Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
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|
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•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cao X |
Year: |
2021 |
Journal: |
J Biol Chem |
Title: |
Opposing roles of E3 ligases TRIM23 and TRIM21 in regulation of ion channel ANO1 protein levels. |
|
|
Pages: |
100738 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cipriani G |
Year: |
2011 |
Journal: |
J Cell Mol Med |
Title: |
NK receptors, Substance P, Ano1 expression and ultrastructural features of the muscle coat in Cav-1(-/-) mouse ileum. |
Volume: |
15 |
Issue: |
11 |
Pages: |
2411-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sonneville F |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology. |
Volume: |
8 |
Issue: |
1 |
Pages: |
710 |
|
•
•
•
•
•
|
Allele |
Name: |
low set ears |
Allele Type: |
Spontaneous |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Luzzio A |
Year: |
2023 |
Journal: |
Mamm Genome |
Title: |
The spontaneous mouse mutant low set ears (Lse) is caused by tandem duplication of Fgf3 and Fgf4. |
Volume: |
34 |
Issue: |
3 |
Pages: |
453-463 |
|
•
•
•
•
•
|
Publication |
First Author: |
Theiler K |
Year: |
1986 |
Journal: |
Anat Embryol (Berl) |
Title: |
Low set ears (Lse), a new mutation of the house mouse. |
Volume: |
175 |
Issue: |
2 |
Pages: |
241-6 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Lse/Lse<+> |
Background: |
B6C3Fe a/a-Lse/J |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Lse/Lse |
Background: |
B6C3Fe a/a-Lse/J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Lse/Lse<+> Twist1/Twist1<+> |
Background: |
involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
Baseline |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim Y |
Year: |
2005 |
Journal: |
Eukaryot Cell |
Title: |
Interaction among Btn1p, Btn2p, and Ist2p reveals potential interplay among the vacuole, amino acid levels, and ion homeostasis in the yeast Saccharomyces cerevisiae. |
Volume: |
4 |
Issue: |
2 |
Pages: |
281-8 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents the anoctamin family, which includes anoctamin1-10 (Ano1-10 or TMEM16A-J); 7 members could be divided into two subfamilies, Ca(2+)-dependent Cl(-) channels (TMEM16A and 16B) and Ca(2+)-dependent lipid scramblases (TMEM16C, 16D, 16F, 16G, and 16J) []. This entry also includes anoctamin-like protein At1g73020 from Arabidopsis and increased sodium tolerance protein 2 (Ist2) from budding yeasts. Ano1 and Ano2 (also known as TMEM16A and TMEM16B) are calcium-activated chloride channels (CaCC), which play a role in transepithelial anion transport and smooth muscle contraction [, ]. Ano3-10 do not exhibit calcium-activated chloride channel (CaCC) activity [, ]. Ist2 may be involved in ion homeostasis together with BTN1 or BTN2 []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
188
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamanoi Y |
Year: |
2023 |
Journal: |
Commun Biol |
Title: |
TRPV3-ANO1 interaction positively regulates wound healing in keratinocytes. |
Volume: |
6 |
Issue: |
1 |
Pages: |
88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee J |
Year: |
2023 |
Journal: |
iScience |
Title: |
Major depression-related factor NEGR1 controls salivary secretion in mouse submandibular glands. |
Volume: |
26 |
Issue: |
5 |
Pages: |
106773 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim H |
Year: |
2018 |
Journal: |
Cell Calcium |
Title: |
Anoctamin 9/TMEM16J is a cation channel activated by cAMP/PKA signal. |
Volume: |
71 |
|
Pages: |
75-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cha JY |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia. |
Volume: |
112 |
Issue: |
31 |
Pages: |
9722-7 |
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•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, spontaneous mutation |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
960
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
955
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1060
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
859
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Stöhr H |
Year: |
2009 |
Journal: |
J Neurosci |
Title: |
TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals. |
Volume: |
29 |
Issue: |
21 |
Pages: |
6809-18 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1002
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
981
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
747
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
904
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
659
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
356
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
190
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1017
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
998
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
936
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
69
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1014
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
176
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
478
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
230
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1104
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
498
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
492
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
290
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
181
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
155
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
965
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
149
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
982
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1040
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
903
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
335
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
920
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Das S |
Year: |
2007 |
Journal: |
Cancer Res |
Title: |
NGEP, a prostate-specific plasma membrane protein that promotes the association of LNCaP cells. |
Volume: |
67 |
Issue: |
4 |
Pages: |
1594-601 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takayama Y |
Year: |
2014 |
Journal: |
FASEB J |
Title: |
Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1. |
Volume: |
28 |
Issue: |
5 |
Pages: |
2238-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu MH |
Year: |
2016 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
Na+-K+-Cl- cotransporter (NKCC) maintains the chloride gradient to sustain pacemaker activity in interstitial cells of Cajal. |
Volume: |
311 |
Issue: |
6 |
Pages: |
G1037-G1046 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baker SA |
Year: |
2021 |
Journal: |
Cell Calcium |
Title: |
Ca(2+) transients in ICC-MY define the basis for the dominance of the corpus in gastric pacemaking. |
Volume: |
99 |
|
Pages: |
102472 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hannigan KI |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
A novel intramuscular Interstitial Cell of Cajal is a candidate for generating pacemaker activity in the mouse internal anal sphincter. |
Volume: |
10 |
Issue: |
1 |
Pages: |
10378 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mazzone A |
Year: |
2019 |
Journal: |
FASEB J |
Title: |
Direct repression of anoctamin 1 (ANO1) gene transcription by Gli proteins. |
Volume: |
33 |
Issue: |
5 |
Pages: |
6632-6642 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koh SD |
Year: |
2022 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Propulsive colonic contractions are mediated by inhibition-driven poststimulus responses that originate in interstitial cells of Cajal. |
Volume: |
119 |
Issue: |
18 |
Pages: |
e2123020119 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu Z |
Year: |
2023 |
Journal: |
Biomolecules |
Title: |
Functional and Transcriptomic Characterization of Postnatal Maturation of ENS and SIP Syncytium in Mice Colon. |
Volume: |
13 |
Issue: |
12 |
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
911
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
932
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
466
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
193
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Ramos D |
Year: |
2019 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Vascular Interstitial Cells in Retinal Arteriolar Annuli Are Altered During Hypertension. |
Volume: |
60 |
Issue: |
2 |
Pages: |
473-487 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mattheij NJ |
Year: |
2016 |
Journal: |
FASEB J |
Title: |
Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage. |
Volume: |
30 |
Issue: |
2 |
Pages: |
727-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zheng H |
Year: |
2020 |
Journal: |
Front Physiol |
Title: |
Na+/Ca2 + Exchange and Pacemaker Activity of Interstitial Cells of Cajal. |
Volume: |
11 |
|
Pages: |
230 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chang B |
Year: |
2005 |
Journal: |
Vis Neurosci |
Title: |
Mouse models of ocular diseases. |
Volume: |
22 |
Issue: |
5 |
Pages: |
587-93 |
|
•
•
•
•
•
|