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Search results 801 to 900 out of 1061 for Ccr6

0.059s
Type Details Score
Publication
First Author: Baba M
Year: 1997
Journal: J Biol Chem
Title: Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC.
Volume: 272
Issue: 23
Pages: 14893-8
Publication
First Author: Liao F
Year: 1999
Journal: J Immunol
Title: CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha.
Volume: 162
Issue: 1
Pages: 186-94
Publication
First Author: Power CA
Year: 1997
Journal: J Exp Med
Title: Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells.
Volume: 186
Issue: 6
Pages: 825-35
Publication
First Author: Acosta-Rodriguez EV
Year: 2007
Journal: Nat Immunol
Title: Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells.
Volume: 8
Issue: 6
Pages: 639-46
Publication
First Author: Yang D
Year: 1999
Journal: Science
Title: Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6.
Volume: 286
Issue: 5439
Pages: 525-8
Publication
First Author: Wang K
Year: 2009
Journal: Am J Hum Genet
Title: Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.
Volume: 84
Issue: 3
Pages: 399-405
Protein Domain
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).CC chemokine receptors are a subfamily of the chemokine receptors that specifically bind and respond to cytokines of the CC chemokine family. There are currently ten members of the CC chemokine receptor subfamily, named CCR1 to 10. The receptors receptors are found in monocytes, lymphocytes, basophils and eosinophils.This entry represents CC chemokine receptor 6 (CCR6). It is expressed on unactivated memory T-cells [, ]and some dendritic cells [, ]. CCR6 is also expressed on Th17 cells [], but is down-regulated in activated T-cells []. The receptor is noted as playing a role in Crohn's disease []. CCR6 major ligand is CCL20, also known as Liver and Activation-Regulated Chemokine but it can also bind non-chemokine ligands such as beta-defensines [, ]. Binding to beta-defensine 1 (DEFB1) is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity []and it mediates the chemotactic effects of defensins DEFB4 and DEFB4A/B [].
Publication
First Author: Montoya MM
Year: 2017
Journal: J Immunol
Title: A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation.
Volume: 199
Issue: 2
Pages: 559-569
Publication
First Author: Zhong X
Year: 2024
Journal: Cell Rep
Title: Distinct RORγt-dependent Th17 immune responses are required for autoimmune pathogenesis and protection against bacterial infection.
Volume: 43
Issue: 11
Pages: 114951
Publication
First Author: Burger ML
Year: 2021
Journal: Cell
Title: Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors.
Volume: 184
Issue: 19
Pages: 4996-5014.e26
Publication    
First Author: Peligero-Cruz C
Year: 2020
Journal: Elife
Title: IL18 signaling promotes homing of mature Tregs into the thymus.
Volume: 9
Publication
First Author: Coquet JM
Year: 2013
Journal: Immunity
Title: The CD27 and CD70 costimulatory pathway inhibits effector function of T helper 17 cells and attenuates associated autoimmunity.
Volume: 38
Issue: 1
Pages: 53-65
Publication
First Author: Khoja H
Year: 2000
Journal: Gene
Title: Cloning of CCRL1, an orphan seven transmembrane receptor related to chemokine receptors, expressed abundantly in the heart.
Volume: 246
Issue: 1-2
Pages: 229-38
Publication
First Author: Marks BR
Year: 2009
Journal: Nat Immunol
Title: Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation.
Volume: 10
Issue: 10
Pages: 1125-32
Publication
First Author: Verrier T
Year: 2016
Journal: J Immunol
Title: Phenotypic and Functional Plasticity of Murine Intestinal NKp46+ Group 3 Innate Lymphoid Cells.
Volume: 196
Issue: 11
Pages: 4731-8
Publication
First Author: Morrison GM
Year: 2002
Journal: Mamm Genome
Title: Identification and characterization of a novel murine beta-defensin-related gene.
Volume: 13
Issue: 8
Pages: 445-51
Publication
First Author: Wu M
Year: 2009
Journal: J Immunol
Title: Beta-defensin-2 promotes resistance against infection with P. aeruginosa.
Volume: 182
Issue: 3
Pages: 1609-16
Publication
First Author: Wu M
Year: 2009
Journal: J Immunol
Title: Beta-defensins 2 and 3 together promote resistance to Pseudomonas aeruginosa keratitis.
Volume: 183
Issue: 12
Pages: 8054-60
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Yamaguchi Y
Year: 2001
Journal: J Biol Chem
Title: A novel mouse beta-defensin, mBD-6, predominantly expressed in skeletal muscle.
Volume: 276
Issue: 34
Pages: 31510-4
Publication  
First Author: McCullough BJ
Year: 2006
Journal: Int J Mass Spectrometry
Title: Characterisation of DEFB107 by mass spectrometry: Lessons from an anti-antimicrobial defensin.
Volume: 252
Pages: 180-188
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692941
Age: postnatal adult
Image: BCM_2398499
Note: vas deferens
Specimen Label: BCM_2398499
Detected: true
Specimen Num: 1
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692941
Age: postnatal adult
Image: BCM_2398500
Note: vas deferens
Specimen Label: BCM_2398500
Detected: true
Specimen Num: 2
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692941
Age: postnatal adult
Image: BCM_2398500
Specimen Label: BCM_2398500
Detected: true
Specimen Num: 2
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1928728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692941
Age: postnatal adult
Image: BCM_2398499
Specimen Label: BCM_2398499
Detected: true
Specimen Num: 1
Publication    
First Author: Conejo-Garcia JR
Year: 2001
Journal: GenBank Submission
Title: Mus musculus gene partial Defb8 for beta-defensin 8
Pages: AJ300673
Publication    
First Author: Conejo-Garcia JR
Year: 2001
Journal: GenBank Submission
Title: Mus musculus mNRA for beta-defensin 8
Pages: AJ300674
Publication
First Author: Morrison GM
Year: 2003
Journal: Mol Biol Evol
Title: Signal sequence conservation and mature peptide divergence within subgroups of the murine beta-defensin gene family.
Volume: 20
Issue: 3
Pages: 460-70
Publication
First Author: Lüttichau HR
Year: 2003
Journal: J Biol Chem
Title: A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6.
Volume: 278
Issue: 13
Pages: 10928-33
Publication
First Author: Tweedy J
Year: 2015
Journal: J Gen Virol
Title: Analyses of germline, chromosomally integrated human herpesvirus 6A and B genomes indicate emergent infection and new inflammatory mediators.
Volume: 96
Issue: Pt 2
Pages: 370-89
Protein Domain
Type: Family
Description: Human herpesvirus 6A (HHV-6A) and HHV-6B are classified as roseoloviruses and are highly prevalent in the human population. Roseolovirus reactivation in an immunocompromised host can cause severe pathologies []. HHV6 A/B encode two putative chemokine receptors and a chemokine-like protein. The HHV6 U83 gene encodes a CC chemokine, which functions as a highly selective and efficacious agonist for the human CCR2 receptor, both in respect of signal transduction and the ability to induce chemotaxis. Homologues of the U83 gene products are found in Human cytomegalovirus encoded chemokines vCXC1 and vCXC2.HHV-6 U83, also known as vCCL4, contains a region with the CC/CX3C chemokine motif and a glycosaminoglycan (GAG)-binding epitope, BBXB (B being a basic residue), found right before the third Cys residue, which very likely forms a disulfide bridge back to the first Cys of the protein []. This gene is the only HHV-6A/B divergent gene that is specific for these viruses. The U83 chemokine gene is distinct between HHV-6A and HHV-6B strains, encoding up to 13 amino acid differences. The HHV-6A (U83A) and HHV-6B (U83B) chemokines have distinct specificities which determine chemoattraction or diversion of different leukocyte subsets for infection or immune evasion, thus an early component of cellular tropism as well as mediator of innate immunity. U83 also has a varied gene structure, with N-terminal length variation determining production of the encoded mature secreted chemokine, coupled with control by cell-directed splicing which truncates the chemokine gene early in replication to encode an antagonist. The 'long' active form of U83A has a unique broad specificity for receptors CCR1, CCR4, CCR5, CCR6 and CCR8 present on plasmacytoid and myeloid dendritic and monocyte/macrophage antigen presenting cells, as well as both TH1 and TH2 skin homing lymphocytes and NK cells; it is also amongst the highest affinity ligands for CCR5 and inhibits HIV-1 binding at this coreceptor. U83A can both block and divert human chemokine action while occupying the human chemokine receptors [].
Publication
First Author: Yamaguchi Y
Year: 2002
Journal: J Immunol
Title: Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice.
Volume: 169
Issue: 5
Pages: 2516-23
Publication
First Author: Schutte BC
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Discovery of five conserved beta -defensin gene clusters using a computational search strategy.
Volume: 99
Issue: 4
Pages: 2129-33
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory