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Search results 801 to 900 out of 1013 for Braf

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Type Details Score
Genotype
Genotype
Symbol: Braf/Braf<+>
Background: involves: 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
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Publication
23441035 | J:196873
First Author: Ortiz O
Year: 2013
Journal: Genesis
Title: Reversible and tissue-specific activation of MAP kinase signaling by tamoxifen in Braf(V637)ER(T2) mice.
Volume: 51
Issue: 6
Pages: 448-55
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Publication
22072743 | -
First Author: Chiappetta G
Year: 2012
Journal: J Clin Endocrinol Metab
Title: BAG3 down-modulation reduces anaplastic thyroid tumor growth by enhancing proteasome-mediated degradation of BRAF protein.
Volume: 97
Issue: 1
Pages: E115-20
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Genotype
Genotype
Symbol: Braf/? Tg(TPO-cre)1Shk/?
Background: involves: 129P2/OlaHsd * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Publication
32719131 | J:293934
First Author: Niitsu Y
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: A CRAF/glutathione-S-transferase P1 complex sustains autocrine growth of cancers with KRAS and BRAF mutations.
Volume: 117
Issue: 32
Pages: 19435-19445
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(Tg-cre/ERT2)#Mmcm/?
Background: involves: 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(TPO-cre/ERT2)1139Tyj/?
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tg(TPO-cre)1Shk/?
Background: involves: 129P2/OlaHsd * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tg(Tyr-cre/ERT2)13Bos/?
Background: involves: 129P2/OlaHsd * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tg(Itgax-cre)1-1Reiz/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Strain
MGI:3699356 | 129-Braf<tm1Sva>/J
Attribute String: mutant strain, targeted mutation, coisogenic
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Strain
MGI:5499508 | STOCK Braf<tm1Bbd>/Cnbc
Attribute String: targeted mutation, mutant stock
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Strain
MGI:4947063 | B6.129-Braf<tm1Bbd>
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:6147229 | B6.Cg-Braf<tm1Tumg>/Rbrc
Attribute String: mutant strain, targeted mutation, congenic
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Strain
MGI:6147302 | 129.Cg-Braf<tm1Tumg>
Attribute String: mutant strain, congenic, targeted mutation
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Strain
MGI:6147303 | C.Cg-Braf<tm1Tumg>/TumgRbrc
Attribute String: mutant strain, congenic, targeted mutation
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Strain
MGI:6147230 | STOCK Braf<tm1.1Tumg>/TumgRbrc
Attribute String: targeted mutation, mutant stock
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Strain
MGI:7590796 | C57BL/6J-Braf<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7587984 | C57BL/6J-Braf<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Braf/Braf
Background: involves: 129
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf
Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf
Background: involves: 129/Sv * C57BL/6 * CD-1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf
Background: involves: 129S1/Sv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf
Background: involves: 129S1/Sv * C57BL/6 * CD-1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf
Background: either: (involves: 129S2/SvPas * FVB/N ) or (involves: 129S2/SvPas * BALB/c * C57BL/6)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf
Background: either: (involves: 129S2/SvPas * FVB/N ) or (involves: 129S2/SvPas * BALB/c * C57BL/6)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf
Background: involves: 129 * C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf
Background: involves: 129 * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf
Background: involves: 129 * C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(CMV-cre)1Cgn/?
Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(Mx1-cre)1Cgn/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Cd207/Cd207<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Cdkn2a/Cdkn2a
Background: involves: 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Trp53/Trp53
Background: involves: 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(Tyr-cre/ERT2)13Bos/?
Background: involves: 129P2/OlaHsd * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(Tyr-cre/ERT2)13Bos/?
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(TPO-cre/ERT2)1139Tyj/? Trp53/Trp53
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac
Zygosity: cn
Has Mutant Allele: true
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Allele
Tg(tetO-BRAF*V600E)26Jaf | MGI:5524276
Name: transgene insertion 26, James A Fagin
Allele Type: Transgenic
Attribute String: Constitutively active, Epitope tag, Inducible, Inserted expressed sequence
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Genotype
Genotype
Symbol: Braf/Braf<+> Polr2a/Polr2a<+>
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Strain
MGI:6792071 | STOCK Braf<tm1Mmcm> Gt(ROSA)26Sor<tm14(CAG-tdTomato)Hze> Tg(Mitf-cre)7114Gsb/Cvrk
Attribute String: mutant stock, targeted mutation, transgenic
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Genotype
Genotype
Symbol: Braf/Braf Tshr/Tshr Tg(TPO-cre)1Shk/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Gnas/Gnas Tg(TPO-cre)1Shk/?
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Pten/Pten Tg(Tyr-cre/ERT2)13Bos/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Pten/Pten Tg(Tyr-cre/ERT2)13Bos/?
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Protein Domain
IPR046933 | SAM_KSR1_N_sf
Type: Homologous_superfamily
Description: Pseudokinases kinase suppressor of Ras 1 and 2 (KSR1/2) are scaffolds that bridge RAF isoforms and their substrate, mitogen-activated protein kinase kinase (MEK). They dimerize with kinase-competent RAFs (ARAF, BRAF and CRAF) to stimulate catalysis allosterically []. This entry represents the N-terminal helical hairpin which, together with the SAM-like domain () constitutes the N-terminal regulatory region that mediates heterodimerization of BRAF with KSR1. Additionally, MEK binding to the kinase domain of KSR1 asymmetrically drives BRAF-KSR1 heterodimerization, resulting in the concomitant stimulation of BRAF catalytic activity towards free MEK molecules [].
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Protein Domain
IPR046861 | SAM_KSR1_N
Type: Domain
Description: Pseudokinases kinase suppressor of Ras 1 and 2 (KSR1/2) are scaffolds that bridge RAF isoforms and their substrate, mitogen-activated protein kinase kinase (MEK). They dimerize with kinase-competent RAFs (ARAF, BRAF and CRAF) to stimulate catalysis allosterically []. This entry represents the N-terminal helical hairpin which, together with the SAM-like domain () constitutes the N-terminal regulatory region that mediates heterodimerization of BRAF with KSR1. Additionally, MEK binding to the kinase domain of KSR1 asymmetrically drives BRAF-KSR1 heterodimerization, resulting in the concomitant stimulation of BRAF catalytic activity towards free MEK molecules [].
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Strain
MGI:5440170 | B6.Cg-Braf<tm2Cpri> Tg(CMV-cre)1Cgn
Attribute String: targeted mutation, transgenic, congenic, mutant strain
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Genotype
Genotype
Symbol: Braf/Braf Tg(Camk2a-cre)1557Sva/?
Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tg(Tek-cre/ERT2)1Arnd/?
Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+>
Background: B6.129-Braf
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+>
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tg(Nes-cre)1Kln/?
Background: involves: 129 * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tg(Nes-cre)1Kln/?
Background: involves: 129 * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+>
Background: involves: 129
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tg(Camk2a-cre/ERT2)2Gsc/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+>
Background: involves: C57BL/6J * CBA/J
Zygosity: ht
Has Mutant Allele: true
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Strain
MGI:4948437 | B6.Cg-Tg(Tyr-cre/ERT2)13Bos Braf<tm1Mmcm> Pten<tm1Hwu>/BosJ
Attribute String: transgenic, targeted mutation, mutant strain, congenic
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Strain
MGI:5447425 | B6.Cg-Braf<tm1Mmcm> Tg(Tyr-cre/ERT2)1Lru Pten<tm1Mro>
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Braf/Braf Cdkn2a/Cdkn2a Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Pten/Pten Tg(Tyr-cre/ERT2)1Lru/?
Background: B6.Cg-Braf Tg(Tyr-cre/ERT2)1Lru Pten
Zygosity: cn
Has Mutant Allele: true
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Protein Domain
IPR025561 | KSR_SAM-like_dom
Type: Domain
Description: This SAM-like domain is found in kinase suppressor of Ras proteins, which are location-regulated scaffolding proteins connecting MEK to RAF []. This domain is part of the N-terminal regulatory region that mediates heterodimerization of BRAF with KSR1.
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Protein
Q68FD9
Organism: Mus musculus/domesticus
Length: 1940  
Fragment?: false
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Protein
A0A2R8VHF1
Organism: Mus musculus/domesticus
Length: 1415  
Fragment?: false
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Protein
A2BI30
Organism: Mus musculus/domesticus
Length: 1677  
Fragment?: true
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Protein
Q8C3K4
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: false
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Protein
D3YZ21
Organism: Mus musculus/domesticus
Length: 1414  
Fragment?: false
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Protein
Q8BXF0
Organism: Mus musculus/domesticus
Length: 509  
Fragment?: true
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Protein
A0A2R8VKG2
Organism: Mus musculus/domesticus
Length: 2099  
Fragment?: false
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Protein
D3YTS3
Organism: Mus musculus/domesticus
Length: 1799  
Fragment?: false
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Protein
F6ZGR6
Organism: Mus musculus/domesticus
Length: 1300  
Fragment?: false
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Publication
19937730 | -
First Author: Tatevossian RG
Year: 2010
Journal: J Cell Physiol
Title: MAPK pathway activation and the origins of pediatric low-grade astrocytomas.
Volume: 222
Issue: 3
Pages: 509-14
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Protein Domain
IPR024606 | DUF3827
Type: Family
Description: The function of the proteins in this entry is not currently known, but one of the human proteins () has been implicated in pilocytic astrocytomas [, , ]. In the majority of cases of pilocytic astrocytomas a tandem duplication produces an in-frame fusion of the gene encoding this protein and the BRAF oncogene. The resulting fusion protein has constitutive BRAF kinase activity and is capable of transforming cells.
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Genotype
Genotype
Symbol: Braf/Braf<+> Trp53/Trp53<+> Tg(TPO-cre/ERT2)1139Tyj/?
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Trp53/Trp53 Tg(TPO-cre/ERT2)1139Tyj/?
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Nkx3-1/Nkx3-1<+> Pten/Pten<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Scn10a/Scn10a<+>
Background: involves: 129 * 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Pten/Pten<+> Tg(Tyr-cre/ERT2)13Bos/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Mitf-cre)7114Gsb/?
Background: STOCK Braf Gt(ROSA)26Sor Tg(Mitf-cre)7114Gsb/Cvrk
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Raf1/Raf1
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Raf1/Raf1
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(CMV-cre)1Cgn/?
Background: B6.Cg-Braf Tg(CMV-cre)1Cgn
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(Vil1-cre)997Gum/?
Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tg(CAG-cre)2Osb/?
Background: involves: C57BL * C57BL/6J * DBA * ICR
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(Camk2a-cre)159Kln/?
Background: involves: C57BL/6J * CBA/J
Zygosity: cn
Has Mutant Allele: true
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Strain
MGI:6711383 | STOCK Braf<tm1Mmcm> Gt(ROSA)26Sor<tm3(CAG-EYFP)Hze> Nkx3-1<tm4(cre/ERT2)Mms> Pten<tm1Hwu>/AbshnJ
Attribute String: mutant stock, targeted mutation
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HT Experiment
E-GEOD-33618 | MAPK Signaling Determines Anxiety in the Juvenile Mouse Brain but Depression-like Behavior in Adults
Series Id: GSE33618
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Genotype
Genotype
Symbol: Braf/Braf<+> Grp/Grp Scn10a/Scn10a<+>
Background: involves: 129 * 129P2/OlaHsd * 129X1/SvJ * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Grpr/? Scn10a/Scn10a<+>
Background: involves: 129 * 129P2/OlaHsd * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(CAG-cre)2Osb/?
Background: involves: C57BL * C57BL/6J * DBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Raf1/Raf1 Tg(Nes-cre)1Kln/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tg(Nes-cre)1Kln/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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•
•
•
•
Genotype
Genotype
Symbol: Braf/Braf Tg(Nes-cre)1Kln/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Braf/Braf<+> Raf1/Raf1 Tg(Nes-cre)1Kln/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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•
•
•
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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