| Type |
Details |
Score |
| Publication |
| First Author: |
Tang SC |
| Year: |
2014 |
| Journal: |
Int J Cancer |
| Title: |
Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar. |
| Volume: |
134 |
| Issue: |
6 |
| Pages: |
1484-94 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jiang Z |
| Year: |
2018 |
| Journal: |
Mol Genet Metab |
| Title: |
Delayed development of ossification centers in the tibia of prenatal and early postnatal MPS VII mice. |
| Volume: |
124 |
| Issue: |
2 |
| Pages: |
135-142 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
| Allele |
| Name: |
ALK and LTK ligand 2; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
ALK and LTK ligand 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Alkal2/Alkal2 |
| Background: |
involves: C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Alkal2/Alkal2 |
| Background: |
C57BL/6NJ-Alkal2/Mmjax |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
501
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Allele |
| Name: |
anaplastic lymphoma kinase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Defaye M |
| Year: |
2022 |
| Journal: |
J Clin Invest |
| Title: |
The neuronal tyrosine kinase receptor ligand ALKAL2 mediates persistent pain. |
| Volume: |
132 |
| Issue: |
12 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang H |
| Year: |
2014 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome. |
| Volume: |
111 |
| Issue: |
44 |
| Pages: |
15741-5 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
481
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Alkal2/Alkal2 |
| Background: |
involves: C57BL/6N |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Alkal2/Alkal2<+> |
| Background: |
C57BL/6NJ-Alkal2/Mmjax |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Reshetnyak AV |
| Year: |
2018 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α). |
| Volume: |
115 |
| Issue: |
33 |
| Pages: |
8340-8345 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
140
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
168
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Allele |
| Name: |
collagen, type I, alpha 1; targeted mutation 1, Kwok-Kin Wong |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence, Inducible, Inserted expressed sequence |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 5, Hiroaki Honda |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 9, Hiroaki Honda |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Alkal1/Alkal1 Alkal2/Alkal2 |
| Background: |
involves: C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Alkal1/Alkal1<+> Alkal2/Alkal2 |
| Background: |
involves: C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Alkal1/Alkal1 Alkal2/Alkal2<+> |
| Background: |
involves: C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, coisogenic, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, coisogenic, transgenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen Z |
| Year: |
2010 |
| Journal: |
Cancer Res |
| Title: |
Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene. |
| Volume: |
70 |
| Issue: |
23 |
| Pages: |
9827-36 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
2312
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 2, Louis Chesler |
| Allele Type: |
Transgenic |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
anaplastic lymphoma kinase; targeted mutation 1, Stephan W Morris |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 60, Johannes H Schulte |
| Allele Type: |
Transgenic |
| Attribute String: |
Conditional ready, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1100
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wienke J |
| Year: |
2024 |
| Journal: |
Cancer Cell |
| Title: |
Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy. |
| Volume: |
42 |
| Issue: |
2 |
| Pages: |
283-300.e8 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Alk/Alk |
| Background: |
involves: 129P2/OlaHsd * C57BL/6J |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Alk/Alk |
| Background: |
involves: 129P2/OlaHsd |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Allele |
| Name: |
anaplastic lymphoma kinase; targeted mutation 1.1, Hideki Enomoto |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Col1a1/Col1a1<+> Tg(Scgb1a1-rtTA)1Jaw/? |
| Background: |
involves: 129 * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Alk/Alk Ltk/Ltk |
| Background: |
involves: 129 * 129P2/OlaHsd |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bassermann F |
| Year: |
2005 |
| Journal: |
Cell |
| Title: |
NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry. |
| Volume: |
122 |
| Issue: |
1 |
| Pages: |
45-57 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry contains Nuclear-interacting partner of ALK (NIPA) and NIPA like proteins, as well as mRNA export factor Rsm1, all of which contain a C3HC-type zinc finger. The domain represented in this entry is found C-terminal to the zinc-finger like domain . Rsm1 is involved in mRNA export from the nucleus []. NIPA is an essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry []. |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1233
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
770
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cohen MA |
| Year: |
2020 |
| Journal: |
Cell Stem Cell |
| Title: |
Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras. |
| Volume: |
26 |
| Issue: |
4 |
| Pages: |
579-592.e6 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Th-ALK*F1174L)2Loch/? Tg(Th-MYCN)41Waw/? |
| Background: |
involves: 129X1/SvJ * BALB/c * C57BL/6J * CBA |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(CAG-Alk*F1174L,-luc)60Jhsc/? Tg(Dbh-icre)1Gsc/? |
| Background: |
involves: C57BL/6 * FVB/N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(CAG-Alk*F1174L,-luc)60Jhsc/? Th/Th<+> |
| Background: |
involves: 129X1/SvJ * C57BL/6 * FVB/N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
Baseline |
| Source: |
GEO |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
428
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
488
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
595
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(CAG-Alk*F1174L,-luc)60Jhsc/? Tg(Dbh-icre)1Gsc/? Tg(Th-MYCN)41Waw/? |
| Background: |
involves: 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J * FVB/N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Alk/Alk |
| Background: |
involves: 129X1/SvJ * C57BL/6 * C57BL/6N * SJL |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Alk/Alk Tg(Mpz-cre)94Imeg/? |
| Background: |
involves: 129X1/SvJ * C57BL/6 * C57BL/6N * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chiarle R |
| Year: |
2005 |
| Journal: |
Nat Med |
| Title: |
Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target. |
| Volume: |
11 |
| Issue: |
6 |
| Pages: |
623-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lastwika KJ |
| Year: |
2016 |
| Journal: |
Cancer Res |
| Title: |
Control of PD-L1 Expression by Oncogenic Activation of the AKT-mTOR Pathway in Non-Small Cell Lung Cancer. |
| Volume: |
76 |
| Issue: |
2 |
| Pages: |
227-38 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huang S |
| Year: |
2012 |
| Journal: |
Cell |
| Title: |
MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling. |
| Volume: |
151 |
| Issue: |
5 |
| Pages: |
937-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yanagisawa H |
| Year: |
2010 |
| Journal: |
Neurosci Res |
| Title: |
Pleiotrophin induces neurite outgrowth and up-regulates growth-associated protein (GAP)-43 mRNA through the ALK/GSK3beta/beta-catenin signaling in developing mouse neurons. |
| Volume: |
66 |
| Issue: |
1 |
| Pages: |
111-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Agrotis A |
| Year: |
1996 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Vascular smooth muscle cells express multiple type I receptors for TGF-beta, activin, and bone morphogenetic proteins. |
| Volume: |
219 |
| Issue: |
2 |
| Pages: |
613-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ardini E |
| Year: |
2010 |
| Journal: |
Cancer Lett |
| Title: |
Anaplastic Lymphoma Kinase: role in specific tumours, and development of small molecule inhibitors for cancer therapy. |
| Volume: |
299 |
| Issue: |
2 |
| Pages: |
81-94 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mano H |
| Year: |
2012 |
| Journal: |
Cancer Discov |
| Title: |
ALKoma: a cancer subtype with a shared target. |
| Volume: |
2 |
| Issue: |
6 |
| Pages: |
495-502 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tucker ER |
| Year: |
2015 |
| Journal: |
Cancer Res |
| Title: |
Tackling Crizotinib Resistance: The Pathway from Drug Discovery to the Pediatric Clinic. |
| Volume: |
75 |
| Issue: |
14 |
| Pages: |
2770-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wong CO |
| Year: |
2015 |
| Journal: |
Cell Rep |
| Title: |
Diminished MTORC1-Dependent JNK Activation Underlies the Neurodevelopmental Defects Associated with Lysosomal Dysfunction. |
| Volume: |
12 |
| Issue: |
12 |
| Pages: |
2009-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Giaccone G |
| Year: |
2023 |
| Journal: |
Semin Cancer Biol |
| Title: |
Current knowledge of small cell lung cancer transformation from non-small cell lung cancer. |
| Volume: |
94 |
|
| Pages: |
1-10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Qin Z |
| Year: |
2024 |
| Journal: |
J Exp Med |
| Title: |
EML4-ALK fusions drive lung adeno-to-squamous transition through JAK-STAT activation. |
| Volume: |
221 |
| Issue: |
3 |
|
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
482
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
424
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1064
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1302
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rusan M |
| Year: |
2018 |
| Journal: |
Cancer Discov |
| Title: |
Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression. |
| Volume: |
8 |
| Issue: |
1 |
| Pages: |
59-73 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Alk/Alk Tmem163/Tmem163<+> |
| Background: |
involves: 129X1/SvJ * C57BL/6 * C57BL/6N * FVB/N * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Alk/Alk Tg(Mpz-cre)94Imeg/? Tg(Th-MYCN)41Waw/? |
| Background: |
involves: 129X1/SvJ * BALB/c * C57BL/6 * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Alk/Alk<+> Tg(Mpz-cre)94Imeg/? Tg(Th-MYCN)41Waw/? |
| Background: |
involves: 129X1/SvJ * BALB/c * C57BL/6 * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Umapathy G |
| Year: |
2017 |
| Journal: |
Sci Signal |
| Title: |
MEK inhibitor trametinib does not prevent the growth of anaplastic lymphoma kinase (ALK)-addicted neuroblastomas. |
| Volume: |
10 |
| Issue: |
507 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chiarle R |
| Year: |
2003 |
| Journal: |
Blood |
| Title: |
NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors. |
| Volume: |
101 |
| Issue: |
5 |
| Pages: |
1919-27 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
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