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Search results 801 to 853 out of 853 for Chd8

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Type Details Score
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:389486
     
First Author: Mouse Genome Informatics and Ensembl Genome Database Project
Year: 2026
Journal: Database Release
Title: MGI Strain Genome Feature and Gene Model Load from Ensembl.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Protein
Q09XV5-2
Organism: Mus musculus/domesticus
Length: 751  
Fragment?: false
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HT Experiment
GSE99331 | Germline Chd8 haploinsufficiency alters brain development in mouse
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE182815 | Transcriptome analysis of CHD8 ko mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE167053 | Transcriptome analysis of Chd8 S62X heterozygote mutant and wild-type mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
39185167 | J:360831
     
First Author: Yim KM
Year: 2024
Journal: bioRxiv
Title: Cell type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development.
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HT Experiment
GSE121381 | Non-monotonic regulation of gene expression, neural progenitor fate and brain growth by the chromatin remodeller CHD8
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
26626481 | J:232817
First Author: Shen C
Year: 2015
Journal: Mol Cell
Title: NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.
Volume: 60
Issue: 6
Pages: 847-59
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HT Experiment
GSE146885 | The Autism-Associated Protein CHD8 Is Required for Cerebellar Development and Motor Function
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
23285124 | J:195755
First Author: Batsukh T
Year: 2012
Journal: PLoS One
Title: Identification and characterization of FAM124B as a novel component of a CHD7 and CHD8 containing complex.
Volume: 7
Issue: 12
Pages: e52640
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Publication
40328966 | J:377008
First Author: Waterhouse M
Year: 2025
Journal: EMBO J
Title: CHD8 interacts with BCL11A to induce oncogenic transcription in triple negative breast cancer.
Volume: 44
Issue: 12
Pages: 3448-3467
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HT Experiment
GSE142208 | Chd8 haploinsufficiency impairs early brain development and impacts protein homeostasis later in life
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE252121 | Chromatin remodeler CHD8 is required for spermatogonial proliferation and early meiotic progression
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE81103 | Altered Neocortical Gene Expression, Brain Overgrowth and Functional Over-Connectivity in Chd8 Haploinsufficient Mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE103377 | Hippocampus transcriptome analysis of CHD8 Asn2373LysfsX2 heterozygote mutation mice age of P25
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE108206 | Cortex transcriptome analysis of CHD8 Asn2373LysfsX2 heterozygote mutation mice age of P25
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE80803 | Comparison of DEG between neonatal male and female mice age of P0 by CHD8 Asn2373LysfsX2 heterozygote mutation
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE87367 | Comparison of DEG between neonatal male and female mice age of P25 by CHD8 Asn2373LysfsX2 heterozygote mutation.
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE273765 | Cell type-specific dysregulation of gene expression due to Chd8 loss of function during mouse cortical development [snRNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE273271 | Cell type-specific dysregulation of gene expression due to Chd8 loss of function during mouse cortical development [scRNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE273270 | Cell type-specific dysregulation of gene expression due to Chd8 loss of function during mouse cortical development [bulk RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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GXD Expression
GXD Expression
 
Probe: MGI:7491678
Assay Type: RNA in situ
Annotation Date: 2023-06-20
Strength: Trace
Sex: Not Specified
Emaps: EMAPS:3284228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7491681
Age: postnatal day 20
Note: Very low expression in neocortex compared to that of Chd8 and Chd2.
Specimen Label: 6Bc
Detected: true
Specimen Num: 33
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Allele
Chd8<em1Smoc> | MGI:7288960
Name: chromodomain helicase DNA binding protein 8; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
28533432 | -
First Author: Manning BJ
Year: 2017
Journal: J Biol Chem
Title: The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities.
Volume: 292
Issue: 28
Pages: 11927-11936
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Strain
MGI:6474985 | C57BL/6JSmoc-Chd8<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Chd8<tm2.1Kei> | MGI:6144040
Name: chromodomain helicase DNA binding protein 8; targeted mutation 2.1, Keiichi I Nakayama
Allele Type: Targeted
Attribute String: Modified isoform(s)
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Strain
MGI:6189102 | B6J.129P2-Chd8<tm2.1Kei>
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:6147245 | B6.129P2-Chd8<tm2.1Kei>/Rbrc
Attribute String: targeted mutation, mutant strain, congenic
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Genotype
Genotype
Symbol: Chd8/Chd8<+>
Background: B6J.129P2-Chd8
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Chd8/Chd8
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Chd8/Chd8<+>
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Publication
16554032 | -
First Author: Surapureddi S
Year: 2006
Journal: Biochem Biophys Res Commun
Title: PRIC320, a transcription coactivator, isolated from peroxisome proliferator-binding protein complex.
Volume: 343
Issue: 2
Pages: 535-43
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Publication
16314513 | -
First Author: Nioi P
Year: 2005
Journal: Mol Cell Biol
Title: The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation.
Volume: 25
Issue: 24
Pages: 10895-906
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Protein Domain
IPR056342 | HTH_CHD6-9
Type: Domain
Description: This domain is found in human Chromodomain-helicase-DNA-binding proteins 6-9 (CHD6-9) which are DNA-dependent ATPases that play a role in chromatin remodelling and transcriptional regulation [, , ]. CHD8 acts as a transcription repressor by remodelling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. It also acts as a negative regulator of Wnt signalling pathway by regulating beta-catenin (CTNNB1) activity [, ]. CHD6 regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2 [, ]. CHD9 acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors [].This domain is predicted to form a tri-helical structure, with a three-membered ��-helical bundle and a two-stranded antiparallel ��-sheet. Members of this family are predominantly found in vertebrates.
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Publication
37925436 | J:342393
First Author: Rowland ME
Year: 2023
Journal: Nat Commun
Title: Systemic and intrinsic functions of ATRX in glial cell fate and CNS myelination in male mice.
Volume: 14
Issue: 1
Pages: 7090
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Publication
20308527 | J:162265
First Author: Menon T
Year: 2010
Journal: Mol Endocrinol
Title: Regulation of androgen-responsive transcription by the chromatin remodeling factor CHD8.
Volume: 24
Issue: 6
Pages: 1165-74
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Publication
42801681 | J:392839
   
First Author: Huang Y
Year: 2026
Journal: Adv Sci (Weinh)
Title: CHD8-Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs.
Pages: e77823
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Genotype
Genotype
Symbol: Chd8/Chd8 Tg(Ddx4-cre)1Dcas/?
Background: involves: 129P2/OlaHsd * C57BL/6J * FVB
Zygosity: cn
Has Mutant Allele: true
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Protein
F7AL76
Organism: Mus musculus/domesticus
Length: 1031  
Fragment?: true
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Publication
19144319 | J:143718
First Author: Trost M
Year: 2009
Journal: Immunity
Title: The phagosomal proteome in interferon-gamma-activated macrophages.
Volume: 30
Issue: 1
Pages: 143-54
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Protein
A2AJK6
Organism: Mus musculus/domesticus
Length: 2986  
Fragment?: false
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Protein
A3KFM7
Organism: Mus musculus/domesticus
Length: 2711  
Fragment?: false
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Protein
Q8BYH8
Organism: Mus musculus/domesticus
Length: 2885  
Fragment?: false
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Protein
B7ZNF8
Organism: Mus musculus/domesticus
Length: 2884  
Fragment?: false
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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