic atrophy, and deafness []. It is a rare autosomal recessive disorder, and may give rise to other complications affecting the bladder and nervous system.Wolframin homologues have been identified in a range of species, from mammals and amphibia to insects. Notwithstanding regions of high similarity, vertebrate and invertebrate wolframins exhibit characteristic lineage- specific differences. This entry represents the Wolframin family, and includes homologues from invertebrates.
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HT Experiment
E-GEOD-30628 | Gene expression analysis of ER-stressed growth plate chondrocytes in two mouse models of Schmid chondrodysplasia
Series Id: GSE30628
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
24227685 | J:208989
First Author: Shang L
Year: 2014
Journal: Diabetes
Title: β-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome.
Volume: 63
Issue: 3
Pages: 923-33
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Publication
26371510 | J:226995
   
First Author: Shrestha P
Year: 2015
Journal: Elife
Title: Layer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors.
Volume: 4
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Publication
32327644 | J:292192
First Author: Puighermanal E
Year: 2020
Journal: Nat Commun
Title: Functional and molecular heterogeneity of D2R neurons along dorsal ventral axis in the striatum.
Volume: 11
Issue: 1
Pages: 1957
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Publication
32516721 | J:301632
First Author: Han KA
Year: 2020
Journal: iScience
Title: PTPσ Controls Presynaptic Organization of Neurotransmitter Release Machinery at Excitatory Synapses.
Volume: 23
Issue: 6
Pages: 101203
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Publication
38056456 | J:344402
First Author: Yokose J
Year: 2024
Journal: Neuron
Title: Visuotactile integration facilitates mirror-induced self-directed behavior through activation of hippocampal neuronal ensembles in mice.
Volume: 112
Issue: 2
Pages: 306-318.e8
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Publication
28823555 | J:252495
First Author: Roy DS
Year: 2017
Journal: Cell
Title: Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories.
Volume: 170
Issue: 5
Pages: 1000-1012.e19
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Protein
F7D926
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: true
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Publication
32117448 | -
 
First Author: Schäffer DE
Year: 2020
Journal: Front Genet
Title: Functional Innovation in the Evolution of the Calcium-Dependent System of the Eukaryotic Endoplasmic Reticulum.
Volume: 11
Pages: 34
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Publication
19292454 | -
First Author: Yurimoto S
Year: 2009
Journal: Biochemistry
Title: Identification and characterization of wolframin, the product of the wolfram syndrome gene (WFS1), as a novel calmodulin-binding protein.
Volume: 48
Issue: 18
Pages: 3946-55
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Protein Domain
IPR045400 | Wolframin_Cys-rich
Type: Domain
Description: Located N-terminal to the wolframin OB-fold domain, this region could represent an extension to the core of the OB fold domain. The observed conserved cysteine residues could contribute to disulfide-bond-mediated cross-linking in calcium-stores regulation [].Wolframin, a multi-pass membrane protein found in the endoplasmic reticulum, is expressed by the Wolfram syndrome 1 gene (WFS1) []. The detailed molecular function of the protein is not known, but it is believed to participate, at least in part, in the regulation of cellular calcium homeostasis by modulating the filling state of the endoplasmic reticulum calcium store.Defects in WFS1 cause Wolfram Syndrome (WFS), also referred to as DIDMOAD []- this syndrome is characterised by diabetes insipidus, childhood-onset diabetes mellitus, gradual loss of vision owing to optic atrophy, and deafness []. It is a rare autosomal recessive disorder, and may give rise to other complications affecting the bladder and nervous system.Wolframin homologues have been identified in a range of species, from mammals and amphibia to insects. Notwithstanding regions of high similarity, vertebrate and invertebrate wolframins exhibit characteristic lineage- specific differences. This entry represents the Wolframin family, and includes homologues from invertebrates.
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Protein Domain
IPR045460 | Wolframin_EF-hand
Type: Domain
Description: This domain contains two characteristic copies of the bihelical repeat forming the basic EF-hand unit. The absence of the characteristic calcium-binding motif DxDxDG suggests that it could self-dimerize or dimerize with other EF-hand-containing proteins [].Wolframin, a multi-pass membrane protein found in the endoplasmic reticulum, is expressed by the Wolfram syndrome 1 gene (WFS1) []. The detailed molecular function of the protein is not known, but it is believed to participate, at least in part, in the regulation of cellular calcium homeostasis by modulating the filling state of the endoplasmic reticulum calcium store.Defects in WFS1 cause Wolfram Syndrome (WFS), also referred to as DIDMOAD []- this syndrome is characterised by diabetes insipidus, childhood-onset diabetes mellitus, gradual loss of vision owing to optic atrophy, and deafness []. It is a rare autosomal recessive disorder, and may give rise to other complications affecting the bladder and nervous system.Wolframin homologues have been identified in a range of species, from mammals and amphibia to insects. Notwithstanding regions of high similarity, vertebrate and invertebrate wolframins exhibit characteristic lineage- specific differences. This entry represents the Wolframin family, and includes homologues from invertebrates.
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Protein Domain
IPR045461 | Wolframin_OB_fold
Type: Domain
Description: This is the OB-fold domain found at the C terminus of the wolframin protein. It localizes to the ER lumen and lacks the conserved polar residues typical of OB-fold domain-mediated nucleic acid-binding. It has been predicted to mediate protein-protein interactions [].Wolframin, a multi-pass membrane protein found in the endoplasmic reticulum, is expressed by the Wolfram syndrome 1 gene (WFS1) []. The detailed molecular function of the protein is not known, but it is believed to participate, at least in part, in the regulation of cellular calcium homeostasis by modulating the filling state of the endoplasmic reticulum calcium store.Defects in WFS1 cause Wolfram Syndrome (WFS), also referred to as DIDMOAD []- this syndrome is characterised by diabetes insipidus, childhood-onset diabetes mellitus, gradual loss of vision owing to optic atrophy, and deafness []. It is a rare autosomal recessive disorder, and may give rise to other complications affecting the bladder and nervous system.Wolframin homologues have been identified in a range of species, from mammals and amphibia to insects. Notwithstanding regions of high similarity, vertebrate and invertebrate wolframins exhibit characteristic lineage- specific differences. This entry represents the Wolframin family, and includes homologues from invertebrates.
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Protein Domain
IPR045458 | Wolframin_Sel1-like_rpt
Type: Repeat
Description: This entry represents the N-terminal Sel1-like repeats found in the wolframin protein. This region has been linked to calmodulin-binding, suggesting these repeats may mediate a protein interaction [, ].Wolframin, a multi-pass membrane protein found in the endoplasmic reticulum, is expressed by the Wolfram syndrome 1 gene (WFS1) []. The detailed molecular function of the protein is not known, but it is believed to participate, at least in part, in the regulation of cellular calcium homeostasis by modulating the filling state of the endoplasmic reticulum calcium store.Defects in WFS1 cause Wolfram Syndrome (WFS), also referred to as DIDMOAD []- this syndrome is characterised by diabetes insipidus, childhood-onset diabetes mellitus, gradual loss of vision owing to optic atrophy, and deafness []. It is a rare autosomal recessive disorder, and may give rise to other complications affecting the bladder and nervous system.Wolframin homologues have been identified in a range of species, from mammals and amphibia to insects. Notwithstanding regions of high similarity, vertebrate and invertebrate wolframins exhibit characteristic lineage- specific differences. This entry represents the Wolframin family, and includes homologues from invertebrates.
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Protein
P56695
Organism: Mus musculus/domesticus
Length: 890  
Fragment?: false
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Protein
Q3UN10
Organism: Mus musculus/domesticus
Length: 814  
Fragment?: false
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Protein
Q3TDI2
Organism: Mus musculus/domesticus
Length: 890  
Fragment?: false
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Protein
Q3UMA8
Organism: Mus musculus/domesticus
Length: 890  
Fragment?: false
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Protein
Q80UI9
Organism: Mus musculus/domesticus
Length: 890  
Fragment?: false
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Publication
24198826 | J:311763
 
First Author: Han H
Year: 2013
Journal: Front Genet
Title: Altered methylation and expression of ER-associated degradation factors in long-term alcohol and constitutive ER stress-induced murine hepatic tumors.
Volume: 4
Pages: 224
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Publication
33610659 | J:341846
 
First Author: Gaines CH
Year: 2021
Journal: Behav Brain Res
Title: Behavioral characterization of a novel Cisd2 mutant mouse.
Volume: 405
Pages: 113187
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Publication
38321214 | J:345909
First Author: Hu R
Year: 2024
Journal: Cell Death Differ
Title: ISR inhibition reverses pancreatic β-cell failure in Wolfram syndrome models.
Volume: 31
Issue: 3
Pages: 322-334
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Publication
31548233 | J:291053
First Author: Sammons RP
Year: 2019
Journal: J Neurosci
Title: Electrophysiological and Molecular Characterization of the Parasubiculum.
Volume: 39
Issue: 45
Pages: 8860-8876
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Publication
27708103 | J:255267
First Author: Okuyama T
Year: 2016
Journal: Science
Title: Ventral CA1 neurons store social memory.
Volume: 353
Issue: 6307
Pages: 1536-1541
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Publication
21935428 | J:177882
First Author: Cameron TL
Year: 2011
Journal: PLoS One
Title: Transcriptional profiling of chondrodysplasia growth plate cartilage reveals adaptive ER-stress networks that allow survival but disrupt hypertrophy.
Volume: 6
Issue: 9
Pages: e24600
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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