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Search results 801 to 900 out of 954 for Crh

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Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Nes-cre)1Kln/?
Background: involves: 129S2/SvPas * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crh/Crh<+> Mc4r/Mc4r
Background: involves: 129S4/SvJaeSor * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Crh-cre)1Kres/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Crh-cre)1Kres/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(CAG-Bgeo/GFP)21Lbe/? Tg(Crh-cre)1Kres/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crh/Crh<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
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Publication
7853396 | -
First Author: van Nuland NA
Year: 1995
Journal: J Mol Biol
Title: High-resolution structure of the phosphorylated form of the histidine-containing phosphocarrier protein HPr from Escherichia coli determined by restrained molecular dynamics from NMR-NOE data.
Volume: 246
Issue: 1
Pages: 180-93
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Publication
1549615 | -
First Author: Herzberg O
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Structure of the histidine-containing phosphocarrier protein HPr from Bacillus subtilis at 2.0-A resolution.
Volume: 89
Issue: 6
Pages: 2499-503
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Publication
7704530 | -
First Author: Liao DI
Year: 1994
Journal: Structure
Title: Refined structures of the active Ser83-->Cys and impaired Ser46-->Asp histidine-containing phosphocarrier proteins.
Volume: 2
Issue: 12
Pages: 1203-16
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Publication
11054290 | -
First Author: Audette GF
Year: 2000
Journal: J Mol Biol
Title: The 1.9 A resolution structure of phospho-serine 46 HPr from Enterococcus faecalis.
Volume: 303
Issue: 4
Pages: 545-53
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Publication
15713472 | -
First Author: Sridharan S
Year: 2005
Journal: J Mol Biol
Title: The HPr proteins from the thermophile Bacillus stearothermophilus can form domain-swapped dimers.
Volume: 346
Issue: 3
Pages: 919-31
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Publication
16316990 | -
First Author: Schumacher MA
Year: 2006
Journal: J Biol Chem
Title: Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation.
Volume: 281
Issue: 10
Pages: 6793-800
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Protein Domain
IPR000032 | HPr-like
Type: Domain
Description: This entry represents a structural domain found in both the histidine-containing phosphocarrier protein HPr, as well as its structural homologues, which includes the catabolite repression protein Crh found in Bacillus subtilis [, ]. This domain has a alpha+beta structure found in two layers with an overall architecture of an open faced β-sandwich in which a β-sheet is packed against three α-helices. The histidine-containing phosphocarrier protein (HPr) is a central component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), which transfers metabolic carbohydrates across the cell membrane in many bacterial species [, ]. PTS catalyses the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The general mechanism of the PTS is as follows: a phosphoryl group from phosphoenolpyruvate (PEP) is transferred to Enzyme I (EI) of the PTS, which in turn transfers it to the phosphoryl carrier protein (HPr) [, ]. Phospho-HPr then transfers the phosphoryl group to a sugar-specific permease complex (enzymes EII/EIII). HPr [, ]is a small cytoplasmic protein of 70 to 90 amino acid residues. In some bacteria, HPr is a domain in a larger protein that includes a EIII(Fru) (IIA) domain and in some cases also the EI domain. A conserved histidine in the N-terminal section of HPr serves as an acceptor for the phosphoryl group of EI. In the central part of HPr, there is a conserved serine which (in Gram-positive bacteria only) is phosphorylated by an ATP-dependent protein kinase; a process which probably play a regulatory role in sugar transport. Regulatory phosphorylation at the conserved Ser residue does not appear to induce large structural changes to the HPr domain, in particular in the region of the active site [, ].
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Protein Domain
IPR035895 | HPr-like_sf
Type: Homologous_superfamily
Description: This entry represents a structural domain found in both the histidine-containing phosphocarrier protein HPr, as well as its structural homologues, which includes the catabolite repression protein Crh found in Bacillus subtilis [, ]. This domain has a alpha+beta structure found in two layers with an overall architecture of an open faced β-sandwich in which a β-sheet is packed against three α-helices. The histidine-containing phosphocarrier protein (HPr) is a central component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), which transfers metabolic carbohydrates across the cell membrane in many bacterial species [, ]. PTS catalyses the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The general mechanism of the PTS is as follows: a phosphoryl group from phosphoenolpyruvate (PEP) is transferred to Enzyme I (EI) of the PTS, which in turn transfers it to the phosphoryl carrier protein (HPr) [, ]. Phospho-HPr then transfers the phosphoryl group to a sugar-specific permease complex (enzymes EII/EIII). HPr [, ]is a small cytoplasmic protein of 70 to 90 amino acid residues. In some bacteria, HPr is a domain in a larger protein that includes a EIII(Fru) (IIA) domain and in some cases also the EI domain. A conserved histidine in the N-terminal section of HPr serves as an acceptor for the phosphoryl group of EI. In the central part of HPr, there is a conserved serine which (in Gram-positive bacteria only) is phosphorylated by an ATP-dependent protein kinase; a process which probably play a regulatory role in sugar transport. Regulatory phosphorylation at the conserved Ser residue does not appear to induce large structural changes to the HPr domain, in particular in the region of the active site [, ].
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Publication
7556876 | J:27447
First Author: Cortright DN
Year: 1995
Journal: Mol Cell Endocrinol
Title: Molecular and biochemical characterization of the mouse brain corticotropin-releasing hormone-binding protein.
Volume: 111
Issue: 2
Pages: 147-57
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Publication
12973355 | J:85745
First Author: Müller MB
Year: 2003
Journal: Nat Neurosci
Title: Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.
Volume: 6
Issue: 10
Pages: 1100-7
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Publication
9703949 | J:49069
First Author: Zídek V
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Quantitative trait loci for compensatory renal hypertrophy in the mouse.
Volume: 248
Issue: 3
Pages: 473-5
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Publication
10500222 | J:57963
First Author: Karolyi IJ
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Altered anxiety and weight gain in corticotropin-releasing hormone-binding protein-deficient mice.
Volume: 96
Issue: 20
Pages: 11595-600
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Publication
17904108 | J:127335
First Author: Bjursell M
Year: 2007
Journal: Biochem Biophys Res Commun
Title: GPR10 deficiency in mice results in altered energy expenditure and obesity.
Volume: 363
Issue: 3
Pages: 633-8
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Publication
26135556 | J:248600
First Author: Hooper A
Year: 2016
Journal: Hippocampus
Title: Characterization of a novel subtype of hippocampal interneurons that express corticotropin-releasing hormone.
Volume: 26
Issue: 1
Pages: 41-53
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Publication
11329063 | J:114061
First Author: Hsu SY
Year: 2001
Journal: Nat Med
Title: Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor.
Volume: 7
Issue: 5
Pages: 605-11
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Publication
7956345 | J:22103
First Author: Broad TE
Year: 1995
Journal: Cytogenet Cell Genet
Title: Assignment of five loci from human chromosome 8q onto sheep chromosome 9.
Volume: 68
Issue: 1-2
Pages: 102-6
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Publication
12960076 | J:85769
First Author: Araki O
Year: 2003
Journal: Endocrinology
Title: Expression of type 2 iodothyronine deiodinase in corticotropin-secreting mouse pituitary tumor cells is stimulated by glucocorticoid and corticotropin-releasing hormone.
Volume: 144
Issue: 10
Pages: 4459-65
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Publication
15923664 | J:99194
First Author: Iserentant H
Year: 2005
Journal: J Cell Sci
Title: Mapping of the interface between leptin and the leptin receptor CRH2 domain.
Volume: 118
Issue: Pt 11
Pages: 2519-27
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Publication
25430741 | J:218182
First Author: Romanov RA
Year: 2015
Journal: EMBO J
Title: A secretagogin locus of the mammalian hypothalamus controls stress hormone release.
Volume: 34
Issue: 1
Pages: 36-54
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Publication
30535142 | J:269093
First Author: Kameda H
Year: 2019
Journal: Endocrinology
Title: Proton Sensitivity of Corticotropin-Releasing Hormone Receptor 1 Signaling to Proopiomelanocortin in Male Mice.
Volume: 160
Issue: 2
Pages: 276-291
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Publication
27240530 | J:339554
First Author: Hartmann J
Year: 2017
Journal: Mol Psychiatry
Title: Forebrain glutamatergic, but not GABAergic, neurons mediate anxiogenic effects of the glucocorticoid receptor.
Volume: 22
Issue: 3
Pages: 466-475
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Publication
22030710 | J:225021
First Author: Thoeringer CK
Year: 2012
Journal: Neuropsychopharmacology
Title: Consolidation of remote fear memories involves Corticotropin-Releasing Hormone (CRH) receptor type 1-mediated enhancement of AMPA receptor GluR1 signaling in the dentate gyrus.
Volume: 37
Issue: 3
Pages: 787-96
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Publication
29593501 | J:276737
 
First Author: Gong Q
Year: 2018
Journal: Front Cell Neurosci
Title: Chronic Stress Reduces Nectin-1 mRNA Levels and Disrupts Dendritic Spine Plasticity in the Adult Mouse Perirhinal Cortex.
Volume: 12
Pages: 67
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Genotype
Genotype
Symbol: Crh/Crh<+> Mc4r/Mc4r Oxt/Oxt<+>
Background: involves: 129S4/SvJaeSor * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crh/Crh<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crh/Crh<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crh/Crh Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129 * C57BL/6J * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
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Publication
17596444 | J:122977
First Author: Heisler LK
Year: 2007
Journal: J Neurosci
Title: Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation.
Volume: 27
Issue: 26
Pages: 6956-64
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Publication
7565810 | J:44768
First Author: Stenzel P
Year: 1995
Journal: Mol Endocrinol
Title: Identification of a novel murine receptor for corticotropin-releasing hormone expressed in the heart.
Volume: 9
Issue: 5
Pages: 637-45
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Publication
8637571 | J:34303
First Author: Qu D
Year: 1996
Journal: Nature
Title: A role for melanin-concentrating hormone in the central regulation of feeding behaviour.
Volume: 380
Issue: 6571
Pages: 243-7
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Publication
19321449 | J:222151
First Author: Rambaud J
Year: 2009
Journal: J Biol Chem
Title: TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77.
Volume: 284
Issue: 21
Pages: 14147-56
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Publication
10600221 | J:58721
First Author: Shanks N
Year: 1999
Journal: Brain Behav Immun
Title: Alterations in hypothalamic-pituitary-adrenal function correlated with the onset of murine SLE in MRL +/+ and lpr/lpr mice.
Volume: 13
Issue: 4
Pages: 348-60
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Publication
9387853 | J:44206
First Author: Frederic F
Year: 1997
Journal: Neuroendocrinology
Title: Enhanced endocrine response to novel environment stress and endotoxin in Lurcher mutant mice.
Volume: 66
Issue: 5
Pages: 341-7
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Publication
16141396 | J:129687
First Author: Chida D
Year: 2005
Journal: Endocrinology
Title: Involvement of corticotropin-releasing hormone- and interleukin (IL)-6-dependent proopiomelanocortin induction in the anterior pituitary during hypothalamic-pituitary-adrenal axis activation by IL-1alpha.
Volume: 146
Issue: 12
Pages: 5496-502
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Publication
19193887 | J:144947
First Author: Elander L
Year: 2009
Journal: J Neurosci
Title: Inducible prostaglandin E2 synthesis interacts in a temporally supplementary sequence with constitutive prostaglandin-synthesizing enzymes in creating the hypothalamic-pituitary-adrenal axis response to immune challenge.
Volume: 29
Issue: 5
Pages: 1404-13
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Publication
17095588 | J:119240
First Author: Smart JL
Year: 2007
Journal: Endocrinology
Title: Central dysregulation of the hypothalamic-pituitary-adrenal axis in neuron-specific proopiomelanocortin-deficient mice.
Volume: 148
Issue: 2
Pages: 647-59
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Publication
18372344 | J:136159
First Author: Zhao L
Year: 2008
Journal: Mol Endocrinol
Title: Central nervous system-specific knockout of steroidogenic factor 1 results in increased anxiety-like behavior.
Volume: 22
Issue: 6
Pages: 1403-15
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Publication
22171026 | J:248630
First Author: Sarkar J
Year: 2011
Journal: J Neurosci
Title: Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors.
Volume: 31
Issue: 50
Pages: 18198-210
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Publication
19213843 | J:158061
First Author: Schmidt MV
Year: 2009
Journal: Endocrinology
Title: Postnatal glucocorticoid excess due to pituitary glucocorticoid receptor deficiency: differential short- and long-term consequences.
Volume: 150
Issue: 6
Pages: 2709-16
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Publication
16825606 | J:127795
First Author: Luque RM
Year: 2006
Journal: Am J Physiol Endocrinol Metab
Title: Evidence that endogenous SST inhibits ACTH and ghrelin expression by independent pathways.
Volume: 291
Issue: 2
Pages: E395-403
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Publication
24632224 | J:254108
 
First Author: Ferrer B
Year: 2014
Journal: Brain Behav Immun
Title: Muscle-specific interleukin-6 deletion influences body weight and body fat in a sex-dependent manner.
Volume: 40
Pages: 121-30
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Publication
23979842 | J:210716
First Author: Laryea G
Year: 2013
Journal: Mol Endocrinol
Title: Disrupting hypothalamic glucocorticoid receptors causes HPA axis hyperactivity and excess adiposity.
Volume: 27
Issue: 10
Pages: 1655-65
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Publication
12021198 | J:77511
First Author: Kellendonk C
Year: 2002
Journal: Endocrinology
Title: Inactivation of the GR in the nervous system affects energy accumulation.
Volume: 143
Issue: 6
Pages: 2333-40
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Publication
28890385 | J:302771
 
First Author: Hanif A
Year: 2017
Journal: Prostaglandins Other Lipid Mediat
Title: Reduced coronary reactive hyperemia in mice was reversed by the soluble epoxide hydrolase inhibitor (t-AUCB): Role of adenosine A2A receptor and plasma oxylipins.
Volume: 131
Pages: 83-95
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Publication
27583776 | J:327161
First Author: Hanif A
Year: 2016
Journal: PLoS One
Title: Effect of Soluble Epoxide Hydrolase on the Modulation of Coronary Reactive Hyperemia: Role of Oxylipins and PPARγ.
Volume: 11
Issue: 9
Pages: e0162147
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Publication
10650957 | J:60181
First Author: MacLusky NJ
Year: 2000
Journal: Endocrinology
Title: Neuroendocrine function and response to stress in mice with complete disruption of glucagon-like peptide-1 receptor signaling.
Volume: 141
Issue: 2
Pages: 752-62
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Publication
16631135 | J:109674
First Author: Akasaka S
Year: 2006
Journal: Brain Res
Title: The hypothalamo-pituitary axis responses to lipopolysaccharide-induced endotoxemia in mice lacking inducible nitric oxide synthase.
Volume: 1089
Issue: 1
Pages: 1-9
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Publication
21420442 | J:171703
First Author: Fenzl T
Year: 2011
Journal: Behav Brain Res
Title: Wake-promoting effects of orexin: Its independent actions against the background of an impaired corticotropine-releasing hormone receptor system.
Volume: 222
Issue: 1
Pages: 43-50
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Publication
24053666 | J:202687
 
First Author: Byerly MS
Year: 2013
Journal: BMC Physiol
Title: Estrogen-related receptor β deficiency alters body composition and response to restraint stress.
Volume: 13
Pages: 10
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Publication
21296667 | J:172771
First Author: Wang XD
Year: 2011
Journal: Neurobiol Dis
Title: Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling.
Volume: 42
Issue: 3
Pages: 300-10
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Publication
22672268 | J:207663
First Author: Wang XD
Year: 2012
Journal: Eur J Neurosci
Title: Early-life stress-induced anxiety-related behavior in adult mice partially requires forebrain corticotropin-releasing hormone receptor 1.
Volume: 36
Issue: 3
Pages: 2360-7
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Publication
10742109 | J:61485
First Author: Kishimoto T
Year: 2000
Journal: Nat Genet
Title: Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2.
Volume: 24
Issue: 4
Pages: 415-9
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Publication
20164342 | J:157835
First Author: Kolber BJ
Year: 2010
Journal: J Neurosci
Title: Transient early-life forebrain corticotropin-releasing hormone elevation causes long-lasting anxiogenic and despair-like changes in mice.
Volume: 30
Issue: 7
Pages: 2571-81
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Publication
25015995 | J:320854
First Author: Liu Y
Year: 2014
Journal: Endocr Relat Cancer
Title: The role of corticotropin-releasing hormone receptor 1 in the development of colitis-associated cancer in mouse model.
Volume: 21
Issue: 4
Pages: 639-51
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Publication
12399950 | J:104025
First Author: Yoshida-Hiroi M
Year: 2002
Journal: Mol Psychiatry
Title: Chromaffin cell function and structure is impaired in corticotropin-releasing hormone receptor type 1-null mice.
Volume: 7
Issue: 9
Pages: 967-74
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Publication
10742108 | J:61484
First Author: Bale TL
Year: 2000
Journal: Nat Genet
Title: Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress.
Volume: 24
Issue: 4
Pages: 410-4
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Publication
17194743 | J:129581
First Author: Cota D
Year: 2007
Journal: Endocrinology
Title: Requirement of cannabinoid receptor type 1 for the basal modulation of hypothalamic-pituitary-adrenal axis function.
Volume: 148
Issue: 4
Pages: 1574-81
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Publication
12897210 | J:84918
First Author: Cota D
Year: 2003
Journal: J Clin Invest
Title: The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis.
Volume: 112
Issue: 3
Pages: 423-31
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Publication
23106615 | J:192163
First Author: Gotoh K
Year: 2013
Journal: J Neurochem
Title: Nesfatin-1, corticotropin-releasing hormone, thyrotropin-releasing hormone, and neuronal histamine interact in the hypothalamus to regulate feeding behavior.
Volume: 124
Issue: 1
Pages: 90-9
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Publication
11442356 | J:130612
First Author: Pedersen WA
Year: 2001
Journal: Neurobiol Dis
Title: Corticotropin-releasing hormone protects neurons against insults relevant to the pathogenesis of Alzheimer's disease.
Volume: 8
Issue: 3
Pages: 492-503
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Publication
22232675 | J:179918
First Author: Jeanneteau FD
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus.
Volume: 109
Issue: 4
Pages: 1305-10
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Publication
25740517 | J:219933
First Author: Gray JM
Year: 2015
Journal: J Neurosci
Title: Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety.
Volume: 35
Issue: 9
Pages: 3879-92
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Publication
29609111 | J:272193
 
First Author: Savarese A
Year: 2018
Journal: Psychoneuroendocrinology
Title: Regulation of anxiety-like behavior and Crhr1 expression in the basolateral amygdala by LMO3.
Volume: 92
Pages: 13-20
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Publication
15231703 | J:105619
First Author: Coll AP
Year: 2004
Journal: Endocrinology
Title: The effects of proopiomelanocortin deficiency on murine adrenal development and responsiveness to adrenocorticotropin.
Volume: 145
Issue: 10
Pages: 4721-7
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Publication
15178147 | J:96350
First Author: Bhatnagar S
Year: 2004
Journal: Physiol Behav
Title: Changes in anxiety-related behaviors and hypothalamic-pituitary-adrenal activity in mice lacking the 5-HT-3A receptor.
Volume: 81
Issue: 4
Pages: 545-55
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Publication
11441072 | J:107150
First Author: Murray SE
Year: 2001
Journal: J Immunol
Title: A genetic model of stress displays decreased lymphocytes and impaired antibody responses without altered susceptibility to Streptococcus pneumoniae.
Volume: 167
Issue: 2
Pages: 691-8
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Publication
27175972 | J:239721
First Author: Cordoba-Chacón J
Year: 2016
Journal: Endocrinology
Title: Cortistatin Is a Key Factor Regulating the Sex-Dependent Response of the GH and Stress Axes to Fasting in Mice.
Volume: 157
Issue: 7
Pages: 2810-23
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Publication
18451093 | J:136973
First Author: Kublaoui BM
Year: 2008
Journal: Mol Endocrinol
Title: Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice.
Volume: 22
Issue: 7
Pages: 1723-34
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Publication
21199868 | J:170548
First Author: Ullrich M
Year: 2011
Journal: J Biol Chem
Title: Identification of SPRED2 (sprouty-related protein with EVH1 domain 2) as a negative regulator of the hypothalamic-pituitary-adrenal axis.
Volume: 286
Issue: 11
Pages: 9477-88
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