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Search results 801 to 900 out of 1112 for Cbs

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Type Details Score
Publication
35338694 | -
     
First Author: Knejzlík Z
Year: 2022
Journal: FEBS J
Title: The mycobacterial guaB1 gene encodes a guanosine 5'-monophosphate reductase with a cystathionine-β-synthase domain.
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Protein Domain
IPR016426 | MA1821-like
Type: Family
Description: In Methanosarcina acetivorans, MA1821 is a L-aspartate semialdehyde sulfurtransferase required for O-acetylhomoserine sulfhydrylase (OAHS)-independent homocysteine (Hcy) biosynthesis [, ]. It contains two C-terminal cystathionine beta-synthase (CBS) domains. The CBS domains bind S-adenosyl-l-methionine (SAM) and 5'-methylthioadenosine (MTA), which induce a conformational change consistent with regulatory function. Another protein in the same pathway, MA1822, is involved in the reduction of the disulfide formed in MA1821 during the conversion of Asa (aspartate semialdehyde) to Hcy [, ].
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Protein Domain
IPR005991 | GUAB1-like
Type: Family
Description: This family of proteins restricted to the high GC Gram-positive bacteria includes GMP reductase from Mycobacterium smegmatis (GUAB1), which is involved in the purine-salvage pathway. This protein is composed of two domains: a catalytic domain with a TIM barrel structure and another that folds as a typical Bateman domain composed of two CBS domains (cystathionine-beta-synthase domain, CBS, ), which are essential for the NADPH-dependent conversion of GMP to IMP [].
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HT Experiment
E-GEOD-54286 | The Atlas of Chromatoid Body Components [RNA-seq]
Series Id: GSE54286
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-54287 | The Atlas of Chromatoid Body Components [small RNA-seq]
Series Id: GSE54287
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Coding Gene
MGI:2151055 | Cnnm3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0014038 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGI:1891366 | Cnnm1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0022979 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0015925 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_129S1SvImJ_G0025151 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0015909 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0025128 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0015864 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0025096 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0015863 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0025122 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0015696 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024882 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2151055 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1891366 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0016316 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0025565 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015277 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0024347 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0015668 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024862 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0015769 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0024994 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0015771 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0024955 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0015839 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0025080 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0015791 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0024986 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0016363 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0025623 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015060 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0024096 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0015339 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0024417 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0014469 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_PahariEiJ_G0027284 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0014842 | -
Type: protein_coding_gene
Organism: Mus spretus
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Protein Coding Gene
MGP_SPRETEiJ_G0023900 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
15840172 | J:243403
 
First Author: Guo D
Year: 2005
Journal: Mol Pain
Title: Physical interaction and functional coupling between ACDP4 and the intracellular ion chaperone COX11, an implication of the role of ACDP4 in essential metal ion transport and homeostasis.
Volume: 1
Pages: 15
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Publication
27251091 | J:236500
First Author: Chandran U
Year: 2016
Journal: Biol Reprod
Title: Expression of Cnnm1 and Its Association with Stemness, Cell Cycle, and Differentiation in Spermatogenic Cells in Mouse Testis.
Volume: 95
Issue: 1
Pages: 7
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Publication
- | J:67139
   
First Author: Wang C
Year: 2000
Journal: GenBank Submission
Title: Mus musculus ancient conserved domain protein 3 (Adcp3) mRNA, compkete cds
Pages: AF216964
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Publication
16390329 | -
First Author: Meredith TC
Year: 2006
Journal: Biochem J
Title: Characterization of Escherichia coli D-arabinose 5-phosphate isomerase encoded by kpsF: implications for group 2 capsule biosynthesis.
Volume: 395
Issue: 2
Pages: 427-32
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Publication
7490287 | -
First Author: Bohmann K
Year: 1995
Journal: J Cell Biol
Title: Mutational analysis of p80 coilin indicates a functional interaction between coiled bodies and the nucleolus.
Volume: 131
Issue: 4
Pages: 817-31
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Publication
11102515 | -
First Author: Hebert MD
Year: 2000
Journal: Mol Biol Cell
Title: Self-association of coilin reveals a common theme in nuclear body localization.
Volume: 11
Issue: 12
Pages: 4159-71
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Protein Domain
IPR031722 | Coilin_N
Type: Domain
Description: Coilin is a nuclear phosphoprotein that concentrates within Cajal bodies (CBs) and has a role in small nuclear ribonucleoprotein (snRNP) biogenesis []. Coilin also acts to repress polymerase I activity in response to cisplatin-induced DNA damage, which could indicate a link between the DNA damage response and the inhibition of rRNA synthesis [].Conservation at the amino acid level is highest within coilin's N- and C-termini. The first N-terminal 92-amino acid domain have been shown to self-interact and to be essential for proper targeting of coilin to CBs [, ].
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Publication
30768359 | J:292066
First Author: Maclean KN
Year: 2019
Journal: FASEB J
Title: Taurine alleviates repression of betaine-homocysteine S-methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine β-synthase-deficient homocystinuria.
Volume: 33
Issue: 5
Pages: 6339-6353
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Publication
25706610 | J:223521
First Author: Marechal D
Year: 2015
Journal: PLoS One
Title: Dosage of the Abcg1-U2af1 region modifies locomotor and cognitive deficits observed in the Tc1 mouse model of Down syndrome.
Volume: 10
Issue: 2
Pages: e0115302
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Publication
25315403 | -
First Author: Rauch BJ
Year: 2014
Journal: Mol Microbiol
Title: Novel proteins for homocysteine biosynthesis in anaerobic microorganisms.
Volume: 94
Issue: 6
Pages: 1330-42
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Publication
25938369 | -
First Author: Allen KD
Year: 2015
Journal: Biochemistry
Title: Homocysteine is biosynthesized from aspartate semialdehyde and hydrogen sulfide in methanogenic archaea.
Volume: 54
Issue: 20
Pages: 3129-32
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Publication
20163190 | -
First Author: Resch CT
Year: 2010
Journal: Biochemistry
Title: The putative Na+/H+ antiporter of Vibrio cholerae, Vc-NhaP2, mediates the specific K+/H+ exchange in vivo.
Volume: 49
Issue: 11
Pages: 2520-8
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Publication
14723793 | J:67136
First Author: Wang CY
Year: 2004
Journal: BMC Genomics
Title: Molecular cloning and characterization of the mouse Acdp gene family.
Volume: 5
Issue: 1
Pages: 7
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Publication
27149095 | J:232557
First Author: Fanourgakis G
Year: 2016
Journal: PLoS Genet
Title: Chromatoid Body Protein TDRD6 Supports Long 3' UTR Triggered Nonsense Mediated mRNA Decay.
Volume: 12
Issue: 5
Pages: e1005857
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Publication
21383078 | J:170319
First Author: Yabuta Y
Year: 2011
Journal: J Cell Biol
Title: TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice.
Volume: 192
Issue: 5
Pages: 781-95
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Publication
27365395 | J:235789
First Author: Kabil O
Year: 2016
Journal: J Biol Chem
Title: Heme-dependent Metabolite Switching Regulates H2S Synthesis in Response to Endoplasmic Reticulum (ER) Stress.
Volume: 291
Issue: 32
Pages: 16418-16423
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Publication
35817979 | J:330443
First Author: Anania C
Year: 2022
Journal: Nat Genet
Title: In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation.
Volume: 54
Issue: 7
Pages: 1026-1036
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Pseudogene
MGI:3645567 | Gemin6-ps
Type: pseudogene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914492 | Gemin6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2384300 | Gemin8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q5SU73
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
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Protein
E9Q284
Organism: Mus musculus/domesticus
Length: 573  
Fragment?: false
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Protein
Q3UJN9
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
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Publication
21289084 | -
First Author: Gilder AS
Year: 2011
Journal: Mol Biol Cell
Title: Coilin participates in the suppression of RNA polymerase I in response to cisplatin-induced DNA damage.
Volume: 22
Issue: 7
Pages: 1070-9
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Protein Domain
IPR001093 | IMP_DH_GMPRt
Type: Domain
Description: Synonym(s): Inosine-5'-monophosphate dehydrogenase, Inosinic acid dehydrogenase; Synonym(s): Guanosine 5'-monophosphate oxidoreductase This entry contains two related enzymes: IMP dehydrogenase and GMP reductase. These enzymes adopt a TIM barrel structure.IMP dehydrogenase () (IMPDH) catalyses the rate-limiting reaction of de novoGTP biosynthesis, the NAD-dependent reduction of IMP into XMP [].Inosine 5-phosphate + NAD++ H2O = xanthosine 5-phosphate + NADHIMP dehydrogenase is associated with cell proliferation and is a possible target for cancer chemotherapy. Mammalian and bacterial IMPDHs are tetramers of identical chains. There are two IMP dehydrogenase isozymes in humans []. IMP dehydrogenase nearly always contains a long insertion that has two CBS domains within it.GMP reductase () catalyses the irreversible and NADPH-dependent reductive deamination of GMP into IMP [].NADPH + guanosine 5-phosphate = NADP++ inosine 5-phosphate + NH3It converts nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and maintains intracellular balance of A and G nucleotides.
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Protein Domain
IPR015875 | IMP_DH/GMP_Rdtase_CS
Type: Conserved_site
Description: Synonym(s): Inosine-5'-monophosphate dehydrogenase, Inosinic acid dehydrogenase; Synonym(s): Guanosine 5'-monophosphate oxidoreductase This entry contains two related enzymes: IMP dehydrogenase and GMP reductase. These enzymes adopt a TIM barrel structure.IMP dehydrogenase () (IMPDH) catalyses the rate-limiting reaction of de novoGTP biosynthesis, the NAD-dependent reduction of IMP into XMP [].Inosine 5-phosphate + NAD++ H2O = xanthosine 5-phosphate + NADHIMP dehydrogenase is associated with cell proliferation and is a possible target for cancer chemotherapy. Mammalian and bacterial IMPDHs are tetramers of identical chains. There are two IMP dehydrogenase isozymes in humans []. IMP dehydrogenase nearly always contains a long insertion that has two CBS domains within it.GMP reductase () catalyses the irreversible and NADPH-dependent reductive deamination of GMP into IMP [].NADPH + guanosine 5-phosphate = NADP++ inosine 5-phosphate + NH3It converts nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and maintains intracellular balance of A and G nucleotides.
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Publication
2904262 | -
First Author: Andrews SC
Year: 1988
Journal: Biochem J
Title: Nucleotide sequence of the gene encoding the GMP reductase of Escherichia coli K12.
Volume: 255
Issue: 1
Pages: 35-43
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Publication
2902093 | -
First Author: Collart FR
Year: 1988
Journal: J Biol Chem
Title: Cloning and sequence analysis of the human and Chinese hamster inosine-5'-monophosphate dehydrogenase cDNAs.
Volume: 263
Issue: 30
Pages: 15769-72
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Publication
1969416 | -
First Author: Natsumeda Y
Year: 1990
Journal: J Biol Chem
Title: Two distinct cDNAs for human IMP dehydrogenase.
Volume: 265
Issue: 9
Pages: 5292-5
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Publication
1779764 | -
First Author: Gibson MM
Year: 1991
Journal: Mol Microbiol
Title: Magnesium transport in Salmonella typhimurium: the influence of new mutations conferring Co2+ resistance on the CorA Mg2+ transport system.
Volume: 5
Issue: 11
Pages: 2753-62
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Protein Coding Gene
MGI:2151060 | Cnnm4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0014037 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGI:2151054 | Cnnm2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0023045 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0015924 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_129S1SvImJ_G0025217 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0015908 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0025193 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0015863 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0025162 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0015862 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0025188 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0015695 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024948 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2151060 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2151054 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0016315 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0025631 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015276 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0024413 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0015667 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024928 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0015768 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0025060 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0015770 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom