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Search results 801 to 900 out of 976 for Crebbp

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Type Details Score
Allele
Srcap<Gt(E199B10)Wrst> | MGI:3918191
 
Name: Snf2-related CREBBP activator protein; gene trap E199B10, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST10161G11)Tigm> | MGI:3940561
 
Name: Snf2-related CREBBP activator protein; gene trap IST10161G11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(W176A04)Wrst> | MGI:4123232
 
Name: Snf2-related CREBBP activator protein; gene trap W176A04, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Srcap<Gt(PST9161)Mfgc> | MGI:4344099
 
Name: Snf2-related CREBBP activator protein; gene trap PST9161, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
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Allele
Srcap<Gt(PST4602)Mfgc> | MGI:4342102
 
Name: Snf2-related CREBBP activator protein; gene trap PST4602, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
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Allele
Srcap<Gt(PST5182)Mfgc> | MGI:4342253
 
Name: Snf2-related CREBBP activator protein; gene trap PST5182, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
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Allele
Srcap<Gt(F024E01)Wrst> | MGI:4333063
 
Name: Snf2-related CREBBP activator protein; gene trap F024E01, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Srcap<Gt(P045D08)Wrst> | MGI:4351895
 
Name: Snf2-related CREBBP activator protein; gene trap P045D08, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Srcap<Gt(EUCE0237b11)Hmgu> | MGI:4378302
 
Name: Snf2-related CREBBP activator protein; gene trap EUCE0237b11, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Srcap<Gt(EUCE0252c05)Hmgu> | MGI:4387151
 
Name: Snf2-related CREBBP activator protein; gene trap EUCE0252c05, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Srcap<Gt(EUCE0019e11)Hmgu> | MGI:4395524
 
Name: Snf2-related CREBBP activator protein; gene trap EUCE0019e11, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Srcap<Gt(EUCE0057c05)Hmgu> | MGI:4394323
 
Name: Snf2-related CREBBP activator protein; gene trap EUCE0057c05, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Srcap<Gt(EUCJ00118b02)Hmgu> | MGI:4873703
 
Name: Snf2-related CREBBP activator protein; gene trap EUCJ00118b02, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Srcap<Gt(EUCJ0005d07)Hmgu> | MGI:4878330
 
Name: Snf2-related CREBBP activator protein; gene trap EUCJ0005d07, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST13639D8)Tigm> | MGI:5179298
 
Name: Snf2-related CREBBP activator protein; gene trap IST13639D8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST13508C5)Tigm> | MGI:5170269
 
Name: Snf2-related CREBBP activator protein; gene trap IST13508C5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST13557C6)Tigm> | MGI:5177092
 
Name: Snf2-related CREBBP activator protein; gene trap IST13557C6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST13595A2)Tigm> | MGI:5181286
 
Name: Snf2-related CREBBP activator protein; gene trap IST13595A2, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST13675C7)Tigm> | MGI:5183068
 
Name: Snf2-related CREBBP activator protein; gene trap IST13675C7, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST13796B6)Tigm> | MGI:5187734
 
Name: Snf2-related CREBBP activator protein; gene trap IST13796B6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST13968G5)Tigm> | MGI:5200101
 
Name: Snf2-related CREBBP activator protein; gene trap IST13968G5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST13960H10)Tigm> | MGI:5197720
 
Name: Snf2-related CREBBP activator protein; gene trap IST13960H10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST13769H10)Tigm> | MGI:5192497
 
Name: Snf2-related CREBBP activator protein; gene trap IST13769H10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST14185C12)Tigm> | MGI:5215869
 
Name: Snf2-related CREBBP activator protein; gene trap IST14185C12, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST14229G10)Tigm> | MGI:5217748
 
Name: Snf2-related CREBBP activator protein; gene trap IST14229G10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST14463F9)Tigm> | MGI:5231467
 
Name: Snf2-related CREBBP activator protein; gene trap IST14463F9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST14566F6)Tigm> | MGI:5238731
 
Name: Snf2-related CREBBP activator protein; gene trap IST14566F6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST14358F3)Tigm> | MGI:5229964
 
Name: Snf2-related CREBBP activator protein; gene trap IST14358F3, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<Gt(IST14944D10)Tigm> | MGI:5272434
 
Name: Snf2-related CREBBP activator protein; gene trap IST14944D10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Srcap<em1(IMPC)Wtsi> | MGI:6153626
Name: Snf2-related CREBBP activator protein; endonuclease-mediated mutation 1, Wellcome Trust Sanger Institute
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7577167 | C57BL/6JGpt-Srcap<em1Gpt>/Gpt
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:8374559 | C57BL/6JGpt-Srcap<em2Gpt>/Gpt
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Srcap/Srcap
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Allele
Crebbp<tm1Dli> | MGI:1926888
Name: CREB binding protein; targeted mutation 1, David Livingston
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:2174146 | B6.129S6-Crebbp<tm1Dli>/J
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Crebbp/Crebbp
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crebbp/Crebbp<+>
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crebbp/Crebbp<+>
Background: involves: 129S6/SvEvTac * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Strain
MGI:6335356 | C57BL/6N-Srcap<em1(IMPC)Wtsi>/Wtsi
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:7381020 | C57BL/6N-Srcap<em1(IMPC)Wtsi>/WtsiOulu
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Crebbp<Gt(U-San)112Imeg> | MGI:1928775
Name: CREB binding protein; gene trap 112, Institute of Molecular Embryology and Genetics
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
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Genotype
Genotype
Symbol: Srcap/Srcap<+>
Background: C57BL/6N-Srcap/Wtsi
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crebbp/Crebbp
Background: involves: C57BL/6 * CBA
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crebbp/Crebbp<+>
Background: involves: C57BL/6 * CBA
Zygosity: ht
Has Mutant Allele: true
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HT Experiment
E-GEOD-24773 | Expression data from WT, Crebbp+/- and Ep300+/- bone marrow stroma
Series Id: GSE24773
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
16634648 | J:320032
First Author: Ruhl DD
Year: 2006
Journal: Biochemistry
Title: Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes.
Volume: 45
Issue: 17
Pages: 5671-7
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Publication
24361270 | -
First Author: Plotnikov AN
Year: 2014
Journal: Structure
Title: Structural insights into acetylated-histone H4 recognition by the bromodomain-PHD finger module of human transcriptional coactivator CBP.
Volume: 22
Issue: 2
Pages: 353-60
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Publication
27190605 | -
First Author: Taylor AM
Year: 2016
Journal: ACS Med Chem Lett
Title: Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).
Volume: 7
Issue: 5
Pages: 531-6
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Publication
28630323 | -
First Author: Park S
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Role of the CBP catalytic core in intramolecular SUMOylation and control of histone H3 acetylation.
Volume: 114
Issue: 27
Pages: E5335-E5342
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Publication
31314496 | -
First Author: Ghosh R
Year: 2019
Journal: Biochemistry
Title: Tumor Suppressor p53-Mediated Structural Reorganization of the Transcriptional Coactivator p300.
Volume: 58
Issue: 32
Pages: 3434-3443
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Protein Domain
IPR056484 | PHD_P300
Type: Domain
Description: This domain is found in human Histone acetyltransferase p300 (EP300), Histone lysine acetyltransferase CREBBP and similar animal proteins. EP300 functions as a histone acetyltransferase and regulates transcription via chromatin remodelling [, ]. Histone lysine acetyltransferase CREBBP acetylates histones, giving a specific tag for transcriptional activation [, ]. It mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) []. CREBBP also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 [, ].This entry represents the PHD domain, which forms a module with the bromodomain () and the RING domain () that associates intimately with the HAT domain () through numerous conserved contacts [].
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Genotype
Genotype
Symbol: Crebbp/Crebbp<+> Ep300/Ep300<+>
Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Protein Domain
IPR064044 | CBP/p300/RT109_HAT
Type: Domain
Description: This domain is found in human Histone acetyltransferase p300 (EP300), mouse Histone lysine acetyltransferase CREBBP (CPB), yeast Histone acetyltransferase RTT109 and similar eukaryotic proteins.Histone acetylation is required in many cellular processes including transcription, DNA repair, and chromatin assembly.EP300 functions as a histone acetyltransferase and regulates transcription via chromatin remodelling [, ]. Histone lysine acetyltransferase CREBBP acetylates histones, giving a specific tag for transcriptional activation [, ]. It mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) []. CREBBP also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 [, ].The fungal RTT109 protein is required for H3K56 acetylation. Loss of RTT109 results in the loss of H3K56 acetylation, both on bulk histone and on chromatin []. RTT109 and H3K56 acetylation appear to correlate with actively transcribed genes and associate with the elongating form of Pol II in yeast []. The p300/CBP histone acetyltransferase domain has different catalytic properties and cofactor regulation to RTT109 [].
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Publication
35675826 | J:351461
First Author: Zhou N
Year: 2022
Journal: Cell Metab
Title: Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses.
Volume: 34
Issue: 7
Pages: 1023-1041.e8
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Publication
21131905 | J:168692
First Author: Jin Q
Year: 2011
Journal: EMBO J
Title: Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.
Volume: 30
Issue: 2
Pages: 249-62
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Publication
23415232 | -
First Author: Tropberger P
Year: 2013
Journal: Cell
Title: Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer.
Volume: 152
Issue: 4
Pages: 859-72
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Publication
24616510 | -
First Author: Das C
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation.
Volume: 111
Issue: 12
Pages: E1072-81
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Publication
28062671 | J:238052
First Author: H?pken UE
Year: 2017
Journal: Cancer Discov
Title: Targeting HDAC3 in CREBBP-Mutant Lymphomas Counterstrikes Unopposed Enhancer Deacetylation of B-cell Signaling and Immune Response Genes.
Volume: 7
Issue: 1
Pages: 14-16
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Publication
30540930 | -
First Author: Iyer-Bierhoff A
Year: 2018
Journal: Cell Rep
Title: SIRT7-Dependent Deacetylation of Fibrillarin Controls Histone H2A Methylation and rRNA Synthesis during the Cell Cycle.
Volume: 25
Issue: 11
Pages: 2946-2954.e5
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Publication
17046836 | -
First Author: Schneider J
Year: 2006
Journal: J Biol Chem
Title: Rtt109 is required for proper H3K56 acetylation: a chromatin mark associated with the elongating RNA polymerase II.
Volume: 281
Issue: 49
Pages: 37270-4
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Protein Domain
IPR056993 | TRIP4_3rd_dom
Type: Domain
Description: This entry represents a presumed domain found in Activating signal cointegrator 1 (TRIP4, also known as ASC-1) from human and related sequences from animals and some plant species. The function of this domain is unknown.TRIP4 is the orthologue of yeast RQT4 and is part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation [, , ]. TRIP4 has also been described as a transcription coactivator which associates with nuclear receptors and transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription [, ].
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Publication
29138493 | J:256297
First Author: Ye B
Year: 2017
Journal: Nat Commun
Title: Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2.
Volume: 8
Issue: 1
Pages: 1518
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Publication
34398873 | J:309041
First Author: Aiderus A
Year: 2021
Journal: PLoS Genet
Title: Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progression.
Volume: 17
Issue: 8
Pages: e1009094
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Publication
35171684 | J:321525
First Author: Kim KB
Year: 2022
Journal: Sci Adv
Title: KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer.
Volume: 8
Issue: 7
Pages: eabl4618
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Publication
39863613 | J:373774
First Author: Lv J
Year: 2025
Journal: Cell Death Dis
Title: Pifithrin-? sensitizes mTOR-activated liver cancer to sorafenib treatment.
Volume: 16
Issue: 1
Pages: 42
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Publication
42066769 | J:389062
First Author: Kunitomi H
Year: 2026
Journal: Cell Stem Cell
Title: eIF4G2-mediated selective translation of chromatin regulators safeguards adult intestinal stem cell identity and differentiation.
Volume: 33
Issue: 6
Pages: 1000-1015.e11
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Publication
23934153 | -
First Author: Delvecchio M
Year: 2013
Journal: Nat Struct Mol Biol
Title: Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation.
Volume: 20
Issue: 9
Pages: 1040-6
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Publication
11701890 | -
First Author: Xu W
Year: 2001
Journal: Science
Title: A transcriptional switch mediated by cofactor methylation.
Volume: 294
Issue: 5551
Pages: 2507-11
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Publication
34075040 | J:307864
First Author: Horisawa-Takada Y
Year: 2021
Journal: Nat Commun
Title: Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis.
Volume: 12
Issue: 1
Pages: 3184
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Publication
16287980 | -
First Author: Kuo HY
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx.
Volume: 102
Issue: 47
Pages: 16973-8
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Publication
15907476 | J:98945
First Author: Ballas N
Year: 2005
Journal: Cell
Title: REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis.
Volume: 121
Issue: 4
Pages: 645-657
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Protein
A0A0U1RP23
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
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Protein
A0A0U1RP46
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: true
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Publication
11359896 | -
First Author: Manning ET
Year: 2001
Journal: Mol Cell Biol
Title: p300 forms a stable, template-committed complex with chromatin: role for the bromodomain.
Volume: 21
Issue: 12
Pages: 3876-87
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Publication
15313412 | -
First Author: Kalkhoven E
Year: 2004
Journal: Biochem Pharmacol
Title: CBP and p300: HATs for different occasions.
Volume: 68
Issue: 6
Pages: 1145-55
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Publication
15313417 | -
First Author: Fu M
Year: 2004
Journal: Biochem Pharmacol
Title: Acetylation of nuclear receptors in cellular growth and apoptosis.
Volume: 68
Issue: 6
Pages: 1199-208
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Publication
16140033 | -
First Author: Shi YJ
Year: 2005
Journal: Mol Cell
Title: Regulation of LSD1 histone demethylase activity by its associated factors.
Volume: 19
Issue: 6
Pages: 857-64
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Publication
11349124 | -
First Author: Gizard F
Year: 2001
Journal: J Biol Chem
Title: A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression.
Volume: 276
Issue: 36
Pages: 33881-92
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Publication
21573134 | -
First Author: Hao Y
Year: 2011
Journal: PLoS Genet
Title: Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex.
Volume: 7
Issue: 5
Pages: e1002065
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Protein Domain
IPR051066 | CoREST
Type: Family
Description: This family comprises the REST corepressor (CoREST) proteins, as well as related transcriptional regulators such as zinc finger protein 541 (ZNF541), mitotic deacetylase-associated SANT domain protein (MIDEAS), and transcriptional-regulating factor 1 (TRERF1). Members of this family typically function as components of histone deacetylase (HDAC) complexes to regulate gene expression. For example, mammalian RCOR1 (CoREST) is an essential component of the BHC complex, which represses the transcription of neuron-specific genes in non-neuronal cells by deacetylating and demethylating specific sites on histones [, , ]. ZNF541 is a component of an HDAC complex that regulates the progression of the pachytene stage of meiotic prophase during spermatogenesis [, ]. MIDEAS is a component of the MiDAC histone deacetylase complex []. TRERF1 interacts with CREBBP and EP300 to activate the transcription of specific genes []. These proteins typically share a conserved domain architecture that includes an ELM2 domain and one or more SANT domains, which mediate protein-protein interactions and nucleosome binding [, ].
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Protein Domain
IPR056994 | TRI4_N
Type: Domain
Description: This entry represents a presumed domain found at the N-terminal of Activating signal cointegrator 1 (TRIP4, also known as ASC-1) from human and related animal sequences. The function of this domain is unknown. According to structure predictions, this domain may adopt a four helical bundle fold.TRIP4 is the orthologue of yeast RQT4 and is part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation [, , ]. TRIP4 has also been described as a transcription coactivator which associates with nuclear receptors and transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription [, ].
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Protein Domain
IPR013178 | Histone_AcTrfase_CBP/p300
Type: Family
Description: Histone acetylation is required in many cellular processes including transcription, DNA repair, and chromatin assembly. This family contains human Histone acetyltransferase p300 (EP300), mouse Histone lysine acetyltransferase CREBBP (CPB) and similar plant and animal proteins.EP300 functions as a histone acetyltransferase and regulates transcription via chromatin remodelling [, ]. CPB is a transcriptional co-activator that acetylates both histones and non-histone proteins [, , ]. CBP binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes [, ].I t gives histones a specific tag for transcriptional activation [, ]. It mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) []. This protein also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 [, ].
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Publication
11694877 | J:76593
First Author: Bamforth SD
Year: 2001
Journal: Nat Genet
Title: Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.
Volume: 29
Issue: 4
Pages: 469-74
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Publication
35244684 | J:328717
First Author: Lord T
Year: 2022
Journal: Biol Reprod
Title: A novel high throughput screen to identify candidate molecular networks that regulate spermatogenic stem cell functions?.
Volume: 106
Issue: 6
Pages: 1175-1190
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Publication
30274972 | J:268224
First Author: Dominguez PM
Year: 2018
Journal: Cancer Discov
Title: TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis.
Volume: 8
Issue: 12
Pages: 1632-1653
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Publication
18305227 | J:140811
First Author: Zeng Z
Year: 2008
Journal: Biol Reprod
Title: Delayed parturition and altered myometrial progesterone receptor isoform A expression in mice null for Kr?ppel-like factor 9.
Volume: 78
Issue: 6
Pages: 1029-37
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Publication
31915197 | J:285817
First Author: Mondello P
Year: 2020
Journal: Cancer Discov
Title: Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma.
Volume: 10
Issue: 3
Pages: 440-459
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Publication
22442722 | J:380342
First Author: Lavi-Itzkovitz A
Year: 2012
Journal: PLoS One
Title: Functional consequences of necdin nucleocytoplasmic localization.
Volume: 7
Issue: 3
Pages: e33786
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Publication
18568037 | -
First Author: Tang Y
Year: 2008
Journal: Nat Struct Mol Biol
Title: Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP.
Volume: 15
Issue: 7
Pages: 738-45
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Publication
29091030 | J:380781
   
First Author: Kopp Y
Year: 2017
Journal: Elife
Title: CHIP as a membrane-shuttling proteostasis sensor.
Volume: 6
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Publication
19794495 | J:186056
First Author: Morini?re J
Year: 2009
Journal: Nature
Title: Cooperative binding of two acetylation marks on a histone tail by a single bromodomain.
Volume: 461
Issue: 7264
Pages: 664-8
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Protein
D3Z3P3
Organism: Mus musculus/domesticus
Length: 56  
Fragment?: true
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Publication
35752625 | -
First Author: Zhang J
Year: 2022
Journal: Nat Commun
Title: Structural mechanism of protein recognition by the FW domain of autophagy receptor Nbr1.
Volume: 13
Issue: 1
Pages: 3650
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Publication
29802199 | -
First Author: Ambrose RL
Year: 2018
Journal: J Biol Chem
Title: C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response.
Volume: 293
Issue: 27
Pages: 10561-10573
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Publication
10449787 | -
First Author: Andr?s ME
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: CoREST: a functional corepressor required for regulation of neural-specific gene expression.
Volume: 96
Issue: 17
Pages: 9873-8
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Protein Domain
IPR038547 | RING_CBP-p300_sf
Type: Homologous_superfamily
Description: CBP (CREB-binding protein) and p300 (also known as CREBBP or KAT3A and EP300 or KAT3B, respectively) are two histone acetyltransferases (HATs) that associate with and acetylate transcriptional regulators and chromatin. The catalytic core of animal CBP-p300 contains a bromodomain, a CH2 region containing a discontinuous PHD domain interrupted by this RING domain, and a HAT domain. Bromodomain-RING-PHD forms a compact module in which the RING domain is juxtaposed with the HAT substrate-binding site. This ring domain contains only a single zinc ion-binding cluster instead of two; instead of a second zinc atom, a network of hydrophobic interactions stabilizes the domain. The RING domain has an inhibitory role. Disease mutations that disrupt RING attachment lead to upregulation of HAT activity. HAT regulation may require repositioning of the RING domain to facilitate access to an otherwise partially occluded HAT active site. Plant CBP-p300 type HATs lack a bromodomain whose role in the animal animal CBP-p300's is to bind acetylated histones; it has been suggested that these plant proteins may utilize a different domain or another bromodomain protein to perform this function [].
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Protein Domain
IPR010303 | RING_CBP-p300
Type: Domain
Description: CBP (CREB-binding protein) and p300 (also known as CREBBP or KAT3A and EP300 or KAT3B, respectively) are two histone acetyltransferases (HATs) that associate with and acetylate transcriptional regulators and chromatin. The catalytic core of animal CBP-p300 contains a bromodomain, a CH2 region containing a discontinuous PHD domain interrupted by this RING domain, and a HAT domain. Bromodomain-RING-PHD forms a compact module in which the RING domain is juxtaposed with the HAT substrate-binding site. This ring domain contains only a single zinc ion-binding cluster instead of two; instead of a second zinc atom, a network of hydrophobic interactions stabilizes the domain. The RING domain has an inhibitory role. Disease mutations that disrupt RING attachment lead to upregulation of HAT activity. HAT regulation may require repositioning of the RING domain to facilitate access to an otherwise partially occluded HAT active site. Plant CBP-p300 type HATs lack a bromodomain whose role in the animal animal CBP-p300's is to bind acetylated histones; it has been suggested that these plant proteins may utilize a different domain or another bromodomain protein to perform this function []. This RING domain has also been referred to as DUF902.
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Protein Domain
IPR032350 | Nbr1_FW
Type: Domain
Description: This entry represents the FW domain found in Nbr1 and similar eukaryotic proteins, including JOKA2 from Solanum tuberosum. In the fungus Chaetomium thermophilum it has been shown to bind the alpha-mannosidase Ams1, a cargo of selective autophagy in both budding yeast and fission yeast, and delivers Ams1 to the vacuole by autophagy in heterologous fission yeast. The FW domain has also been shown to interact with the microtubule-associated protein MAP1B []. Structurally, the FW domain adopts an immunoglobulin-like ��-sandwich structure and recognises the quaternary structure of the Ams1 tetramer [].Nbr1 (Next to BRCA1 gene 1) is a ubiquitin-binding autophagy adapter that participates in different processes, including host defence or intracellular homeostasis []. Nbr1-like molecules contain an N-terminal PB1 domain, one (animals, plants) or more (fungi) ZZ domains, an FW domain, and a C-terminal UBA domain [].JOKA2 activates ATG8CL-mediated selective autophagy, and contributes to defense against the fungal pathogen Phytophtora infestans [, ].ILRUN is a negative regulator of the innate antiviral response that blocks IRF3-dependent cytokine production, including IFNA, IFNB and TNF. ILRUN interacts with IRF3 and inhibits its recruitment to type I IFN promoter sequences, while also reducing nuclear levels of the coactivators EP300 and CREBBP []. It is a paralog of NRBF2.
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Protein
A0A0U1RPL2
Organism: Mus musculus/domesticus
Length: 1107  
Fragment?: true
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Protein
Q3UBZ2
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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