Type |
Details |
Score |
Genotype |
Symbol: |
Apoe/Apoe<+> |
Background: |
either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J) |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apoe/Apoe |
Background: |
either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J) |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apoe/Apoe Cx3cr1/Cx3cr1 |
Background: |
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apoe/Apoe Plg/Plg |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apoe/Apoe |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apoe/Apoe Mapk9/Mapk9 |
Background: |
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apoe/Apoe Mapk8/Mapk8 |
Background: |
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apoe/Apoe Ltb4r1/Ltb4r1 |
Background: |
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apoe/Apoe Bcl2/Bcl2 Lyz2/Lyz2<+> |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apoe/Apoe |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apoe/Apoe |
Background: |
B6.129P2-Apoe |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apoe/Apoe Esr1/Esr1 |
Background: |
B6.129P2-Apoe Esr1 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apoe/Apoe Ifngr1/Ifngr1 |
Background: |
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apoe/Apoe Cd59a/Cd59a |
Background: |
involves: 129 * 129P2/OlaHsd |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apoe/Apoe C6/C6 |
Background: |
involves: 129P2/OlaHsd |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, spontaneous mutation, targeted mutation, transgenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee J |
Year: |
2013 |
Journal: |
BMC Immunol |
Title: |
Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice. |
Volume: |
14 |
|
Pages: |
53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Svoboda DS |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain. |
Volume: |
116 |
Issue: |
50 |
Pages: |
25293-25303 |
|
•
•
•
•
•
|
Publication |
First Author: |
Westerterp M |
Year: |
2007 |
Journal: |
Circulation |
Title: |
Apolipoprotein C-I is crucially involved in lipopolysaccharide-induced atherosclerosis development in apolipoprotein E-knockout mice. |
Volume: |
116 |
Issue: |
19 |
Pages: |
2173-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dansky HM |
Year: |
1999 |
Journal: |
J Clin Invest |
Title: |
Apo A-I inhibits foam cell formation in Apo E-deficient mice after monocyte adherence to endothelium. |
Volume: |
104 |
Issue: |
1 |
Pages: |
31-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ostos MA |
Year: |
2001 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Antioxidative and antiatherosclerotic effects of human apolipoprotein A-IV in apolipoprotein E-deficient mice. |
Volume: |
21 |
Issue: |
6 |
Pages: |
1023-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
van Ree JH |
Year: |
1995 |
Journal: |
Hum Mol Genet |
Title: |
Inactivation of Apoe and Apoc1 by two consecutive rounds of gene targeting: effects on mRNA expression levels of gene cluster members. |
Volume: |
4 |
Issue: |
8 |
Pages: |
1403-9 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apoc1/Apoc1 Apoe/Apoe |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee SJ |
Year: |
2004 |
Journal: |
J Lipid Res |
Title: |
Chylomicron remnant uptake in the livers of mice expressing human apolipoproteins E3, E2 (Arg158-->Cys), and E3-Leiden. |
Volume: |
45 |
Issue: |
12 |
Pages: |
2199-210 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yin Y |
Year: |
2015 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Early hyperlipidemia promotes endothelial activation via a caspase-1-sirtuin 1 pathway. |
Volume: |
35 |
Issue: |
4 |
Pages: |
804-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang XC |
Year: |
2001 |
Journal: |
Nat Med |
Title: |
Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency. |
Volume: |
7 |
Issue: |
7 |
Pages: |
847-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feig JE |
Year: |
2010 |
Journal: |
J Clin Invest |
Title: |
LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression. |
Volume: |
120 |
Issue: |
12 |
Pages: |
4415-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jeong Ts |
Year: |
1998 |
Journal: |
J Clin Invest |
Title: |
Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase. |
Volume: |
101 |
Issue: |
4 |
Pages: |
905-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
George J |
Year: |
1999 |
Journal: |
J Autoimmun |
Title: |
The involvement of beta2-glycoprotein I (beta2-GPI) in human and murine atherosclerosis. |
Volume: |
13 |
Issue: |
1 |
Pages: |
57-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Calara F |
Year: |
2001 |
Journal: |
J Pathol |
Title: |
Spontaneous plaque rupture and secondary thrombosis in apolipoprotein E-deficient and LDL receptor-deficient mice. |
Volume: |
195 |
Issue: |
2 |
Pages: |
257-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thorp E |
Year: |
2009 |
Journal: |
Cell Metab |
Title: |
Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. |
Volume: |
9 |
Issue: |
5 |
Pages: |
474-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gallagher EJ |
Year: |
2017 |
Journal: |
Oncogene |
Title: |
Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia. |
Volume: |
36 |
Issue: |
46 |
Pages: |
6462-6471 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tangirala RK |
Year: |
1995 |
Journal: |
J Lipid Res |
Title: |
Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice. |
Volume: |
36 |
Issue: |
11 |
Pages: |
2320-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carlo AS |
Year: |
2013 |
Journal: |
J Neurosci |
Title: |
The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain. |
Volume: |
33 |
Issue: |
1 |
Pages: |
358-70 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, spontaneous mutation, targeted mutation, transgenic, congenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Soncin I |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma. |
Volume: |
9 |
Issue: |
1 |
Pages: |
582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Strickland AB |
Year: |
2023 |
Journal: |
iScience |
Title: |
Alternatively activated lung alveolar and interstitial macrophages promote fungal growth. |
Volume: |
26 |
Issue: |
5 |
Pages: |
106717 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grune J |
Year: |
2022 |
Journal: |
Nat Cardiovasc Res |
Title: |
Neutrophils incite and macrophages avert electrical storm after myocardial infarction. |
Volume: |
1 |
Issue: |
7 |
Pages: |
649-664 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vanneste D |
Year: |
2023 |
Journal: |
Nat Immunol |
Title: |
MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation. |
Volume: |
24 |
Issue: |
5 |
Pages: |
827-840 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Y |
Year: |
2012 |
Journal: |
Nat Immunol |
Title: |
IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. |
Volume: |
13 |
Issue: |
8 |
Pages: |
753-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou LJ |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain. |
Volume: |
27 |
Issue: |
13 |
Pages: |
3844-3859.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weilinger NL |
Year: |
2023 |
Journal: |
Cell Rep |
Title: |
Pannexin-1 opening in neuronal edema causes cell death but also leads to protection via increased microglia contacts. |
Volume: |
42 |
Issue: |
10 |
Pages: |
113128 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pridans C |
Year: |
2013 |
Journal: |
Sci Rep |
Title: |
CSF1R mutations in hereditary diffuse leukoencephalopathy with spheroids are loss of function. |
Volume: |
3 |
|
Pages: |
3013 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang N |
Year: |
2021 |
Journal: |
J Exp Med |
Title: |
LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth. |
Volume: |
218 |
Issue: |
12 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zuo C |
Year: |
2023 |
Journal: |
J Exp Med |
Title: |
Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy. |
Volume: |
220 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Babaeijandaghi F |
Year: |
2023 |
Journal: |
Nat Commun |
Title: |
DPPIV(+) fibro-adipogenic progenitors form the niche of adult skeletal muscle self-renewing resident macrophages. |
Volume: |
14 |
Issue: |
1 |
Pages: |
8273 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bourette RP |
Year: |
1993 |
Journal: |
Blood |
Title: |
Expression of human colony-stimulating factor-1 (CSF-1) receptor in murine pluripotent hematopoietic NFS-60 cells induces long-term proliferation in response to CSF-1 without loss of erythroid differentiation potential. |
Volume: |
81 |
Issue: |
10 |
Pages: |
2511-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hampe A |
Year: |
1984 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Nucleotide sequence of the feline retroviral oncogene v-fms shows unexpected homology with oncogenes encoding tyrosine-specific protein kinases. |
Volume: |
81 |
Issue: |
1 |
Pages: |
85-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sapi E |
Year: |
2004 |
Journal: |
Exp Biol Med (Maywood) |
Title: |
The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update. |
Volume: |
229 |
Issue: |
1 |
Pages: |
1-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rademakers R |
Year: |
2011 |
Journal: |
Nat Genet |
Title: |
Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids. |
Volume: |
44 |
Issue: |
2 |
Pages: |
200-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Woolford J |
Year: |
1988 |
Journal: |
Cell |
Title: |
Activation of the feline c-fms proto-oncogene: multiple alterations are required to generate a fully transformed phenotype. |
Volume: |
55 |
Issue: |
6 |
Pages: |
965-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tamura T |
Year: |
1991 |
Journal: |
Behring Inst Mitt |
Title: |
Transforming mechanism of the feline sarcoma virus encoded v-fms oncogene product. |
|
Issue: |
89 |
Pages: |
93-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rettenmier CW |
Year: |
1986 |
Journal: |
Princess Takamatsu Symp |
Title: |
Requirements for transformation by the fms oncogene product (CSF-1 receptor). |
Volume: |
17 |
|
Pages: |
211-8 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents a macrophage colony-stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR) or CD115 (Cluster of Differentiation 115). CSF1R is a tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes []. CSF-1 and CSF-1R play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis []. Mutations in the CSF1R gene cause hereditary diffuse leukoencephalopathy with spheroids, which is an autosomal-dominant central nervous system white-matter disease with variable clinical presentations, including personality and behavioral changes, dementia, depression, parkinsonism, seizures and other phenotypes [].This entry also includes the tyrosine-protein kinase transforming protein v-fms from Feline sarcoma virus. CSF1R (the c-fms product) is its cellular counterpart. It differs in some amino acid substitutions and the replacement of 50 C-terminal amino acids by 11 unrelated residues in v-fms [, , ]. v-fms can bind CSF-1 and has constitutive tyrosine-specific protein kinase activity, providing growth stimulatory signals in the absence of ligand []. |
|
•
•
•
•
•
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Publication |
First Author: |
Kunin V |
Year: |
2007 |
Journal: |
Genome Biol |
Title: |
Evolutionary conservation of sequence and secondary structures in CRISPR repeats. |
Volume: |
8 |
Issue: |
4 |
Pages: |
R61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Barrangou R |
Year: |
2007 |
Journal: |
Science |
Title: |
CRISPR provides acquired resistance against viruses in prokaryotes. |
Volume: |
315 |
Issue: |
5819 |
Pages: |
1709-12 |
|
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•
•
•
•
|
Publication |
First Author: |
Makarova KS |
Year: |
2006 |
Journal: |
Biol Direct |
Title: |
A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action. |
Volume: |
1 |
|
Pages: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Howard JA |
Year: |
2011 |
Journal: |
Biochem J |
Title: |
Helicase dissociation and annealing of RNA-DNA hybrids by Escherichia coli Cas3 protein. |
Volume: |
439 |
Issue: |
1 |
Pages: |
85-95 |
|
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•
•
•
•
|
Publication |
First Author: |
Brendel J |
Year: |
2014 |
Journal: |
J Biol Chem |
Title: |
A complex of Cas proteins 5, 6, and 7 is required for the biogenesis and stability of clustered regularly interspaced short palindromic repeats (crispr)-derived rnas (crrnas) in Haloferax volcanii. |
Volume: |
289 |
Issue: |
10 |
Pages: |
7164-77 |
|
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•
•
•
•
|
Publication |
First Author: |
Ramsey SA |
Year: |
2014 |
Journal: |
PLoS Genet |
Title: |
Epigenome-guided analysis of the transcriptome of plaque macrophages during atherosclerosis regression reveals activation of the Wnt signaling pathway. |
Volume: |
10 |
Issue: |
12 |
Pages: |
e1004828 |
|
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•
•
•
•
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Publication |
First Author: |
Plump AS |
Year: |
1999 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Increased atherosclerosis in ApoE and LDL receptor gene knock-out mice as a result of human cholesteryl ester transfer protein transgene expression. |
Volume: |
19 |
Issue: |
4 |
Pages: |
1105-10 |
|
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•
•
•
•
|
Publication |
First Author: |
Masucci-Magoulas L |
Year: |
1996 |
Journal: |
J Clin Invest |
Title: |
Profound induction of hepatic cholesteryl ester transfer protein transgene expression in apolipoprotein E and low density lipoprotein receptor gene knockout mice. A novel mechanism signals changes in plasma cholesterol levels. |
Volume: |
97 |
Issue: |
1 |
Pages: |
154-61 |
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•
•
•
•
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Publication |
First Author: |
Kobayashi T |
Year: |
2004 |
Journal: |
J Clin Invest |
Title: |
Roles of thromboxane A(2) and prostacyclin in the development of atherosclerosis in apoE-deficient mice. |
Volume: |
114 |
Issue: |
6 |
Pages: |
784-94 |
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•
•
•
•
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Publication |
First Author: |
Janova H |
Year: |
2018 |
Journal: |
J Clin Invest |
Title: |
Microglia ablation alleviates myelin-associated catatonic signs in mice. |
Volume: |
128 |
Issue: |
2 |
Pages: |
734-745 |
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•
•
•
•
|
Publication |
First Author: |
Liu F |
Year: |
2022 |
Journal: |
Int J Biol Sci |
Title: |
Csf1r mediates enhancement of intestinal tumorigenesis caused by inactivation of Mir34a. |
Volume: |
18 |
Issue: |
14 |
Pages: |
5415-5437 |
|
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•
•
•
•
|
Publication |
First Author: |
Theurl I |
Year: |
2016 |
Journal: |
Nat Med |
Title: |
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver. |
Volume: |
22 |
Issue: |
8 |
Pages: |
945-51 |
|
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•
•
•
•
|
Publication |
First Author: |
Larsen MC |
Year: |
2023 |
Journal: |
Int J Mol Sci |
Title: |
AhR and CYP1B1 Control Oxygen Effects on Bone Marrow Progenitor Cells: The Enrichment of Multiple Olfactory Receptors as Potential Microbiome Sensors. |
Volume: |
24 |
Issue: |
23 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Muthukrishnan SD |
Year: |
2018 |
Journal: |
Dis Model Mech |
Title: |
Nephron progenitor cell death elicits a limited compensatory response associated with interstitial expansion in the neonatal kidney. |
Volume: |
11 |
Issue: |
1 |
|
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•
•
•
•
•
|
Publication |
First Author: |
Mathsyaraja H |
Year: |
2015 |
Journal: |
Oncogene |
Title: |
CSF1-ETS2-induced microRNA in myeloid cells promote metastatic tumor growth. |
Volume: |
34 |
Issue: |
28 |
Pages: |
3651-61 |
|
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•
•
•
•
|
Publication |
First Author: |
Qin L |
Year: |
2014 |
Journal: |
Cancer Res |
Title: |
NCOA1 Directly Targets M-CSF1 Expression to Promote Breast Cancer Metastasis. |
Volume: |
74 |
Issue: |
13 |
Pages: |
3477-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
DeNardo DG |
Year: |
2011 |
Journal: |
Cancer Discov |
Title: |
Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. |
Volume: |
1 |
Issue: |
1 |
Pages: |
54-67 |
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•
•
•
•
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Publication |
First Author: |
Amano S |
Year: |
2023 |
Journal: |
J Immunol |
Title: |
Commensal Bacteria and the Lung Environment Are Responsible for Th2-Mediated Memory Yielding Natural IgE in MyD88-Deficient Mice. |
Volume: |
210 |
Issue: |
7 |
Pages: |
959-972 |
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•
•
•
•
•
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Publication |
First Author: |
Qian BZ |
Year: |
2015 |
Journal: |
J Exp Med |
Title: |
FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis. |
Volume: |
212 |
Issue: |
9 |
Pages: |
1433-48 |
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•
•
•
•
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Publication |
First Author: |
Marzan DE |
Year: |
2021 |
Journal: |
Glia |
Title: |
Activated microglia drive demyelination via CSF1R signaling. |
Volume: |
69 |
Issue: |
6 |
Pages: |
1583-1604 |
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•
•
•
•
•
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Publication |
First Author: |
Garcia AJ |
Year: |
2014 |
Journal: |
Mol Cell Biol |
Title: |
Pten null prostate epithelium promotes localized myeloid-derived suppressor cell expansion and immune suppression during tumor initiation and progression. |
Volume: |
34 |
Issue: |
11 |
Pages: |
2017-28 |
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•
•
•
•
•
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Publication |
First Author: |
Toejing P |
Year: |
2023 |
Journal: |
Int J Mol Sci |
Title: |
Accelerated Bone Loss in Transgenic Mice Expressing Constitutively Active TGF-β Receptor Type I. |
Volume: |
24 |
Issue: |
13 |
|
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•
•
•
•
•
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Publication |
First Author: |
Zhou K |
Year: |
2022 |
Journal: |
J Neuroinflammation |
Title: |
An overlooked subset of Cx3cr1wt/wt microglia in the Cx3cr1CreER-Eyfp/wt mouse has a repopulation advantage over Cx3cr1CreER-Eyfp/wt microglia following microglial depletion. |
Volume: |
19 |
Issue: |
1 |
Pages: |
20 |
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•
•
•
•
•
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Publication |
First Author: |
Aikawa S |
Year: |
2020 |
Journal: |
Cell Death Differ |
Title: |
Uterine deficiency of high-mobility group box-1 (HMGB1) protein causes implantation defects and adverse pregnancy outcomes. |
Volume: |
27 |
Issue: |
5 |
Pages: |
1489-1504 |
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•
•
•
•
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Publication |
First Author: |
Zhang X |
Year: |
2018 |
Journal: |
J Mol Cell Cardiol |
Title: |
Brg1 trans-activates endothelium-derived colony stimulating factor to promote calcium chloride induced abdominal aortic aneurysm in mice. |
Volume: |
125 |
|
Pages: |
6-17 |
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•
•
•
•
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Publication |
First Author: |
He H |
Year: |
2012 |
Journal: |
Blood |
Title: |
Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages. |
Volume: |
120 |
Issue: |
15 |
Pages: |
3152-62 |
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•
•
•
•
•
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Publication |
First Author: |
Cheng B |
Year: |
2021 |
Journal: |
Front Immunol |
Title: |
Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival. |
Volume: |
12 |
|
Pages: |
633796 |
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•
•
•
•
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Publication |
First Author: |
Qing X |
Year: |
2016 |
Journal: |
Eur J Immunol |
Title: |
iRhom2 regulates CSF1R cell surface expression and non-steady state myelopoiesis in mice. |
Volume: |
46 |
Issue: |
12 |
Pages: |
2737-2748 |
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•
•
•
•
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Publication |
First Author: |
Stables J |
Year: |
2022 |
Journal: |
Development |
Title: |
A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling. |
Volume: |
149 |
Issue: |
8 |
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•
•
•
•
•
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Publication |
First Author: |
Barrott JJ |
Year: |
2016 |
Journal: |
J Exp Med |
Title: |
Modeling synovial sarcoma metastasis in the mouse: PI3'-lipid signaling and inflammation. |
Volume: |
213 |
Issue: |
13 |
Pages: |
2989-3005 |
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•
•
•
•
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Publication |
First Author: |
Galletti G |
Year: |
2016 |
Journal: |
Leukemia |
Title: |
B cells and macrophages pursue a common path toward the development and progression of chronic lymphocytic leukemia. |
Volume: |
30 |
Issue: |
12 |
Pages: |
2293-2301 |
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•
•
•
•
•
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Publication |
First Author: |
Hawley CA |
Year: |
2018 |
Journal: |
J Immunol |
Title: |
Csf1r-mApple Transgene Expression and Ligand Binding In Vivo Reveal Dynamics of CSF1R Expression within the Mononuclear Phagocyte System. |
Volume: |
200 |
Issue: |
6 |
Pages: |
2209-2223 |
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•
•
•
•
•
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Publication |
First Author: |
Akcora D |
Year: |
2013 |
Journal: |
Stem Cell Res |
Title: |
The CSF-1 receptor fashions the intestinal stem cell niche. |
Volume: |
10 |
Issue: |
2 |
Pages: |
203-12 |
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•
•
•
•
•
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Publication |
First Author: |
Bhattacharjee O |
Year: |
2021 |
Journal: |
Front Immunol |
Title: |
Epithelial-Macrophage Crosstalk Initiates Sterile Inflammation in Embryonic Skin. |
Volume: |
12 |
|
Pages: |
718005 |
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•
•
•
•
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Publication |
First Author: |
Stewart AN |
Year: |
2025 |
Journal: |
J Neurosci |
Title: |
Nonresolving Neuroinflammation Regulates Axon Regeneration in Chronic Spinal Cord Injury. |
Volume: |
45 |
Issue: |
1 |
|
|
•
•
•
•
•
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Publication |
First Author: |
Jacome-Galarza CE |
Year: |
2019 |
Journal: |
Nature |
Title: |
Developmental origin, functional maintenance and genetic rescue of osteoclasts. |
Volume: |
568 |
Issue: |
7753 |
Pages: |
541-545 |
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•
•
•
•
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Publication |
First Author: |
Zhu M |
Year: |
2021 |
Journal: |
PLoS One |
Title: |
Selective deletion of the receptor for CSF1, c-fms, in osteoclasts results in a high bone mass phenotype, smaller osteoclasts in vivo and an impaired response to an anabolic PTH regimen. |
Volume: |
16 |
Issue: |
2 |
Pages: |
e0247199 |
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•
•
•
•
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Publication |
First Author: |
Forget MA |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Macrophage colony-stimulating factor augments Tie2-expressing monocyte differentiation, angiogenic function, and recruitment in a mouse model of breast cancer. |
Volume: |
9 |
Issue: |
6 |
Pages: |
e98623 |
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•
•
•
•
•
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Publication |
First Author: |
Summers KM |
Year: |
2017 |
Journal: |
J Leukoc Biol |
Title: |
Identification of the macrophage-specific promoter signature in FANTOM5 mouse embryo developmental time course data. |
Volume: |
102 |
Issue: |
4 |
Pages: |
1081-1092 |
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•
•
•
•
•
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Publication |
First Author: |
Patsialou A |
Year: |
2015 |
Journal: |
Oncogene |
Title: |
Autocrine CSF1R signaling mediates switching between invasion and proliferation downstream of TGFβ in claudin-low breast tumor cells. |
Volume: |
34 |
Issue: |
21 |
Pages: |
2721-31 |
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•
•
•
•
•
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Publication |
First Author: |
Anderson SR |
Year: |
2019 |
Journal: |
J Neurosci |
Title: |
Complement Targets Newborn Retinal Ganglion Cells for Phagocytic Elimination by Microglia. |
Volume: |
39 |
Issue: |
11 |
Pages: |
2025-2040 |
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•
•
•
•
•
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Publication |
First Author: |
Wendt S |
Year: |
2022 |
Journal: |
Redox Biol |
Title: |
Simultaneous imaging of redox states in dystrophic neurites and microglia at Aβ plaques indicate lysosome accumulation not microglia correlate with increased oxidative stress. |
Volume: |
56 |
|
Pages: |
102448 |
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•
•
•
•
•
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Publication |
First Author: |
Bautista CA |
Year: |
2023 |
Journal: |
Front Physiol |
Title: |
CD206+ tendon resident macrophages and their potential crosstalk with fibroblasts and the ECM during tendon growth and maturation. |
Volume: |
14 |
|
Pages: |
1122348 |
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•
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
977
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
945
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
977
 |
Fragment?: |
false |
|
•
•
•
•
•
|