| Type |
Details |
Score |
| Publication |
| First Author: |
Bailey PJ |
| Year: |
2006 |
| Journal: |
Exp Cell Res |
| Title: |
A global genomic transcriptional code associated with CNS-expressed genes. |
| Volume: |
312 |
| Issue: |
16 |
| Pages: |
3108-19 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Freeman TC |
| Year: |
1998 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Expression Mapping of Mouse Genes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yokoyama S |
| Year: |
2009 |
| Journal: |
Dev Cell |
| Title: |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
| Volume: |
17 |
| Issue: |
6 |
| Pages: |
836-48 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gray PA |
| Year: |
2004 |
| Journal: |
Science |
| Title: |
Mouse brain organization revealed through direct genome-scale TF expression analysis. |
| Volume: |
306 |
| Issue: |
5705 |
| Pages: |
2255-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Thompson CL |
| Year: |
2014 |
| Journal: |
Neuron |
| Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
| Volume: |
83 |
| Issue: |
2 |
| Pages: |
309-323 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bedogni F |
| Year: |
2021 |
| Journal: |
Front Mol Neurosci |
| Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
| Volume: |
14 |
|
| Pages: |
686034 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2009 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GUDMAP Consortium |
| Year: |
2004 |
| Journal: |
www.gudmap.org |
| Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Magdaleno S |
| Year: |
2006 |
| Journal: |
PLoS Biol |
| Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
| Volume: |
4 |
| Issue: |
4 |
| Pages: |
e86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Skarnes WC |
| Year: |
2011 |
| Journal: |
Nature |
| Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
| Volume: |
474 |
| Issue: |
7351 |
| Pages: |
337-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
| Year: |
2004 |
| Journal: |
Database Release |
| Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5289047 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2017-02-07 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603910 |
|
| Stage: |
TS10 |
| Assay Id: |
MGI:5823398 |
| Age: |
embryonic day 7.0 |
|
|
| Specimen Label: |
Zic2 +/+ |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5289047 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2017-02-07 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603910 |
|
| Stage: |
TS10 |
| Assay Id: |
MGI:5823398 |
| Age: |
embryonic day 7.0 |
|
|
| Specimen Label: |
Zic2 Ku/Ku |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5288877 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2017-02-07 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603910 |
|
| Stage: |
TS10 |
| Assay Id: |
MGI:5823399 |
| Age: |
embryonic day 7.0 |
|
|
| Specimen Label: |
Zic2 +/+ |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5288877 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2017-02-07 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603910 |
|
| Stage: |
TS10 |
| Assay Id: |
MGI:5823399 |
| Age: |
embryonic day 7.0 |
|
|
| Specimen Label: |
Zic2 Ku/Ku |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Zic2/Zic2 |
| Background: |
involves: 129S4/SvJae * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Allele |
| Name: |
zinc finger protein of the cerebellum 2; targeted mutation 1, Jun Aruga |
| Allele Type: |
Targeted |
| Attribute String: |
Hypomorph |
|
•
•
•
•
•
|
| Allele |
| Name: |
zinc finger protein of the cerebellum 2; kumba |
| Allele Type: |
Chemically induced (ENU) |
|
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis. |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Zic2/Zic2 |
| Background: |
C3.CAnNCrl-Zic2 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Zic2/Zic2 |
| Background: |
129S.CAnNCrl(C3)-Zic2 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Allele |
| Name: |
zinc finger protein of the cerebellum 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:23226 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2017-02-07 |
| Strength: |
Ambiguous |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1614015 |
| Pattern: |
Not Specified |
| Stage: |
TS15 |
| Assay Id: |
MGI:5823402 |
| Age: |
embryonic day 9.5 |
|
| Note: |
Decreasing Nodal function on the Zic2 Ku background leads to moderate or severe truncation. |
| Specimen Label: |
1I |
|
| Specimen Num: |
9 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:23226 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2017-02-07 |
| Strength: |
Ambiguous |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1664015 |
| Pattern: |
Not Specified |
| Stage: |
TS15 |
| Assay Id: |
MGI:5823402 |
| Age: |
embryonic day 9.5 |
|
| Note: |
Decreasing Nodal function on the Zic2 Ku background leads to moderate or severe truncation. |
| Specimen Label: |
1I |
|
| Specimen Num: |
9 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7709414 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-08-15 |
| Strength: |
Strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1716824 |
| Pattern: |
Regionally restricted |
| Stage: |
TS24 |
| Assay Id: |
MGI:7709441 |
| Age: |
embryonic day 16.5 |
|
| Note: |
Highly expressed in ventral areas, excluded from the most peripheral region. Unc5c and Zic2 were expressed in mutually exclusive patterns. |
| Specimen Label: |
5A/A' |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:23226 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2017-02-07 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1614015 |
| Pattern: |
Not Specified |
| Stage: |
TS15 |
| Assay Id: |
MGI:5823402 |
| Age: |
embryonic day 9.5 |
|
| Note: |
Embryos heterozygous for the severe loss of function kumba (Ku) allele of Zic2 have no discernible phenotype. |
| Specimen Label: |
1D |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:23226 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2017-02-07 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1664015 |
| Pattern: |
Not Specified |
| Stage: |
TS15 |
| Assay Id: |
MGI:5823402 |
| Age: |
embryonic day 9.5 |
|
| Note: |
Embryos heterozygous for the severe loss of function kumba (Ku) allele of Zic2 have no discernible phenotype. |
| Specimen Label: |
1D |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| Allele |
| Name: |
zinc finger protein of the cerebellum 2; endonuclease-mediated mutation 1, Kenneth R Chien |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
zinc finger protein of the cerebellum 2; endonuclease-mediated mutation 2, Kenneth R Chien |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:23226 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2017-02-07 |
| Strength: |
Ambiguous |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1664015 |
| Pattern: |
Not Specified |
| Stage: |
TS15 |
| Assay Id: |
MGI:5823402 |
| Age: |
embryonic day 9.5 |
|
| Note: |
Embryos homozygous for the severe loss of function kumba (Ku) allele of Zic2 exhibit forebrain dysmorphology that can include a mild loss of telencephalic tissue. |
| Specimen Label: |
1E |
|
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vural B |
| Year: |
2005 |
| Journal: |
Cancer |
| Title: |
Frequency of SOX Group B (SOX1, 2, 3) and ZIC2 antibodies in Turkish patients with small cell lung carcinoma and their correlation with clinical parameters. |
| Volume: |
103 |
| Issue: |
12 |
| Pages: |
2575-83 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:2149733 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-08-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3573923 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:7708043 |
| Age: |
embryonic day 15.5 |
| Image: |
1a |
| Note: |
Expression was detected in postmitotic retinal ganglion cells (RGC's) in the ventrotemporal retina. Co-label with Zic2 was seen in ipsilateral RGC's. Few of the RGC's were co-labeled with EdU when injected at E11. |
| Specimen Label: |
1a |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:2149733 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-08-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3573923 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:7708043 |
| Age: |
embryonic day 15.5 |
| Image: |
1e |
| Note: |
Expression was detected in postmitotic retinal ganglion cells in the ventrotemporal retina. Co-label with Zic2 was seen in ipsilateral RGC's. Few of the RGC's were co-labeled with EdU when injected at E12. |
| Specimen Label: |
1e |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:2149733 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-08-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3573923 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:7708043 |
| Age: |
embryonic day 15.5 |
| Image: |
1i |
| Note: |
Expression was detected in postmitotic retinal ganglion cells in the ventrotemporal retina. Co-label with Zic2 was seen in ipsilateral RGC's. The number of RGC's co-labeled with EdU was higher when injected at E13 than when injected at previous ages. |
| Specimen Label: |
1i |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:2149733 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-08-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3573923 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:7708043 |
| Age: |
embryonic day 15.5 |
| Image: |
1m |
| Note: |
Expression was detected in postmitotic retinal ganglion cells in the ventrotemporal retina. Co-label with Zic2 was seen in ipsilateral RGC's. The number of RGC's co-labeled with EdU was highest when injected at E14 than when injected at previous ages. |
| Specimen Label: |
1m |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| Allele |
| Name: |
zinc finger protein of the cerebellum 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion HT146, GENSAT Project at Rockefeller University |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1453, Rudiger Klein |
| Allele Type: |
Transgenic |
| Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE60731 |
| Experiment Type: |
RNA-Seq |
| Study Type: |
Baseline |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, transgenic |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1463, Rudiger Klein |
| Allele Type: |
Transgenic |
| Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Zic2/Zic2<+> |
| Background: |
B6.129S4-Zic2 |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Zic2/Zic2<+> |
| Background: |
involves: 129S4/SvJae * C57BL/6J |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Zic2/Zic2<+> |
| Background: |
involves: 129S4/SvJae * C57BL/6 |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Zic2/Zic2 |
| Background: |
involves: 129S4/SvJae * BALB/c * C57BL/6J |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Zic2/Zic2 |
| Background: |
B6.129S4-Zic2 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Zic2/Zic2 |
| Background: |
involves: 129S4/SvJae |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Zic2/Zic2<+> |
| Background: |
involves: 129S4/SvJae |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Zic2/Zic2<+> |
| Background: |
involves: 129S4/SvJae * BALB/c * C57BL/6J |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Paixão S |
| Year: |
2019 |
| Journal: |
Neuron |
| Title: |
Identification of Spinal Neurons Contributing to the Dorsal Column Projection Mediating Fine Touch and Corrective Motor Movements. |
| Volume: |
104 |
| Issue: |
4 |
| Pages: |
749-764.e6 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Zic1/Zic1<+> Zic2/Zic2<+> |
| Background: |
involves: 129S4/SvJae * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Zic2/Zic2<+> Zic3/? |
| Background: |
involves: 129S4/SvJae * BNT/LeJ * Balb/c * C57BL/6J |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Zic1/Zic1<+> Zic2/Zic2<+> |
| Background: |
involves: 129S4/SvJae |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Zic2/Zic2 Zic3/? |
| Background: |
involves: 129S4/SvJae * BNT/LeJ * Balb/c * C57BL/6J |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Martindill DM |
| Year: |
2007 |
| Journal: |
Nat Cell Biol |
| Title: |
Nucleolar release of Hand1 acts as a molecular switch to determine cell fate. |
| Volume: |
9 |
| Issue: |
10 |
| Pages: |
1131-41 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
247
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kusano S |
| Year: |
2002 |
| Journal: |
Mol Cell Biol |
| Title: |
I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways. |
| Volume: |
22 |
| Issue: |
18 |
| Pages: |
6393-405 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
251
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
207
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
189
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
68
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
329
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
200
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
143
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
153
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
186
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
112
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
124
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Thébault S |
| Year: |
2000 |
| Journal: |
J Biol Chem |
| Title: |
Molecular cloning of a novel human I-mfa domain-containing protein that differently regulates human T-cell leukemia virus type I and HIV-1 expression. |
| Volume: |
275 |
| Issue: |
7 |
| Pages: |
4848-57 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gautier VW |
| Year: |
2005 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Direct interaction of the human I-mfa domain-containing protein, HIC, with HIV-1 Tat results in cytoplasmic sequestration and control of Tat activity. |
| Volume: |
102 |
| Issue: |
45 |
| Pages: |
16362-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Young TM |
| Year: |
2003 |
| Journal: |
Mol Cell Biol |
| Title: |
The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription. |
| Volume: |
23 |
| Issue: |
18 |
| Pages: |
6373-84 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This family consists of MyoD family inhibitor (I-mfa, MDFI) and MyoD family inhibitor domain-containing protein. I-mfa acts as a transcriptional activator or repressor. It retains nuclear Zic family proteins (ZIC1, ZIC2 and ZIC3) in the cytoplasm and consequently inhibits their transcriptional activation ability []. I-mfa domain-containing protein interacts with HAND1 (bHLH transcription factor), leading to sequester HAND1 into the nucleolus and prevent its activity []. In humans modulates the expression from both cellular and viral promoters. It down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. It also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR [, , ]. Both I-mfa and I-mfa domain-containing protein interact with the axin complex and affect axin regulation of both the Wnt and the JNK activation pathways []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brown SA |
| Year: |
1998 |
| Journal: |
Nat Genet |
| Title: |
Holoprosencephaly due to mutations in ZIC2, a homologue of Drosophila odd-paired. |
| Volume: |
20 |
| Issue: |
2 |
| Pages: |
180-3 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Zic2-cre/ERT2)1453Kln/? |
| Background: |
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aruga J |
| Year: |
1996 |
| Journal: |
Gene |
| Title: |
Identification and characterization of Zic4, a new member of the mouse Zic gene family. |
| Volume: |
172 |
| Issue: |
2 |
| Pages: |
291-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sanchez-Ferras O |
| Year: |
2014 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Induction and dorsal restriction of Paired-box 3 (Pax3) gene expression in the caudal neuroectoderm is mediated by integration of multiple pathways on a short neural crest enhancer. |
| Volume: |
1839 |
| Issue: |
7 |
| Pages: |
546-58 |
|
•
•
•
•
•
|