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Search results 7801 to 7900 out of 8285 for C2

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Type Details Score
Publication
36070687 | J:328554
First Author: Wei X
Year: 2022
Journal: Cell Rep
Title: Ablating Lgr5-expressing prostatic stromal cells activates the ERK-mediated mechanosensory signaling and disrupts prostate tissue homeostasis.
Volume: 40
Issue: 10
Pages: 111313
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Publication
15033168 | J:107647
First Author: Thuret S
Year: 2004
Journal: Mol Cell Neurosci
Title: Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta.
Volume: 25
Issue: 3
Pages: 394-405
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Publication
22323595 | J:181994
First Author: Kamileri I
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria.
Volume: 109
Issue: 8
Pages: 2995-3000
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Publication
- | J:175295
     
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
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Protein
Q6DFY8
Organism: Mus musculus/domesticus
Length: 783  
Fragment?: false
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Protein
Q920P3
Organism: Mus musculus/domesticus
Length: 760  
Fragment?: false
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Protein
Q9JMG1
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: false
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Protein
A1L314
Organism: Mus musculus/domesticus
Length: 713  
Fragment?: false
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Protein
Q5RKV8
Organism: Mus musculus/domesticus
Length: 702  
Fragment?: false
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Protein
A0A668KL63
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: true
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Protein
Q61223
Organism: Mus musculus/domesticus
Length: 46  
Fragment?: true
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Protein
A0A668KL79
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: true
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Protein
B1AQT5
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: true
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Protein
H3BKT3
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: true
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Protein
A0A0A6YWU9
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: false
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Protein
Q9CSW6
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: true
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Protein
E9QN37
Organism: Mus musculus/domesticus
Length: 720  
Fragment?: false
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Protein
Q9JI82
Organism: Mus musculus/domesticus
Length: 752  
Fragment?: false
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Protein
H3BKV6
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: true
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Publication
15234264 | -
First Author: Anthony C
Year: 2004
Journal: Arch Biochem Biophys
Title: The quinoprotein dehydrogenases for methanol and glucose.
Volume: 428
Issue: 1
Pages: 2-9
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Publication
10801492 | -
First Author: Walsh MA
Year: 2000
Journal: Structure
Title: Structure of cyanase reveals that a novel dimeric and decameric arrangement of subunits is required for formation of the enzyme active site.
Volume: 8
Issue: 5
Pages: 505-14
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Publication
9514739 | -
First Author: Papageorgiou AC
Year: 1998
Journal: J Mol Biol
Title: Crystal structure of microbial superantigen staphylococcal enterotoxin B at 1.5 A resolution: implications for superantigen recognition by MHC class II molecules and T-cell receptors.
Volume: 277
Issue: 1
Pages: 61-79
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Publication
12388743 | -
First Author: Whittaker CA
Year: 2002
Journal: Mol Biol Cell
Title: Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere.
Volume: 13
Issue: 10
Pages: 3369-87
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Publication
10830113 | -
First Author: Tuckwell D
Year: 1999
Journal: Biochem Soc Trans
Title: Evolution of von Willebrand factor A (VWA) domains.
Volume: 27
Issue: 6
Pages: 835-40
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Publication
14592531 | -
First Author: Lo SH
Year: 2004
Journal: Int J Biochem Cell Biol
Title: Tensin.
Volume: 36
Issue: 1
Pages: 31-4
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Publication
26001273 | -
   
First Author: Gatta AT
Year: 2015
Journal: Elife
Title: A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport.
Volume: 4
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Protein Domain
IPR022682 | Calpain_domain_III
Type: Domain
Description: This group of cysteine peptidases belong to the MEROPS peptidase family C2 (calpain family, clan CA). A type example is calpain, which is an intracellular protease involved in many important cellular functions that are regulated by calcium [, ]. The protein is a complex of 2 polypeptide chains (light and heavy), with eleven known active peptidases in humans and two non-peptidase homologues known as calpamodulin and androglobin []. These include a highly calcium-sensitive (i.e., micro-molar range) form known as mu-calpain, mu-CANP or calpain I; a form sensitive to calcium in the milli-molar range, known as m-calpain, m-CANP or calpain II; and a third form, known as p94, which is found in skeletal muscle only [].All forms have identical light but different heavy chains. Both mu- and m-calpain are heterodimers containing an identical 28kDa subunit and an 80kDa subunit that shares 55-65% sequence homology between the two proteases [, ]. The crystallographic structure of m-calpain reveals six "domains"in the 80kDa subunit [, ]: A 19-amino acid NH2-terminal sequence;Active site domain IIa;Active site domain IIb. Domain 2 showslow levels of sequence similarity to papain; although the catalytic His hasnot been located by biochemical means, it is likely that calpain and papainare related [].Domain III;An 18-amino acid extended sequence linking domain III to domain IV;Domain IV, which resembles the penta EF-hand family of polypeptides, binds calcium and regulates activity []. Ca2+-binding causes a rearrangement of the protein backbone, the net effect of which is that a Trp side chain, which acts as a wedge between catalytic domains IIa and IIb in the apo state, moves away from the active site cleft allowing for the proper formation of the catalytic triad []. Calpain-like mRNAs have been identified in other organisms including bacteria, but the molecules encoded by these mRNAs have not been isolated, so little is known about their properties. How calpain activity is regulated in these organisms cells is still unclear In metazoans, the activity of calpain is controlled by a single proteinase inhibitor, calpastatin (). The calpastatin gene can produce eight or more calpastatin polypeptides ranging from 17 to 85kDa by use of different promoters and alternative splicing events. The physiological significance of these different calpastatins is unclear, although all bind to three different places on the calpain molecule; binding to at least two of the sites is Ca2+ dependent. The calpains ostensibly participate in a variety of cellular processes including remodelling of cytoskeletal/membrane attachments, different signal transduction pathways, and apoptosis. Deregulated calpain activity following loss of Ca2+ homeostasis results in tissue damage in response to events such as myocardial infarcts, stroke, and brain trauma []. This entry represents domain III. The function of the domain III and I are currently unknown. Domain II is a cysteine protease and domain IV is a calcium binding domain. Calpains are believed to participate in intracellular signaling pathways mediated by calcium ions.
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Protein
Q8VCC9
Organism: Mus musculus/domesticus
Length: 807  
Fragment?: false
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Protein
Q6BCW3
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: true
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Protein
Q3UAS8
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: true
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Protein
Q69ZZ7
Organism: Mus musculus/domesticus
Length: 729  
Fragment?: true
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Protein
Q6A088
Organism: Mus musculus/domesticus
Length: 333  
Fragment?: true
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Publication
17717151 | -
First Author: Rosado CJ
Year: 2007
Journal: Science
Title: A common fold mediates vertebrate defense and bacterial attack.
Volume: 317
Issue: 5844
Pages: 1548-51
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Publication
33915109 | J:305565
     
First Author: Devi S
Year: 2021
Journal: Immunity
Title: Adrenergic regulation of the vasculature impairs leukocyte interstitial migration and suppresses immune responses.
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Publication
9396712 | J:45058
 
First Author: Sorimachi H
Year: 1997
Journal: Biochem J
Title: Structure and physiological function of calpains.
Volume: 328 ( Pt 3)
Pages: 721-32
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Publication
2555341 | -
First Author: Sorimachi H
Year: 1989
Journal: J Biol Chem
Title: Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and mu-types. Specific expression of the mRNA in skeletal muscle.
Volume: 264
Issue: 33
Pages: 20106-11
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Publication
2539381 | -
First Author: Hata A
Year: 1989
Journal: J Biol Chem
Title: Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium-dependent protease.
Volume: 264
Issue: 11
Pages: 6404-11
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Publication
11914728 | -
First Author: Khorchid A
Year: 2002
Journal: Nat Struct Biol
Title: How calpain is activated by calcium.
Volume: 9
Issue: 4
Pages: 239-41
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Publication
11328585 | -
First Author: Sorimachi H
Year: 2001
Journal: J Biochem
Title: The structure of calpain.
Volume: 129
Issue: 5
Pages: 653-64
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Publication
11517928 | -
First Author: Reverter D
Year: 2001
Journal: Biol Chem
Title: Structural basis for possible calcium-induced activation mechanisms of calpains.
Volume: 382
Issue: 5
Pages: 753-66
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Publication
21864727 | -
First Author: Ono Y
Year: 2012
Journal: Biochim Biophys Acta
Title: Calpains: an elaborate proteolytic system.
Volume: 1824
Issue: 1
Pages: 224-36
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Publication
17114649 | J:187362
First Author: Munton RP
Year: 2007
Journal: Mol Cell Proteomics
Title: Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.
Volume: 6
Issue: 2
Pages: 283-93
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Protein
Q9R1S8
Organism: Mus musculus/domesticus
Length: 813  
Fragment?: false
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Protein
Q3U1I0
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
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Publication
29688375 | J:250512
   
First Author: Li J
Year: 2018
Journal: Database (Oxford)
Title: CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice.
Volume: 2018
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Protein
Q9ESK3
Organism: Mus musculus/domesticus
Length: 666  
Fragment?: false
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Protein
Q6J756
Organism: Mus musculus/domesticus
Length: 714  
Fragment?: false
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Protein
Q91VA3
Organism: Mus musculus/domesticus
Length: 703  
Fragment?: false
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Protein
D6RGR0
Organism: Mus musculus/domesticus
Length: 507  
Fragment?: false
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Protein
Q3UF24
Organism: Mus musculus/domesticus
Length: 543  
Fragment?: true
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Protein
Q8R486
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: true
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Protein
A0A0A6YVU9
Organism: Mus musculus/domesticus
Length: 690  
Fragment?: false
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Protein
A0A0R4J0K6
Organism: Mus musculus/domesticus
Length: 703  
Fragment?: false
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HT Experiment
GSE110284 | Developmental spatial transcriptome for the molecular annotation of germ layer formation and the acquisition of tissue lineage attributes of post-implantation mouse embryo
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Protein
Q05DG3
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
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Protein
A0A0A0MQJ1
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: false
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Protein
G3UXP4
Organism: Mus musculus/domesticus
Length: 513  
Fragment?: false
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Protein
Q99MT5
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: true
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Protein
B8JJM3
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: true
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Protein
F6W2T4
Organism: Mus musculus/domesticus
Length: 259  
Fragment?: true
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Protein
D6RGN2
Organism: Mus musculus/domesticus
Length: 574  
Fragment?: false
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Publication
12151228 | -
First Author: Djordjevic S
Year: 2002
Journal: Trends Biochem Sci
Title: Structural insight into substrate specificity and regulatory mechanisms of phosphoinositide 3-kinases.
Volume: 27
Issue: 8
Pages: 426-32
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Publication
10600388 | -
First Author: Craik DJ
Year: 1999
Journal: J Mol Biol
Title: Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif.
Volume: 294
Issue: 5
Pages: 1327-36
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Publication
12946412 | -
First Author: Svangård E
Year: 2003
Journal: Phytochemistry
Title: Primary and 3-D modelled structures of two cyclotides from Viola odorata.
Volume: 64
Issue: 1
Pages: 135-42
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Publication
12482868 | -
First Author: Rosengren KJ
Year: 2003
Journal: J Biol Chem
Title: Twists, knots, and rings in proteins. Structural definition of the cyclotide framework.
Volume: 278
Issue: 10
Pages: 8606-16
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Publication
12482862 | -
First Author: Daly NL
Year: 2003
Journal: J Biol Chem
Title: Disulfide folding pathways of cystine knot proteins. Tying the knot within the circular backbone of the cyclotides.
Volume: 278
Issue: 8
Pages: 6314-22
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Publication
21596752 | -
First Author: Nguyen GK
Year: 2011
Journal: J Biol Chem
Title: Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family.
Volume: 286
Issue: 27
Pages: 24275-87
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Publication
10512203 | J:93290
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
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Publication
15840001 | J:110088
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
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Publication
15145078 | J:91381
First Author: Bouwman J
Year: 2004
Journal: Neuroscience
Title: Quantification of synapse formation and maintenance in vivo in the absence of synaptic release.
Volume: 126
Issue: 1
Pages: 115-26
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Publication
- | J:38088
First Author: Sanders S
Year: 1996
Journal: Mouse Genome
Title: A Glucose-6-Phosphate Dehydrogenase (G6PD) pseudogene in the Mouse
Volume: 94
Issue: 4
Pages: 880-882
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Protein
Q3UW68
Organism: Mus musculus/domesticus
Length: 665  
Fragment?: false
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Protein
Q91W69
Organism: Mus musculus/domesticus
Length: 636  
Fragment?: false
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Protein
Q499E0
Organism: Mus musculus/domesticus
Length: 766  
Fragment?: false
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Protein
Q6PD24
Organism: Mus musculus/domesticus
Length: 605  
Fragment?: false
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Protein
Q8K0L0
Organism: Mus musculus/domesticus
Length: 634  
Fragment?: false
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Protein
Q80UP5
Organism: Mus musculus/domesticus
Length: 588  
Fragment?: false
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Protein
Q5F259
Organism: Mus musculus/domesticus
Length: 626  
Fragment?: false
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Protein
P70298
Organism: Mus musculus/domesticus
Length: 1426  
Fragment?: false
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Protein
O08755
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
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Protein
B9EJ80
Organism: Mus musculus/domesticus
Length: 1147  
Fragment?: false
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Protein
Q80VP1
Organism: Mus musculus/domesticus
Length: 575  
Fragment?: false
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Protein
P53564
Organism: Mus musculus/domesticus
Length: 1515  
Fragment?: false
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Protein
Q8CHU3
Organism: Mus musculus/domesticus
Length: 595  
Fragment?: false
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Protein
Q8K557
Organism: Mus musculus/domesticus
Length: 490  
Fragment?: false
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Protein
Q6XBJ3
Organism: Mus musculus/domesticus
Length: 505  
Fragment?: false
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Protein
Q9WTM3
Organism: Mus musculus/domesticus
Length: 931  
Fragment?: false
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Protein
Q5U5Q9
Organism: Mus musculus/domesticus
Length: 727  
Fragment?: false
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Protein
O35226
Organism: Mus musculus/domesticus
Length: 376  
Fragment?: false
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Protein
Q5NCM6
Organism: Mus musculus/domesticus
Length: 577  
Fragment?: false
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Protein
E9Q577
Organism: Mus musculus/domesticus
Length: 727  
Fragment?: false
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Protein
B7UCC5
Organism: Mus musculus/domesticus
Length: 87  
Fragment?: true
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Protein
E9Q613
Organism: Mus musculus/domesticus
Length: 963  
Fragment?: false
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Protein
Q3V2M8
Organism: Mus musculus/domesticus
Length: 460  
Fragment?: false
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Protein
H3BK24
Organism: Mus musculus/domesticus
Length: 1504  
Fragment?: false
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Protein
Q5BL05
Organism: Mus musculus/domesticus
Length: 1426  
Fragment?: false
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Protein
J3QNT7
Organism: Mus musculus/domesticus
Length: 640  
Fragment?: false
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Protein
Q9CY29
Organism: Mus musculus/domesticus
Length: 370  
Fragment?: false
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Protein
E9QKE9
Organism: Mus musculus/domesticus
Length: 1426  
Fragment?: false
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Protein
Q3U0V3
Organism: Mus musculus/domesticus
Length: 588  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom