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Search results 7701 to 7800 out of 8780 for Shh

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Type Details Score
HT Experiment
E-GEOD-14876 | Requirement for Shh and Fox family genes at different stages in sweat gland development (P5)
Series Id: GSE14876
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-14874 | Requirement for Shh and Fox family genes at different stages in sweat gland development (P3)
Series Id: GSE14874
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-14873 | Requirement for Shh and Fox family genes at different stages in sweat gland development (P1)
Series Id: GSE14873
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-14872 | Requirement for Shh and Fox family genes at different stages in sweat gland development (E17.5)
Series Id: GSE14872
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-14871 | Requirement for Shh and Fox family genes at different stages in sweat gland development (E16.5)
Series Id: GSE14871
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-14870 | Requirement for Shh and Fox family genes at different stages in sweat gland development (E15.5)
Series Id: GSE14870
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
21539826 | J:173637
First Author: Horner VL
Year: 2011
Journal: Dev Biol
Title: Disrupted dorsal neural tube BMP signaling in the cilia mutant Arl13b hnn stems from abnormal Shh signaling.
Volume: 355
Issue: 1
Pages: 43-54
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Publication
14623234 | J:86665
First Author: Laurikkala J
Year: 2003
Journal: Dev Biol
Title: Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot.
Volume: 264
Issue: 1
Pages: 91-105
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Publication
18480159 | J:137136
First Author: Blaess S
Year: 2008
Journal: Development
Title: Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling.
Volume: 135
Issue: 12
Pages: 2093-103
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Publication
32112900 | J:286791
 
First Author: Niesen J
Year: 2020
Journal: Cancer Lett
Title: Pik3ca mutations significantly enhance the growth of SHH medulloblastoma and lead to metastatic tumour growth in a novel mouse model.
Volume: 477
Pages: 10-18
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Publication
17164417 | J:117074
First Author: Pummila M
Year: 2007
Journal: Development
Title: Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression.
Volume: 134
Issue: 1
Pages: 117-25
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Publication
19700758 | J:153120
First Author: Sharov AA
Year: 2009
Journal: Am J Pathol
Title: Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways.
Volume: 175
Issue: 3
Pages: 1303-14
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Publication
34104947 | J:317268
First Author: Liu Y
Year: 2021
Journal: Biol Reprod
Title: A high level of KLF12 causes folic acid-resistant neural tube defects by activating the Shh signaling pathway in mice†.
Volume: 105
Issue: 4
Pages: 837-845
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Publication
38093377 | J:349162
First Author: Li X
Year: 2023
Journal: Epigenetics Chromatin
Title: Folate deficiency reduced aberrant level of DOT1L-mediated histone H3K79 methylation causes disruptive SHH gene expression involved in neural tube defects.
Volume: 16
Issue: 1
Pages: 50
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HT Experiment
GSE211701 | Developmental trajectories of thalamic nuclei revealed by single-cell transcriptome profiling and Shh perturbation
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
32169219 | J:352731
First Author: Kvon EZ
Year: 2020
Journal: Cell
Title: Comprehensive In Vivo Interrogation Reveals Phenotypic Impact of Human Enhancer Variants.
Volume: 180
Issue: 6
Pages: 1262-1271.e15
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Publication
33789113 | J:306567
First Author: Dang MT
Year: 2021
Journal: Cell Rep
Title: Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality.
Volume: 34
Issue: 13
Pages: 108917
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Publication
38094249 | J:343426
First Author: Malawsky DS
Year: 2023
Journal: iScience
Title: Chronic AMPK inactivation slows SHH medulloblastoma progression by inhibiting mTORC1 signaling and depleting tumor stem cells.
Volume: 26
Issue: 12
Pages: 108443
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Publication
29996106 | J:271145
First Author: Akgül S
Year: 2018
Journal: Cell Rep
Title: Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma.
Volume: 24
Issue: 2
Pages: 463-478.e5
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Publication
31863004 | J:283843
First Author: Ocasio J
Year: 2019
Journal: Nat Commun
Title: scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy.
Volume: 10
Issue: 1
Pages: 5829
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GO Term
GO:0007224 | smoothened signaling pathway
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Publication
- | J:13913
 
First Author: Sweet HO
Year: 1982
Journal: Mouse News Lett
Title: Hm and Hx are not alleles
Volume: 66
Pages: 66
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GXD Expression
GXD Expression
Probe: MGI:3798170
Assay Type: In situ reporter (knock in)
Annotation Date: 2024-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3648123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7574113
Age: embryonic day 15.5
Image: 1F Cyfip2-lacZ bottom
Note: Authors report colocalization with Shh expression.
Specimen Label: 1F Cyfip2-lacZ bottom
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:3798170
Assay Type: In situ reporter (knock in)
Annotation Date: 2024-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3639223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7574113
Age: embryonic day 15.5
Image: 1F Cyfip2-lacZ top
Note: Authors report colocalization with Shh expression.
Specimen Label: 1F Cyfip2-lacZ top
Detected: true
Specimen Num: 1
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Publication
34399854 | J:310473
First Author: Gao FJ
Year: 2021
Journal: Acta Neuropathol Commun
Title: Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermates.
Volume: 9
Issue: 1
Pages: 137
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Interaction Experiment
Galli A (2010)
Description: Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development.
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Protein
Q62226
Organism: Mus musculus/domesticus
Length: 437  
Fragment?: false
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Publication
21664577 | J:173603
First Author: Izzi L
Year: 2011
Journal: Dev Cell
Title: Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation.
Volume: 20
Issue: 6
Pages: 788-801
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Publication
10433919 | J:56563
First Author: Sasaki H
Year: 1999
Journal: Development
Title: Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling.
Volume: 126
Issue: 17
Pages: 3915-24
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Genotype
Genotype
Symbol: Disp1/Disp1 Shh/Shh<+>
Background: involves: 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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DO Term
DOID:0110875 | holoprosencephaly 3
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Publication
28710291 | J:320682
First Author: Amano T
Year: 2017
Journal: G3 (Bethesda)
Title: Two Types of Etiological Mutation in the Limb-Specific Enhancer of Shh.
Volume: 7
Issue: 9
Pages: 2991-2998
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Publication
27773569 | J:345259
First Author: Leal F
Year: 2016
Journal: Curr Biol
Title: Loss and Re-emergence of Legs in Snakes by Modular Evolution of Sonic hedgehog and HOXD Enhancers.
Volume: 26
Issue: 21
Pages: 2966-2973
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HT Experiment
E-MTAB-10207 | GAS1 is required for Notch-dependent facilitation of SHH signalling in forebrain development
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE155851 | The Neocortical Progenitor Specification Program Is Established through Combined Modulation of SHH and FGF Signaling
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE159941 | Onset of taste cell renewal starts at birth and coincides with a shift in SHH function
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE183532 | Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling [RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Sample
GSM279675 1
Organism Name: mouse, laboratory
Sex: Pooled
Age: embryonic day 11.5
Stage: 19
Structure . Name: forelimb bud
Notes: sample of phenotypically wild-type forelimbs (mixture of Shh +/+ and Shh +/-)
Curation Status: Curated
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HT Sample
GSM279676 1
Organism Name: mouse, laboratory
Sex: Pooled
Age: embryonic day 11.5
Stage: 19
Structure . Name: forelimb bud
Notes: sample of phenotypically wild-type forelimbs (mixture of Shh +/+ and Shh +/-)
Curation Status: Curated
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HT Sample
GSM279677 1
Organism Name: mouse, laboratory
Sex: Pooled
Age: embryonic day 11.5
Stage: 19
Structure . Name: forelimb bud
Notes: sample of phenotypically wild-type forelimbs (mixture of Shh +/+ and Shh +/-)
Curation Status: Curated
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HT Sample
GSM279678 1
Organism Name: mouse, laboratory
Sex: Pooled
Age: embryonic day 11.5
Stage: 19
Structure . Name: forelimb bud
Notes: sample of phenotypically wild-type forelimbs (mixture of Shh +/+ and Shh +/-)
Curation Status: Curated
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GXD Expression
GXD Expression
 
Probe: MGI:6202368
Assay Type: Immunohistochemistry
Annotation Date: 2018-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6202410
Age: embryonic day 10.5
Note: Pifo expression was detected in regions of high Shh activity.
Specimen Label: S4B
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:1329444
Assay Type: RNA in situ
Annotation Date: 2002-10-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1678117
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:2388194
Age: embryonic day 10.5
Image: 2A,B
Note: Expression overlaps with Shh expression (see assay MGI:2388203).
Specimen Label: 2A,B
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
Probe: MGI:6404228
Assay Type: RNA in situ
Annotation Date: 2020-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:6404387
Age: embryonic day 11.5
Image: 1F
Note: Expression reduced in anterior-most region where Shh is ectopically expressed.
Specimen Label: 1F
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:7258443
Assay Type: RNA in situ
Annotation Date: 2022-04-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:7258467
Age: embryonic day 11.5
Image: 4D
Note: Expression in cells adjacent to Shh expression domain.
Specimen Label: 4D
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:7258444
Assay Type: RNA in situ
Annotation Date: 2022-04-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:7258469
Age: embryonic day 11.5
Image: 4G
Note: Expression in cells adjacent to Shh expression domain.
Specimen Label: 4G
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:3526027
Assay Type: Immunohistochemistry
Annotation Date: 2005-02-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672820
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3526070
Age: embryonic day 12.5
Image: 1c
Note: Authors report less severe hypoplasia compared with Shh -/- lungs
Specimen Label: 1c
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:3526027
Assay Type: Immunohistochemistry
Annotation Date: 2005-02-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672821
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3526070
Age: embryonic day 13.5
Image: 1f
Note: Authors report less severe hypoplasia compared with Shh -/- lungs
Specimen Label: 1f
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:3526043
Assay Type: RNA in situ
Annotation Date: 2005-02-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:3526098
Age: embryonic day 15.5
Image: 5Bf
Note: Transcript levels are relatively higher than in Shh -/- lungs.
Specimen Label: 5Bf
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:3526044
Assay Type: RNA in situ
Annotation Date: 2005-02-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:3526099
Age: embryonic day 15.5
Image: 5Bi
Note: Transcript levels are relatively higher than in Shh -/- lungs.
Specimen Label: 5Bi
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:1329444
Assay Type: RNA in situ
Annotation Date: 2002-10-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270519
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:2388194
Age: embryonic day 11.5
Note: Expression remains distinct from that of Shh (see assay MGI:2388203).
Specimen Label: Not shown
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
Probe: MGI:6392058
Assay Type: Immunohistochemistry
Annotation Date: 2020-02-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689615
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:6392060
Age: embryonic day 9.5
Image: S3A/D/E
Note: In dorsomedial terminal hypothalamus, co-expression with Shh at hypothalamic midline.
Specimen Label: S3A/D/E
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6392058
Assay Type: Immunohistochemistry
Annotation Date: 2020-02-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689615
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:6392060
Age: embryonic day 9.5
Image: S3F/I/J
Note: In dorsomedial terminal hypothalamus, co-expression with Shh at hypothalamic midline.
Specimen Label: S3F/I/J
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:6392058
Assay Type: Immunohistochemistry
Annotation Date: 2020-02-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6392060
Age: embryonic day 10.5
Image: S4A/D/E
Note: In dorsomedial terminal hypothalamus, co-expression with Shh at hypothalamic midline.
Specimen Label: S4A/D/E
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:6392058
Assay Type: Immunohistochemistry
Annotation Date: 2020-02-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6392060
Age: embryonic day 10.5
Image: S4F/I/J
Note: In dorsomedial terminal hypothalamus, co-expression with Shh at hypothalamic midline.
Specimen Label: S4F/I/J
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
Probe: MGI:6885872
Assay Type: RNA in situ
Annotation Date: 2022-03-03
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1894928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6885883
Age: postnatal adult
Image: 6I/K
Note: Strong expression in basal cells, overlapping with Shh expression.
Specimen Label: 6I/K
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:6404228
Assay Type: RNA in situ
Annotation Date: 2020-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1677919
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:6404387
Age: embryonic day 11.5
Image: S1F
Note: Expression reduced in anterior-most region where Shh is ectopically expressed.
Specimen Label: S1F
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:7287685
Assay Type: RNA in situ
Annotation Date: 2022-06-23
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1736420
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:7287694
Age: embryonic day 12.5
Note: Expressed in condensed mesenchyme adjacent to regions of Shh expression.
Specimen Label: 2D
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7287685
Assay Type: RNA in situ
Annotation Date: 2022-06-23
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1736421
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:7287694
Age: embryonic day 13.5
Note: Expressed in condensed mesenchyme adjacent to regions of Shh expression.
Specimen Label: 2E
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7287685
Assay Type: RNA in situ
Annotation Date: 2022-06-23
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1736420
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:7287694
Age: embryonic day 12.5
Note: Expressed in condensed mesenchyme adjacent to regions of Shh expression.
Specimen Label: 4A
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:6202368
Assay Type: Immunohistochemistry
Annotation Date: 2018-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6202410
Age: embryonic day 10.5
Note: Pifo expression was detected in regions of high Shh activity.
Specimen Label: S4D
Detected: true
Specimen Num: 7
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Regulatory Region
MGI:6836729 | Rr115
Type: enhancer
Organism: mouse, laboratory
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Publication
29330329 | J:257769
First Author: Paliou C
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Large genomic insertion at the Shh locus results in hammer toes through enhancer adoption.
Volume: 115
Issue: 5
Pages: 839-841
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Publication
- | J:133634
     
First Author: RIKEN BioResource Center/RIKEN Genomic Sciences Center
Year: 2008
Journal: PhenoSITE, World Wide Web (URL: http://www.brc.riken.jp/lab/gsc/mouse/)
Title: A Large Scale Mutagenesis Program in RIKEN GSC
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Regulatory Region
MGI:5499537 | Rr29
Type: enhancer
Organism: mouse, laboratory
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Publication
- | J:13476
 
First Author: Dickie MM
Year: 1968
Journal: Mouse News Lett
Title: Hemimelic extra toes, Hx
Volume: 38
Pages: 24
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HT Experiment
GSE114252 | SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds [RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Regulatory Region
MGI:6117281 | Rr45
Type: enhancer
Organism: mouse, laboratory
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Allele
Del(5Rr78-Rr116)2Tshir | MGI:6470875
Name: deletion, Chr 5, Toshihiko Shiroishi 2
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Allele
Shh<em1(cre/ERT2)Smoc> | MGI:6758052
Name: sonic hedgehog; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
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Allele
Shh<em2(icre)Smoc> | MGI:6758053
Name: sonic hedgehog; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Recombinase, Reporter
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Allele
Del(5Rr459-Rr114)4Tshir | MGI:7530808
Name: deletion, Chr 5, Toshihiko Shiroishi 4
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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GXD Expression
GXD Expression
 
Probe: MGI:3613644
Assay Type: RNA in situ
Annotation Date: 2024-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1675717
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:7703743
Age: embryonic day 10.5
Note: Close association of Hhip and Shh expression maintained in caudal region at tail bud stages.
Specimen Label: 3d
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6404229
Assay Type: RNA in situ
Annotation Date: 2020-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:6404389
Age: embryonic day 11.5
Image: 1H
Note: Expression barely detectable in anterior-most region where Shh is ectopically expressed.
Specimen Label: 1H
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:1332585
Assay Type: RNA in situ
Annotation Date: 1999-03-25
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1614013
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:1332605
Age: embryonic day 8.5
Note: The ventral boundary of Gli expression apparently coincides with the Shh boundary.
Specimen Label: not shown
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:3526039
Assay Type: RNA in situ
Annotation Date: 2005-02-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672820
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3526091
Age: embryonic day 12.5
Image: 5Ai
Note: Relatively higher expression compared to Shh -/-; not as high as in wild-type.
Specimen Label: 5Ai
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:3526040
Assay Type: RNA in situ
Annotation Date: 2005-02-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672820
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3526092
Age: embryonic day 12.5
Image: 5Al
Note: Relatively higher expression compared to Shh -/-; not as high as in wild-type.
Specimen Label: 5Al
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:3526040
Assay Type: RNA in situ
Annotation Date: 2005-02-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:3526092
Age: embryonic day 15.5
Image: 5Bc
Note: Transcript levels are relatively higher than in Shh -/- lungs; not as high as in wild-type.
Specimen Label: 5Bc
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:6283459
Assay Type: RNA in situ
Annotation Date: 2019-03-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6283549
Age: embryonic day 10.5
Note: Expressed in the zona limitans intrathalamica. Within the regions in which Shh was expressed.
Specimen Label: 9E
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6283460
Assay Type: RNA in situ
Annotation Date: 2019-03-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6283513
Age: embryonic day 10.5
Note: Expressed in the zona limitans intrathalamica. Within the regions in which Shh was expressed.
Specimen Label: 9D
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
Probe: MGI:3034142
Assay Type: Immunohistochemistry
Annotation Date: 2005-02-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286621
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:3526072
Age: embryonic day 13.5
Image: 4Ac
Note: Expression appears to be enhanced in both epithelium and mesenchyme, compared with Shh -/-.
Specimen Label: 4Ac
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:1328239
Assay Type: Immunohistochemistry
Annotation Date: 2005-02-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:3526078
Age: embryonic day 15.5
Image: 6Ac
Note: Pecam1-positive cells in the interstitial mesenchyme are enhanced compared with Shh -/- lungs.
Specimen Label: 6Ac
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:3526032
Assay Type: Immunohistochemistry
Annotation Date: 2005-02-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:3526079
Age: embryonic day 15.5
Image: 6Ai
Note: Enhanced expression in the interstiial mesenchyme, compared with Shh -/- lungs.
Specimen Label: 6Ai
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:1277646
Assay Type: RNA in situ
Annotation Date: 2012-11-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647017
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5441016
Age: embryonic day 10.5
Image: 1J
Note: Expression flanks the floor plate where Shh is expressed. Expression is strongest at the posterior end.
Specimen Label: 1J
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:1277656
Assay Type: RNA in situ
Annotation Date: 2012-11-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647017
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5441022
Age: embryonic day 10.5
Image: 1K
Note: Expression flanks the floor plate where Shh is expressed. Expression is strongest at the posterior end.
Specimen Label: 1K
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:6303779
Assay Type: Immunohistochemistry
Annotation Date: 2024-06-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3638620
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:7645347
Age: embryonic day 11.5
Image: 2i
Note: Shh KO mice showed genital tubercle agenesis, but Trp63 was still expressed in such epithelia.
Specimen Label: 2i
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6303779
Assay Type: Immunohistochemistry
Annotation Date: 2024-06-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1683220
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:7645347
Age: embryonic day 11.5
Image: 2i
Note: Shh KO mice showed genital tubercle agenesis, but Trp63 was still expressed in such epithelia.
Specimen Label: 2i
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:1329444
Assay Type: RNA in situ
Annotation Date: 2002-10-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640817
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:2388194
Age: embryonic day 10.5
Image: 2C
Note: The expression domain is proximally restricted and separate from Shh expression (see assay MGI:2388203).
Specimen Label: 2C
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:3613644
Assay Type: RNA in situ
Annotation Date: 2024-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3116917
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:7703743
Age: embryonic day 10.5
Note: Close association of Hhip and Shh expression maintained in caudal region at tail bud stages.
Specimen Label: 3d
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1332585
Assay Type: RNA in situ
Annotation Date: 1999-03-25
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1614413
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:1332605
Age: embryonic day 8.5
Note: The ventral boundary of Gli expression apparently coincides with the Shh boundary.
Specimen Label: not shown
Detected: true
Specimen Num: 3
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•
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GXD Expression
GXD Expression
Probe: MGI:4838601
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1894922
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6885891
Age: embryonic day 14.5
Image: 10E/G
Note: Expression in nerve fibers touching basement membrane of a few cells clusters with high Shh expression.
Specimen Label: 10E/G
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:3034142
Assay Type: Immunohistochemistry
Annotation Date: 2005-02-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286021
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:3526072
Age: embryonic day 13.5
Image: 4Ac
Note: Expression appears to be enhanced in both epithelium and mesenchyme, compared with Shh -/-.
Specimen Label: 4Ac
Detected: true
Specimen Num: 3
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•
•
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GXD Expression
GXD Expression
Probe: MGI:5287686
Assay Type: RNA in situ
Annotation Date: 2023-04-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3660420
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:7461456
Age: embryonic day 12.5
Image: 11M/O
Note: Expression was slightly narrower than that of Shh within the ZLI and was centered caudally.
Specimen Label: 11M/O
Detected: true
Specimen Num: 17
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GXD Expression
GXD Expression
Probe: MGI:4461919
Assay Type: RNA in situ
Annotation Date: 2010-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4461955
Age: embryonic day 10.5
Image: 4B Tectonic-/- Shh-/-
Note: Expression was increased in the Tcnt1/Shh double mutant compared to the Shh single mutant.
Specimen Label: 4B Tectonic-/- Shh-/-
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:4461972
Assay Type: RNA in situ
Annotation Date: 2010-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4461975
Age: embryonic day 10.5
Image: 4D Tectonic-/- Shh-/-
Note: Expression in the Tcnt1/Shh double mutant was higher than in the Shh single mutant.
Specimen Label: 4D Tectonic-/- Shh-/-
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:1277646
Assay Type: RNA in situ
Annotation Date: 1998-12-10
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1677918
Pattern: Graded
Stage: TS18
Assay Id: MGI:1314737
Age: embryonic day 11.0
Image: 6e
Note: Gli expression is highest in cells close to the Shh domain.
Specimen Label: 6e
Detected: true
Specimen Num: 1
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•
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GXD Expression
GXD Expression
Probe: MGI:1277646
Assay Type: RNA in situ
Annotation Date: 1998-12-10
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1677918
Pattern: Graded
Stage: TS18
Assay Id: MGI:1314737
Age: embryonic day 11.0
Image: 6f
Note: Gli expression is highest in cells close to the Shh domain.
Specimen Label: 6f
Detected: true
Specimen Num: 2
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•
•
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•
GXD Expression
GXD Expression
Probe: MGI:6404229
Assay Type: RNA in situ
Annotation Date: 2020-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1677919
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:6404389
Age: embryonic day 11.5
Image: S1H
Note: Expression barely detectable in anterior-most region where Shh is ecoptically expressed.
Specimen Label: S1H
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
Probe: MGI:3833867
Assay Type: RNA in situ
Annotation Date: 2009-02-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752521
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:3833903
Age: embryonic day 13.5
Image: 5A
Note: Expression in hair and whisker follicles, in rings surrounding a central domain of Shh expression.
Specimen Label: 5A
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
Probe: MGI:3833867
Assay Type: RNA in situ
Annotation Date: 2009-02-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2672021
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:3833903
Age: embryonic day 13.5
Image: 5A
Note: Expression in hair and whisker follicles, in rings surrounding a central domain of Shh expression.
Specimen Label: 5A
Detected: true
Specimen Num: 12
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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