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Search results 801 to 900 out of 2972 for Ca2

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Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Ksr1/Ksr1
Background: involves: DBA/1LacJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Kit-cre)151Eks/? Tg(CAG-lacZ)32And/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Drd1a-cre)1Gsc/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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MP Term
MP:0008284 | abnormal hippocampus pyramidal cell layer
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MP Term
MP:0011151 | abnormal hippocampus stratum radiatum morphology
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Allele
Man2b1<tm1Psa> | MGI:3584185
Name: mannosidase 2, alpha B1; targeted mutation 1, Paul Saftig
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
34242703 | J:352551
 
First Author: Campbell LA
Year: 2021
Journal: J Neurosci Methods
Title: Protein-retention expansion microscopy for visualizing subcellular organelles in fixed brain tissue.
Volume: 361
Pages: 109285
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Publication
1916821 | J:11485
First Author: Lowe N
Year: 1991
Journal: Genomics
Title: Physical mapping of the human carbonic anhydrase gene cluster on chromosome 8.
Volume: 10
Issue: 4
Pages: 882-8
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Publication
31417591 | -
 
First Author: Cutolo E
Year: 2019
Journal: Front Plant Sci
Title: The High Light Response in Arabidopsis Requires the Calcium Sensor Protein CAS, a Target of STN7- and STN8-Mediated Phosphorylation.
Volume: 10
Pages: 974
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Publication
21919914 | -
First Author: Huang SS
Year: 2012
Journal: Physiol Plant
Title: Calcium and calcium receptor CAS promote Arabidopsis thaliana de-etiolation.
Volume: 144
Issue: 1
Pages: 73-82
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Publication
21940718 | -
First Author: Wang WH
Year: 2012
Journal: J Exp Bot
Title: Calcium-sensing receptor regulates stomatal closure through hydrogen peroxide and nitric oxide in response to extracellular calcium in Arabidopsis.
Volume: 63
Issue: 1
Pages: 177-90
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Protein Domain
IPR044690 | CAS_plant
Type: Family
Description: The calcium sensing receptor (CAS) from Arabidopsis is a thylakoid-localised phosphoprotein that possesses a single transmembrane domain that splits the protein into two halves: the N-terminal domain which binds Ca2 with low affinity and high capacity, and the C-terminal domain that contains a non-catalytic rhodanese homology domain and phosphorylation sites []. It modulates cytoplasmic Ca2 levels and it is required for proper stomatal regulation in response to elevated levels of external Ca2 []and it is also involved in de-etiolation []. This protein also plays a role in the STN7/STN8/TAP38 network of phosphorylation-mediated photoacclimation processes in Arabidopsis [].
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Publication
24361611 | J:210863
First Author: Mardones P
Year: 2014
Journal: Biochim Biophys Acta
Title: Cyclic AMP and alkaline pH downregulate carbonic anhydrase 2 in mouse fibroblasts.
Volume: 1840
Issue: 6
Pages: 1765-70
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Publication
8883907 | J:35418
First Author: Nagatomo I
Year: 1996
Journal: Brain Res
Title: Sparse distribution of NADPH diaphorase neurons in the hippocampal formation of the inbred mutant strain EL mouse.
Volume: 730
Issue: 1-2
Pages: 223-6
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Publication
14688294 | -
First Author: Reddy VS
Year: 2004
Journal: Plant Cell
Title: KIC, a novel Ca2+ binding protein with one EF-hand motif, interacts with a microtubule motor protein and regulates trichome morphogenesis.
Volume: 16
Issue: 1
Pages: 185-200
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Publication
22323814 | -
First Author: Liao J
Year: 2012
Journal: Science
Title: Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger.
Volume: 335
Issue: 6069
Pages: 686-90
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Publication
27183196 | -
First Author: Liao J
Year: 2016
Journal: Nat Struct Mol Biol
Title: Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger.
Volume: 23
Issue: 6
Pages: 590-599
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Protein Domain
IPR043549 | C2C4C/C2C4D
Type: Family
Description: The function of C2 calcium-dependent domain-containing protein 4C/4D is not known. The C2 domain is a Ca2 -dependent membrane-targeting module found in many cellular proteins involved in signal transduction or membrane trafficking.
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Protein Domain
IPR044205 | KIC/PBP1/KRP1
Type: Family
Description: This entry represents a group of plant calcium-binding proteins, including KRP1/PBP1/KIC from Arabidopsis. KIC interacts with kinesin-like calmodulin binding protein (KCBP) and modulates its activity in response to changes in cytosolic Ca2 and regulates trichome morphogenesis [].
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Protein Domain
IPR044880 | NCX_ion-bd_dom_sf
Type: Homologous_superfamily
Description: Na/Ca2 exchangers (NCX) are membrane transporters that play an essential role in maintaining the homeostasis of cytosolic Ca2 for cell signalling. Ca2 is moved into or out of the cytosol depending on Na concentration. NCXhas a symmetrical structure containing ten transmembrane helices, divided in two halves with a similar structure but opposite orientation. Based on its symmetry, NCX is able to catalyse bidirectional ion-exchange reactions. Four ion-binding sites cluster at the centre of the protein: one specific for Ca2 and three that likely bind Na. Two passageways allow for Na and Ca2 access to the central ion-binding sites from the extracellular side [, ].This superfamily entry represents the large central ion-binding region made up of 8 transmembrane helices, also known as the intracellular regulatory domain.
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Protein Domain
IPR042798 | EFCAB9
Type: Family
Description: EF-hand calcium-binding domain-containing protein 9 (EFCAB9) is a pH-dependent Ca2 sensor modulating the channel activity and the domain organization of CatSper, a sperm-specific, pH-sensitive calcium channel essential for hyperactivated motility and male fertility [].
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Allele
Clstn3<tm1.1Amcr> | MGI:5521290
Name: calsyntenin 3; targeted mutation 1.1, Ann Marie Craig
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Pik3r4<mbe> | MGI:6324670
Name: phosphoinositide-3-kinase regulatory subunit 4; marble
Allele Type: Chemically induced (ENU)
Attribute String: Hypomorph
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Publication
19883615 | J:155434
First Author: Costanzo-Garvey DL
Year: 2009
Journal: Cell Metab
Title: KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity.
Volume: 10
Issue: 5
Pages: 366-78
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Publication
22301919 | J:204635
First Author: Gramling MW
Year: 2012
Journal: Cell Death Differ
Title: Suppression of Ras/Mapk pathway signaling inhibits Myc-induced lymphomagenesis.
Volume: 19
Issue: 7
Pages: 1220-7
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Publication
25542970 | J:219199
First Author: Kimura A
Year: 2015
Journal: Am J Pathol
Title: Valproic acid prevents NMDA-induced retinal ganglion cell death via stimulation of neuronal TrkB receptor signaling.
Volume: 185
Issue: 3
Pages: 756-64
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Publication
21304518 | J:180352
 
First Author: Harada C
Year: 2011
Journal: Nat Commun
Title: Glia- and neuron-specific functions of TrkB signalling during retinal degeneration and regeneration.
Volume: 2
Pages: 189
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Allele
Tg(Camk2a-rtTA)1237Kndl | MGI:3716991
Name: transgene insertion 1237, Eric R Kandel
Allele Type: Transgenic
Attribute String: Transactivator
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Genotype
Genotype
Symbol: Psen1/Psen1 Tg(Thy1-APP)28Lpr/?
Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kcnj6/Kcnj6
Background: involves: C57BL/6J * CBA
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lrp8/Lrp8
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
7956345 | J:22103
First Author: Broad TE
Year: 1995
Journal: Cytogenet Cell Genet
Title: Assignment of five loci from human chromosome 8q onto sheep chromosome 9.
Volume: 68
Issue: 1-2
Pages: 102-6
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Protein Coding Gene
MGI:108554 | Dab1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107286 | Man2b1
Type: protein_coding_gene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Man2b1/Man2b1
Background: involves: 129 * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Agtr2/?
Background: involves: 129P2/OlaHsd
Zygosity: ot
Has Mutant Allele: true
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Publication
8307146 | J:16589
First Author: Coppola T
Year: 1994
Journal: FEBS Lett
Title: Molecular cloning of a murine N-type calcium channel alpha 1 subunit. Evidence for isoforms, brain distribution, and chromosomal localization.
Volume: 338
Issue: 1
Pages: 1-5
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Publication
36924980 | J:335507
     
First Author: Ding Z
Year: 2023
Journal: Biol Psychiatry
Title: Genetic Ablation of GIGYF1, Associated With Autism, Causes Behavioral and Neurodevelopmental Defects in Zebrafish and Mice.
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Publication
17382888 | J:126510
First Author: Shimizu K
Year: 2007
Journal: Cell
Title: Proteolytic degradation of SCOP in the hippocampus contributes to activation of MAP kinase and memory.
Volume: 128
Issue: 6
Pages: 1219-29
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Strain
MGI:3716992 | C57BL/6-Tg(Camk2a-rtTA)1237Kndl/Orl
Attribute String: mutant strain, transgenic
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Publication
17884610 | J:139629
First Author: Havekes R
Year: 2008
Journal: Neurobiol Learn Mem
Title: Transgenic inhibition of neuronal calcineurin activity in the forebrain facilitates fear conditioning, but inhibits the extinction of contextual fear memories.
Volume: 89
Issue: 4
Pages: 595-8
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Publication
18003876 | J:147818
First Author: Tong G
Year: 2008
Journal: J Neurophysiol
Title: Modulation of NMDA receptor properties and synaptic transmission by the NR3A subunit in mouse hippocampal and cerebrocortical neurons.
Volume: 99
Issue: 1
Pages: 122-32
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Publication
20202082 | J:160244
First Author: Pitzer C
Year: 2010
Journal: J Neurochem
Title: The hematopoietic factor granulocyte-colony stimulating factor improves outcome in experimental spinal cord injury.
Volume: 113
Issue: 4
Pages: 930-42
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Allele
Tg(Amigo2-icre/ERT2)1Ehs | MGI:6754158
Name: transgene insertion 1, National Institute of Environmental Health Science
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Allele
Tg(Amigo2-icre/ERT2)2Ehs | MGI:6754159
Name: transgene insertion 2, National Institute of Environmental Health Science
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Genotype
Genotype
Symbol: Ksr1/Ksr1 Tg(MMTV-PyVT)634Mul/?
Background: involves: C57BL/6 * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ksr1/Ksr1 Tg(DO11.10)10Dlo/?
Background: involves: BALB/c * C3H * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Camk4/Camk4 Tg(Drd1a-cre)1Gsc/?
Background: involves: 129 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Cacng5-cre)181Tjmc/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Allele
Pebp1<tm1.1Norm> | MGI:6450937
Name: phosphatidylethanolamine binding protein 1; targeted mutation 1.1, Noriyuki Matsukawa
Allele Type: Targeted
Attribute String: Conditional ready
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Genotype
Genotype
Symbol: Pafah1b1/Pafah1b1<+>
Background: involves: 129S6/SvEvTac
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dcx/Dcx<+>
Background: involves: 129S6/SvEvTac * 129X1/SvJ * Black Swiss
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Reln/Reln
Background: involves: 129S4/SvJaeSor * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dab1/Dab1
Background: involves: 129S4/SvJaeSor
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dab1/Dab1
Background: involves: 129S4/SvJaeSor
Zygosity: hm
Has Mutant Allele: true
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Protein Coding Gene
MGI:103022 | Reln
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q925Q3
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: false
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Protein
Q99MU1
Organism: Mus musculus/domesticus
Length: 369  
Fragment?: false
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Protein
D3Z018
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: true
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Protein
A0A0N4SUW2
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
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Protein
D3Z226
Organism: Mus musculus/domesticus
Length: 529  
Fragment?: false
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Protein
A0A0N4SVI2
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: false
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Protein
A0A0N4SVH0
Organism: Mus musculus/domesticus
Length: 222  
Fragment?: true
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Protein
A0A0N4SW75
Organism: Mus musculus/domesticus
Length: 222  
Fragment?: false
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Protein
A0A0N4SW46
Organism: Mus musculus/domesticus
Length: 230  
Fragment?: true
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Publication
22206669 | -
First Author: Jin G
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Two G-protein-coupled-receptor candidates, Cand2 and Cand7, are involved in Arabidopsis root growth mediated by the bacterial quorum-sensing signals N-acyl-homoserine lactones.
Volume: 417
Issue: 3
Pages: 991-5
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Publication
29702752 | -
First Author: Wei J
Year: 2018
Journal: J Pineal Res
Title: Phytomelatonin receptor PMTR1-mediated signaling regulates stomatal closure in Arabidopsis thaliana.
Volume: 65
Issue: 2
Pages: e12500
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Protein Domain
IPR018781 | TPRA1/CAND2/CAND8
Type: Family
Description: This family of membrane proteins are conserved from plants to humans, including CAND2 and CAND8 from Arabidopsis. CAND2 and CAND8 are predicted G-protein coupled receptors []. CAND2 plays a role in plants and microbes interactions []and acts as a phytomelatonin receptor that regulates stomatal closure through the Galpha subunit-mediated H2O2 production and Ca2 flux dynamics [].
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Genotype
Genotype
Symbol: Pafah1b1/Pafah1b1
Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Clstn3/Clstn3
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pik3r4/Pik3r4
Background: involves: C3H/HeH * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
38878815 | J:352539
     
First Author: Buss EW
Year: 2024
Journal: Neuroscience
Title: Regulation by Presynaptic NMDA Receptors of Non-Linear Postsynaptic Summation of the Cortical Input to CA1 Pyramidal Neurons.
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Publication
37797581 | J:341983
First Author: Shih YT
Year: 2023
Journal: Neuron
Title: An inhibitory circuit-based enhancer of DYRK1A function reverses Dyrk1a-associated impairment in social recognition.
Volume: 111
Issue: 19
Pages: 3084-3101.e5
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Publication
16446138 | J:106973
First Author: Chang Q
Year: 2006
Journal: Neuron
Title: The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression.
Volume: 49
Issue: 3
Pages: 341-8
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Publication
31745235 | J:290184
     
First Author: McCann KE
Year: 2019
Journal: Mol Psychiatry
Title: Novel role for mineralocorticoid receptors in control of a neuronal phenotype.
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Publication
27133464 | J:239575
First Author: Stempel AV
Year: 2016
Journal: Neuron
Title: Cannabinoid Type 2 Receptors Mediate a Cell Type-Specific Plasticity in the Hippocampus.
Volume: 90
Issue: 4
Pages: 795-809
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Publication
31442405 | J:290398
First Author: Suh J
Year: 2019
Journal: Cell
Title: Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.
Volume: 178
Issue: 5
Pages: 1159-1175.e17
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Publication
36623761 | J:333881
 
First Author: Katsube S
Year: 2023
Journal: Neurosci Lett
Title: The murine ortholog of Kaufman oculocerebrofacial syndrome gene Ube3b is crucial for the maintenance of the excitatory synapses in the young adult stage.
Volume: 797
Pages: 137059
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Publication
10594652 | J:89423
First Author: Sakaguchi G
Year: 1999
Journal: Eur J Neurosci
Title: Doc2alpha is an activity-dependent modulator of excitatory synaptic transmission.
Volume: 11
Issue: 12
Pages: 4262-8
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Publication
9792239 | J:95720
First Author: Insausti AM
Year: 1998
Journal: Neurosci Lett
Title: Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of Down syndrome.
Volume: 253
Issue: 3
Pages: 175-8
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Publication
39446584 | J:358351
First Author: Jiang YQ
Year: 2024
Journal: Cell Rep
Title: Hypothalamic regulation of hippocampal CA1 interneurons by the supramammillary nucleus.
Volume: 43
Issue: 11
Pages: 114898
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Publication
31597108 | J:286410
First Author: Farris S
Year: 2019
Journal: Cell Rep
Title: Hippocampal Subregions Express Distinct Dendritic Transcriptomes that Reveal Differences in Mitochondrial Function in CA2.
Volume: 29
Issue: 2
Pages: 522-539.e6
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Publication
30517859 | J:352063
First Author: Hashimotodani Y
Year: 2018
Journal: Cell Rep
Title: Supramammillary Nucleus Afferents to the Dentate Gyrus Co-release Glutamate and GABA and Potentiate Granule Cell Output.
Volume: 25
Issue: 10
Pages: 2704-2715.e4
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Publication
33719157 | J:311404
First Author: Bertling E
Year: 2021
Journal: EMBO Rep
Title: Carbonic anhydrase seven bundles filamentous actin and regulates dendritic spine morphology and density.
Volume: 22
Issue: 4
Pages: e50145
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Publication
38382521 | J:346681
     
First Author: Boyle LM
Year: 2024
Journal: Neuron
Title: Tuned geometries of hippocampal representations meet the computational demands of social memory.
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Publication
8069696 | J:18321
First Author: Kaisho Y
Year: 1994
Journal: Brain Res
Title: Expression of neurotrophin genes in the brain of senescence-accelerated mouse (SAM) during postnatal development.
Volume: 647
Issue: 1
Pages: 139-44
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Publication
9837756 | J:51345
First Author: Park C
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Expression of fas antigen in the normal mouse brain.
Volume: 252
Issue: 3
Pages: 623-8
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Allele
Agtr2<tm1Tin> | MGI:2178475
Name: angiotensin II receptor, type 2; targeted mutation 1, Tadashi Inagami
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Ctnnb1<tm2Kem> | MGI:2148567
Name: catenin beta 1; targeted mutation 2, Rolf Kemler
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Publication
10508862 | J:57915
First Author: Wang X
Year: 1999
Journal: J Cell Biol
Title: Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin.
Volume: 147
Issue: 1
Pages: 151-62
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Publication
11285225 | J:68769
First Author: Gerber SH
Year: 2001
Journal: EMBO J
Title: An unusual C(2)-domain in the active-zone protein piccolo: implications for Ca(2+) regulation of neurotransmitter release.
Volume: 20
Issue: 7
Pages: 1605-19
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Protein Domain
IPR042720 | PCLO_FYVE1
Type: Domain
Description: Protein piccolo, also known as aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones []. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics []. It also functions as a presynaptic low-affinity Ca2 sensor and has been implicated in Ca2 regulation of neurotransmitter release []. Piccolo is a multi-domain protein containing two N-terminal FYVE zinc fingers, a polyproline tract, and a PDZ domain and two C-terminal C2 domains. This entry represents the first FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.
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Publication
31199454 | J:283448
First Author: Sun SC
Year: 2019
Journal: Brain
Title: Mutations in C1orf194, encoding a calcium regulator, cause dominant Charcot-Marie-Tooth disease.
Volume: 142
Issue: 8
Pages: 2215-2229
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Protein
Q9DAD0
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: false
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Publication
20813840 | J:170219
First Author: Yamazaki H
Year: 2010
Journal: J Biol Chem
Title: Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening.
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First Author: Chan J
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Journal: J Biol Chem
Title: Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating.
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Year: 2008
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Title: Identification of cardiac-specific myosin light chain kinase.
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Title: Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8.
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Journal: J Cell Sci
Title: A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.
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Title: Myosin light chain kinase and the role of myosin light chain phosphorylation in skeletal muscle.
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