Type |
Details |
Score |
Strain |
Attribute String: |
transgenic, mutant strain, congenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, transgenic |
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•
•
•
•
•
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Publication |
First Author: |
Huang M |
Year: |
2022 |
Journal: |
Cancer Lett |
Title: |
Tumor perivascular cell-derived extracellular vesicles promote angiogenesis via the Gas6/Axl pathway. |
Volume: |
524 |
|
Pages: |
131-143 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion H, Dwight E Bergles |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
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•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, transgenic |
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•
•
•
•
•
|
Allele |
Name: |
transgene insertion, Berislav V Zlokovic |
Allele Type: |
Transgenic |
Attribute String: |
Inducible, Recombinase |
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•
•
•
•
•
|
Genotype |
Symbol: |
Cspg4/Cspg4<+> |
Background: |
involves: 129P2/OlaHsd * C57BL/6N |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Cspg4-cre)1Rkl/? |
Background: |
involves: 129X1/SvJ * FVB |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, transgenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Hughes EG |
Year: |
2013 |
Journal: |
Nat Neurosci |
Title: |
Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain. |
Volume: |
16 |
Issue: |
6 |
Pages: |
668-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cooke VG |
Year: |
2012 |
Journal: |
Cancer Cell |
Title: |
Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway. |
Volume: |
21 |
Issue: |
1 |
Pages: |
66-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Karmouch J |
Year: |
2017 |
Journal: |
Circ Res |
Title: |
Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes. |
Volume: |
121 |
Issue: |
12 |
Pages: |
1346-1359 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bhattacharyya S |
Year: |
2023 |
Journal: |
J Alzheimers Dis Rep |
Title: |
Increased Cerebral Serum Amyloid A2 and Parameters of Oxidation in Arylsulfatase B (N-Acetylgalactosamine-4-Sulfatase)-Null Mice. |
Volume: |
7 |
Issue: |
1 |
Pages: |
527-534 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Y |
Year: |
2022 |
Journal: |
J Lipid Res |
Title: |
Loss of ABCA8B decreases myelination by reducing oligodendrocyte precursor cells in mice. |
Volume: |
63 |
Issue: |
1 |
Pages: |
100147 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakashima K |
Year: |
2023 |
Journal: |
Commun Biol |
Title: |
POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis. |
Volume: |
6 |
Issue: |
1 |
Pages: |
996 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fukushi J |
Year: |
2004 |
Journal: |
Mol Biol Cell |
Title: |
NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. |
Volume: |
15 |
Issue: |
8 |
Pages: |
3580-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li J |
Year: |
2003 |
Journal: |
Dev Biol |
Title: |
The muscle integrin binding protein (MIBP) interacts with alpha7beta1 integrin and regulates cell adhesion and laminin matrix deposition. |
Volume: |
261 |
Issue: |
1 |
Pages: |
209-19 |
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•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Integrins are the major metazoan receptors for cell adhesion to extracellular matrix proteins and, in vertebrates, also play important roles in certain cell-cell adhesions, make transmembrane connections to the cytoskeleton and activate many intracellular signalling pathways [, ]. An integrin receptor is a heterodimer composed of alpha and beta subunits. Each subunit crosses the membrane once, with most of the polypeptide residing in the extracellular space, and has twoshort cytoplasmic domains. Some members of this family have EGF repeats at the C terminus and also have a vWA domain inserted within the integrin domain at the N terminus.Most integrins recognise relatively short peptide motifs, and in general require an acidic amino acid to be present. Ligand specificity depends upon both the alpha and beta subunits []. There are at least 18 types of alpha and 8 types of beta subunits recognised in humans []. Each alpha subunit tends to associate only with one type of beta subunit, but there are exceptions to this rule []. Each association of alpha and beta subunits has its own binding specificity and signalling properties. Many integrins require activation on the cell surface before they can bind ligands. Integrins frequently intercommunicate, and binding at one integrin receptor activate or inhibit another.This entry represent integrin beta-1. Beta-1 integrin associates with alpha subunits to form receptor complexes that bind a variety of ligands. Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Alpha7beta1 integrin regulates cell adhesion and laminin matrix deposition []. Integrin alpha-4/beta-1 is a receptor for VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4 and has a role in endothelial cell motility and angiogenesis []. |
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•
•
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Publication |
First Author: |
Hughes EG |
Year: |
2018 |
Journal: |
Nat Neurosci |
Title: |
Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex. |
Volume: |
21 |
Issue: |
5 |
Pages: |
696-706 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chung SH |
Year: |
2015 |
Journal: |
Cell Death Dis |
Title: |
The p38α mitogen-activated protein kinase is a key regulator of myelination and remyelination in the CNS. |
Volume: |
6 |
|
Pages: |
e1748 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nelson AR |
Year: |
2020 |
Journal: |
Front Aging Neurosci |
Title: |
Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo. |
Volume: |
12 |
|
Pages: |
108 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Pdgfrb-FLP1,Cspg4-cre/ERT2)#Bvz/? |
Background: |
involves: 129S6/SvEvTac * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu M |
Year: |
2022 |
Journal: |
J Neuroinflammation |
Title: |
The effect of topical decorin on temporal changes to corneal immune cells after epithelial abrasion. |
Volume: |
19 |
Issue: |
1 |
Pages: |
90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nikolakopoulou AM |
Year: |
2019 |
Journal: |
Nat Neurosci |
Title: |
Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss. |
Volume: |
22 |
Issue: |
7 |
Pages: |
1089-1098 |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
58
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
LeBleu VS |
Year: |
2013 |
Journal: |
Nat Med |
Title: |
Origin and function of myofibroblasts in kidney fibrosis. |
Volume: |
19 |
Issue: |
8 |
Pages: |
1047-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pekayvaz K |
Year: |
2023 |
Journal: |
Immunity |
Title: |
Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation. |
Volume: |
56 |
Issue: |
10 |
Pages: |
2325-2341.e15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mastorakos P |
Year: |
2021 |
Journal: |
Nat Neurosci |
Title: |
Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury. |
Volume: |
24 |
Issue: |
2 |
Pages: |
245-258 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kenney HM |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
Lineage tracing reveals evidence of a popliteal lymphatic muscle progenitor cell that is distinct from skeletal and vascular muscle progenitors. |
Volume: |
10 |
Issue: |
1 |
Pages: |
18088 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu YJ |
Year: |
2023 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Cspg4(high) microglia contribute to microgliosis during neurodegeneration. |
Volume: |
120 |
Issue: |
8 |
Pages: |
e2210643120 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
92
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
112
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
LeBleu VS |
Year: |
2024 |
Journal: |
Life Sci Alliance |
Title: |
Genetic reprogramming with stem cells regenerates glomerular epithelial podocytes in Alport syndrome. |
Volume: |
7 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kim JE |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
Single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches. |
Volume: |
11 |
Issue: |
1 |
Pages: |
334 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
798
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Demetriou MC |
Year: |
2004 |
Journal: |
J Cell Biochem |
Title: |
Integrin clipping: a novel adhesion switch? |
Volume: |
91 |
Issue: |
1 |
Pages: |
26-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheresh DA |
Year: |
1989 |
Journal: |
Cell |
Title: |
A novel vitronectin receptor integrin (alpha v beta x) is responsible for distinct adhesive properties of carcinoma cells. |
Volume: |
57 |
Issue: |
1 |
Pages: |
59-69 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arnaout MA |
Year: |
2002 |
Journal: |
Immunol Rev |
Title: |
Integrin structure: new twists and turns in dynamic cell adhesion. |
Volume: |
186 |
|
Pages: |
125-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hynes RO |
Year: |
2002 |
Journal: |
Cell |
Title: |
Integrins: bidirectional, allosteric signaling machines. |
Volume: |
110 |
Issue: |
6 |
Pages: |
673-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bökel C |
Year: |
2002 |
Journal: |
Dev Cell |
Title: |
Integrins in development: moving on, responding to, and sticking to the extracellular matrix. |
Volume: |
3 |
Issue: |
3 |
Pages: |
311-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2005 |
Journal: |
Unpublished |
Title: |
Information obtained from The Jackson Laboratory, Bar Harbor, ME |
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