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Search results 801 to 900 out of 1045 for Brca2

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:974192
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4823442
Age: embryonic day 14.5
Image: euxassay_006212_22
Specimen Label: euxassay_006212_22
Detected: true
Specimen Num: 22
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GXD Expression
GXD Expression
 
Probe: MGI:974192
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4823442
Age: embryonic day 14.5
Image: euxassay_006212_23
Specimen Label: euxassay_006212_23
Detected: true
Specimen Num: 23
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GXD Expression
GXD Expression
 
Probe: MGI:974192
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4823442
Age: embryonic day 14.5
Image: euxassay_006212_24
Specimen Label: euxassay_006212_24
Detected: true
Specimen Num: 24
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GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-05-15
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1607211
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:5485217
Age: embryonic day 7.5
Specimen Label: 1C upper right
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3273213
Pattern: Widespread
Stage: TS13
Assay Id: MGI:5485217
Age: embryonic day 8.5
Note: Expressed both at the anterior and posterior regions.
Specimen Label: 1C lower right
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1750328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692875
Age: postnatal adult
Image: JAX_1798801
Specimen Label: JAX_1798801
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692875
Age: postnatal adult
Image: JAX_1798826
Specimen Label: JAX_1798826
Detected: true
Specimen Num: 38
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GXD Expression
GXD Expression
 
Probe: MGI:974192
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1697923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823442
Age: embryonic day 14.5
Image: euxassay_006212_07
Specimen Label: euxassay_006212_07
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:974192
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1697923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823442
Age: embryonic day 14.5
Image: euxassay_006212_08
Specimen Label: euxassay_006212_08
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:974192
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1697923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823442
Age: embryonic day 14.5
Image: euxassay_006212_09
Specimen Label: euxassay_006212_09
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:974192
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1697923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823442
Age: embryonic day 14.5
Image: euxassay_006212_10
Specimen Label: euxassay_006212_10
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:974192
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1697923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823442
Age: embryonic day 14.5
Image: euxassay_006212_11
Specimen Label: euxassay_006212_11
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:974192
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1697923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823442
Age: embryonic day 14.5
Image: euxassay_006212_12
Specimen Label: euxassay_006212_12
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:974192
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1697923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823442
Age: embryonic day 14.5
Image: euxassay_006212_13
Specimen Label: euxassay_006212_13
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:974192
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1697923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823442
Age: embryonic day 14.5
Image: euxassay_006212_14
Specimen Label: euxassay_006212_14
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
 
Probe: MGI:974192
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1697923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823442
Age: embryonic day 14.5
Image: euxassay_006212_15
Specimen Label: euxassay_006212_15
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
 
Probe: MGI:974192
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1697923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823442
Age: embryonic day 14.5
Image: euxassay_006212_16
Specimen Label: euxassay_006212_16
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1876828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692875
Age: postnatal adult
Image: JAX_1798804
Specimen Label: JAX_1798804
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1683328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692875
Age: postnatal adult
Image: JAX_1798825
Specimen Label: JAX_1798825
Detected: true
Specimen Num: 37
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1832128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692875
Age: postnatal adult
Image: JAX_1798813
Specimen Label: JAX_1798813
Detected: true
Specimen Num: 25
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1754028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692875
Age: postnatal adult
Image: JAX_1798808
Specimen Label: JAX_1798808
Detected: true
Specimen Num: 20
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3599828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692875
Age: postnatal adult
Image: JAX_1798823
Specimen Label: JAX_1798823
Detected: true
Specimen Num: 35
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1702128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692875
Age: postnatal adult
Image: JAX_1798805
Specimen Label: JAX_1798805
Detected: true
Specimen Num: 17
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1929028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692875
Age: postnatal adult
Image: JAX_1798810
Specimen Label: JAX_1798810
Detected: true
Specimen Num: 22
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3273028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692875
Age: postnatal adult
Image: JAX_1798819
Specimen Label: JAX_1798819
Detected: true
Specimen Num: 31
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692875
Age: postnatal adult
Image: JAX_1798824
Specimen Label: JAX_1798824
Detected: true
Specimen Num: 36
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692875
Age: postnatal adult
Image: JAX_1798803
Specimen Label: JAX_1798803
Detected: true
Specimen Num: 15
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•
GXD Expression
GXD Expression
 
Probe: MGI:974192
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1778223
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4823442
Age: embryonic day 14.5
Image: euxassay_006212_12
Specimen Label: euxassay_006212_12
Detected: true
Specimen Num: 12
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:974192
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1778223
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4823442
Age: embryonic day 14.5
Image: euxassay_006212_13
Specimen Label: euxassay_006212_13
Detected: true
Specimen Num: 13
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:974192
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1778223
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4823442
Age: embryonic day 14.5
Image: euxassay_006212_17
Specimen Label: euxassay_006212_17
Detected: true
Specimen Num: 17
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•
GXD Expression
GXD Expression
 
Probe: MGI:974192
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1778223
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4823442
Age: embryonic day 14.5
Image: euxassay_006212_18
Specimen Label: euxassay_006212_18
Detected: true
Specimen Num: 18
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692875
Age: postnatal adult
Image: JAX_1798830
Specimen Label: JAX_1798830
Detected: true
Specimen Num: 42
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692875
Age: postnatal adult
Image: JAX_1798807
Specimen Label: JAX_1798807
Detected: true
Specimen Num: 19
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692875
Age: postnatal adult
Image: JAX_1798811
Specimen Label: JAX_1798811
Detected: true
Specimen Num: 23
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Protein
Q80VS5
Organism: Mus musculus/domesticus
Length: 365  
Fragment?: true
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Allele
Tg(Brca2*)1Sks | MGI:3830346
Name: transgene insertion 1, Shyam Sharan
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Cntrob<Gt(AN0733)Wtsi> | MGI:3856901
 
Name: centrobin, centrosomal BRCA2 interacting protein; gene trap AN0733, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Cntrob<Gt(BB0144)Wtsi> | MGI:3857964
 
Name: centrobin, centrosomal BRCA2 interacting protein; gene trap BB0144, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Cntrob<tm1a(KOMP)Wtsi> | MGI:4363017
Name: centrobin, centrosomal BRCA2 interacting protein; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Cntrob<tm1e(KOMP)Wtsi> | MGI:4364150
Name: centrobin, centrosomal BRCA2 interacting protein; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Cntrob<Gt(EUCE322g01)Hmgu> | MGI:4388353
 
Name: centrobin, centrosomal BRCA2 interacting protein; gene trap EUCE322g01, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Bccip<tm1a(EUCOMM)Hmgu> | MGI:4435867
Name: BRCA2 and CDKN1A interacting protein; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Bccip<tm1e(EUCOMM)Hmgu> | MGI:4436524
Name: BRCA2 and CDKN1A interacting protein; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Cntrob<Gt(IST13618E6)Tigm> | MGI:5177477
 
Name: centrobin, centrosomal BRCA2 interacting protein; gene trap IST13618E6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Cntrob<Gt(IST13913D8)Tigm> | MGI:5198597
 
Name: centrobin, centrosomal BRCA2 interacting protein; gene trap IST13913D8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Bccip<tm1b(EUCOMM)Hmgu> | MGI:5548513
Name: BRCA2 and CDKN1A interacting protein; targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Cntrob<em1(IMPC)Bay> | MGI:6361235
Name: centrobin, centrosomal BRCA2 interacting protein; endonuclease-mediated mutation 1, Baylor College of Medicine
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Bccip<tm1d(EUCOMM)Hmgu> | MGI:6489524
Name: BRCA2 and CDKN1A interacting protein; targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Bccip<tm1c(EUCOMM)Hmgu> | MGI:6489522
Name: BRCA2 and CDKN1A interacting protein; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Bccip<em16Gpt> | MGI:7295845
Name: BRCA2 and CDKN1A interacting protein; endonuclease-mediated mutation 16, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Bccip<em1Gpt> | MGI:7295846
Name: BRCA2 and CDKN1A interacting protein; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Cntrob<em1Gpt> | MGI:7297240
Name: centrobin, centrosomal BRCA2 interacting protein; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
25016020 | J:267154
First Author: Simhadri S
Year: 2014
Journal: J Biol Chem
Title: Male fertility defect associated with disrupted BRCA1-PALB2 interaction in mice.
Volume: 289
Issue: 35
Pages: 24617-29
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Allele
Brca2<tm1Kamc> | MGI:2448890
Name: breast cancer 2, early onset; targeted mutation 1, Kimberly A McAllister
Allele Type: Targeted
Attribute String: Null/knockout
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Gene
5892 | RAD51D
Type: gene
Organism: human
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Publication
9212093 | J:41377
First Author: Brugarolas J
Year: 1997
Journal: Nat Med
Title: Double indemnity: p53, BRCA and cancer. p53 mutation partially rescues developmental arrest in Brca1 and Brca2 null mice, suggesting a role for familial breast cancer genes in DNA damage repair.
Volume: 3
Issue: 7
Pages: 721-2
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Publication
29047390 | J:317891
First Author: Droz-Rosario R
Year: 2017
Journal: Breast Cancer Res
Title: Roles of BCCIP deficiency in mammary tumorigenesis.
Volume: 19
Issue: 1
Pages: 115
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Publication
14651845 | -
First Author: Hughes-Davies L
Year: 2003
Journal: Cell
Title: EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.
Volume: 115
Issue: 5
Pages: 523-35
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GO Term
GO:0002111 | BRCA2-BRAF35 complex
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GO Term
GO:0033593 | BRCA2-MAGE-D1 complex
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Interaction Experiment
Atanassov BS (2005)
Description: Homozygous germ line mutation in exon 27 of murine Brca2 disrupts the Fancd2-Brca2 pathway in the homologous recombination-mediated DNA interstrand cross-links repair but does not affect meiosis.
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Allele
Tg(MMTV-cre)4Mam | MGI:2176166
Name: transgene insertion 4, Lothar Hennighausen
Allele Type: Transgenic
Attribute String: Recombinase
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Genotype
Genotype
Symbol: Brca2/Brca2
Background: involves: 129P2/OlaHsd * BALB/c
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0111089 | Fanconi anemia complementation group D1
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Gene
5889 | RAD51C
Type: gene
Organism: human
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Strain
MGI:4843242 | B6;129P2-Cntrob<Gt(AN0733)Wtsi>/Mmucd
Attribute String: gene trap, mutant stock
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Strain
MGI:7381066 | C57BL/6NTac-Bccip<tm1a(EUCOMM)Hmgu>/Ieg
Attribute String: coisogenic, mutant strain, targeted mutation
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Strain
MGI:6122062 | C57BL/6N-Bccip<tm1b(EUCOMM)Hmgu>/Ieg
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:7388717 | C57BL/6N-Cntrob<em1(IMPC)Bay>/BayMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:6866065 | C57BL/6N-Cntrob<em1(IMPC)Bay>/Mmmh
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Bccip/Bccip
Background: C57BL/6N-Bccip/Ieg
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cntrob/Cntrob
Background: C57BL/6N-Cntrob/BayMmucd
Zygosity: hm
Has Mutant Allele: true
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Publication
24145349 | J:206526
First Author: Huang YY
Year: 2013
Journal: Cancer Res
Title: BCCIP suppresses tumor initiation but is required for tumor progression.
Volume: 73
Issue: 23
Pages: 7122-33
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Publication
29739757 | J:264253
First Author: Mahdi AH
Year: 2018
Journal: Cancer Res
Title: Evidence of Intertissue Differences in the DNA Damage Response and the Pro-oncogenic Role of NF-κB in Mice with Disengaged BRCA1-PALB2 Interaction.
Volume: 78
Issue: 14
Pages: 3969-3981
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Publication
17535851 | J:124008
First Author: Jeong Y
Year: 2007
Journal: J Cell Sci
Title: Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization.
Volume: 120
Issue: Pt 12
Pages: 2106-16
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Publication
24896180 | -
First Author: Bhatia V
Year: 2014
Journal: Nature
Title: BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.
Volume: 511
Issue: 7509
Pages: 362-5
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Publication
17767921 | -
First Author: Min J
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Identification of Rad51 regulation by BRCA2 using Caenorhabditis elegans BRCA2 and bimolecular fluorescence complementation analysis.
Volume: 362
Issue: 4
Pages: 958-64
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Genotype
Genotype
Symbol: Bccip/Bccip<+>
Background: C57BL/6N-Bccip/Ieg
Zygosity: ht
Has Mutant Allele: true
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Allele
Trp53<tm1Brd> | MGI:1857590
Name: transformation related protein 53; targeted mutation 1, Allan Bradley
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Brca1<tm2Cxd> | MGI:1931238
Name: breast cancer 1, early onset; targeted mutation 2, Chu-Xia Deng
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Brca1/Brca1 Trp53/Trp53<+> Tg(MMTV-cre)4Mam/?
Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Brca1/Brca1 Tg(MMTV-cre)4Mam/? Tg(MMTV-rtTA)1Lach/? Tg(tetO-Esr1)#Paf/? Trp53/Trp53<+>
Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
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DO Term
DOID:5683 | hereditary breast ovarian cancer syndrome
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Protein Domain
IPR031920 | PALB2_WD40
Type: Domain
Description: This domain is found at the C terminus of partner and localiser of BRCA2 (PALB2). It is a seven-bladed WD40-type β-propeller. It binds to the N terminus of BRCA2 [].
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Publication
23650262 | J:203561
First Author: Huo Y
Year: 2013
Journal: Cancer Discov
Title: Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer.
Volume: 3
Issue: 8
Pages: 894-907
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Publication
29426838 | J:262752
First Author: Chiang HC
Year: 2018
Journal: Sci Rep
Title: Gene-Specific Genetic Complementation between Brca1 and Cobra1 During Mouse Mammary Gland Development.
Volume: 8
Issue: 1
Pages: 2731
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Publication
28240985 | J:244866
   
First Author: Luijsterburg MS
Year: 2017
Journal: Elife
Title: A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation.
Volume: 6
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Genotype
Genotype
Symbol: Brca1/Brca1 Trp53/Trp53<+> Tg(MMTV-cre)4Mam/?
Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
Zygosity: cn
Has Mutant Allele: true
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Publication
15611632 | -
First Author: Fei P
Year: 2005
Journal: Cell Cycle
Title: New advances in the DNA damage response network of Fanconi anemia and BRCA proteins. FAAP95 replaces BRCA2 as the true FANCB protein.
Volume: 4
Issue: 1
Pages: 80-6
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Publication
16127665 | -
First Author: Atanassov BS
Year: 2005
Journal: Genes Chromosomes Cancer
Title: Homozygous germ line mutation in exon 27 of murine Brca2 disrupts the Fancd2-Brca2 pathway in the homologous recombination-mediated DNA interstrand cross-links' repair but does not affect meiosis.
Volume: 44
Issue: 4
Pages: 429-37
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Publication
21966279 | J:176115
First Author: Lu H
Year: 2011
Journal: PLoS Genet
Title: Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes.
Volume: 7
Issue: 9
Pages: e1002291
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Publication
19117032 | J:149267
First Author: Sonn S
Year: 2009
Journal: Mol Reprod Dev
Title: Nip2/centrobin may be a substrate of Nek2 that is required for proper spindle assembly during mitosis in early mouse embryos.
Volume: 76
Issue: 6
Pages: 587-92
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Publication
10878006 | -
First Author: Ono T
Year: 2000
Journal: J Biol Chem
Title: TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase.
Volume: 275
Issue: 40
Pages: 31145-54
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Publication
12912920 | -
First Author: Audhya A
Year: 2003
Journal: EMBO J
Title: Regulation of PI4,5P2 synthesis by nuclear-cytoplasmic shuttling of the Mss4 lipid kinase.
Volume: 22
Issue: 16
Pages: 4223-36
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Publication
14726710 | -
First Author: Meng X
Year: 2004
Journal: Cell Cycle
Title: Inhibition of G1 to S cell cycle progression by BCCIP beta.
Volume: 3
Issue: 3
Pages: 343-8
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Publication
17947333 | -
First Author: Lu H
Year: 2007
Journal: Nucleic Acids Res
Title: BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage.
Volume: 35
Issue: 21
Pages: 7160-70
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Protein Domain
IPR025602 | BCP1_family
Type: Family
Description: This family of proteins includes BRCA2 and CDKN1A-interacting protein (BCCIP) and Bcp1. In fungi, Bcp1 is involved in nuclear export, actin cytoskeleton organisation and vesicular transport []. Its homologue in human and mouse, BCCIP, may promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A/p21 and may be required for repair of DNA damage by homologous recombination in conjunction with BRCA2 [, , , ].
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Gene
672 | BRCA1
Type: gene
Organism: human
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Publication
22315412 | J:182010
First Author: Ezell SA
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY.
Volume: 109
Issue: 10
Pages: E613-21
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Publication
15102447 | -
First Author: Bochkarev A
Year: 2004
Journal: Curr Opin Struct Biol
Title: From RPA to BRCA2: lessons from single-stranded DNA binding by the OB-fold.
Volume: 14
Issue: 1
Pages: 36-42
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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