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Search results 801 to 854 out of 854 for Clu

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Type Details Score
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
23342118 | -
First Author: Sen A
Year: 2013
Journal: PLoS One
Title: Drosophila clueless is highly expressed in larval neuroblasts, affects mitochondrial localization and suppresses mitochondrial oxidative damage.
Volume: 8
Issue: 1
Pages: e54283
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Publication
9207087 | -
First Author: Zhu Q
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: The cluA- mutant of Dictyostelium identifies a novel class of proteins required for dispersion of mitochondria.
Volume: 94
Issue: 14
Pages: 7308-13
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Publication
19638420 | -
First Author: Cox RT
Year: 2009
Journal: Dis Model Mech
Title: Clueless, a conserved Drosophila gene required for mitochondrial subcellular localization, interacts genetically with parkin.
Volume: 2
Issue: 9-10
Pages: 490-9
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Publication
14617080 | -
First Author: Logan DC
Year: 2003
Journal: Plant J
Title: The genetic control of plant mitochondrial morphology and dynamics.
Volume: 36
Issue: 4
Pages: 500-9
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Publication
9601101 | -
 
First Author: Fields SD
Year: 1998
Journal: J Cell Sci
Title: The S. cerevisiae CLU1 and D. discoideum cluA genes are functional homologues that influence mitochondrial morphology and distribution.
Volume: 111 ( Pt 12)
Pages: 1717-27
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Protein
Q5SW19
Organism: Mus musculus/domesticus
Length: 1315  
Fragment?: false
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Protein
A0A0R4J140
Organism: Mus musculus/domesticus
Length: 1353  
Fragment?: false
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Protein
Z4YLI8
Organism: Mus musculus/domesticus
Length: 1302  
Fragment?: false
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Allele
Clu<em3Smoc> | MGI:7262980
Name: clusterin; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Clu<em1.1(cre/ERT2)Algr> | MGI:6716263
Name: clusterin; endonuclease-mediated mutation 1, Alex Gregorieff
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
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Allele
Tg(Clu-EGFP)OD95Gsat | MGI:4940543
Name: transgene insertion OD95, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:6770661 | C57BL/6JSmoc-Clu<em3Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:5004304 | STOCK Tg(Clu-EGFP)OD95Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Protein
Q3V245
Organism: Mus musculus/domesticus
Length: 76  
Fragment?: true
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Publication
21953454 | -
First Author: Leskov KS
Year: 2011
Journal: J Biol Chem
Title: CRM1 protein-mediated regulation of nuclear clusterin (nCLU), an ionizing radiation-stimulated, Bax-dependent pro-death factor.
Volume: 286
Issue: 46
Pages: 40083-90
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Publication
22588555 | -
First Author: Kususda Y
Year: 2012
Journal: Br J Cancer
Title: Clusterin inhibition using OGX-011 synergistically enhances antitumour activity of sorafenib in a human renal cell carcinoma model.
Volume: 106
Issue: 12
Pages: 1945-52
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Publication
21505792 | -
First Author: Wyatt AR
Year: 2011
Journal: Cell Mol Life Sci
Title: Clusterin facilitates in vivo clearance of extracellular misfolded proteins.
Volume: 68
Issue: 23
Pages: 3919-31
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Publication
19535339 | -
First Author: Wyatt AR
Year: 2009
Journal: J Biol Chem
Title: Structural characterization of clusterin-chaperone client protein complexes.
Volume: 284
Issue: 33
Pages: 21920-7
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Publication
22025968 | -
First Author: Kim N
Year: 2011
Journal: Anat Cell Biol
Title: Proapoptotic role of nuclear clusterin in brain.
Volume: 44
Issue: 3
Pages: 169-75
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Publication
11720815 | -
First Author: Li DQ
Year: 2001
Journal: FEMS Immunol Med Microbiol
Title: Binding of human clusterin by Staphylococcus epidermidis.
Volume: 31
Issue: 3
Pages: 197-202
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Genotype
Genotype
Symbol: Clu/Clu<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Publication
10675623 | J:60371
First Author: Zhang Q
Year: 2000
Journal: Gene
Title: Molecular cloning, characterization and expression of a novel retinal clusterin-like protein cDNA.
Volume: 243
Issue: 1-2
Pages: 151-60
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Publication
14507903 | -
First Author: Zhang Q
Year: 2003
Journal: Invest Ophthalmol Vis Sci
Title: Comparative analysis and expression of CLUL1, a cone photoreceptor-specific gene.
Volume: 44
Issue: 10
Pages: 4542-9
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Protein Domain
IPR016016 | Clusterin
Type: Family
Description: Clusterin (Clu), also known as apolipoprotein J, is a vertebrate glycoprotein []. Clusterin expression is complex, appearing as different forms indifferent cell compartments. One set of proteins is directed for secretion, and other clusterin species are expressed in thecytoplasm and nucleus. The secretory form of the clusterin protein (sCLU) is targeted to the ER by an initial leader peptide. This ~60kDa pre-sCLU protein is proteolytically cleaved into alpha- and beta-subunits and further glycosylated to form mature disulfide-linked heterodimeric secretory CLU (sCLU). sCLU is an 80kDa protein and acts as a molecular chaperone, scavenging denatured proteins outside cells [, ]. sCLU possesses nonspecific binding activity to hydrophobic domains of various non-native proteins [], binds to some bacteria and bacterial proteins [], and interacts with different immune molecules [].A specific nuclear form of CLU (nCLU) acts as a pro-death signal, inhibiting cell growth andsurvival. ThenCLU protein has two coiled-coil domains, one at its N terminus that is unable to bind Ku70, and a C-terminal coiled-coil domain that is uniquely able to associatewith Ku70 and is minimally required forcell death. The sCLU protein is cytoprotective and anti-apoptotic, whereas the nCLU protein is pro-apoptotic [, , ].
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Protein Domain
IPR000753 | Clusterin-like
Type: Family
Description: Clusterin (Clu), also known as apolipoprotein J, is a vertebrate glycoprotein []. Clusterin expression is complex, appearing as different forms indifferent cell compartments. One set of proteins is directed for secretion, and other clusterin species are expressed in thecytoplasm and nucleus. The secretory form of the clusterin protein (sCLU) is targeted to the ER by an initial leader peptide. This ~60kDa pre-sCLU protein is proteolytically cleaved into alpha- and beta-subunits and further glycosylated to form mature disulfide-linked heterodimeric secretory CLU (sCLU). sCLU is an 80kDa protein and acts as a molecular chaperone, scavenging denatured proteins outside cells [, ]. sCLU possesses nonspecific binding activity to hydrophobic domains of various non-native proteins [], binds to some bacteria and bacterial proteins [], and interacts with different immune molecules [].A specific nuclear form of CLU (nCLU) acts as a pro-death signal, inhibiting cell growth andsurvival. ThenCLU protein has two coiled-coil domains, one at its N terminus that is unable to bind Ku70, and a C-terminal coiled-coil domain that is uniquely able to associatewith Ku70 and is minimally required for cell death. The sCLU protein is cytoprotective and anti-apoptotic, whereas the nCLU protein is pro-apoptotic [, , ].This family also includes clusterin-like protein 1 (CLUL1), which is expressed specifically in cone photoreceptor cells []and is likely to be necessary for normal cone function [].
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Protein
E9PUU2
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: true
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Protein
E9PXG5
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: true
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Protein
E9Q8Y5
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: true
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Protein
E9Q2G2
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: true
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Protein
E9Q9B8
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: true
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Protein
Q06890
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: false
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Protein
Q9JK98
Organism: Mus musculus/domesticus
Length: 372  
Fragment?: false
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Protein
Q549A5
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: false
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Publication
1585460 | -
First Author: Jenne DE
Year: 1992
Journal: Trends Biochem Sci
Title: Clusterin: the intriguing guises of a widely expressed glycoprotein.
Volume: 17
Issue: 4
Pages: 154-9
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Publication
20035974 | J:356707
First Author: Chen J
Year: 2010
Journal: Urology
Title: 2,8-dihydroxyadenine nephrolithiasis induces developmental stage-specific alterations in gene expression in mouse kidney.
Volume: 75
Issue: 4
Pages: 914-22
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Publication
39031722 | J:352093
First Author: Zhao H
Year: 2024
Journal: J Cell Mol Med
Title: Deletion of Fbxw7 in oocytes causes follicle loss and premature ovarian insufficiency in mice.
Volume: 28
Issue: 12
Pages: e18487
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Publication
22956607 | J:214056
First Author: Matthaei M
Year: 2012
Journal: Invest Ophthalmol Vis Sci
Title: Endothelial Cdkn1a (p21) overexpression and accelerated senescence in a mouse model of Fuchs endothelial corneal dystrophy.
Volume: 53
Issue: 10
Pages: 6718-27
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Publication
11272792 | J:67915
First Author: Lindgren G
Year: 2001
Journal: Chromosome Res
Title: Mapping of 13 horse genes by fluorescence in-situ hybridization (FISH) and somatic cell hybrid analysis.
Volume: 9
Issue: 1
Pages: 53-9
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Publication
18397380 | J:151157
First Author: Mulligan MK
Year: 2008
Journal: Genes Brain Behav
Title: Alcohol trait and transcriptional genomic analysis of C57BL/6 substrains.
Volume: 7
Issue: 6
Pages: 677-89
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Publication
28971894 | J:253645
First Author: Saewu A
Year: 2017
Journal: Reproduction
Title: Clusterin in the mouse epididymis: possible roles in sperm maturation and capacitation.
Volume: 154
Issue: 6
Pages: 867-880
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Publication
32913257 | J:296152
First Author: He J
Year: 2020
Journal: Sci Rep
Title: Glomerular clusterin expression is increased in diabetic nephropathy and protects against oxidative stress-induced apoptosis in podocytes.
Volume: 10
Issue: 1
Pages: 14888
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Publication
33052230 | J:313884
First Author: Chen Z
Year: 2020
Journal: Theranostics
Title: Inactivation of tumor suppressor gene Clusterin leads to hyperactivation of TAK1-NF-κB signaling axis in lung cancer cells and denotes a therapeutic opportunity.
Volume: 10
Issue: 25
Pages: 11520-11534
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Protein
Q3ZRW6
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: false
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Protein Domain
IPR016014 | Clusterin_N
Type: Domain
Description: Clusterin is a vertebrate glycoprotein [], the exact function of which is not yet clear. Clusterin expression is complex, appearing as different forms indifferent cell compartments. One set of proteins is directed for secretion, and other clusterin species are expressed in thecytoplasm and nucleus. The secretory form of the clusterin protein (sCLU) is targeted to the ER by an initialleader peptide. This ~60kDa pre-sCLU protein is further glycosylated and proteolytically cleaved into alpha- and beta-subunits, held together by disulphide bonds.External sCLU is an 80kDa protein and may act as a molecular chaperone, scavenging denatured proteins outside cells following specific stress-induced injury such as heat shock. sCLU possesses nonspecific binding activity to hydrophobic domains of various proteins in vitro[].A specific nuclear form of CLU (nCLU) acts as a pro-death signal, inhibiting cell growth andsurvival. ThenCLU protein has two coiled-coil domains, one at its N terminus that is unable to bind Ku70, and a C-terminal coiled-coil domain that is uniquely able to associatewith Ku70 and is minimally required for cell death.Clusterin is synthesized as a precursor polypeptide of about 400 amino acids which is post-translationally cleaved to form two subunits of about 200 amino acids each. The two subunits are linked by five disulphide bonds to form anantiparallel ladder-like structure []. In each of the mature subunits the five cysteines that are involved in disulphide bonds are clustered in domains of about 30 amino acids located in the central part of the subunits.This entry represents the N-terminal domain of the clusterin precursor.
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Protein Domain
IPR016015 | Clusterin_C
Type: Domain
Description: Clusterin is a vertebrate glycoprotein [], the exact function of which is not yet clear. Clusterinexpression is complex, appearing as different forms indifferent cell compartments. One set of proteins is directed for secretion, and other clusterin species are expressed in thecytoplasm and nucleus. The secretory form of the clusterin protein (sCLU) is targeted to the ER by an initialleader peptide. This ~60kDa pre-sCLU protein is further glycosylated and proteolytically cleaved into alpha- and beta-subunits, held together by disulphide bonds.External sCLU is an 80kDa protein and may act as a molecular chaperone, scavenging denatured proteins outside cells following specific stress-induced injury such as heat shock. sCLU possesses nonspecific binding activity to hydrophobic domains of various proteins in vitro[].A specific nuclear form of CLU (nCLU) acts as a pro-death signal, inhibiting cell growth andsurvival. ThenCLU protein has two coiled-coil domains, one at its N terminus that is unable to bind Ku70, and a C-terminal coiled-coil domain that is uniquely able to associatewith Ku70 and is minimally required for cell death.Clusterin is synthesized as a precursor polypeptide of about 400 amino acids which is post-translationally cleaved to form two subunits of about 200 amino acids each. The two subunits are linked by five disulphide bonds to form anantiparallel ladder-like structure []. In each of the mature subunits the five cysteines that are involved in disulphide bonds are clustered in domains of about 30 amino acids located in the central part of the subunits.This entry represents the C-terminal domain of the custerin precursor.
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Publication
25051234 | J:219013
First Author: Zhou Y
Year: 2014
Journal: PLoS One
Title: Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease.
Volume: 9
Issue: 7
Pages: e103187
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Publication
1491011 | -
First Author: Choi-Miura NH
Year: 1992
Journal: J Biochem
Title: Identification of the disulfide bonds in human plasma protein SP-40,40 (apolipoprotein-J).
Volume: 112
Issue: 4
Pages: 557-61
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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