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Search results 7601 to 7700 out of 8285 for C2

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Type Details Score
Protein Domain
IPR015428 | Synaptotagmin1
Type: Family
Description: Synaptotagmins are synaptic vesicle membrane proteins found in abundance in nerve cells and some endocrine cells [, ]. The amino acid sequence of synaptotagmin comprises a single transmembrane region with a short vesicular N-terminal region, and a cytoplasmic C-terminal region containing 2 internal repeats similar to the C2 regulatory domain of protein kinase C. The protein is believed to be important in the docking and fusion of synaptic vesicles with the plasma membrane, i.e. with neurotransmitter release [, ].Synaptotagmin 1 (originally called p65) and synaptotagmin 2 were the first to members identified in the synaptotagmin family [, ]. Synaptotagmin 1 may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse []. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone [, ]. It has been shown to function as a Ca2+ sensor on the synaptic vesicle surface, therefore to regulate Ca2+ dependent neurotransmitter release [, ].
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Protein Domain
IPR035652 | RasGAP_SH3
Type: Domain
Description: Ras GTPase-activating protein 1 (also known as p120-RasGAP) is an inhibitory regulator of the Ras-cyclic AMP pathway [, ]. Its C-terminal catalytic domain promotes GTP hydrolysis and plays a key role in the regulation of Ras-GTP bound []. Its N-terminal part contains two SH2, SH3, PH (pleckstrin homology) and CaLB/C2 (calcium-dependent phospholipid-binding domain) domains, which allow various functions such as anti-/pro-apoptosis, proliferation and cell migration [].Alternative splicing results in two isoforms. The shorter isoform which lacks the N-terminal hydrophobic region, has the same activity, and is expressed in placental tissues. In general the longer isoform contains two SH2 domains, an SH3 domain, a pleckstrin homology (PH) domain, and a calcium-dependent phospholipid-binding C2 domain. The C terminus contains the catalytic domain of RasGap which catalyzes the activation of Ras by hydrolyzing GTP-bound active Ras into an inactive GDP-bound form of Ras [].This entry represents the SH3 domain of RasGAP []. The SH3 domain of RasGAP is unable to bind proline-rich sequences but have been shown to interact with protein partners such as the G3BP protein, Aurora kinases, and the Calpain small subunit 1. The RasGAP SH3 domain is necessary for the downstream signaling of Ras and it also influences Rho-mediated cytoskeletal reorganization [].
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Protein Domain
IPR001711 | PLipase_C_Pinositol-sp_Y
Type: Domain
Description: Phosphatidylinositol-specific phospholipase C (), an eukaryotic intracellular enzyme, plays an important role in signal transduction processes [](see ). It catalyzes the hydrolysis of 1-phosphatidyl-D-myo-inositol-3,4,5-triphosphate into the second messenger molecules diacylglycerol and inositol-1,4,5-triphosphate. This catalytic process is tightly regulated by reversible phosphorylation and binding of regulatory proteins [, , ].In mammals, there are at least 6 different isoforms of PI-PLC, they differ in their domain structure, their regulation, and their tissue distribution. Lower eukaryotes also possess multiple isoforms of PI-PLC.All eukaryotic PI-PLCs contain two regions of homology, sometimes referred to as 'X-box' (see ) and 'Y-box'. The order of these two regions is always the same (NH2-X-Y-COOH), but the spacing is variable. In most isoforms, the distance between these two regions is only 50-100 residues but in the gamma isoforms one PH domain, two SH2 domains, and one SH3 domain are inserted between the two PLC-specific domains. The two conserved regions have been shown to be important for the catalytic activity. At the C-terminal of the Y-box, there is a C2 domain (see ) possibly involved in Ca-dependent membrane attachment.
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Protein Domain
IPR043159 | Lectin_gal-bd_sf
Type: Homologous_superfamily
Description: The D-galactoside binding lectin purified from sea urchin (Anthocidaris crassispina) eggs exists as a disulphide-linked homodimer of two subunits; the dimeric form is essential for hemagglutination activity []. The sea urchin egg lectin (SUEL) forms a new class of lectins. Although SUEL was first isolated as a D-galactoside binding lectin, it was latter shown that it bind to L-rhamnose preferentially [, ]. L-rhamnose and D-galactose share the same hydroxyl group orientation at C2 and C4 of the pyranose ring structure.A cysteine-rich domain homologous to the SUEL protein has been identified in the following proteins [, , ]:Plant beta-galactosidases () (lactases).Mammalian latrophilin, the calcium independent receptor of alpha-latrotoxin (CIRL). The galactose-binding lectin domain is not required for alpha-latratoxin binding [].Human lectomedin-1.Rhamnose-binding lectin (SAL) from catfish (Silurus asotus, Namazu) eggs. This protein is composed of three tandem repeat domains homologous to the SUEL lectin domain. All cysteine positions of each domain are completely conserved [].The hypothetical B0457.1, F32A7.3A and F32A7.3B proteins from Caenorhabditis elegans.The human KIAA0821 protein.Structurally, the rhamnose-binding lectin domain (also known as the N-terminal lectin domain, Lec) is composed of five β-strands , a single, long α-helix, and two small helical elements. The overall fold is that of a β-sandwich with two antiparallel sheets [].
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Protein
Q6PF84
Organism: Mus musculus/domesticus
Length: 738  
Fragment?: false
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Publication
19926274 | -
First Author: Filippakopoulos P
Year: 2009
Journal: Curr Opin Struct Biol
Title: SH2 domains: modulators of nonreceptor tyrosine kinase activity.
Volume: 19
Issue: 6
Pages: 643-9
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Protein
O08908
Organism: Mus musculus/domesticus
Length: 722  
Fragment?: false
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Protein
Q3UK33
Organism: Mus musculus/domesticus
Length: 722  
Fragment?: false
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Protein
A0A2X0SZ21
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: true
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Protein
O88188
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: false
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Protein
Q9JHF9
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: false
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Protein
Q3UYD7
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false
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Protein
Q3TQ19
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: true
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Protein
A0A087WQZ9
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: false
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Protein
F6UKG4
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: true
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Protein
Q3UQ39
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: false
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Protein
Q64HC9
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: false
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Protein
F6R587
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: true
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Protein
V9GXM6
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: true
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Protein
G3V016
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
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Protein
Q14AM4
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: false
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Publication
19665973 | -
First Author: Bae JH
Year: 2009
Journal: Cell
Title: The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site.
Volume: 138
Issue: 3
Pages: 514-24
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Publication
35931031 | J:327239
First Author: Vasquez EG
Year: 2022
Journal: Cell Stem Cell
Title: Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia.
Volume: 29
Issue: 8
Pages: 1213-1228.e8
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Publication
16306063 | J:104560
First Author: Turk R
Year: 2006
Journal: FASEB J
Title: Common pathological mechanisms in mouse models for muscular dystrophies.
Volume: 20
Issue: 1
Pages: 127-9
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Strain
MGI:6188050 | SJL/JArc
Attribute String: inbred strain
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Publication
38722309 | J:348041
 
First Author: Kögl T
Year: 2024
Journal: J Exp Med
Title: Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect.
Volume: 221
Issue: 7
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Publication
30355617 | J:269896
First Author: Fan X
Year: 2018
Journal: J Exp Med
Title: CD49b defines functionally mature Treg cells that survey skin and vascular tissues.
Volume: 215
Issue: 11
Pages: 2796-2814
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Publication
32169167 | J:358567
First Author: Fumagalli A
Year: 2020
Journal: Cell Stem Cell
Title: Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer.
Volume: 26
Issue: 4
Pages: 569-578.e7
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Publication
38589357 | J:352017
First Author: Morral C
Year: 2024
Journal: Nat Commun
Title: p53 promotes revival stem cells in the regenerating intestine after severe radiation injury.
Volume: 15
Issue: 1
Pages: 3018
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Publication
25526309 | J:302262
First Author: Prakash MD
Year: 2014
Journal: Immunity
Title: Granzyme B promotes cytotoxic lymphocyte transmigration via basement membrane remodeling.
Volume: 41
Issue: 6
Pages: 960-72
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Publication
35314700 | J:323000
First Author: Higa T
Year: 2022
Journal: Nat Commun
Title: Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium.
Volume: 13
Issue: 1
Pages: 1500
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Publication
21042537 | J:166709
First Author: Mazur PK
Year: 2010
Journal: PLoS One
Title: Identification of epidermal Pdx1 expression discloses different roles of Notch1 and Notch2 in murine Kras(G12D)-induced skin carcinogenesis in vivo.
Volume: 5
Issue: 10
Pages: e13578
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Publication
24120136 | J:214484
First Author: Stange DE
Year: 2013
Journal: Cell
Title: Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium.
Volume: 155
Issue: 2
Pages: 357-68
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Publication
25030697 | J:214957
First Author: Abraham J
Year: 2014
Journal: Genes Dev
Title: Lineage of origin in rhabdomyosarcoma informs pharmacological response.
Volume: 28
Issue: 14
Pages: 1578-91
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Publication
19332644 | J:157754
First Author: Nishijo K
Year: 2009
Journal: FASEB J
Title: Biomarker system for studying muscle, stem cells, and cancer in vivo.
Volume: 23
Issue: 8
Pages: 2681-90
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Publication
16688530 | J:105543
First Author: Crozat K
Year: 2006
Journal: Mamm Genome
Title: Analysis of the MCMV resistome by ENU mutagenesis.
Volume: 17
Issue: 5
Pages: 398-406
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Publication
23853545 | J:201417
First Author: Vahl JC
Year: 2013
Journal: PLoS Biol
Title: NKT cell-TCR expression activates conventional T cells in vivo, but is largely dispensable for mature NKT cell biology.
Volume: 11
Issue: 6
Pages: e1001589
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Publication
26119937 | J:234215
First Author: Hessmann E
Year: 2016
Journal: Oncogene
Title: MYC in pancreatic cancer: novel mechanistic insights and their translation into therapeutic strategies.
Volume: 35
Issue: 13
Pages: 1609-18
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Publication
15020428 | J:88776
First Author: Du X
Year: 2004
Journal: Genetics
Title: Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice.
Volume: 166
Issue: 1
Pages: 331-40
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Publication
32142681 | J:305918
First Author: Chang W
Year: 2020
Journal: Cell Stem Cell
Title: Hormonal Suppression of Stem Cells Inhibits Symmetric Cell Division and Gastric Tumorigenesis.
Volume: 26
Issue: 5
Pages: 739-754.e8
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Publication
24945774 | J:215492
First Author: Ozkan ED
Year: 2014
Journal: Neuron
Title: Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons.
Volume: 82
Issue: 6
Pages: 1317-33
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Publication
26317471 | J:224904
First Author: Arpaia N
Year: 2015
Journal: Cell
Title: A Distinct Function of Regulatory T Cells in Tissue Protection.
Volume: 162
Issue: 5
Pages: 1078-89
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Publication
38861924 | J:349941
First Author: Geels SN
Year: 2024
Journal: Cancer Cell
Title: Interruption of the intratumor CD8(+) T cell:Treg crosstalk improves the efficacy of PD-1 immunotherapy.
Volume: 42
Issue: 6
Pages: 1051-1066.e7
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Publication
32259486 | J:291059
First Author: Dekoninck S
Year: 2020
Journal: Cell
Title: Defining the Design Principles of Skin Epidermis Postnatal Growth.
Volume: 181
Issue: 3
Pages: 604-620.e22
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Publication
38848677 | J:352744
First Author: Capdevila C
Year: 2024
Journal: Cell
Title: Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells.
Volume: 187
Issue: 12
Pages: 3039-3055.e14
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Publication
32084390 | J:307135
First Author: Murata K
Year: 2020
Journal: Cell Stem Cell
Title: Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells.
Volume: 26
Issue: 3
Pages: 377-390.e6
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Publication
31019301 | J:283362
First Author: Ayyaz A
Year: 2019
Journal: Nature
Title: Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell.
Volume: 569
Issue: 7754
Pages: 121-125
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Publication
30455457 | J:271665
First Author: Michaelson SD
Year: 2018
Journal: Nat Neurosci
Title: SYNGAP1 heterozygosity disrupts sensory processing by reducing touch-related activity within somatosensory cortex circuits.
Volume: 21
Issue: 12
Pages: 1-13
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Publication
28813421 | J:253067
First Author: Sigal M
Year: 2017
Journal: Nature
Title: Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.
Volume: 548
Issue: 7668
Pages: 451-455
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Publication
33503423 | J:319855
First Author: Tan SH
Year: 2021
Journal: Cell Rep
Title: A constant pool of Lgr5+ intestinal stem cells is required for intestinal homeostasis.
Volume: 34
Issue: 4
Pages: 108633
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Publication
29097544 | J:248462
First Author: Hirabayashi Y
Year: 2017
Journal: Science
Title: ER-mitochondria tethering by PDZD8 regulates Ca2+ dynamics in mammalian neurons.
Volume: 358
Issue: 6363
Pages: 623-630
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Protein
S4R1B4
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: false
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Protein
A0A1L1ST98
Organism: Mus musculus/domesticus
Length: 577  
Fragment?: true
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Protein
Q3UPW0
Organism: Mus musculus/domesticus
Length: 558  
Fragment?: true
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Publication
11884135 | -
First Author: Au SW
Year: 2002
Journal: J Mol Biol
Title: Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit.
Volume: 316
Issue: 4
Pages: 955-68
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Publication
10025402 | J:52577
First Author: Ostermeier C
Year: 1999
Journal: Cell
Title: Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A.
Volume: 96
Issue: 3
Pages: 363-74
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Publication
7973627 | -
First Author: Schumacher MA
Year: 1994
Journal: Science
Title: Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices.
Volume: 266
Issue: 5186
Pages: 763-70
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Publication
10700279 | -
First Author: Bell CE
Year: 2000
Journal: Nat Struct Biol
Title: A closer view of the conformation of the Lac repressor bound to operator.
Volume: 7
Issue: 3
Pages: 209-14
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Publication
9237914 | -
First Author: Penin F
Year: 1997
Journal: J Mol Biol
Title: Three-dimensional structure of the DNA-binding domain of the fructose repressor from Escherichia coli by 1H and 15N NMR.
Volume: 270
Issue: 3
Pages: 496-510
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Publication
11583619 | -
First Author: Reményi A
Year: 2001
Journal: Mol Cell
Title: Differential dimer activities of the transcription factor Oct-1 by DNA-induced interface swapping.
Volume: 8
Issue: 3
Pages: 569-80
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Publication
16449791 | -
First Author: Lee I
Year: 2006
Journal: FASEB J
Title: Diverse membrane-associated proteins contain a novel SMP domain.
Volume: 20
Issue: 2
Pages: 202-6
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Publication
21712437 | -
First Author: Limbach C
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site.
Volume: 108
Issue: 31
Pages: E392-401
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Publication
15180595 | -
First Author: Fernández-Montalván A
Year: 2004
Journal: Biochem J
Title: Electrostatic interactions of domain III stabilize the inactive conformation of mu-calpain.
Volume: 382
Issue: Pt 2
Pages: 607-17
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Protein Domain
IPR014032 | Peptidase_A24A_bac
Type: Family
Description: Cysteine protease activity is dependent on an active dyad of cysteine andhistidine, the order and spacing of these residues varying in the 20 or soknown families. Cysteine proteases have been grouped into two clans (CA andCB). Families C1, C2 and C10 are loosely termed papain-like and belong to clan CA; five cysteine proteases belong to clan CB; other families havenot been assigned to clans. Nearly half of all cysteine proteases are found exclusively in viruses. The order of catalytic cysteine and histidine residues within the primary structure differs between the families and is an indication of convergent evolution [, ].Bacteria produce a number of protein precursors that undergo post-translational methylation and proteolysis prior to secretion as activeproteins. Type IV prepilin leader peptidases, which belong to the C20 familyof cysteine proteases, are enzymes that mediate this type of post-translational modification. Type IV pilin is a protein found on the surfaceof Pseudomonas aeruginosa, Neisseria gonorrhoeae and other Gram-negativepathogens. Pilin subunits attach the infecting organism to the surface of host epithelial cells. They are synthesised as prepilin subunits, which differ from mature pilin by virtue of containing a 6-8 residue leaderpeptide consisting of charged amino acids. Mature type IV pilins alsocontain a methylated N-terminal phenylalanine residue. Prepilin leader peptidases are found on the cytosolic membrane surface,where they have dual activity, involving cleavage of glycine-phenylalaninebonds and methylation of the newly-revealed N-terminal phenylalanine. Theconsensus sequence for the site of proteolytic cleavage is -G+F-T-L/I-, inwhich the Gly P1 residue is essential []. The peptidases are suseptible to thiol blocking reagents. Site directed mutagenesis has indicated four highlyconserved cysteine residues that affect both the protease and methylase activity.
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Protein Domain
IPR036213 | Calpain_III_sf
Type: Homologous_superfamily
Description: This group of cysteine peptidases belong to the MEROPS peptidase family C2 (calpain family, clan CA). A type example is calpain, which is an intracellular protease involved in many important cellular functions that are regulated by calcium [, ]. The protein is a complex of 2 polypeptide chains (light and heavy), with eleven known active peptidases in humans and two non-peptidase homologues known as calpamodulin and androglobin []. These include a highly calcium-sensitive (i.e., micro-molar range) form known as mu-calpain, mu-CANP or calpain I; a form sensitive to calcium in the milli-molar range, known as m-calpain, m-CANP or calpain II; and a third form, known as p94, which is found in skeletal muscle only [].All forms have identical light but different heavy chains. Both mu- and m-calpain are heterodimers containing an identical 28kDa subunit and an 80kDa subunit that shares 55-65% sequence homology between the two proteases [, ]. The crystallographic structure of m-calpain reveals six "domains"in the 80kDa subunit [, ]: A 19-amino acid NH2-terminal sequence;Active site domain IIa;Active site domain IIb. Domain 2 showslow levels of sequence similarity to papain; although the catalytic His hasnot been located by biochemical means, it is likely that calpain and papainare related [].Domain III;An 18-amino acid extended sequence linking domain III to domain IV;Domain IV, which resembles the penta EF-hand family of polypeptides, binds calcium and regulates activity []. Ca2+-binding causes a rearrangement of the protein backbone, the net effect of which is that a Trp side chain, which acts as a wedge between catalytic domains IIa and IIb in the apo state, moves away from the active sitecleft allowing for the proper formation of the catalytic triad []. This superfamily describes domain III. Calpains are activated via rearrangement of the catalytic domain II induced by cooperative binding of Ca2+ to several sites of the molecule. A cluster of acidic residues in domain III, the acidic loop, has been proposed to function as part of an electrostatic switch in the activation process [].
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Protein Domain
IPR035023 | PLC-gamma_C-SH2
Type: Domain
Description: This entry represents the C-terminal SH2 domain of phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma (PLC-gamma).PLC-gamma is a signaling molecule that is recruited to the C-terminal tail of the receptor upon autophosphorylation of a highly conserved tyrosine. PLC-gamma is composed of a pleckstrin homology (PH) domain followed by an elongation factor (EF) domain, two catalytic regions of PLC domains that flank two tandem SH2 domains (N-SH2, C-SH2), and ending with a SH3 domain and C2 domain. N-SH2 domain-mediated interactions represent a crucial step in transmembrane signaling by receptor tyrosine kinases []. SH2 domains recognize phosphotyrosine (pY) in the context of particular sequence motifs in receptor phosphorylation sites. Both N-SH2 and C-SH2 have a very similar binding affinity to pY. But in growth factor stimulated cells these domains bind to different target proteins. N-SH2 binds to pY containing sites in the C-terminal tails of tyrosine kinases and other receptors. Recently it has been shown that this interaction is mediated by phosphorylation-independent interactions between a secondary binding site found exclusively on the N-SH2 domain and a region of the FGFR1 tyrosine kinase domain. This secondary site on the SH2 cooperates with the canonical pY site to regulate selectivity in mediating a specific cellular process. C-SH2 binds to an intramolecular site on PLC-gamma itself which allows it to hydrolyze phosphatidylinositol-4,5-bisphosphate into diacylglycerol and inositol triphosphate. These then activate protein kinase C and release calcium []. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated site [].
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Protein Domain
IPR035024 | PLC-gamma_N-SH2
Type: Domain
Description: This entry represents the N-terminal SH2 domain of phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma (PLC-gamma).PLC-gamma is a signaling molecule that is recruited to the C-terminal tail of the receptor upon autophosphorylation of a highly conserved tyrosine. PLC-gamma is composed of a pleckstrin homology (PH) domain followed by an elongation factor (EF) domain, two catalytic regions of PLC domains that flank two tandem SH2 domains (N-SH2, C-SH2), and ending with a SH3 domain and C2 domain. N-SH2 domain-mediated interactions represent a crucial step in transmembrane signaling by receptor tyrosine kinases []. SH2 domains recognize phosphotyrosine (pY) in the context of particular sequence motifs in receptor phosphorylation sites. Both N-SH2 and C-SH2 have a very similar binding affinity to pY. But in growth factor stimulated cells these domains bind to different target proteins. N-SH2 binds to pY containing sites in the C-terminal tails of tyrosine kinases and other receptors. Recently it has been shown that this interaction is mediated by phosphorylation-independent interactions between a secondary binding site found exclusively on the N-SH2 domain and a region of the FGFR1 tyrosine kinase domain. This secondary site on the SH2 cooperates with the canonical pY site to regulate selectivity in mediating a specific cellular process. C-SH2 binds to an intramolecular site on PLC-gamma itself which allows it to hydrolyze phosphatidylinositol-4,5-bisphosphate into diacylglycerol and inositol triphosphate. These then activate protein kinase C and release calcium []. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated site [].
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Protein Domain
IPR010982 | Lambda_DNA-bd_dom_sf
Type: Homologous_superfamily
Description: Bacteriophage lambda C1 repressor controls the expression of viral genes as part of the lysogeny/lytic growth switch. C1 is essential for maintaining lysogeny, where the phage replicates non-disruptively along with the host. If the host cell is threatened, then lytic growth is induced. The Lambda C1 repressor consists of two domains connected by a linker: an N-terminal DNA-binding domain that also mediates interactions with RNA polymerase, and a C-terminal dimerisation domain []. The DNA-binding domain consists of four helices in a closed folded leaf motif. Several different phage repressors from different helix-turn-helix families contain DNA-binding domains that adopt a similar topology. These include the Lambda Cro repressor, Bacteriophage 434 C1 and Cro repressors, P22 C2 repressor, and Bacteriophage Mu Ner protein.The DNA-binding domain of Bacillus subtilis spore inhibition repressor SinR is identical to that of phage repressors []. SinR represses sporulation, which only occurs in response to adverse conditions. This provides a possible evolutionary link between the two adaptive responses of bacterial sporulation and prophage induction.Other DNA-binding domains also display similar structural folds to that of Lambda C1. These include bacterial regulators such as the purine repressor (PurR), the lactose repressor (Lacr) and the fructose repressor (FruR), each of which has an N-terminal DNA-binding domain that exhibits a fold similar to that of lambda C1, except that they lack the first helix [, , ]. POU-specific domains found in transcription factors such as in Oct-1, Pit-1 and Hepatocyte nuclear factor 1a (LFB1/HNF1) display four-helical fold DNA-binding domains similar to that of Lambda C1 [, , ]. The N-terminal domain of cyanase has an α-helix bundle motif similar to Lambda C1, but it probably does not bind DNA. Cyanase is an enzyme found in bacteria and plants that catalyses the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide in response to extracellular cyanate [].
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Publication
18354201 | J:133380
First Author: Higashio H
Year: 2008
Journal: J Immunol
Title: Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells.
Volume: 180
Issue: 7
Pages: 4774-84
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Protein
P26450
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: false
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Protein
Q3TP23
Organism: Mus musculus/domesticus
Length: 106  
Fragment?: true
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Protein
F6VMI1
Organism: Mus musculus/domesticus
Length: 552  
Fragment?: true
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Protein
Q3US86
Organism: Mus musculus/domesticus
Length: 557  
Fragment?: true
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Protein
P70304
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: false
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Protein
F6YXW9
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: true
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Publication
1319994 | -
First Author: Rhee SG
Year: 1992
Journal: J Biol Chem
Title: Regulation of inositol phospholipid-specific phospholipase C isozymes.
Volume: 267
Issue: 18
Pages: 12393-6
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Publication
1335185 | -
First Author: Sternweis PC
Year: 1992
Journal: Trends Biochem Sci
Title: Regulation of phospholipase C by G proteins.
Volume: 17
Issue: 12
Pages: 502-6
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Publication
10619026 | -
First Author: Maesaki R
Year: 1999
Journal: Mol Cell
Title: The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1.
Volume: 4
Issue: 5
Pages: 793-803
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Publication
10520995 | J:57949
First Author: Tamagnone L
Year: 1999
Journal: Cell
Title: Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.
Volume: 99
Issue: 1
Pages: 71-80
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Publication
12829596 | -
First Author: Sanui T
Year: 2003
Journal: Blood
Title: DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1.
Volume: 102
Issue: 8
Pages: 2948-50
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Publication
29617656 | J:263646
First Author: Horiuchi K
Year: 2018
Journal: Cell Rep
Title: Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice.
Volume: 23
Issue: 1
Pages: 143-155
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Publication
22365545 | J:182705
First Author: Choe Y
Year: 2012
Journal: Neuron
Title: A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation.
Volume: 73
Issue: 4
Pages: 698-712
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Publication
19591821 | J:152419
First Author: Mugford JW
Year: 2009
Journal: Dev Biol
Title: High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population.
Volume: 333
Issue: 2
Pages: 312-23
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Publication
26371508 | J:226997
   
First Author: Bebee TW
Year: 2015
Journal: Elife
Title: The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development.
Volume: 4
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Publication
24449835 | J:208341
First Author: Seth A
Year: 2014
Journal: Development
Title: Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment.
Volume: 141
Issue: 3
Pages: 538-47
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Publication
30104731 | J:267025
First Author: Jung H
Year: 2018
Journal: Nat Neurosci
Title: Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice.
Volume: 21
Issue: 9
Pages: 1218-1228
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Publication
32504627 | J:293793
First Author: Basta JM
Year: 2020
Journal: Dev Biol
Title: The core SWI/SNF catalytic subunit Brg1 regulates nephron progenitor cell proliferation and differentiation.
Volume: 464
Issue: 2
Pages: 176-187
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Publication
16498401 | J:106993
First Author: Briançon N
Year: 2006
Journal: EMBO J
Title: In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping.
Volume: 25
Issue: 6
Pages: 1253-62
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Publication
24335282 | J:212358
First Author: Singh AP
Year: 2014
Journal: Nucleic Acids Res
Title: Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation.
Volume: 42
Issue: 5
Pages: 2958-75
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Publication
30030361 | J:320063
First Author: Signes A
Year: 2018
Journal: Essays Biochem
Title: Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes.
Volume: 62
Issue: 3
Pages: 255-270
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Publication
16964442 | J:112870
First Author: Mager J
Year: 2006
Journal: Mamm Genome
Title: Identification of candidate maternal-effect genes through comparison of multiple microarray data sets.
Volume: 17
Issue: 9
Pages: 941-9
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Publication
34174788 | J:307968
First Author: He Y
Year: 2021
Journal: Aging Cell
Title: Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation.
Volume: 20
Issue: 7
Pages: e13424
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Publication
35512705 | J:325251
First Author: Chen A
Year: 2022
Journal: Cell
Title: Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays.
Volume: 185
Issue: 10
Pages: 1777-1792.e21
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Publication
9422725 | J:45159
First Author: Gramolini AO
Year: 1998
Journal: J Biol Chem
Title: Muscle and neural isoforms of agrin increase utrophin expression in cultured myotubes via a transcriptional regulatory mechanism.
Volume: 273
Issue: 2
Pages: 736-43
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Protein Coding Gene
MGI:88052 | Apob
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
A0A1W2P775
Organism: Mus musculus/domesticus
Length: 712  
Fragment?: true
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Publication
32290105 | J:282558
 
First Author: Collin GB
Year: 2020
Journal: Cells
Title: Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.
Volume: 9
Issue: 4
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Protein Coding Gene
MGI:97370 | Enpp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
- | J:165965
     
First Author: Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource
Year: 2010
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Europhenome
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Protein
Q8C6G4
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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