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Search results 801 to 900 out of 992 for Ccr1

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Type Details Score
Protein Domain
IPR004068 | Chemokine_CCR8
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).CC chemokine receptors are a subfamily of the chemokine receptors that specifically bind and respond to cytokines of the CC chemokine family. There are currently ten members of the CC chemokine receptor subfamily, named CCR1 to 10. The receptors receptors are found in monocytes, lymphocytes, basophils and eosinophils.This entry represents CC chemokine receptor 8 (CCR8), which it is expressed predominantly in lymphoid tissues [, ]and has also been found in glomerular podocytes []and human umbilical vein endothelial cells (HUVECs) []. CCR8 is associated with Th2 lymphocytes, which are critical for allergy, and has a role in lymphocyte activation, migration, proliferation and differentiation and in allergic diseases [, , ]. CCR8 binds to CCL1 (also known as I-309) [, ]and to CCL16 (also known as liver expressed chemokine) []. It also exhibits a high affinity for three chemokines of viral origin: vMIP-I, vMIP-II and vMCC-I.
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Protein Domain
IPR002237 | Chemokine_CCR2
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).CC chemokine receptors are a subfamily of the chemokine receptors that specifically bind and respond to cytokines of the CC chemokine family. There are currently ten members of the CC chemokine receptor subfamily, named CCR1 to 10. The receptors receptors are found in monocytes, lymphocytes, basophils and eosinophils.This entry represents CC chemokine receptor 2 (CCR2), it is a receptor for the monocyte chemoattractant protein-1 (CCL2), a chemokine which specifically mediates monocyte chemotaxisis involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis []as well as in the inflammatory response against tumors []. It has also been shown that CCR2 deficient mice develop an accelerated Alzheimer's-like pathology in comparison to wild type mice [, , ]. CCR2 has also been shown to function in blood vessel remodeling []. Following interaction with specific CC chemokine ligands, CCR2 triggers a flux in intracellular calcium ions [, ]and inhibition of adenylyl cyclase []. This causes cell responses, including the recruitment of mononuclear phagocytes into the CNS, leading to chemotaxis [].
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Protein Domain
IPR002239 | Chemokine_CCR4
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).CC chemokine receptors are a subfamily of the chemokine receptors that specifically bind and respond to cytokines of the CC chemokine family. There are currently ten members of the CC chemokine receptor subfamily, named CCR1 to 10. The receptors receptors are found in monocytes, lymphocytes, basophils and eosinophils.This entry represents CC chemokine receptor 4 (CCR4), it is expressed on T(h)2 cells []and is up-regulated by T cell receptor activation. CCR4 is also found in the brain microvascular and coronary artery endothelial cells []and in blood dentric cells []. It has been suggested the receptor is invloved in trafficking of dendritic cells []. CCR4 is noted as playing a role in allergic reactions, particularly in asthma [, , ].
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Protein Domain
IPR002238 | Chemokine_CCR3
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).CC chemokine receptors are a subfamily of the chemokine receptors that specifically bind and respond to cytokines of the CC chemokine family. There are currently ten members of the CC chemokine receptor subfamily, named CCR1 to 10. The receptors receptors are found in monocytes, lymphocytes, basophils and eosinophils.This entry represents CC chemokine receptor 3 (CCR3), it is highly expressed in both eosinophils and basophils [, ], but can also be found in T helper cells [, ]and airway epithelial cells. CCR3 is noted for playing a role in allergic reactions [, , ]. Following interaction with specific CC chemokine ligands, CCR3 triggers a flux in intracellular calcium ions [, ]causing cell responses including chemotaxis [, , ].
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Protein Domain
IPR002240 | Chemokine_CCR5
Type: Family
Description: CC chemokine receptor 5 (CCR5) is found on the surface of white blood cells, such as macrophages [], T cells []and dendritic cells [, ], and expressed in lymphoid organs []. Transfected cells expressing CCR5 receptor bind CCL5 (RANTES), CCL4 (MIP-1beta) and CCL3 (MIP-1alpha), and generate inositol phosphates in response to these chemokines. The same combination of chemokines has been shown to potently inhibit human immunodeficiency virus replication in human peripheral blood leukocytes []. CCR5 is the major coreceptor for HIV-1 entry into target cells and is thought to be a suitable therapeutic target for HIV-1 blockade [].Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).CC chemokine receptors are a subfamily of the chemokine receptors that specifically bind and respond to cytokines of the CC chemokine family. There are currently ten members of the CC chemokine receptor subfamily, named CCR1 to 10. The receptors receptors are found in monocytes, lymphocytes, basophils and eosinophils.
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Protein Domain
IPR001718 | Chemokine_CCR7
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).CC chemokine receptors are a subfamily of the chemokine receptors that specifically bind and respond to cytokines of the CC chemokine family. There are currently ten members of the CC chemokine receptor subfamily, named CCR1 to 10. The receptors receptors are found in monocytes, lymphocytes, basophils and eosinophils.This entry represents CC chemokine receptor 7 (CCR7). It is expressed in various lymphoid tissues and plays an important role in the regulation of the homing and traffic of lymphocytes into and within secondary lymphoid tissues [, , , ]. It has also been shown to induce antiapoptotic signaling in mature dendritic cells []. CCR7 is seen as an important organiser of the primary immune response []. CCR7 is also expressed by various cancer cells, such as non-small lung cancer, gastric cancer and oesophageal cancer [, , ]and the expression of CCR7 by cancer cells has been linked with metastasis to lymph nodes []. CCR7 binds CCL19 and CCL21 [].
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Protein Domain
IPR005382 | Chemokine_CCR10
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to playa much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).CC chemokine receptors are a subfamily of the chemokine receptors that specifically bind and respond to cytokines of the CC chemokine family. There are currently ten membersof the CC chemokine receptor subfamily, named CCR1 to 10. The receptors receptors are found in monocytes, lymphocytes, basophils and eosinophils.This entry represents CC chemokine receptor 10 (CCR10), previously known as G protein-coupled receptor 2 (GPR2) []. CCR10 is a receptor for CCL27 [], and CCL28 []. CCR10 is found in melanocytes [], dermal fibroblasts, dermal micro-vascular endothelial cells and has also been detected in T-cells []. It is involved in T cell-mediated skin inflammation, having been shown to recruit regulatory T cells to mucosal layers []. The receptor may also play a role in directing metastasis [].
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Publication
15240757 | J:92938
First Author: Wareing MD
Year: 2004
Journal: J Leukoc Biol
Title: Chemokine expression during the development and resolution of a pulmonary leukocyte response to influenza A virus infection in mice.
Volume: 76
Issue: 4
Pages: 886-95
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Publication
18624307 | J:138561
First Author: Grégoire C
Year: 2008
Journal: Eur J Immunol
Title: Intrasplenic trafficking of natural killer cells is redirected by chemokines upon inflammation.
Volume: 38
Issue: 8
Pages: 2076-84
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28674178 | J:250818
First Author: Aswad M
Year: 2017
Journal: J Immunol
Title: CCL5 Promotes Resolution-Phase Macrophage Reprogramming in Concert with the Atypical Chemokine Receptor D6 and Apoptotic Polymorphonuclear Cells.
Volume: 199
Issue: 4
Pages: 1393-1404
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Publication
24711619 | J:328368
First Author: Gürtler C
Year: 2014
Journal: J Immunol
Title: SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter.
Volume: 192
Issue: 10
Pages: 4821-32
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Publication
29984403 | J:267599
First Author: González-Guerrero C
Year: 2018
Journal: J Pathol
Title: CCL20 blockade increases the severity of nephrotoxic folic acid-induced acute kidney injury.
Volume: 246
Issue: 2
Pages: 191-204
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Publication
11893739 | J:76841
First Author: Zhang Y
Year: 2002
Journal: J Biol Chem
Title: RANTES-mediated chemokine transcription in astrocytes involves activation and translocation of p90 ribosomal S6 protein kinase (RSK).
Volume: 277
Issue: 21
Pages: 19042-8
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Publication
16940143 | J:113449
First Author: d'Empaire G
Year: 2006
Journal: Infect Immun
Title: The K1 serotype capsular polysaccharide of Porphyromonas gingivalis elicits chemokine production from murine macrophages that facilitates cell migration.
Volume: 74
Issue: 11
Pages: 6236-43
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Publication
23288157 | J:217982
First Author: Iida Y
Year: 2013
Journal: Arterioscler Thromb Vasc Biol
Title: Peptide inhibitor of CXCL4-CCL5 heterodimer formation, MKEY, inhibits experimental aortic aneurysm initiation and progression.
Volume: 33
Issue: 4
Pages: 718-26
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Publication
11099305 | -
First Author: Nanki T
Year: 2000
Journal: Int Immunol
Title: Lack of correlation between chemokine receptor and T(h)1/T(h)2 cytokine expression by individual memory T cells.
Volume: 12
Issue: 12
Pages: 1659-67
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Publication
7542490 | J:26586
First Author: Neugarten J
Year: 1995
Journal: J Am Soc Nephrol
Title: Role of macrophages and colony-stimulating factor-1 in murine antiglomerular basement membrane glomerulonephritis.
Volume: 5
Issue: 11
Pages: 1903-9
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Publication
32358581 | J:291790
First Author: Guo X
Year: 2020
Journal: Nat Commun
Title: Midkine activation of CD8+ T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth.
Volume: 11
Issue: 1
Pages: 2177
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Publication
21814510 | J:183343
First Author: Crawford A
Year: 2011
Journal: PLoS Pathog
Title: A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection.
Volume: 7
Issue: 7
Pages: e1002098
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Publication
33744909 | J:318646
First Author: Seyfried AN
Year: 2021
Journal: Leukemia
Title: CCR5 maintains macrophages in the bone marrow and drives hematopoietic failure in a mouse model of severe aplastic anemia.
Volume: 35
Issue: 11
Pages: 3139-3151
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Publication
16208318 | J:102878
First Author: Tyner JW
Year: 2005
Journal: Nat Med
Title: CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection.
Volume: 11
Issue: 11
Pages: 1180-7
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Publication
34693221 | J:351436
First Author: Li N
Year: 2021
Journal: iScience
Title: Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma.
Volume: 24
Issue: 10
Pages: 103163
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Publication
11744622 | J:74277
First Author: Schuh JM
Year: 2002
Journal: FASEB J
Title: The role of CC chemokine receptor 5 (CCR5) and RANTES/CCL5 during chronic fungal asthma in mice.
Volume: 16
Issue: 2
Pages: 228-30
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Publication
15905535 | J:99016
First Author: Nasser MW
Year: 2005
Journal: J Immunol
Title: Cross-desensitization among CXCR1, CXCR2, and CCR5: role of protein kinase C-epsilon.
Volume: 174
Issue: 11
Pages: 6927-33
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Publication
23553711 | J:233251
First Author: Wintges K
Year: 2013
Journal: J Bone Miner Res
Title: Impaired bone formation and increased osteoclastogenesis in mice lacking chemokine (C-C motif) ligand 5 (Ccl5).
Volume: 28
Issue: 10
Pages: 2070-80
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Publication
29374556 | J:257040
 
First Author: Nie X
Year: 2018
Journal: J Mol Cell Cardiol
Title: CCL5 deficiency rescues pulmonary vascular dysfunction, and reverses pulmonary hypertension via caveolin-1-dependent BMPR2 activation.
Volume: 116
Pages: 41-56
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Publication
34315111 | J:317918
 
First Author: Ho MH
Year: 2021
Journal: Redox Biol
Title: CCL5 via GPX1 activation protects hippocampal memory function after mild traumatic brain injury.
Volume: 46
Pages: 102067
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Publication
30630119 | J:295289
First Author: Chen L
Year: 2019
Journal: Cell Mol Gastroenterol Hepatol
Title: Deletion of C-C Motif Chemokine Ligand 5 Worsens Invariant Natural Killer T-Cell-Mediated Hepatitis via Compensatory Up-regulation of CXCR2-Related Chemokine Activity.
Volume: 7
Issue: 3
Pages: 623-639
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Publication
30990165 | J:275216
   
First Author: Walens A
Year: 2019
Journal: Elife
Title: CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors.
Volume: 8
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Publication
22214846 | J:184384
First Author: Ishida Y
Year: 2012
Journal: J Clin Invest
Title: Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing.
Volume: 122
Issue: 2
Pages: 711-21
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Publication
30760705 | J:294424
First Author: Sun C
Year: 2019
Journal: Cell Death Dis
Title: Astrocytic miR-324-5p is essential for synaptic formation by suppressing the secretion of CCL5 from astrocytes.
Volume: 10
Issue: 2
Pages: 141
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Publication
28132854 | J:240868
First Author: Rezk AF
Year: 2017
Journal: J Invest Dermatol
Title: Misbalanced CXCL12 and CCL5 Chemotactic Signals in Vitiligo Onset and Progression.
Volume: 137
Issue: 5
Pages: 1126-1134
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Publication
21293018 | J:173704
First Author: Muhammad S
Year: 2011
Journal: Stroke
Title: Influenza virus infection aggravates stroke outcome.
Volume: 42
Issue: 3
Pages: 783-91
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Publication
16172501 | J:105162
First Author: Bell TA
Year: 2006
Journal: Genetics
Title: The paternal gene of the DDK syndrome maps to the Schlafen gene cluster on mouse chromosome 11.
Volume: 172
Issue: 1
Pages: 411-23
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Publication
27640148 | J:237999
First Author: Rudemiller NP
Year: 2016
Journal: Am J Pathol
Title: C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration.
Volume: 186
Issue: 11
Pages: 2846-2856
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Publication
31557402 | J:294675
First Author: Lee CP
Year: 2019
Journal: J Cell Mol Med
Title: ALPK1 regulates streptozotocin-induced nephropathy through CCL2 and CCL5 expressions.
Volume: 23
Issue: 11
Pages: 7699-7708
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Publication
26246404 | J:319190
First Author: Yester JW
Year: 2015
Journal: FASEB J
Title: Sphingosine-1-phosphate inhibits IL-1-induced expression of C-C motif ligand 5 via c-Fos-dependent suppression of IFN-β amplification loop.
Volume: 29
Issue: 12
Pages: 4853-65
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Publication
29216863 | J:320237
First Author: Gao D
Year: 2017
Journal: BMC Cancer
Title: CCL5-CCR5 interactions modulate metabolic events during tumor onset to promote tumorigenesis.
Volume: 17
Issue: 1
Pages: 834
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Publication
24855645 | -
First Author: Jin J
Year: 2014
Journal: J Biol Chem
Title: Targeting spare CC chemokine receptor 5 (CCR5) as a principle to inhibit HIV-1 entry.
Volume: 289
Issue: 27
Pages: 19042-52
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Publication
12055238 | -
First Author: Huber TB
Year: 2002
Journal: J Immunol
Title: Expression of functional CCR and CXCR chemokine receptors in podocytes.
Volume: 168
Issue: 12
Pages: 6244-52
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Publication
9689100 | J:49070
First Author: Ma Q
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.
Volume: 95
Issue: 16
Pages: 9448-53
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Publication
11544102 | -
First Author: Horuk R
Year: 2001
Journal: Cytokine Growth Factor Rev
Title: Chemokine receptors.
Volume: 12
Issue: 4
Pages: 313-35
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Publication
10601351 | -
First Author: Charbonnier AS
Year: 1999
Journal: J Exp Med
Title: Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells.
Volume: 190
Issue: 12
Pages: 1755-68
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Publication
9500790 | -
First Author: Sallusto F
Year: 1998
Journal: J Exp Med
Title: Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.
Volume: 187
Issue: 6
Pages: 875-83
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Publication
7592998 | -
First Author: Strieter RM
Year: 1995
Journal: J Biol Chem
Title: The functional role of the ELR motif in CXC chemokine-mediated angiogenesis.
Volume: 270
Issue: 45
Pages: 27348-57
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Publication
8981365 | J:37428
First Author: Wood GW
Year: 1997
Journal: Mol Reprod Dev
Title: Relative role of CSF-1, MCP-1/JE, and RANTES in macrophage recruitment during successful pregnancy.
Volume: 46
Issue: 1
Pages: 62-9; discussion 69-70
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Publication
27660294 | J:252589
First Author: Ortega-Gomez A
Year: 2016
Journal: Circulation
Title: Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment.
Volume: 134
Issue: 16
Pages: 1176-1188
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Publication
10790402 | J:62125
First Author: Pardo-Manuel De Villena F
Year: 2000
Journal: Genetics
Title: Heritability of the maternal meiotic drive system linked to Om and high-resolution mapping of the Responder locus in mouse.
Volume: 155
Issue: 1
Pages: 283-9
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Publication
31809737 | J:307129
First Author: Ortinau LC
Year: 2019
Journal: Cell Stem Cell
Title: Identification of Functionally Distinct Mx1+αSMA+ Periosteal Skeletal Stem Cells.
Volume: 25
Issue: 6
Pages: 784-796.e5
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Publication
31995405 | J:294886
First Author: Tavares LP
Year: 2020
Journal: Am J Physiol Lung Cell Mol Physiol
Title: ACKR2 contributes to pulmonary dysfunction by shaping CCL5:CCR5-dependent recruitment of lymphocytes during influenza A infection in mice.
Volume: 318
Issue: 4
Pages: L655-L670
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Publication
28381538 | J:270132
 
First Author: von Hundelshausen P
Year: 2017
Journal: Sci Transl Med
Title: Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.
Volume: 9
Issue: 384
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Publication
11801530 | J:74341
First Author: Schiltz JF
Year: 2002
Journal: Cell Growth Differ
Title: Hmgi-c-independent Activation of MuRantes in Vivo.
Volume: 13
Issue: 1
Pages: 39-45
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Publication
24244314 | J:209311
First Author: Villegas-Mendez A
Year: 2013
Journal: PLoS One
Title: WSX-1 signalling inhibits CD4⁺ T cell migration to the liver during malaria infection by repressing chemokine-independent pathways.
Volume: 8
Issue: 11
Pages: e78486
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Publication
25617348 | J:224022
First Author: Kizu T
Year: 2015
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Loss of Gab1 adaptor protein in hepatocytes aggravates experimental liver fibrosis in mice.
Volume: 308
Issue: 7
Pages: G613-24
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Publication
30928429 | J:276066
 
First Author: Blin MG
Year: 2019
Journal: J Mol Cell Cardiol
Title: CD146 deficiency promotes plaque formation in a mouse model of atherosclerosis by enhancing RANTES secretion and leukocyte recruitment.
Volume: 130
Pages: 76-87
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Publication
26799785 | J:241191
First Author: Koh MY
Year: 2016
Journal: Hepatology
Title: A new HIF-1α/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice.
Volume: 63
Issue: 5
Pages: 1576-91
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Publication
12093895 | J:77476
First Author: Nikolcheva T
Year: 2002
Journal: J Clin Invest
Title: A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes.
Volume: 110
Issue: 1
Pages: 119-26
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Publication
8216854 | J:15685
First Author: Berger MS
Year: 1993
Journal: DNA Cell Biol
Title: The gene for C10, a member of the beta-chemokine family, is located on mouse chromosome 11 and contains a novel second exon not found in other chemokines.
Volume: 12
Issue: 9
Pages: 839-47
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Publication
9311871 | J:42950
First Author: Asensio VC
Year: 1997
Journal: J Virol
Title: Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis.
Volume: 71
Issue: 10
Pages: 7832-40
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Publication
9730682 | J:51590
First Author: Glabinski AR
Year: 1998
Journal: Neuroimmunomodulation
Title: Expression of chemokines RANTES, MIP-1alpha and GRO-alpha correlates with inflammation in acute experimental autoimmune encephalomyelitis.
Volume: 5
Issue: 3-4
Pages: 166-71
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Publication
17220320 | J:118701
First Author: Keepers TR
Year: 2007
Journal: Infect Immun
Title: Monocyte chemoattractant protein 1, macrophage inflammatory protein 1 alpha, and RANTES recruit macrophages to the kidney in a mouse model of hemolytic-uremic syndrome.
Volume: 75
Issue: 3
Pages: 1229-36
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Publication
16982880 | J:139324
First Author: Marçais A
Year: 2006
Journal: J Immunol
Title: Cell-autonomous CCL5 transcription by memory CD8 T cells is regulated by IL-4.
Volume: 177
Issue: 7
Pages: 4451-7
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Publication
23112334 | J:189209
First Author: Pace L
Year: 2012
Journal: Science
Title: Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory.
Volume: 338
Issue: 6106
Pages: 532-6
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Publication
23918941 | J:201628
First Author: Liou GY
Year: 2013
Journal: J Cell Biol
Title: Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs.
Volume: 202
Issue: 3
Pages: 563-77
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Publication
24464131 | J:209440
First Author: Harikumar KB
Year: 2014
Journal: Nat Immunol
Title: K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5.
Volume: 15
Issue: 3
Pages: 231-8
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Publication
25093679 | J:223165
First Author: Li S
Year: 2014
Journal: PLoS One
Title: Interference with glycosaminoglycan-chemokine interactions with a probe to alter leukocyte recruitment and inflammation in vivo.
Volume: 9
Issue: 8
Pages: e104107
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Publication
7594550 | J:29875
First Author: Hara T
Year: 1995
Journal: J Immunol
Title: Molecular cloning and functional characterization of a novel member of the C-C chemokine family.
Volume: 155
Issue: 11
Pages: 5352-8
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Protein
Q9JL21
Organism: Mus musculus/domesticus
Length: 362  
Fragment?: false
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Publication
10714678 | -
First Author: Zlotnik A
Year: 2000
Journal: Immunity
Title: Chemokines: a new classification system and their role in immunity.
Volume: 12
Issue: 2
Pages: 121-7
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Publication
10995569 | J:64704
First Author: Cohen-Tannoudji M
Year: 2000
Journal: Genomics
Title: A 2-Mb YAC/BAC-based physical map of the ovum mutant (Om) locus region on mouse chromosome 11.
Volume: 68
Issue: 3
Pages: 273-82
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Publication
10594742 | J:59040
First Author: Ross R
Year: 1999
Journal: J Invest Dermatol
Title: Mouse langerhans cells differentially express an activated T cell-attracting CC chemokine.
Volume: 113
Issue: 6
Pages: 991-8
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Publication
25340820 | J:247072
First Author: Bergot AS
Year: 2014
Journal: PLoS Pathog
Title: HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cells.
Volume: 10
Issue: 10
Pages: e1004466
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Publication
25158055 | J:216159
First Author: Peng X
Year: 2015
Journal: J Pathol
Title: IL-17A produced by both γδ T and Th17 cells promotes renal fibrosis via RANTES-mediated leukocyte infiltration after renal obstruction.
Volume: 235
Issue: 1
Pages: 79-89
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Publication
17893273 | J:139837
First Author: Krohn R
Year: 2007
Journal: Circulation
Title: Y-box binding protein-1 controls CC chemokine ligand-5 (CCL5) expression in smooth muscle cells and contributes to neointima formation in atherosclerosis-prone mice.
Volume: 116
Issue: 16
Pages: 1812-20
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Publication
20400704 | J:160992
First Author: Nesbeth YC
Year: 2010
Journal: J Immunol
Title: CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells.
Volume: 184
Issue: 10
Pages: 5654-62
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Publication
15271961 | J:91807
First Author: Santiago HC
Year: 2004
Journal: Infect Immun
Title: Involvement of the chemokine RANTES (CCL5) in resistance to experimental infection with Leishmania major.
Volume: 72
Issue: 8
Pages: 4918-23
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Publication
15860458 | J:133228
First Author: Liu J
Year: 2005
Journal: J Biol Chem
Title: Interferon regulatory factor 1 is an essential and direct transcriptional activator for interferon {gamma}-induced RANTES/CCl5 expression in macrophages.
Volume: 280
Issue: 26
Pages: 24347-55
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Publication
29632086 | J:272624
First Author: Pan Y
Year: 2018
Journal: Genes Dev
Title: Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of Nf1 low-grade glioma growth.
Volume: 32
Issue: 7-8
Pages: 491-496
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Publication
16849492 | J:137974
First Author: Herold S
Year: 2006
Journal: J Immunol
Title: Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules.
Volume: 177
Issue: 3
Pages: 1817-24
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Publication
20038813 | J:156693
First Author: Kovacic JC
Year: 2010
Journal: J Clin Invest
Title: Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice.
Volume: 120
Issue: 1
Pages: 303-14
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Publication
22447977 | J:188467
First Author: Chenoweth MJ
Year: 2012
Journal: J Immunol
Title: IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells.
Volume: 188
Issue: 9
Pages: 4149-57
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Publication
23900076 | J:203132
First Author: Velecela V
Year: 2013
Journal: Hum Mol Genet
Title: WT1 regulates the expression of inhibitory chemokines during heart development.
Volume: 22
Issue: 25
Pages: 5083-95
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Protein
P51683
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
•
•
•
•
•
Protein
O54689
Organism: Mus musculus/domesticus
Length: 367  
Fragment?: false
•
•
•
•
•
Protein
P51680
Organism: Mus musculus/domesticus
Length: 360  
Fragment?: false
•
•
•
•
•
Protein
P51682
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
•
•
•
•
•
Protein
P51678
Organism: Mus musculus/domesticus
Length: 359  
Fragment?: false
•
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•
•
Protein
Q9WUT7
Organism: Mus musculus/domesticus
Length: 369  
Fragment?: false
•
•
•
•
•
Protein
P47774
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: false
•
•
•
•
•
Protein
P56484
Organism: Mus musculus/domesticus
Length: 353  
Fragment?: false
•
•
•
•
•
Protein
Q8BHB8
Organism: Mus musculus/domesticus
Length: 359  
Fragment?: false
•
•
•
•
•
Protein
Q3TDA4
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
•
•
•
•
•
Protein
Q3U5L7
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: false
•
•
•
•
•
Protein
Q27VK4
Organism: Mus musculus/domesticus
Length: 353  
Fragment?: false
•
•
•
•
•
Protein
Q3U3U0
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: true
•
•
•
•
•
Protein
Q3U467
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: true
•
•
•
•
•
Protein
F8WIS0
Organism: Mus musculus/domesticus
Length: 357  
Fragment?: false
•
•
•
•
•
Protein
Q9R1V0
Organism: Mus musculus/domesticus
Length: 367  
Fragment?: false
•
•
•
•
•
Protein
Q3U3J0
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: false
•
•
•
•
•
Protein
Q3ZB17
Organism: Mus musculus/domesticus
Length: 353  
Fragment?: false
•
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•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom