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Search results 7901 to 8000 out of 8780 for Shh

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Type Details Score
GXD Expression
GXD Expression
Probe: MGI:5774792
Assay Type: RNA in situ
Annotation Date: 2016-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614015
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:5774800
Age: embryonic day 9.5
Image: 1G
Note: Expression is located laterally to the Shh-expressing cells. Expression is largely absent in the Shh-expressing domain. There was some overlap between Shh and Gli1 expression at their domain boundaries (low expression).
Specimen Label: 1G
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7664630
Assay Type: RNA in situ
Annotation Date: 2024-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1794323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7664635
Age: embryonic day 15.5
Image: 2CC
Note: Expression throughout internal and external dental epithelium. Strongest expression within internal dental epithelium, extending behond range of Shh expression, particularly on buccal side. Weak expression within external dental epithelium.
Specimen Label: 2CC
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7734702
Assay Type: Immunohistochemistry
Annotation Date: 2024-10-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616415
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:7734742
Age: embryonic day 9.5
Image: 7A Smo
Note: The cilia in the ventral neural tube, where Shh levels are the highest, are prominently stained; those in the dorsal neural tube, where levels of Shh are low, are not.
Specimen Label: 7A Smo
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:7734703
Assay Type: Immunohistochemistry
Annotation Date: 2024-10-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616415
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:7734748
Age: embryonic day 9.5
Image: S9B Smo
Note: The cilia in the ventral neural tube, where Shh levels are the highest, are prominently stained; those in the dorsal neural tube, where levels of Shh are low, are not. Expression levels are quantified in Fig. 7A.
Specimen Label: S9B Smo
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:7734702
Assay Type: Immunohistochemistry
Annotation Date: 2024-10-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1616415
Stage: TS15
Assay Id: MGI:7734742
Age: embryonic day 9.5
Image: S9A Smo
Note: The cilia in the ventral neural tube, where Shh levels are the highest, are prominently stained; those in the dorsal neural tube, where levels of Shh are low, are not.
Specimen Label: S9A Smo
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:1278428
Assay Type: Immunohistochemistry
Annotation Date: 2018-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609217
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6202100
Age: embryonic day 10.5
Image: 6A
Note: Expression was detected in the ventral midline, where it colocalized with Shh in situ hybridization. Low levels of expression were noted in presumptive motor neurons, which do no express Shh.
Specimen Label: 6A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:5641875
Assay Type: RNA in situ
Annotation Date: 2015-06-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5642049
Age: embryonic day 14.5
Image: 6D
Note: Expression was restricted to mesenchyme immediately adjacent to the overlying Shh domain in the rugae. Broad expression was in a posterior domain of the mesenchyme of the presumptive soft palate.
Specimen Label: 6D
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:7664630
Assay Type: RNA in situ
Annotation Date: 2024-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1792223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7664635
Age: embryonic day 15.5
Image: 2DD
Note: Expression throughout internal and external dental epithelium. Strongest expression within internal dental epithelium, extending behond range of Shh expression, particularly on buccal side. Weak expression within external dental epithelium.
Specimen Label: 2DD
Detected: true
Specimen Num: 3
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HT Experiment
E-GEOD-41691 | Early limb bud transcriptome analysis between anterior and posterior domain
Series Id: GSE41691
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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HT Experiment
E-GEOD-78005 | Cis-regulatory architecture of a brain-signaling center predates the origin of chordates
Series Id: GSE78005
Experiment Type: RNA-Seq
Study Type: Baseline
Source: ArrayExpress
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Allele
Hm | MGI:1861096
 
Name: hammer toe; hammertoe
Allele Type: Spontaneous
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Strain
MGI:2684067 | C3.D2-Raz
Attribute String: congenic, mutant stock
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Strain
MGI:4835209 | C3Pas.D2-Raz/Ieg
Attribute String: congenic, chromosome aberration, inversion, mutant strain, radiation induced mutation
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Allele
Tg(Shh-cre)#Dje | MGI:5317189
Name: transgene insertion #, Douglas J Epstein
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Rr29<em1Ezk> | MGI:7711246
Name: regulatory region 29; endonuclease-mediated mutation 1, Evgeny Z Kvon
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Allele
Rr29<em1Axvi> | MGI:7332988
Name: regulatory region 29; endonuclease-mediated mutation 1, Axel Visel
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7367583 | C57BL/6J-Rr115<em1Bobh>
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Rr29<em3Andg> | MGI:7703776
Name: regulatory region 29; endonuclease-mediated mutation 3, Guillaume Andrey
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Allele
Igs2<em1(Rr428-lacZ,-icre)Yzhou> | MGI:7766963
Name: intergenic site 2; endonuclease-mediated mutation 1, Yan Zhou
Allele Type: Endonuclease-mediated
Attribute String: Reporter
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Genotype
Genotype
Symbol: Raz/Raz
Background: C3.D2-Raz
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Raz/Raz<+>
Background: C3.D2-Raz
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr115/Rr115
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hm/Hm<+>
Background: involves: C57BL/6JJcl
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hm/Hm<+>
Background: involves: C57BL/6JJcl
Zygosity: ht
Has Mutant Allele: true
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HT Experiment
E-GEOD-11063 | Expression data from E11.5 mouse embryonic forelimbs - various mutant conditions or dissected limb domains
Series Id: GSE11063
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
8530406 | J:30127
First Author: Kaestner KH
Year: 1995
Journal: J Biol Chem
Title: The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.
Volume: 270
Issue: 50
Pages: 30029-35
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Publication
15231714 | J:91405
First Author: Abdelkhalek HB
Year: 2004
Journal: Genes Dev
Title: The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation.
Volume: 18
Issue: 14
Pages: 1725-36
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Publication
15533813 | J:93513
First Author: Plouhinec JL
Year: 2004
Journal: Gene Expr Patterns
Title: Identification of the mammalian Not gene via a phylogenomic approach.
Volume: 5
Issue: 1
Pages: 11-22
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Publication
23651855 | J:198687
First Author: Nowotschin S
Year: 2013
Journal: Genes Dev
Title: The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo.
Volume: 27
Issue: 9
Pages: 997-1002
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Strain
MGI:5490139 | 129-Foxa2<tm1Jrt>/H
Attribute String: targeted mutation, coisogenic
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Publication
12865419 | J:84920
First Author: Wolfrum C
Year: 2003
Journal: J Clin Invest
Title: Role of Foxa-2 in adipocyte metabolism and differentiation.
Volume: 112
Issue: 3
Pages: 345-56
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Publication
16839541 | J:119304
First Author: Yang YP
Year: 2006
Journal: Dev Biol
Title: Roles of organizer factors and BMP antagonism in mammalian forebrain establishment.
Volume: 296
Issue: 2
Pages: 458-75
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Publication
10498685 | J:53656
First Author: Perea-Gómez A
Year: 1999
Journal: Development
Title: HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo.
Volume: 126
Issue: 20
Pages: 4499-511
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Genotype
Genotype
Symbol: Foxa2/Foxa2
Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Foxa2/Foxa2<+> Nodal/Nodal<+>
Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Foxa2/Foxa2<+>
Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Foxa2/Foxa2<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Foxa2/Foxa2<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Foxa2/Foxa2
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Foxa2/Foxa2
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Foxa2/Foxa2 Gsc/Gsc
Background: involves: 129/Sv * C57BL/6 * CD-1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Foxa2/Foxa2 Gsc/Gsc<+>
Background: involves: 129/Sv * C57BL/6 * CD-1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Foxa2/Foxa2<+> Gsc/Gsc
Background: involves: 129 * C57BL/6 * CD-1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Foxa2/Foxa2<+> Gsc/Gsc<+>
Background: involves: 129 * C57BL/6 * CD-1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Foxa2/Foxa2<+> Nodal/Nodal<+>
Background: involves: 129/Sv * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Foxa2/Foxa2 Lhx1/Lhx1
Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * CD-1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Foxa2/Foxa2
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Foxa2/Foxa2 Nodal/Nodal<+>
Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Protein
A0A1L1SR86
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: true
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Protein
A0A1L1SRJ1
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: true
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Protein Domain
IPR032980 | HHAT-like
Type: Family
Description: Protein-cysteine N-palmitoyltransferase HHAT-like protein, also known as glycerol uptake/transporter homologue (Gup1), negatively regulates the N-terminal palmitoylation of Sonic hedgehog (Shh) by hedgehog acyltransferase (HHAT) Skn []. Shh is a signalling molecule involved in embryonic patterning and organogenesis, and these lipid modifications serve to regulate its movement to form the proper concentration gradient.
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HT Experiment
GSE90480 | The Hippo pathway effector YAP is an essential regulator of submandibular gland ductal progenitor patterning
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE242161 | Morphogen Stimulated Endocytic Recycling Drives Cytoneme Loading for Mammalian Tissue Patterning
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
9825865 | J:50810
First Author: Manova K
Year: 1998
Journal: Dev Dyn
Title: Apoptosis in mouse embryos: elevated levels in pregastrulae and in the distal anterior region of gastrulae of normal and mutant mice.
Volume: 213
Issue: 3
Pages: 293-308
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Genotype
Genotype
Symbol: Foxa2/Foxa2 Tg(Nes-cre)1Wme/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
GSE147178 | DDX3X suppresses neural lineage susceptibility to medulloblastoma [RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE270328 | Anterior and Posterior regions of mouse embryos with combinatory mutations of Fuz and Gpr161
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
9593755 | -
First Author: Pepinsky RB
Year: 1998
Journal: J Biol Chem
Title: Identification of a palmitic acid-modified form of human Sonic hedgehog.
Volume: 273
Issue: 22
Pages: 14037-45
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Publication
25488661 | -
First Author: Matevossian A
Year: 2015
Journal: J Biol Chem
Title: Membrane topology of hedgehog acyltransferase.
Volume: 290
Issue: 4
Pages: 2235-43
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Publication
18534984 | -
First Author: Buglino JA
Year: 2008
Journal: J Biol Chem
Title: Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog.
Volume: 283
Issue: 32
Pages: 22076-88
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Publication
24608521 | -
First Author: Konitsiotis AD
Year: 2014
Journal: PLoS One
Title: Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells.
Volume: 9
Issue: 3
Pages: e89899
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Protein Domain
IPR032981 | HHAT
Type: Family
Description: Protein-cysteine N-palmitoyltransferase, also known as hedgehog acyltransferase (HHAT), catalyses the N-terminal palmitoylation of Sonic hedgehog (Shh) [, , ]. Shh is a signaling molecule involved in embryonic patterning and organogenesis, and these lipid modifications serve to regulate its movement to form the proper concentration gradient. Overexpression of Hedgehog family proteins contributes to the aetiology of many cancers, thus HHAT inhibition is considered a target for tumour growth suppression [].HHAT is a multipass transmembrane enzyme with a membrane-bound O-acyltransferase (MBOAT) homology domain [].
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Strain
MGI:6143848 | B6JJcl.Cg-Hm/TshirMs
Attribute String: congenic, mutant strain, spontaneous mutation
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Strain
MGI:7378686 | B6.Cg-Hm
Attribute String: congenic, mutant strain, spontaneous mutation
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Strain
MGI:5651402 | (C3HeB/FeJLe-Hm/+ x M. m. castaneus)F1
Attribute String: mutant stock
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Strain
MGI:2161327 | NFS.Cg-Hm/J
Attribute String: congenic, mutant strain
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Strain
MGI:3711113 | C3Fe.Cg-Hm
Attribute String: congenic, mutant strain, spontaneous mutation
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Strain
MGI:7608363 | C3FeLe.Cg-Hm
Attribute String: congenic, mutant strain, spontaneous mutation
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Publication
7654334 | J:25744
First Author: Zakeri ZF
Year: 1994
Journal: Biochem Cell Biol
Title: Apoptotic cell death in the limb and its relationship to pattern formation.
Volume: 72
Issue: 11-12
Pages: 603-13
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Publication
- | J:13425
 
First Author: Green MC
Year: 1964
Journal: Mouse News Lett
Title: Hammer-Toe, Hm
Volume: 31
Pages: 27-28
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Publication
15678493 | J:101667
First Author: Kimura S
Year: 2005
Journal: Birth Defects Res A Clin Mol Teratol
Title: Ectopic dermal ridge configurations on the interdigital webbings of Hammertoe mutant mice (Hm): another possible role of programmed cell death in limb development.
Volume: 73
Issue: 2
Pages: 92-102
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Publication
9097019 | J:39336
First Author: Ahuja HS
Year: 1997
Journal: Dev Dyn
Title: Rescue of the limb deformity in hammertoe mutant mice by retinoic acid-induced cell death.
Volume: 208
Issue: 4
Pages: 466-81
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Publication
10967533 | J:64344
First Author: Kimura S
Year: 2000
Journal: Anat Rec
Title: Pads and flexion creases on the plantar surface of hammertoe mutant mouse (Hm).
Volume: 260
Issue: 1
Pages: 26-32
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Publication
8088447 | J:20327
First Author: Zakeri Z
Year: 1994
Journal: Dev Biol
Title: Apoptotic cell death in the mouse limb and its suppression in the hammertoe mutant.
Volume: 165
Issue: 1
Pages: 294-7
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Allele
Tg(UAS-Shh)1Rth | MGI:3047220
Name: transgene insertion 1, David H Rowitch
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Shh)#Dje | MGI:3665473
Name: transgene insertion #, Douglas J Epstein
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Shh<tm1(cre/ERT2)Tshim> | MGI:5294343
Name: sonic hedgehog; targeted mutation 1, Tomomi Shimogori
Allele Type: Targeted
Attribute String: Inducible, Recombinase
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Allele
Tg(Wap-Shh)119Mig | MGI:5645728
Name: transgene insertion 119, Marta I Gallego
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Wap-Shh)186Mig | MGI:5645729
Name: transgene insertion 186, Marta I Gallego
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Shh-cre/ERT2)#aYjg | MGI:5692334
Name: transgene insertion #a, Yongsu Jeong
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Allele
Del(5Rr45-Lmbr1)1Dje | MGI:6836767
Name: deletion, Chr5, Douglas J Epstein 1; deletion, Chr 5, Douglas J Epstein 1
Allele Type: Targeted
Attribute String: Modified regulatory region, Null/knockout
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Allele
Rr29<em2Axvi> | MGI:7334950
Name: regulatory region 29; endonuclease-mediated mutation 2, Axel Visel
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region, Null/knockout
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Allele
Rr29<em3Axvi> | MGI:7334959
Name: regulatory region 29; endonuclease-mediated mutation 3, Axel Visel
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region, Null/knockout
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Allele
Rr29<em4Axvi> | MGI:7334960
Name: regulatory region 29; endonuclease-mediated mutation 4, Axel Visel
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region, Null/knockout
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Allele
Rr29<em5Axvi> | MGI:7334962
Name: regulatory region 29; endonuclease-mediated mutation 5, Axel Visel
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region, Null/knockout
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Genotype
Genotype
Symbol: Hm/Hm<+>
Background: C3Fe.Cg-Hm
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hm/Hm
Background: C3Fe.Cg-Hm
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gas1/Gas1 Shh/Shh<+>
Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gas1/Gas1 Shh/Shh
Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gas1/Gas1<+> Shh/Shh<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gas1/Gas1 Shh/Shh<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ihh/Ihh Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh Tulp3/Tulp3
Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeH * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hm/Hm
Background: involves: C57BL/6JJcl
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hm/Hm<+>
Background: involves: C57BL/6JJcl
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hm/Hm
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Alx4/Alx4 Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ * C3H/FeJLe * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hm/Hm
Background: C3FeLe.Cg-Hm
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hm/Hm
Background: B6.Cg-Hm
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
E-GEOD-19312 | Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair-2
Series Id: GSE19312
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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