| Type |
Details |
Score |
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
149
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kukimoto-Niino M |
| Year: |
2019 |
| Journal: |
Structure |
| Title: |
Structural Basis for the Dual Substrate Specificity of DOCK7 Guanine Nucleotide Exchange Factor. |
| Volume: |
27 |
| Issue: |
5 |
| Pages: |
741-748.e3 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Takahashi T |
| Year: |
1999 |
| Journal: |
Cell |
| Title: |
Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. |
| Volume: |
99 |
| Issue: |
1 |
| Pages: |
59-69 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
102
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
241
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Goshima Y |
| Year: |
2002 |
| Journal: |
J Clin Invest |
| Title: |
Semaphorins as signals for cell repulsion and invasion. |
| Volume: |
109 |
| Issue: |
8 |
| Pages: |
993-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nakamura F |
| Year: |
2000 |
| Journal: |
J Neurobiol |
| Title: |
Molecular basis of semaphorin-mediated axon guidance. |
| Volume: |
44 |
| Issue: |
2 |
| Pages: |
219-29 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brugnera E |
| Year: |
2002 |
| Journal: |
Nat Cell Biol |
| Title: |
Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. |
| Volume: |
4 |
| Issue: |
8 |
| Pages: |
574-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hanawa-Suetsugu K |
| Year: |
2012 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms. |
| Volume: |
109 |
| Issue: |
9 |
| Pages: |
3305-10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yoshida S |
| Year: |
2004 |
| Journal: |
Hum Mol Genet |
| Title: |
Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl. |
| Volume: |
13 |
| Issue: |
14 |
| Pages: |
1487-503 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lavado A |
| Year: |
2013 |
| Journal: |
Development |
| Title: |
Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. |
| Volume: |
140 |
| Issue: |
16 |
| Pages: |
3323-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ohtsuka K |
| Year: |
2000 |
| Journal: |
Cell Stress Chaperones |
| Title: |
Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. |
| Volume: |
5 |
| Issue: |
2 |
| Pages: |
98-112 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Weng J |
| Year: |
2008 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. |
| Volume: |
105 |
| Issue: |
16 |
| Pages: |
6081-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang W |
| Year: |
1996 |
| Journal: |
Genes Dev |
| Title: |
Diversity and specialization of mammalian SWI/SNF complexes. |
| Volume: |
10 |
| Issue: |
17 |
| Pages: |
2117-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Battaglioli E |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
REST repression of neuronal genes requires components of the hSWI.SNF complex. |
| Volume: |
277 |
| Issue: |
43 |
| Pages: |
41038-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sima J |
| Year: |
2018 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation. |
| Volume: |
115 |
| Issue: |
32 |
| Pages: |
8173-8178 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tuoc TC |
| Year: |
2013 |
| Journal: |
Dev Cell |
| Title: |
Chromatin regulation by BAF170 controls cerebral cortical size and thickness. |
| Volume: |
25 |
| Issue: |
3 |
| Pages: |
256-69 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ghazalpour A |
| Year: |
2006 |
| Journal: |
PLoS Genet |
| Title: |
Integrating genetic and network analysis to characterize genes related to mouse weight. |
| Volume: |
2 |
| Issue: |
8 |
| Pages: |
e130 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tiozzo C |
| Year: |
2012 |
| Journal: |
J Clin Invest |
| Title: |
Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype. |
| Volume: |
122 |
| Issue: |
11 |
| Pages: |
3862-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Santos R |
| Year: |
2016 |
| Journal: |
PLoS Biol |
| Title: |
Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects. |
| Volume: |
14 |
| Issue: |
9 |
| Pages: |
e2000197 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Takemoto M |
| Year: |
2006 |
| Journal: |
EMBO J |
| Title: |
Large-scale identification of genes implicated in kidney glomerulus development and function. |
| Volume: |
25 |
| Issue: |
5 |
| Pages: |
1160-74 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nguyen H |
| Year: |
2022 |
| Journal: |
Front Cell Dev Biol |
| Title: |
BAF (mSWI/SNF) complex regulates mediolateral cortical patterning in the developing forebrain. |
| Volume: |
10 |
|
| Pages: |
1011109 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Narayanan R |
| Year: |
2018 |
| Journal: |
iScience |
| Title: |
Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex. |
| Volume: |
4 |
|
| Pages: |
109-126 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Garrison WD |
| Year: |
2006 |
| Journal: |
Gastroenterology |
| Title: |
Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. |
| Volume: |
130 |
| Issue: |
4 |
| Pages: |
1207-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lin JI |
| Year: |
2020 |
| Journal: |
Commun Biol |
| Title: |
Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening. |
| Volume: |
3 |
| Issue: |
1 |
| Pages: |
312 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Walker EM |
| Year: |
2014 |
| Journal: |
Dev Biol |
| Title: |
GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development. |
| Volume: |
392 |
| Issue: |
2 |
| Pages: |
283-94 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Padget RL |
| Year: |
2019 |
| Journal: |
Mech Dev |
| Title: |
Hemodynamic force is required for vascular smooth muscle cell recruitment to blood vessels during mouse embryonic development. |
| Volume: |
156 |
|
| Pages: |
8-19 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brunskill EW |
| Year: |
2011 |
| Journal: |
PLoS One |
| Title: |
Defining the molecular character of the developing and adult kidney podocyte. |
| Volume: |
6 |
| Issue: |
9 |
| Pages: |
e24640 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Grote P |
| Year: |
2013 |
| Journal: |
Dev Cell |
| Title: |
The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse. |
| Volume: |
24 |
| Issue: |
2 |
| Pages: |
206-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cheverud JM |
| Year: |
2014 |
| Journal: |
Heredity (Edinb) |
| Title: |
Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line. |
| Volume: |
112 |
| Issue: |
5 |
| Pages: |
508-18 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Phelan ML |
| Year: |
1999 |
| Journal: |
Mol Cell |
| Title: |
Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. |
| Volume: |
3 |
| Issue: |
2 |
| Pages: |
247-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Klochendler-Yeivin A |
| Year: |
2002 |
| Journal: |
Curr Opin Genet Dev |
| Title: |
SWI/SNF chromatin remodeling and cancer. |
| Volume: |
12 |
| Issue: |
1 |
| Pages: |
73-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang HS |
| Year: |
2000 |
| Journal: |
Cell |
| Title: |
Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. |
| Volume: |
101 |
| Issue: |
1 |
| Pages: |
79-89 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hara R |
| Year: |
2002 |
| Journal: |
Mol Cell Biol |
| Title: |
The SWI/SNF chromatin-remodeling factor stimulates repair by human excision nuclease in the mononucleosome core particle. |
| Volume: |
22 |
| Issue: |
19 |
| Pages: |
6779-87 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ogaki S |
| Year: |
2011 |
| Journal: |
BMC Dev Biol |
| Title: |
An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells. |
| Volume: |
11 |
|
| Pages: |
13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wirtz S |
| Year: |
2011 |
| Journal: |
PLoS One |
| Title: |
Region-specific expression of mitochondrial complex I genes during murine brain development. |
| Volume: |
6 |
| Issue: |
4 |
| Pages: |
e18897 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
185
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
174
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Newton AC |
| Year: |
2003 |
| Journal: |
Biochem J |
| Title: |
Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. |
| Volume: |
370 |
| Issue: |
Pt 2 |
| Pages: |
361-71 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
440
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nakamura Y |
| Year: |
2005 |
| Journal: |
Mol Cell Biol |
| Title: |
Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development. |
| Volume: |
25 |
| Issue: |
24 |
| Pages: |
10979-88 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
333
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
81
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
529
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
131
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
145
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
114
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
446
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
534
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
333
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
269
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
211
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
255
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
141
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
533
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
378
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Krasnoperov V |
| Year: |
1999 |
| Journal: |
J Biol Chem |
| Title: |
Structural requirements for alpha-latrotoxin binding and alpha-latrotoxin-stimulated secretion. A study with calcium-independent receptor of alpha-latrotoxin (CIRL) deletion mutants. |
| Volume: |
274 |
| Issue: |
6 |
| Pages: |
3590-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ozeki Y |
| Year: |
1991 |
| Journal: |
Biochemistry |
| Title: |
Amino acid sequence and molecular characterization of a D-galactoside-specific lectin purified from sea urchin (Anthocidaris crassispina) eggs. |
| Volume: |
30 |
| Issue: |
9 |
| Pages: |
2391-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hosono M |
| Year: |
1999 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Tandem repeat structure of rhamnose-binding lectin from catfish (Silurus asotus) eggs. |
| Volume: |
1472 |
| Issue: |
3 |
| Pages: |
668-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lelianova VG |
| Year: |
1997 |
| Journal: |
J Biol Chem |
| Title: |
Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors. |
| Volume: |
272 |
| Issue: |
34 |
| Pages: |
21504-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tateno H |
| Year: |
1998 |
| Journal: |
J Biol Chem |
| Title: |
Isolation and characterization of rhamnose-binding lectins from eggs of steelhead trout (Oncorhynchus mykiss) homologous to low density lipoprotein receptor superfamily. |
| Volume: |
273 |
| Issue: |
30 |
| Pages: |
19190-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Domin J |
| Year: |
1997 |
| Journal: |
FEBS Lett |
| Title: |
Using structure to define the function of phosphoinositide 3-kinase family members. |
| Volume: |
410 |
| Issue: |
1 |
| Pages: |
91-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schu PV |
| Year: |
1993 |
| Journal: |
Science |
| Title: |
Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. |
| Volume: |
260 |
| Issue: |
5104 |
| Pages: |
88-91 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Volinia S |
| Year: |
1995 |
| Journal: |
EMBO J |
| Title: |
A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system. |
| Volume: |
14 |
| Issue: |
14 |
| Pages: |
3339-48 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Takegawa K |
| Year: |
1995 |
| Journal: |
J Cell Sci |
| Title: |
Schizosaccharomyces pombe Vps34p, a phosphatidylinositol-specific PI 3-kinase essential for normal cell growth and vacuole morphology. |
| Volume: |
108 ( Pt 12) |
|
| Pages: |
3745-56 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Members of this family are Class III phosphatidylinositol 3-kinases (PI3Ks) (catalytic subunits). PI3K is a lipid kinase and a key signalling enzyme involving in cell survival and proliferation, cell motility and adhesion, cytoskeletal rearrangement and vesicle trafficking []. The different PI3K isoforms have cell-specific functions. In yeast, VPS34 is a key enzyme required for cell division, vacuolar protein sorting, and vacuole segregation []. The major components of the yeast VPS intracellular trafficking complex are conserved in humans [].There are three major classes of PI3Ks, I and III (Class I is also subdivided into Ia and Ib), and a more distantly relatedClass IV which contains Ser/Thr kinases. The different classes of PI3K catalyse phosphorylation of the 3'-OH position of phosphatidyl myo-inositol (PtdIns) lipids, generating different 3'-phosphorylated lipid products that act as secondary messengers. The classification of PI3Ks is based upon sequence analysis and domain architecture of the catalytic subunits, but the divisions also reflect the biochemical properties and the differential association with a variety of regulatory adaptor subunits. This division is mirrored not only in their specialised functions but also in the different modes of regulation of the different enzymes in the family []. Furthermore, each of the PI3K classes differ in their preferred lipid substrate. Class III PI3Ks use only phosphatidylinositol as substrate, whereas Class Ia and Ib PI3K activity is focused upon phosphatidylinositol (4,5)-bisphosphate as substrate in vivo []. These substrate-related differences are presumed to result from subtle variations in the structures of the active sites of the different PI3Ks.Class III PI3Ks contain only the core catalytic subunit, which consists of the N-terminal C2 domain, the helical domain and the double-lobed catalytic domain. Class I and II contain an additional Ras-binding domain. The N-terminal C2 domain interacts mainly with the scaffolding helical domain of the enzyme []. The function of the central helical domain is not clear, it has been suggested to be involved in substrate presentation []. The C-terminal catalytic domain is shared by the PI3- and PI4-kinases. This domain is distantly related to the catalytic domain of protein kinases, with a global similarity of the core topological features but significantdifferences in the substrate-binding sites [].For additional information please see []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ng SS |
| Year: |
2020 |
| Journal: |
Nat Immunol |
| Title: |
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation. |
| Volume: |
21 |
| Issue: |
10 |
| Pages: |
1205-1218 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Keller C |
| Year: |
2004 |
| Journal: |
Genes Dev |
| Title: |
Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. |
| Volume: |
18 |
| Issue: |
21 |
| Pages: |
2614-26 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lykens JE |
| Year: |
2011 |
| Journal: |
Blood |
| Title: |
Perforin is a critical physiologic regulator of T-cell activation. |
| Volume: |
118 |
| Issue: |
3 |
| Pages: |
618-26 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kurz AR |
| Year: |
2016 |
| Journal: |
J Clin Invest |
| Title: |
MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane. |
| Volume: |
126 |
| Issue: |
11 |
| Pages: |
4125-4139 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Levine AG |
| Year: |
2017 |
| Journal: |
J Exp Med |
| Title: |
Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity. |
| Volume: |
214 |
| Issue: |
3 |
| Pages: |
609-622 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chora ÂF |
| Year: |
2023 |
| Journal: |
Immunity |
| Title: |
Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis. |
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