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Details |
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Publication |
First Author: |
Zhang M |
Year: |
2017 |
Journal: |
FEBS Lett |
Title: |
NDRG2 acts as a PERK co-factor to facilitate PERK branch and ERS-induced cell death. |
Volume: |
591 |
Issue: |
21 |
Pages: |
3670-3681 |
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Publication |
First Author: |
Zhou J |
Year: |
2018 |
Journal: |
Mol Cell |
Title: |
N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response. |
Volume: |
69 |
Issue: |
4 |
Pages: |
636-647.e7 |
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Kato Y |
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Journal: |
Mol Cell Endocrinol |
Title: |
Presence of activating transcription factor 4 (ATF4) in the porcine anterior pituitary. |
Volume: |
154 |
Issue: |
1-2 |
Pages: |
151-9 |
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Publication |
First Author: |
Clavarino G |
Year: |
2012 |
Journal: |
PLoS Pathog |
Title: |
Induction of GADD34 is necessary for dsRNA-dependent interferon-β production and participates in the control of Chikungunya virus infection. |
Volume: |
8 |
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5 |
Pages: |
e1002708 |
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First Author: |
Liu J |
Year: |
2015 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
Impact of ER stress-regulated ATF4/p16 signaling on the premature senescence of renal tubular epithelial cells in diabetic nephropathy. |
Volume: |
308 |
Issue: |
8 |
Pages: |
C621-30 |
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First Author: |
Martina JA |
Year: |
2016 |
Journal: |
EMBO J |
Title: |
TFEB and TFE3 are novel components of the integrated stress response. |
Volume: |
35 |
Issue: |
5 |
Pages: |
479-95 |
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First Author: |
Yang G |
Year: |
2024 |
Journal: |
Neuron |
Title: |
Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration. |
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Publication |
First Author: |
Podust LM |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA. |
Volume: |
276 |
Issue: |
1 |
Pages: |
505-13 |
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First Author: |
Costa-Mattioli M |
Year: |
2005 |
Journal: |
Nature |
Title: |
Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. |
Volume: |
436 |
Issue: |
7054 |
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1166-73 |
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First Author: |
Carpio MA |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress. |
Volume: |
112 |
Issue: |
23 |
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7201-6 |
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First Author: |
Latreille M |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress. |
Volume: |
281 |
Issue: |
36 |
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26633-44 |
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First Author: |
Galichon P |
Year: |
2017 |
Journal: |
J Am Soc Nephrol |
Title: |
Stress Response Gene Nupr1 Alleviates Cyclosporin A Nephrotoxicity In Vivo. |
Volume: |
28 |
Issue: |
2 |
Pages: |
545-556 |
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First Author: |
Kim MH |
Year: |
2017 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Hepatic ZIP14-mediated zinc transport is required for adaptation to endoplasmic reticulum stress. |
Volume: |
114 |
Issue: |
29 |
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First Author: |
Pereira CM |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation. |
Volume: |
280 |
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Publication |
First Author: |
Yu VW |
Year: |
2009 |
Journal: |
J Cell Biochem |
Title: |
FIAT inhibition increases osteoblast activity by modulating Atf4-dependent functions. |
Volume: |
106 |
Issue: |
1 |
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186-92 |
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Publication |
First Author: |
Isaac R |
Year: |
2017 |
Journal: |
Cell Death Differ |
Title: |
TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response. |
Volume: |
24 |
Issue: |
1 |
Pages: |
132-143 |
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Publication |
First Author: |
Nerlich A |
Year: |
2015 |
Journal: |
Biochim Biophys Acta |
Title: |
C/EBPβ is a transcriptional key regulator of IL-36α in murine macrophages. |
Volume: |
1849 |
Issue: |
8 |
Pages: |
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Publication |
First Author: |
Hayakawa M |
Year: |
2015 |
Journal: |
Neurobiol Aging |
Title: |
Quercetin reduces eIF2α phosphorylation by GADD34 induction. |
Volume: |
36 |
Issue: |
9 |
Pages: |
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First Author: |
Yang S |
Year: |
2024 |
Journal: |
Exp Mol Med |
Title: |
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop. |
Volume: |
56 |
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First Author: |
Agergaard J |
Year: |
2021 |
Journal: |
Sci Rep |
Title: |
Impaired skeletal muscle hypertrophy signaling and amino acid deprivation response in Apoe knockout mice with an unhealthy lipoprotein distribution. |
Volume: |
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First Author: |
Sain Basu D |
Year: |
2022 |
Journal: |
J Cell Sci |
Title: |
FMRP protects the lung from xenobiotic stress by facilitating the integrated stress response. |
Volume: |
135 |
Issue: |
9 |
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First Author: |
Berthoud VM |
Year: |
2016 |
Journal: |
J Biol Chem |
Title: |
The Cataract-linked Mutant Connexin50D47A Causes Endoplasmic Reticulum Stress in Mouse Lenses. |
Volume: |
291 |
Issue: |
34 |
Pages: |
17569-78 |
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First Author: |
Cai Q |
Year: |
2010 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Vasopressin increases expression of UT-A1, UT-A3, and ER chaperone GRP78 in the renal medulla of mice with a urinary concentrating defect. |
Volume: |
299 |
Issue: |
4 |
Pages: |
F712-9 |
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First Author: |
Takahashi K |
Year: |
2014 |
Journal: |
J Biol Chem |
Title: |
Impaired oxidative endoplasmic reticulum stress response caused by deficiency of thyroid hormone receptor α. |
Volume: |
289 |
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18 |
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12485-93 |
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First Author: |
Kuroda R |
Year: |
2021 |
Journal: |
PLoS One |
Title: |
Loss of mitochondrial transcription factor A in neural stem cells leads to immature brain development and triggers the activation of the integral stress response in vivo. |
Volume: |
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Issue: |
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Pages: |
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First Author: |
Alapure BV |
Year: |
2012 |
Journal: |
Exp Eye Res |
Title: |
The unfolded protein response is activated in connexin 50 mutant mouse lenses. |
Volume: |
102 |
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First Author: |
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Year: |
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Journal: |
Sci Rep |
Title: |
Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma. |
Volume: |
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Year: |
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FASEB J |
Title: |
Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress. |
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Year: |
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Biochem J |
Title: |
FGF19 (fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stress. |
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Year: |
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Exp Eye Res |
Title: |
Deficiency of CC chemokine ligand 2 and decay-accelerating factor causes retinal degeneration in mice. |
Volume: |
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First Author: |
Guo W |
Year: |
2021 |
Journal: |
Cell Mol Gastroenterol Hepatol |
Title: |
Fatty Acids Inhibit LAMP2-Mediated Autophagy Flux via Activating ER Stress Pathway in Alcohol-Related Liver Disease. |
Volume: |
12 |
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First Author: |
Agouni A |
Year: |
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Biochem J |
Title: |
Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress. |
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Year: |
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Neurobiol Aging |
Title: |
PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease. |
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PLoS One |
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Transcriptional regulation of VEGF-A by the unfolded protein response pathway. |
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Year: |
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J Biol Chem |
Title: |
Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress. |
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J Biol Chem |
Title: |
Differential control of the CCAAT/enhancer-binding protein beta (C/EBPbeta) products liver-enriched transcriptional activating protein (LAP) and liver-enriched transcriptional inhibitory protein (LIP) and the regulation of gene expression during the response to endoplasmic reticulum stress. |
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Pharmacological inhibition of the integrated stress response accelerates disease progression in an amyotrophic lateral sclerosis mouse model. |
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Year: |
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Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APPSwe Mouse Models of Tauopathy and Amyloidosis. |
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Activation and execution of the hepatic integrated stress response by dietary essential amino acid deprivation is amino acid specific. |
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CDK11 Promotes Cytokine-Induced Apoptosis in Pancreatic Beta Cells Independently of Glucose Concentration and Is Regulated by Inflammation in the NOD Mouse Model. |
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Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery. |
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Front Endocrinol (Lausanne) |
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Baf45a Mediated Chromatin Remodeling Promotes Transcriptional Activation for Osteogenesis and Odontogenesis. |
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Mol Cell Biol |
Title: |
GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology. |
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Sci Signal |
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Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21. |
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Large HBV Surface Protein-Induced Unfolded Protein Response Dynamically Regulates p27 Degradation in Hepatocellular Carcinoma Progression. |
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Exercise Preconditioning Protects against Acute Cardiac Injury Induced by Lipopolysaccharide Through General Control Nonderepressible 2 Kinase. |
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Assessing the contribution of thrombospondin-4 induction and ATF6α activation to endoplasmic reticulum expansion and phenotypic modulation in bladder outlet obstruction. |
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ER-stress response in retinal Müller glia occurs significantly earlier than amyloid pathology in the Alzheimer's mouse brain and retina. |
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Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice. |
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Pages: |
101360 |
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•
•
•
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Publication |
First Author: |
Ito D |
Year: |
2004 |
Journal: |
Mol Cell Biol |
Title: |
Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties. |
Volume: |
24 |
Issue: |
21 |
Pages: |
9456-69 |
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•
•
•
•
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Publication |
First Author: |
Wang Y |
Year: |
2012 |
Journal: |
Cancer Res |
Title: |
The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway. |
Volume: |
72 |
Issue: |
20 |
Pages: |
5396-406 |
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•
•
•
•
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Publication |
First Author: |
Thiaville MM |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells. |
Volume: |
283 |
Issue: |
16 |
Pages: |
10848-57 |
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•
•
•
•
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Publication |
First Author: |
Hull RL |
Year: |
2009 |
Journal: |
Diabetologia |
Title: |
Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress. |
Volume: |
52 |
Issue: |
6 |
Pages: |
1102-11 |
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•
•
•
•
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Publication |
First Author: |
Felkin LE |
Year: |
2011 |
Journal: |
Circulation |
Title: |
Calcineurin splicing variant calcineurin Aβ1 improves cardiac function after myocardial infarction without inducing hypertrophy. |
Volume: |
123 |
Issue: |
24 |
Pages: |
2838-47 |
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•
•
•
•
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Publication |
First Author: |
Wei W |
Year: |
2012 |
Journal: |
J Neurosci |
Title: |
p300/CBP-associated factor selectively regulates the extinction of conditioned fear. |
Volume: |
32 |
Issue: |
35 |
Pages: |
11930-41 |
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•
•
•
•
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Publication |
First Author: |
Zhou C |
Year: |
2017 |
Journal: |
Leukemia |
Title: |
JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia. |
Volume: |
31 |
Issue: |
5 |
Pages: |
1196-1205 |
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•
•
•
•
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Publication |
First Author: |
Jasani N |
Year: |
2025 |
Journal: |
Cancer Res |
Title: |
PHGDH Induction by MAPK Is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability. |
Volume: |
85 |
Issue: |
2 |
Pages: |
314-328 |
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•
•
•
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Publication |
First Author: |
Shan J |
Year: |
2016 |
Journal: |
Nucleic Acids Res |
Title: |
The C/ebp-Atf response element (CARE) location reveals two distinct Atf4-dependent, elongation-mediated mechanisms for transcriptional induction of aminoacyl-tRNA synthetase genes in response to amino acid limitation. |
Volume: |
44 |
Issue: |
20 |
Pages: |
9719-9732 |
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•
•
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Publication |
First Author: |
Lim JKM |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance. |
Volume: |
116 |
Issue: |
19 |
Pages: |
9433-9442 |
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•
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Publication |
First Author: |
Kang SH |
Year: |
2019 |
Journal: |
Ann Hematol |
Title: |
BOK promotes erythropoiesis in a mouse model of myelodysplastic syndrome. |
Volume: |
98 |
Issue: |
9 |
Pages: |
2089-2096 |
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•
•
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Publication |
First Author: |
Feng X |
Year: |
2020 |
Journal: |
EMBO J |
Title: |
UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism. |
Volume: |
39 |
Issue: |
5 |
Pages: |
e102541 |
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•
•
•
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Publication |
First Author: |
Ikegami K |
Year: |
2020 |
Journal: |
Biochem Biophys Res Commun |
Title: |
cAMP response element induces Per1 in vivo. |
Volume: |
531 |
Issue: |
4 |
Pages: |
515-521 |
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•
•
•
•
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Publication |
First Author: |
Xu X |
Year: |
2018 |
Journal: |
Hepatology |
Title: |
Preemptive Activation of the Integrated Stress Response Protects Mice From Diet-Induced Obesity and Insulin Resistance by Fibroblast Growth Factor 21 Induction. |
Volume: |
68 |
Issue: |
6 |
Pages: |
2167-2181 |
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•
•
•
•
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Publication |
First Author: |
Na Y |
Year: |
2023 |
Journal: |
Oncogene |
Title: |
Runx1/3-driven adaptive endoplasmic reticulum stress pathways contribute to neurofibromagenesis. |
Volume: |
42 |
Issue: |
13 |
Pages: |
1038-1047 |
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•
•
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•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
•
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Publication |
First Author: |
Dedhia PH |
Year: |
2010 |
Journal: |
Blood |
Title: |
Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia. |
Volume: |
116 |
Issue: |
8 |
Pages: |
1321-8 |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
795
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
831
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
866
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
958
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
842
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
958
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
900
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
826
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen JJ |
Year: |
2019 |
Journal: |
Blood |
Title: |
Heme-regulated eIF2α kinase in erythropoiesis and hemoglobinopathies. |
Volume: |
134 |
Issue: |
20 |
Pages: |
1697-1707 |
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•
•
•
•
•
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Publication |
First Author: |
Gunn TM |
Year: |
2019 |
Journal: |
Mamm Genome |
Title: |
Chronic and age-dependent effects of the spongiform neurodegeneration-associated MGRN1 E3 ubiquitin ligase on mitochondrial homeostasis. |
Volume: |
30 |
Issue: |
5-6 |
Pages: |
151-165 |
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•
•
•
•
•
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Publication |
First Author: |
Lu Y |
Year: |
2023 |
Journal: |
Front Immunol |
Title: |
ER stress mediates Angiotensin II-augmented innate immunity memory and facilitates distinct susceptibilities of thoracic from abdominal aorta to aneurysm development. |
Volume: |
14 |
|
Pages: |
1268916 |
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•
•
•
•
•
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Publication |
First Author: |
Tang CY |
Year: |
2021 |
Journal: |
PLoS Genet |
Title: |
Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways. |
Volume: |
17 |
Issue: |
1 |
Pages: |
e1009233 |
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•
•
•
•
•
|
Publication |
First Author: |
Felszeghy S |
Year: |
2019 |
Journal: |
Redox Biol |
Title: |
Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration. |
Volume: |
20 |
|
Pages: |
1-12 |
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•
•
•
•
•
|
Publication |
First Author: |
Chen W |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Cbfβ deletion in mice recapitulates cleidocranial dysplasia and reveals multiple functions of Cbfβ required for skeletal development. |
Volume: |
111 |
Issue: |
23 |
Pages: |
8482-7 |
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•
•
•
•
•
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