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Search results 7401 to 7500 out of 8285 for C2

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Type Details Score
Protein
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: false
Publication
First Author: Kukimoto-Niino M
Year: 2019
Journal: Structure
Title: Structural Basis for the Dual Substrate Specificity of DOCK7 Guanine Nucleotide Exchange Factor.
Volume: 27
Issue: 5
Pages: 741-748.e3
Publication
First Author: Takahashi T
Year: 1999
Journal: Cell
Title: Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors.
Volume: 99
Issue: 1
Pages: 59-69
Protein
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: true
Publication
First Author: Goshima Y
Year: 2002
Journal: J Clin Invest
Title: Semaphorins as signals for cell repulsion and invasion.
Volume: 109
Issue: 8
Pages: 993-8
Publication
First Author: Nakamura F
Year: 2000
Journal: J Neurobiol
Title: Molecular basis of semaphorin-mediated axon guidance.
Volume: 44
Issue: 2
Pages: 219-29
Publication
First Author: Brugnera E
Year: 2002
Journal: Nat Cell Biol
Title: Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex.
Volume: 4
Issue: 8
Pages: 574-82
Publication
First Author: Hanawa-Suetsugu K
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.
Volume: 109
Issue: 9
Pages: 3305-10
Publication
First Author: Yoshida S
Year: 2004
Journal: Hum Mol Genet
Title: Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl.
Volume: 13
Issue: 14
Pages: 1487-503
Publication
First Author: Lavado A
Year: 2013
Journal: Development
Title: Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators.
Volume: 140
Issue: 16
Pages: 3323-34
Publication
First Author: Ohtsuka K
Year: 2000
Journal: Cell Stress Chaperones
Title: Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature.
Volume: 5
Issue: 2
Pages: 98-112
Publication
First Author: Weng J
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2.
Volume: 105
Issue: 16
Pages: 6081-6
Publication
First Author: Wang W
Year: 1996
Journal: Genes Dev
Title: Diversity and specialization of mammalian SWI/SNF complexes.
Volume: 10
Issue: 17
Pages: 2117-30
Publication
First Author: Battaglioli E
Year: 2002
Journal: J Biol Chem
Title: REST repression of neuronal genes requires components of the hSWI.SNF complex.
Volume: 277
Issue: 43
Pages: 41038-45
Publication
First Author: Sima J
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation.
Volume: 115
Issue: 32
Pages: 8173-8178
Publication
First Author: Tuoc TC
Year: 2013
Journal: Dev Cell
Title: Chromatin regulation by BAF170 controls cerebral cortical size and thickness.
Volume: 25
Issue: 3
Pages: 256-69
Publication
First Author: Ghazalpour A
Year: 2006
Journal: PLoS Genet
Title: Integrating genetic and network analysis to characterize genes related to mouse weight.
Volume: 2
Issue: 8
Pages: e130
Publication
First Author: Tiozzo C
Year: 2012
Journal: J Clin Invest
Title: Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype.
Volume: 122
Issue: 11
Pages: 3862-72
Publication
First Author: Santos R
Year: 2016
Journal: PLoS Biol
Title: Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects.
Volume: 14
Issue: 9
Pages: e2000197
Publication
First Author: Takemoto M
Year: 2006
Journal: EMBO J
Title: Large-scale identification of genes implicated in kidney glomerulus development and function.
Volume: 25
Issue: 5
Pages: 1160-74
Publication  
First Author: Nguyen H
Year: 2022
Journal: Front Cell Dev Biol
Title: BAF (mSWI/SNF) complex regulates mediolateral cortical patterning in the developing forebrain.
Volume: 10
Pages: 1011109
Publication  
First Author: Narayanan R
Year: 2018
Journal: iScience
Title: Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex.
Volume: 4
Pages: 109-126
Publication
First Author: Garrison WD
Year: 2006
Journal: Gastroenterology
Title: Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon.
Volume: 130
Issue: 4
Pages: 1207-20
Publication
First Author: Lin JI
Year: 2020
Journal: Commun Biol
Title: Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening.
Volume: 3
Issue: 1
Pages: 312
Publication
First Author: Walker EM
Year: 2014
Journal: Dev Biol
Title: GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development.
Volume: 392
Issue: 2
Pages: 283-94
Publication  
First Author: Padget RL
Year: 2019
Journal: Mech Dev
Title: Hemodynamic force is required for vascular smooth muscle cell recruitment to blood vessels during mouse embryonic development.
Volume: 156
Pages: 8-19
Publication
First Author: Brunskill EW
Year: 2011
Journal: PLoS One
Title: Defining the molecular character of the developing and adult kidney podocyte.
Volume: 6
Issue: 9
Pages: e24640
Publication
First Author: Grote P
Year: 2013
Journal: Dev Cell
Title: The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse.
Volume: 24
Issue: 2
Pages: 206-14
Publication
First Author: Cheverud JM
Year: 2014
Journal: Heredity (Edinb)
Title: Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line.
Volume: 112
Issue: 5
Pages: 508-18
Publication
First Author: Phelan ML
Year: 1999
Journal: Mol Cell
Title: Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits.
Volume: 3
Issue: 2
Pages: 247-53
Publication
First Author: Klochendler-Yeivin A
Year: 2002
Journal: Curr Opin Genet Dev
Title: SWI/SNF chromatin remodeling and cancer.
Volume: 12
Issue: 1
Pages: 73-9
Publication
First Author: Zhang HS
Year: 2000
Journal: Cell
Title: Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF.
Volume: 101
Issue: 1
Pages: 79-89
Publication
First Author: Hara R
Year: 2002
Journal: Mol Cell Biol
Title: The SWI/SNF chromatin-remodeling factor stimulates repair by human excision nuclease in the mononucleosome core particle.
Volume: 22
Issue: 19
Pages: 6779-87
Publication  
First Author: Ogaki S
Year: 2011
Journal: BMC Dev Biol
Title: An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.
Volume: 11
Pages: 13
Publication
First Author: Wirtz S
Year: 2011
Journal: PLoS One
Title: Region-specific expression of mitochondrial complex I genes during murine brain development.
Volume: 6
Issue: 4
Pages: e18897
Protein
Organism: Mus musculus/domesticus
Length: 185  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: true
Publication
First Author: Newton AC
Year: 2003
Journal: Biochem J
Title: Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm.
Volume: 370
Issue: Pt 2
Pages: 361-71
Protein
Organism: Mus musculus/domesticus
Length: 440  
Fragment?: false
Publication
First Author: Nakamura Y
Year: 2005
Journal: Mol Cell Biol
Title: Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development.
Volume: 25
Issue: 24
Pages: 10979-88
Protein
Organism: Mus musculus/domesticus
Length: 333  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 529  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 534  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 333  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 269  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 255  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 533  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: true
Publication
First Author: Krasnoperov V
Year: 1999
Journal: J Biol Chem
Title: Structural requirements for alpha-latrotoxin binding and alpha-latrotoxin-stimulated secretion. A study with calcium-independent receptor of alpha-latrotoxin (CIRL) deletion mutants.
Volume: 274
Issue: 6
Pages: 3590-6
Publication
First Author: Ozeki Y
Year: 1991
Journal: Biochemistry
Title: Amino acid sequence and molecular characterization of a D-galactoside-specific lectin purified from sea urchin (Anthocidaris crassispina) eggs.
Volume: 30
Issue: 9
Pages: 2391-4
Publication
First Author: Hosono M
Year: 1999
Journal: Biochim Biophys Acta
Title: Tandem repeat structure of rhamnose-binding lectin from catfish (Silurus asotus) eggs.
Volume: 1472
Issue: 3
Pages: 668-75
Publication
First Author: Lelianova VG
Year: 1997
Journal: J Biol Chem
Title: Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors.
Volume: 272
Issue: 34
Pages: 21504-8
Publication
First Author: Tateno H
Year: 1998
Journal: J Biol Chem
Title: Isolation and characterization of rhamnose-binding lectins from eggs of steelhead trout (Oncorhynchus mykiss) homologous to low density lipoprotein receptor superfamily.
Volume: 273
Issue: 30
Pages: 19190-7
Publication
First Author: Domin J
Year: 1997
Journal: FEBS Lett
Title: Using structure to define the function of phosphoinositide 3-kinase family members.
Volume: 410
Issue: 1
Pages: 91-5
Publication
First Author: Schu PV
Year: 1993
Journal: Science
Title: Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting.
Volume: 260
Issue: 5104
Pages: 88-91
Publication
First Author: Volinia S
Year: 1995
Journal: EMBO J
Title: A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system.
Volume: 14
Issue: 14
Pages: 3339-48
Publication  
First Author: Takegawa K
Year: 1995
Journal: J Cell Sci
Title: Schizosaccharomyces pombe Vps34p, a phosphatidylinositol-specific PI 3-kinase essential for normal cell growth and vacuole morphology.
Volume: 108 ( Pt 12)
Pages: 3745-56
Protein Domain
Type: Family
Description: Members of this family are Class III phosphatidylinositol 3-kinases (PI3Ks) (catalytic subunits). PI3K is a lipid kinase and a key signalling enzyme involving in cell survival and proliferation, cell motility and adhesion, cytoskeletal rearrangement and vesicle trafficking []. The different PI3K isoforms have cell-specific functions. In yeast, VPS34 is a key enzyme required for cell division, vacuolar protein sorting, and vacuole segregation []. The major components of the yeast VPS intracellular trafficking complex are conserved in humans [].There are three major classes of PI3Ks, I and III (Class I is also subdivided into Ia and Ib), and a more distantly relatedClass IV which contains Ser/Thr kinases. The different classes of PI3K catalyse phosphorylation of the 3'-OH position of phosphatidyl myo-inositol (PtdIns) lipids, generating different 3'-phosphorylated lipid products that act as secondary messengers. The classification of PI3Ks is based upon sequence analysis and domain architecture of the catalytic subunits, but the divisions also reflect the biochemical properties and the differential association with a variety of regulatory adaptor subunits. This division is mirrored not only in their specialised functions but also in the different modes of regulation of the different enzymes in the family []. Furthermore, each of the PI3K classes differ in their preferred lipid substrate. Class III PI3Ks use only phosphatidylinositol as substrate, whereas Class Ia and Ib PI3K activity is focused upon phosphatidylinositol (4,5)-bisphosphate as substrate in vivo []. These substrate-related differences are presumed to result from subtle variations in the structures of the active sites of the different PI3Ks.Class III PI3Ks contain only the core catalytic subunit, which consists of the N-terminal C2 domain, the helical domain and the double-lobed catalytic domain. Class I and II contain an additional Ras-binding domain. The N-terminal C2 domain interacts mainly with the scaffolding helical domain of the enzyme []. The function of the central helical domain is not clear, it has been suggested to be involved in substrate presentation []. The C-terminal catalytic domain is shared by the PI3- and PI4-kinases. This domain is distantly related to the catalytic domain of protein kinases, with a global similarity of the core topological features but significantdifferences in the substrate-binding sites [].For additional information please see [].
Publication
First Author: Ng SS
Year: 2020
Journal: Nat Immunol
Title: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation.
Volume: 21
Issue: 10
Pages: 1205-1218
Publication
First Author: Keller C
Year: 2004
Journal: Genes Dev
Title: Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.
Volume: 18
Issue: 21
Pages: 2614-26
Publication
First Author: Lykens JE
Year: 2011
Journal: Blood
Title: Perforin is a critical physiologic regulator of T-cell activation.
Volume: 118
Issue: 3
Pages: 618-26
Publication
First Author: Kurz AR
Year: 2016
Journal: J Clin Invest
Title: MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane.
Volume: 126
Issue: 11
Pages: 4125-4139
Publication
First Author: Levine AG
Year: 2017
Journal: J Exp Med
Title: Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity.
Volume: 214
Issue: 3
Pages: 609-622
Publication
First Author: Chora ÂF
Year: 2023
Journal: Immunity
Title: Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis.
Volume: 56
Issue: 3
Pages: 592-605.e8
Publication
First Author: Di Piazza M
Year: 2012
Journal: Cancer Cell
Title: Loss of cutaneous TSLP-dependent immune responses skews the balance of inflammation from tumor protective to tumor promoting.
Volume: 22
Issue: 4
Pages: 479-93
Publication
First Author: Parsa R
Year: 2022
Journal: Immunity
Title: Newly recruited intraepithelial Ly6A(+)CCR9(+)CD4(+) T cells protect against enteric viral infection.
Volume: 55
Issue: 7
Pages: 1234-1249.e6
Publication
First Author: Fatehullah A
Year: 2021
Journal: Nat Cell Biol
Title: A tumour-resident Lgr5+ stem-cell-like pool drives the establishment and progression of advanced gastric cancers.
Volume: 23
Issue: 12
Pages: 1299-1313
Publication
First Author: Leushacke M
Year: 2017
Journal: Nat Cell Biol
Title: Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach.
Volume: 19
Issue: 7
Pages: 774-786
Publication
First Author: Fernandez Vallone V
Year: 2020
Journal: EMBO Rep
Title: LGR5 controls extracellular matrix production by stem cells in the developing intestine.
Volume: 21
Issue: 7
Pages: e49224
Publication
First Author: Tetteh PW
Year: 2016
Journal: Cell Stem Cell
Title: Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters.
Volume: 18
Issue: 2
Pages: 203-13
Publication
First Author: Kunze B
Year: 2021
Journal: Sci Rep
Title: Notch signaling drives development of Barrett's metaplasia from Dclk1-positive epithelial tuft cells in the murine gastric mucosa.
Volume: 11
Issue: 1
Pages: 4509
Publication
First Author: Basak O
Year: 2017
Journal: Cell Stem Cell
Title: Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells.
Volume: 20
Issue: 2
Pages: 177-190.e4
Publication
First Author: Mustata RC
Year: 2013
Journal: Cell Rep
Title: Identification of Lgr5-independent spheroid-generating progenitors of the mouse fetal intestinal epithelium.
Volume: 5
Issue: 2
Pages: 421-32
Publication
First Author: Asfaha S
Year: 2015
Journal: Cell Stem Cell
Title: Krt19(+)/Lgr5(-) Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine.
Volume: 16
Issue: 6
Pages: 627-38
Publication
First Author: Engler A
Year: 2018
Journal: Cell Rep
Title: Notch2 Signaling Maintains NSC Quiescence in the Murine Ventricular-Subventricular Zone.
Volume: 22
Issue: 4
Pages: 992-1002
Publication
First Author: Clement JP
Year: 2012
Journal: Cell
Title: Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses.
Volume: 151
Issue: 4
Pages: 709-23
Publication  
First Author: Llamosas N
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Syngap1 regulates experience-dependent cortical ensemble plasticity by promoting in vivo excitatory synapse strengthening.
Volume: 118
Issue: 34
Publication
First Author: Niu W
Year: 2022
Journal: Cell
Title: Mouse oocytes develop in cysts with the help of nurse cells.
Volume: 185
Issue: 14
Pages: 2576-2590.e12
Publication
First Author: Fischer JM
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Single cell lineage tracing reveals a role for TgfβR2 in intestinal stem cell dynamics and differentiation.
Volume: 113
Issue: 43
Pages: 12192-12197
Publication
First Author: Ruscitto A
Year: 2023
Journal: Cell Stem Cell
Title: Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identity.
Volume: 30
Issue: 9
Pages: 1179-1198.e7
Publication
First Author: Plaks V
Year: 2013
Journal: Cell Rep
Title: Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis.
Volume: 3
Issue: 1
Pages: 70-8
Publication
First Author: Zhang R
Year: 2019
Journal: Cell Rep
Title: Id4 Downstream of Notch2 Maintains Neural Stem Cell Quiescence in the Adult Hippocampus.
Volume: 28
Issue: 6
Pages: 1485-1498.e6
Publication
First Author: Azkanaz M
Year: 2022
Journal: Nature
Title: Retrograde movements determine effective stem cell numbers in the intestine.
Volume: 607
Issue: 7919
Pages: 548-554
Publication
First Author: Seishima R
Year: 2019
Journal: Nat Commun
Title: Neonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development.
Volume: 10
Issue: 1
Pages: 5378
Publication
First Author: Li Y
Year: 2015
Journal: Nature
Title: Global genetic analysis in mice unveils central role for cilia in congenital heart disease.
Volume: 521
Issue: 7553
Pages: 520-4
Publication      
First Author: Lo C
Year: 2011
Journal: MGI Direct Data Submission (B2B/CvDC)
Title: Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC)
Publication    
First Author: Houy S
Year: 2017
Journal: Elife
Title: Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs.
Volume: 6
Publication
First Author: de Jong AP
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Phosphorylation of synaptotagmin-1 controls a post-priming step in PKC-dependent presynaptic plasticity.
Volume: 113
Issue: 18
Pages: 5095-100
Publication
First Author: Gennarini G
Year: 1989
Journal: J Cell Biol
Title: The mouse neuronal cell surface protein F3: a phosphatidylinositol-anchored member of the immunoglobulin superfamily related to chicken contactin.
Volume: 109
Issue: 2
Pages: 775-88
Publication  
First Author: Mandal NA
Year: 2013
Journal: Exp Eye Res
Title: Expression and localization of CERKL in the mammalian retina, its response to light-stress, and relationship with NeuroD1 gene.
Volume: 106
Pages: 24-33
Publication
First Author: Ibrahim-Hashim A
Year: 2017
Journal: Cancer Res
Title: Defining Cancer Subpopulations by Adaptive Strategies Rather Than Molecular Properties Provides Novel Insights into Intratumoral Evolution.
Volume: 77
Issue: 9
Pages: 2242-2254
Publication
First Author: Tertrais M
Year: 2019
Journal: J Neurosci
Title: Viral Transfer of Mini-Otoferlins Partially Restores the Fast Component of Exocytosis and Uncovers Ultrafast Endocytosis in Auditory Hair Cells of Otoferlin Knock-Out Mice.
Volume: 39
Issue: 18
Pages: 3394-3411