Type |
Details |
Score |
Publication |
First Author: |
Gurdziel K |
Year: |
2016 |
Journal: |
Dev Dyn |
Title: |
Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. |
Volume: |
245 |
Issue: |
5 |
Pages: |
614-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lewandowski JP |
Year: |
2015 |
Journal: |
Dev Biol |
Title: |
Spatiotemporal regulation of GLI target genes in the mammalian limb bud. |
Volume: |
406 |
Issue: |
1 |
Pages: |
92-103 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shimogori T |
Year: |
2010 |
Journal: |
Nat Neurosci |
Title: |
A genomic atlas of mouse hypothalamic development. |
Volume: |
13 |
Issue: |
6 |
Pages: |
767-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Tang F |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Deterministic and stochastic allele specific gene expression in single mouse blastomeres. |
Volume: |
6 |
Issue: |
6 |
Pages: |
e21208 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blackshaw S |
Year: |
2004 |
Journal: |
PLoS Biol |
Title: |
Genomic analysis of mouse retinal development. |
Volume: |
2 |
Issue: |
9 |
Pages: |
E247 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yokoyama S |
Year: |
2009 |
Journal: |
Dev Cell |
Title: |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
Volume: |
17 |
Issue: |
6 |
Pages: |
836-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gray PA |
Year: |
2004 |
Journal: |
Science |
Title: |
Mouse brain organization revealed through direct genome-scale TF expression analysis. |
Volume: |
306 |
Issue: |
5705 |
Pages: |
2255-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thompson CL |
Year: |
2014 |
Journal: |
Neuron |
Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
Volume: |
83 |
Issue: |
2 |
Pages: |
309-323 |
|
•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6430367 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-05-28 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1677919 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6430380 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Zic3 null |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6430367 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-05-28 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1677919 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6430380 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Zic3 null;Gli3+/- |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6430367 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-05-28 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1677919 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6430380 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Zic3 null;Gli3-/- |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2684476 |
Assay Type: |
Western blot |
Annotation Date: |
2020-05-28 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640619 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6430387 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Zic3 null;Gli3+/- |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2684476 |
Assay Type: |
Western blot |
Annotation Date: |
2020-05-28 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640619 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6430387 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Zic3 null;Gli3+/- |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277835 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603912 |
|
Stage: |
TS12 |
Assay Id: |
MGI:7277845 |
Age: |
embryonic day 8.0 |
|
|
Specimen Label: |
Zic3 null |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277836 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603912 |
|
Stage: |
TS12 |
Assay Id: |
MGI:7277846 |
Age: |
embryonic day 8.0 |
|
|
Specimen Label: |
Zic3 null |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277837 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603912 |
|
Stage: |
TS12 |
Assay Id: |
MGI:7277847 |
Age: |
embryonic day 8.0 |
|
|
Specimen Label: |
Zic3 null |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277838 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603912 |
|
Stage: |
TS12 |
Assay Id: |
MGI:7277848 |
Age: |
embryonic day 8.0 |
|
|
Specimen Label: |
Zic3 null |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277839 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603912 |
|
Stage: |
TS12 |
Assay Id: |
MGI:7277849 |
Age: |
embryonic day 8.0 |
|
|
Specimen Label: |
Zic3 null |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277840 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603912 |
|
Stage: |
TS12 |
Assay Id: |
MGI:7277850 |
Age: |
embryonic day 8.0 |
|
|
Specimen Label: |
Zic3 null |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277841 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603912 |
|
Stage: |
TS12 |
Assay Id: |
MGI:7277851 |
Age: |
embryonic day 8.0 |
|
|
Specimen Label: |
Zic3 null |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277842 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603912 |
|
Stage: |
TS12 |
Assay Id: |
MGI:7277852 |
Age: |
embryonic day 8.0 |
|
|
Specimen Label: |
Zic3 null |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277832 |
Assay Type: |
Western blot |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:7277853 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Zic3 null |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277832 |
Assay Type: |
Western blot |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:7277853 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Zic3 null |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277832 |
Assay Type: |
Western blot |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:7277853 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Zic3 null |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277832 |
Assay Type: |
Western blot |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:7277853 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Zic3 null |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277833 |
Assay Type: |
Western blot |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:7277854 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Zic3 null |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277833 |
Assay Type: |
Western blot |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:7277854 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Zic3 null |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277833 |
Assay Type: |
Western blot |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:7277854 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Zic3 null |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277833 |
Assay Type: |
Western blot |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:7277854 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Zic3 null |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277834 |
Assay Type: |
Western blot |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:7277855 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Zic3 null |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277834 |
Assay Type: |
Western blot |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:7277855 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Zic3 null |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277834 |
Assay Type: |
Western blot |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:7277855 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Zic3 null |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277834 |
Assay Type: |
Western blot |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:7277855 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Zic3 null |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277831 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1607512 |
Pattern: |
Regionally restricted |
Stage: |
TS12 |
Assay Id: |
MGI:7277843 |
Age: |
embryonic day 8.0 |
|
Note: |
Node cells less elongated than in wild type. |
Specimen Label: |
S1 Zic3 null |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7277831 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1607512 |
Pattern: |
Regionally restricted |
Stage: |
TS12 |
Assay Id: |
MGI:7277844 |
Age: |
embryonic day 8.0 |
|
Note: |
Node cells less elongated than in wild type. |
Specimen Label: |
S1 Zic3 null |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Preaxial polydactyly caused by Gli3 haploinsufficiency is rescued by Zic3 loss of function in mice. |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Bedard JE |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Identification of a novel ZIC3 isoform and mutation screening in patients with heterotaxy and congenital heart disease. |
Volume: |
6 |
Issue: |
8 |
Pages: |
e23755 |
|
•
•
•
•
•
|
Allele |
Name: |
zinc finger protein of the cerebellum 3; bent tail |
Allele Type: |
Spontaneous |
|
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock |
|
•
•
•
•
•
|
Strain |
Attribute String: |
F1 hybrid, mutant stock |
|
•
•
•
•
•
|
Strain |
Attribute String: |
inbred strain, spontaneous mutation |
|
•
•
•
•
•
|
Allele |
Name: |
zinc finger protein of the cerebellum 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Zic3/Zic3<+> |
Background: |
BNT/LeJ |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Zic3/Zic3 |
Background: |
BNT/LeJ |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Zic3/? |
Background: |
involves: BNT/LeJ * C57BL/6J |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Zic3/? |
Background: |
involves: BNT/LeJ * Balb/c * C57BL/6J |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Zic3/Zic3 |
Background: |
involves: BNT/LeJ * Balb/c * C57BL/6J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion KM21, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
F1 hybrid, mutant stock |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Zic2/Zic2<+> Zic3/? |
Background: |
involves: 129S4/SvJae * BNT/LeJ * Balb/c * C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Zic2/Zic2 Zic3/? |
Background: |
involves: 129S4/SvJae * BNT/LeJ * Balb/c * C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
181
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
158
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This is the ZF1 (Zinc Finger 1) domain found in Zic family proteins found in Eukaryotes. In humans, there are five members of the Zic family that are involved in human congenital anomalies. One of them, ZIC3, causes X-linked heterotaxy (HTX1), which is a left-right axis disturbance that manifests as variable combinations of heart malformation, altered lung lobation, splenic abnormality and gastrointestinal malrotation. Zic faily proteins contain multiple zinc finger domains (ZFD), which are generally composed of five tandemly repeated C2H2 zinc finger (ZF) motifs. Sequence comparison analysis reveal that this N-terminal ZF (ZF1) domain of the Zic zinc finger domains is unique in that it possesses more amino acid residues (6-38 amino acids) between the two cysteine residues of the C2H2 motif compared to Gli and Glis ZF1s or any of the other ZFs (ZF2-5) in the Gli/Glis/Zic superfamily of proteins. Mutations in cysteine 253 (C253S) or histidine 286 (H286R) in ZIC3 ZF1, which are found in heterotaxy patients, result in extranuclear localization of the mutant ZIC3 protein. Furthermore, mutations in the evolutionarily conserved amino acid residues (C253, W255, C268, H281 and H286) of ZF1 generally impair nuclear localization []. |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
Baseline |
Source: |
GEO |
|
•
•
•
•
•
|
Allele |
Name: |
ATPase, copper transporting, alpha polypeptide; tortoiseshell |
Allele Type: |
Spontaneous |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ishiguro A |
Year: |
2004 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family. |
Volume: |
324 |
Issue: |
1 |
Pages: |
302-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vetter K |
Year: |
2001 |
Journal: |
Mech Dev |
Title: |
Expression of a novel mouse gene 'mbFZb' in distinct regions of the developing nervous system and the adult brain. |
Volume: |
100 |
Issue: |
1 |
Pages: |
123-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yanagida K |
Year: |
2020 |
Journal: |
Dev Cell |
Title: |
Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization. |
Volume: |
52 |
Issue: |
6 |
Pages: |
779-793.e7 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
inbred strain, spontaneous mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, spontaneous mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain |
|
•
•
•
•
•
|
Publication |
First Author: |
Dickie MM |
Year: |
1954 |
Journal: |
J Hered |
Title: |
The Tortoise Shell House Mouse. |
Volume: |
45 |
Issue: |
4 |
Pages: |
158-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gacheru S |
Year: |
1993 |
Journal: |
Arch Biochem Biophys |
Title: |
Expression and accumulation of lysyl oxidase, elastin, and type I procollagen in human Menkes and mottled mouse fibroblasts. |
Volume: |
301 |
Issue: |
2 |
Pages: |
325-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sheedlo HJ |
Year: |
1982 |
Journal: |
J Anat |
Title: |
SEM analysis of body hairs and whiskers of heterozygous tortoiseshell (Moto/+) female mice (Mus musculus). |
Volume: |
135 |
Issue: |
Pt 1 |
Pages: |
211-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sheedlo HJ |
Year: |
1981 |
Journal: |
Genet Res |
Title: |
Copper localization in the duodenal mucosa of heterozygous tortoiseshell (Moto/+) female mice (Mus musculus). |
Volume: |
38 |
Issue: |
3 |
Pages: |
333-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Erdman MD |
Year: |
1987 |
Journal: |
Growth |
Title: |
Effects of the sex-linked prenatal lethal gene tortoise (Moto) on reproduction and growth in the mouse. |
Volume: |
51 |
Issue: |
2 |
Pages: |
189-97 |
|
•
•
•
•
•
|