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Search results 801 to 900 out of 1056 for Cdk2

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Type Details Score
Publication
14612403 | J:197596
First Author: Ye X
Year: 2003
Journal: Mol Cell Biol
Title: The cyclin E/Cdk2 substrate p220(NPAT) is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cells.
Volume: 23
Issue: 23
Pages: 8586-600
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Publication
22899714 | J:199756
First Author: Chang KH
Year: 2012
Journal: J Cell Sci
Title: Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death.
Volume: 125
Issue: Pt 21
Pages: 5124-37
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Publication
26598692 | J:228129
First Author: Heijink AM
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: A haploid genetic screen identifies the G1/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity.
Volume: 112
Issue: 49
Pages: 15160-5
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Publication
28439015 | J:242221
First Author: Liu K
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.
Volume: 114
Issue: 19
Pages: E3766-E3775
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Publication
28368414 | J:243603
First Author: Principe DR
Year: 2017
Journal: Oncogene
Title: TGFβ engages MEK/ERK to differentially regulate benign and malignant pancreas cell function.
Volume: 36
Issue: 30
Pages: 4336-4348
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Publication
25394488 | J:259329
First Author: Su M
Year: 2015
Journal: Cell Death Differ
Title: MicroRNA-221 inhibits autophagy and promotes heart failure by modulating the p27/CDK2/mTOR axis.
Volume: 22
Issue: 6
Pages: 986-99
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Publication
30194068 | J:265548
First Author: Caruso JA
Year: 2018
Journal: Cancer Res
Title: Low-Molecular-Weight Cyclin E in Human Cancer: Cellular Consequences and Opportunities for Targeted Therapies.
Volume: 78
Issue: 19
Pages: 5481-5491
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Publication
26530630 | J:269058
 
First Author: Mukai S
Year: 2015
Journal: Sci Rep
Title: Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25B.
Volume: 5
Pages: 16173
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Publication
31816347 | J:283520
First Author: Mahapatra K
Year: 2020
Journal: Biochim Biophys Acta Gen Subj
Title: Assessment of cytotoxic and genotoxic potentials of a mononuclear Fe(II) Schiff base complex with photocatalytic activity in Trigonella.
Volume: 1864
Issue: 3
Pages: 129503
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Publication
30310408 | J:279680
First Author: Choi JY
Year: 2018
Journal: Lab Anim Res
Title: Successful development of squamous cell carcinoma and hyperplasia in RGEN-mediated p27 KO mice after the treatment of DMBA and TPA.
Volume: 34
Issue: 3
Pages: 118-125
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Publication
32075913 | J:287449
First Author: Xia P
Year: 2020
Journal: J Biol Chem
Title: Doxorubicin induces cardiomyocyte apoptosis and atrophy through cyclin-dependent kinase 2-mediated activation of forkhead box O1.
Volume: 295
Issue: 13
Pages: 4265-4276
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Publication
30014245 | J:317273
First Author: Li Q
Year: 2018
Journal: J Mol Histol
Title: Methylation of Cdkn1c may be involved in the regulation of tooth development through cell cycle inhibition.
Volume: 49
Issue: 5
Pages: 459-469
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Publication
26466676 | J:315995
First Author: Yamamori T
Year: 2015
Journal: Mol Biol Cell
Title: Inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) impairs mitochondrial fission and mitotic catastrophe after x-irradiation.
Volume: 26
Issue: 25
Pages: 4607-17
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Protein
Q61457
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: false
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Protein
P0C242
Organism: Mus musculus/domesticus
Length: 352  
Fragment?: false
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Protein
Q9Z238
Organism: Mus musculus/domesticus
Length: 404  
Fragment?: false
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Publication
221923 | -
First Author: DeLeo AB
Year: 1979
Journal: Proc Natl Acad Sci U S A
Title: Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse.
Volume: 76
Issue: 5
Pages: 2420-4
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Protein
Q8K158
Organism: Mus musculus/domesticus
Length: 407  
Fragment?: false
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Protein
Q8R4E6
Organism: Mus musculus/domesticus
Length: 350  
Fragment?: false
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Protein
Q8VDC6
Organism: Mus musculus/domesticus
Length: 35  
Fragment?: true
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Protein
A0JLN2
Organism: Mus musculus/domesticus
Length: 324  
Fragment?: true
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Protein
A0A087WSI6
Organism: Mus musculus/domesticus
Length: 170  
Fragment?: true
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Protein
Q3UKL4
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: false
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Protein
Q9CSV7
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: true
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Protein
A0A087WQM7
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
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Protein
Q7TMS8
Organism: Mus musculus/domesticus
Length: 403  
Fragment?: false
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Protein
Q3TXI3
Organism: Mus musculus/domesticus
Length: 407  
Fragment?: false
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Protein
A2API1
Organism: Mus musculus/domesticus
Length: 403  
Fragment?: false
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Protein
A0A0G2JFR4
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: true
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Protein
Q544H6
Organism: Mus musculus/domesticus
Length: 404  
Fragment?: false
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Protein
B2RWG0
Organism: Mus musculus/domesticus
Length: 352  
Fragment?: false
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Protein
B2RS11
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: false
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Publication
20066118 | -
First Author: Zilfou JT
Year: 2009
Journal: Cold Spring Harb Perspect Biol
Title: Tumor suppressive functions of p53.
Volume: 1
Issue: 5
Pages: a001883
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Publication
12629332 | -
First Author: Smith ND
Year: 2003
Journal: J Urol
Title: The p53 tumor suppressor gene and nuclear protein: basic science review and relevance in the management of bladder cancer.
Volume: 169
Issue: 4
Pages: 1219-28
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Publication
1397838 | -
First Author: Oren M
Year: 1992
Journal: FASEB J
Title: p53: the ultimate tumor suppressor gene?
Volume: 6
Issue: 13
Pages: 3169-76
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Publication
6544917 | -
First Author: Crawford LV
Year: 1984
Journal: Mol Biol Med
Title: The cellular protein p53 in human tumours.
Volume: 2
Issue: 4
Pages: 261-72
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Publication
19826090 | -
First Author: Belyi VA
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: One billion years of p53/p63/p73 evolution.
Volume: 106
Issue: 42
Pages: 17609-10
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Publication
19776744 | -
First Author: Levine AJ
Year: 2009
Journal: Nat Rev Cancer
Title: The first 30 years of p53: growing ever more complex.
Volume: 9
Issue: 10
Pages: 749-58
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Publication
6278740 | -
First Author: Reich NC
Year: 1982
Journal: Virology
Title: Specific interaction of the SV40 T antigen-cellular p53 protein complex with SV40 DNA.
Volume: 117
Issue: 1
Pages: 286-90
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Publication
6318442 | -
First Author: Thomas R
Year: 1983
Journal: Virology
Title: Characterization of human p53 antigens employing primate specific monoclonal antibodies.
Volume: 131
Issue: 2
Pages: 502-17
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Publication
20030809 | -
 
First Author: Brandt T
Year: 2009
Journal: BMC Genomics
Title: Conservation of DNA-binding specificity and oligomerisation properties within the p53 family.
Volume: 10
Pages: 628
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Publication
19524571 | J:150845
First Author: Jiang M
Year: 2009
Journal: FEBS Lett
Title: Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1.
Volume: 583
Issue: 13
Pages: 2171-8
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Publication
20059949 | -
First Author: Davidson G
Year: 2009
Journal: Dev Cell
Title: Cell cycle control of wnt receptor activation.
Volume: 17
Issue: 6
Pages: 788-99
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Publication
8108735 | -
First Author: Kaffman A
Year: 1994
Journal: Science
Title: Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85.
Volume: 263
Issue: 5150
Pages: 1153-6
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Publication
9552356 | -
 
First Author: Levine K
Year: 1995
Journal: Prog Cell Cycle Res
Title: The CLN gene family: central regulators of cell cycle Start in budding yeast.
Volume: 1
Pages: 101-14
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Publication
25619768 | -
First Author: Bhaduri S
Year: 2015
Journal: Curr Biol
Title: A docking interface in the cyclin Cln2 promotes multi-site phosphorylation of substrates and timely cell-cycle entry.
Volume: 25
Issue: 3
Pages: 316-25
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Publication
11124804 | -
First Author: Jeffrey PD
Year: 2000
Journal: Genes Dev
Title: Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors.
Volume: 14
Issue: 24
Pages: 3115-25
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Publication
10368294 | -
First Author: Schulze-Gahmen U
Year: 1999
Journal: Structure
Title: Crystal structure of a viral cyclin, a positive regulator of cyclin-dependent kinase 6.
Volume: 7
Issue: 3
Pages: 245-54
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Publication
9372954 | -
First Author: Ko LJ
Year: 1997
Journal: Mol Cell Biol
Title: p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner.
Volume: 17
Issue: 12
Pages: 7220-9
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Publication
9840937 | -
First Author: Schneider E
Year: 1998
Journal: Oncogene
Title: Regulation of CAK kinase activity by p53.
Volume: 17
Issue: 21
Pages: 2733-41
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Publication
16327805 | -
First Author: Larochelle S
Year: 2006
Journal: Nat Struct Mol Biol
Title: Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.
Volume: 13
Issue: 1
Pages: 55-62
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Publication
27759017 | -
 
First Author: Deshmukh AS
Year: 2016
Journal: Sci Rep
Title: Cdk7 mediates RPB1-driven mRNA synthesis in Toxoplasma gondii.
Volume: 6
Pages: 35288
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Publication
25691663 | -
First Author: Devos M
Year: 2015
Journal: Mol Cell Biol
Title: Fission yeast Cdk7 controls gene expression through both its CAK and C-terminal domain kinase activities.
Volume: 35
Issue: 9
Pages: 1480-90
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Publication
8752210 | -
First Author: Kaldis P
Year: 1996
Journal: Cell
Title: The Cdk-activating kinase (CAK) from budding yeast.
Volume: 86
Issue: 4
Pages: 553-64
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Protein Domain
IPR006671 | Cyclin_N
Type: Domain
Description: Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2 (Herpesvirus saimiri) and Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [].Cyclins contain two domains of similar all-α fold, of which this entry is associated with the N-terminal domain.
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Protein Domain
IPR004367 | Cyclin_C-dom
Type: Domain
Description: Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2 (Herpesvirus saimiri) and Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [].This is the C-terminal domain of cyclins.
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Protein Domain
IPR014399 | Cyclin_CLN
Type: Family
Description: This entry represents a G1-class of cyclins which has so far only been identified in fungi [, ]. These proteins are important for the control of the cell cycle at the G1/S transition and interact with the cdc2 protein kinase.Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2 (Herpesvirus saimiri) and Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [].
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Protein Domain
IPR039361 | Cyclin
Type: Family
Description: Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2 (Herpesvirus saimiri) and Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [].
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Protein Domain
IPR013922 | Cyclin_PHO80-like
Type: Family
Description: Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.Cyclin homologues have been found in various viruses, includingSaimiriine herpesvirus 2 (Herpesvirus saimiri) and Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [].This entry includes cyclin PHO80 and other cyclins that partner with the cyclin-dependent kinase (CDK) PHO85. The PHO80/PHO85 cyclin-cdk complex is used for a regulatory process other than cell-cycle control []. This entry also includes other PHO80-like cyclins that are involved in the cell-cycle control. They belong to the P/U family and interact preferentially with CDKA1 [].
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Protein Domain
IPR012167 | Cyclin_epsilonretrovir
Type: Family
Description: Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2 (Herpesvirus saimiri) and Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [].This group represents a predicted cyclin found in epsilon-retroviruses, including walleye epidermal hyperplasia virus and walleye dermal sarcoma virus (WDSV).
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Protein Domain
IPR012399 | Cyclin_Y
Type: Family
Description: Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2 (Herpesvirus saimiri) and Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [].This group represents cyclin Y (also known as cyclin X) and related cyclins. Cyclin Y is a positive regulatory subunit of the cyclin-dependent kinase CDK14/PFTK1. Cyclin Y acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway [, ].
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Protein Domain
IPR017285 | Cyclin_herpesvir
Type: Family
Description: Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2 (Herpesvirus saimiri) and Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [].This group represents a viral cyclin.
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Protein Domain
IPR015164 | K-cyclin_C
Type: Domain
Description: Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). Thereare two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2 (Herpesvirus saimiri) and Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [].This domain adopts a secondary structure consisting of a five α-helix cyclin fold. Interaction with cyclin dependent kinases (CDKs) at a PSTAIRE sequence motif within the catalytic cleft of CDK results in the regulation of CDK activity [].
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Protein Domain
IPR015322 | Cyclin_dom_herpesvir
Type: Domain
Description: Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2 (Herpesvirus saimiri) and Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [].This entry represents a domain found in a family of viral cyclins that specifically activate CDK6 of host cells to a very high degree []. This domain adopts a helical structure consisting of five α-helices, with one helix surrounded by the others.
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Protein Domain
IPR037770 | CDK7
Type: Family
Description: Cyclin-dependent kinase 7 (CDK7) is a serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. It is activated by binding to a cyclin; binding to a different cyclin and phosphorylation of another kinase progresses the cell cycle. CDK7 binds cyclin-B and phosphorylates CDK1 during G2-M transition, and phosphorylates CDK2 and binds to cyclins during G1-S transition [, ]. CDK7 phosphorylates and activates p53 following DNA damage [], but CDK7 is then inactivated by p53, which arrests the cell cycle, allowing the cell to recover or undergo apoptosis []. CDK7 is also the catalytic subunit of the CDK-activating kinase (CAK) complex, which also contains cyclin-H (CCNH) and MAT1 [, ]. In turn, the CAK associates with the core-TFIIH to form the TFIIH basal transcription factor [].This entry includes CDK7 from animals, Kin28 from budding yeasts and Crk1 (also known as Mcs6) from fission yeasts. S. pombe possesses two CAKs, the nonessential Csk1 and the essential Mcs6 kinases, corresponding to the yeast Cak1 and the metazoan CDK7, respectively. Mcs6 modulates gene expression through both its CAK and CTD kinase activities []. Kin28 is the closest homologue of CDK7 from budding yeasts. It forms a complex with Ccl1 and Tfb3. This complex associate with TFIIH for transcription regulating activity, but does not display CAK activity []. Instead, Cak1, a single-subunit kinase distantly related to Cdk, catalyzes Cdk activation at both transitions of the budding yeast cell cycle [].
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Protein Domain
IPR011615 | p53_DNA-bd
Type: Domain
Description: P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes [, , , , , , , , , ].This domain is found in p53 transcription factors, where it is responsible for DNA-binding. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilise the protein-DNA complex []. Protein interactions may also serve to stabilise the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability []. The DNA-binding domain consists of a β-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.
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Publication
12910258 | -
First Author: Galderisi U
Year: 2003
Journal: Oncogene
Title: Cell cycle regulation and neural differentiation.
Volume: 22
Issue: 33
Pages: 5208-19
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Protein
O08918
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: false
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Protein
Q9Z2V9
Organism: Mus musculus/domesticus
Length: 377  
Fragment?: false
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Protein
Q8BGU5
Organism: Mus musculus/domesticus
Length: 341  
Fragment?: false
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Protein
P51945
Organism: Mus musculus/domesticus
Length: 294  
Fragment?: false
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Protein
Q8C7E2
Organism: Mus musculus/domesticus
Length: 377  
Fragment?: false
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Protein
E9Q226
Organism: Mus musculus/domesticus
Length: 291  
Fragment?: false
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Protein
Q6LC40
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: true
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Protein
Q5D0F7
Organism: Mus musculus/domesticus
Length: 272  
Fragment?: true
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Protein
Q3U5X0
Organism: Mus musculus/domesticus
Length: 294  
Fragment?: false
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Protein
F7AV51
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
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Protein
Q3TG40
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: false
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Protein
D3YUJ3
Organism: Mus musculus/domesticus
Length: 367  
Fragment?: false
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Protein
Q5HZK4
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: false
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Protein
Q3TCL9
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: false
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Protein
Q3TX40
Organism: Mus musculus/domesticus
Length: 294  
Fragment?: false
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Protein
D3Z680
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
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Protein
A0A0J9YU25
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: true
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Protein
Q3TV43
Organism: Mus musculus/domesticus
Length: 294  
Fragment?: false
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Protein
Q8C9K5
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: false
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Protein
A0A6I8MWW6
Organism: Mus musculus/domesticus
Length: 2498  
Fragment?: false
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Protein
Q99LF2
Organism: Mus musculus/domesticus
Length: 377  
Fragment?: false
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Protein
Q3TKC9
Organism: Mus musculus/domesticus
Length: 294  
Fragment?: false
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Protein
D3Z602
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: true
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Protein
Q5NC86
Organism: Mus musculus/domesticus
Length: 294  
Fragment?: false
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Publication
8984634 | -
First Author: Nasmyth K
Year: 1996
Journal: Science
Title: Viewpoint: putting the cell cycle in order.
Volume: 274
Issue: 5293
Pages: 1643-5
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Publication
14643426 | -
First Author: Duncker BP
Year: 2003
Journal: Mutat Res
Title: Cdc7 kinases (DDKs) and checkpoint responses: lessons from two yeasts.
Volume: 532
Issue: 1-2
Pages: 21-7
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Publication
8943332 | -
First Author: Hardy CF
Year: 1996
Journal: Mol Cell Biol
Title: A novel role for Cdc5p in DNA replication.
Volume: 16
Issue: 12
Pages: 6775-82
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Publication
8066465 | -
First Author: Dowell SJ
Year: 1994
Journal: Science
Title: Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo.
Volume: 265
Issue: 5176
Pages: 1243-6
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Publication
7935441 | J:21039
First Author: Matsuoka M
Year: 1994
Journal: Mol Cell Biol
Title: Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase.
Volume: 14
Issue: 11
Pages: 7265-75
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Publication
18382684 | J:134259
First Author: Cheng N
Year: 2008
Journal: PLoS One
Title: p27 deficiency cooperates with Bcl-2 but not Bax to promote T-cell lymphoma.
Volume: 3
Issue: 4
Pages: e1911
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Publication
18701472 | J:139145
First Author: Short JD
Year: 2008
Journal: Cancer Res
Title: AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27.
Volume: 68
Issue: 16
Pages: 6496-506
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Publication
23000166 | J:190092
First Author: Tateishi Y
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Development of mice without Cip/Kip CDK inhibitors.
Volume: 427
Issue: 2
Pages: 285-92
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Publication
10913196 | J:63560
First Author: Franklin DS
Year: 2000
Journal: Mol Cell Biol
Title: Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity.
Volume: 20
Issue: 16
Pages: 6147-58
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