Type |
Details |
Score |
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
•
•
•
|
Allele |
Name: |
E26 avian leukemia oncogene 1, 5' domain; targeted mutation 1.1, Tsuneyasu Kaisho |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Publication |
First Author: |
Hou Y |
Year: |
2016 |
Journal: |
Blood |
Title: |
High-dose dexamethasone corrects impaired myeloid-derived suppressor cell function via Ets1 in immune thrombocytopenia. |
Volume: |
127 |
Issue: |
12 |
Pages: |
1587-97 |
|
•
•
•
•
•
|
Allele |
Name: |
E26 avian leukemia oncogene 1, 5' domain; targeted mutation 2, Jeffrey M Leiden |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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•
•
•
•
•
|
Publication |
First Author: |
Nakazawa Y |
Year: |
2007 |
Journal: |
Oncogene |
Title: |
Cooperative interaction between ETS1 and GFI1 transcription factors in the repression of Bax gene expression. |
Volume: |
26 |
Issue: |
24 |
Pages: |
3541-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peyret V |
Year: |
2018 |
Journal: |
Mol Cancer Res |
Title: |
Functional Toll-like Receptor 4 Overexpression in Papillary Thyroid Cancer by MAPK/ERK-Induced ETS1 Transcriptional Activity. |
Volume: |
16 |
Issue: |
5 |
Pages: |
833-845 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sato M |
Year: |
1998 |
Journal: |
Oncogene |
Title: |
Transcriptional regulation of osteopontin gene in vivo by PEBP2alphaA/CBFA1 and ETS1 in the skeletal tissues. |
Volume: |
17 |
Issue: |
12 |
Pages: |
1517-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu H |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
AML1/Runx1 recruits calcineurin to regulate granulocyte macrophage colony-stimulating factor by Ets1 activation. |
Volume: |
279 |
Issue: |
28 |
Pages: |
29398-408 |
|
•
•
•
•
•
|
Publication |
First Author: |
Landry JR |
Year: |
2005 |
Journal: |
Blood |
Title: |
Fli1, Elf1, and Ets1 regulate the proximal promoter of the LMO2 gene in endothelial cells. |
Volume: |
106 |
Issue: |
8 |
Pages: |
2680-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Babayeva ND |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Structural basis of Ets1 cooperative binding to widely separated sites on promoter DNA. |
Volume: |
7 |
Issue: |
3 |
Pages: |
e33698 |
|
•
•
•
•
•
|
Allele |
Name: |
E26 avian leukemia oncogene 1, 5' domain; targeted mutation 1, Eric C Svensson |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready |
|
•
•
•
•
•
|
Allele |
Name: |
regulatory region 547; endonuclease-mediated mutation 1, Golnaz Vahedi |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Modified regulatory region |
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•
•
•
•
•
|
Publication |
First Author: |
Li R |
Year: |
2000 |
Journal: |
Oncogene |
Title: |
EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes. |
Volume: |
19 |
Issue: |
6 |
Pages: |
745-53 |
|
•
•
•
•
•
|
Allele |
Name: |
regulatory region 29; endonuclease-mediated mutation 6, Axel Visel |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Modified regulatory region, Null/knockout |
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•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Ets1 is a member of the Ets family of transcription factors in which the DNA-binding activity is in an autoinhibited state. The autoinhibition of Ets1 is mediated by structural coupling of the regions flanking the Ets domain. The inhibitory regions are folded as helices HI1 and HI2 N-terminal to the ETS domain and as H4 C-terminal to the ETS domain, which are packed together to form an inhibitory module [].This domain represents the N-terminal flanking region of Ets domain which contains the residues forming HI1 and HI2 helices and additional residues (244-301) N-terminal to HI1. HI1 and HI2 exert the autoinhibitory function by directing the inhibitory residues N-terminal to HI1 to mask the Ets domain DNA-binding surface. These residues are flexible and function by masking the DNA-binding surface of the Ets domain. Phosphorylation of serine residues present in this region enhances autoinhibition dramatically. These inhibitory sequences are required for cooperative DNA binding []. Members of this entry are found among chordates. |
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•
•
•
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•
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Publication |
First Author: |
Watson DK |
Year: |
1988 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Mammalian ets-1 and ets-2 genes encode highly conserved proteins. |
Volume: |
85 |
Issue: |
21 |
Pages: |
7862-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Riggan L |
Year: |
2022 |
Journal: |
Nat Immunol |
Title: |
The transcription factor Fli1 restricts the formation of memory precursor NK cells during viral infection. |
Volume: |
23 |
Issue: |
4 |
Pages: |
556-567 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koyama T |
Year: |
2015 |
Journal: |
Exp Cell Res |
Title: |
Global increase in O-linked N-acetylglucosamine modification promotes osteoblast differentiation. |
Volume: |
338 |
Issue: |
2 |
Pages: |
194-202 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gabrielli S |
Year: |
2017 |
Journal: |
Eur J Immunol |
Title: |
Murine thymic NK cells are distinct from ILC1s and have unique transcription factor requirements. |
Volume: |
47 |
Issue: |
5 |
Pages: |
800-805 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kvon EZ |
Year: |
2016 |
Journal: |
Cell |
Title: |
Progressive Loss of Function in a Limb Enhancer during Snake Evolution. |
Volume: |
167 |
Issue: |
3 |
Pages: |
633-642.e11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rinon A |
Year: |
2011 |
Journal: |
Development |
Title: |
p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes. |
Volume: |
138 |
Issue: |
9 |
Pages: |
1827-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Hara SP |
Year: |
2017 |
Journal: |
J Biol Chem |
Title: |
ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A. |
Volume: |
292 |
Issue: |
12 |
Pages: |
4833-4846 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pearce RB |
Year: |
1998 |
Journal: |
Autoimmunity |
Title: |
Fine-mapping of the mouse T lymphocyte fraction (Tlf) locus on chromosome 9: association with autoimmune diabetes. |
Volume: |
28 |
Issue: |
1 |
Pages: |
31-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Z |
Year: |
2017 |
Journal: |
Genes Chromosomes Cancer |
Title: |
Integrated expression analysis identifies transcription networks in mouse and human gastric neoplasia. |
Volume: |
56 |
Issue: |
7 |
Pages: |
535-547 |
|
•
•
•
•
•
|
Publication |
First Author: |
Champion KJ |
Year: |
2008 |
Journal: |
Cancer Res |
Title: |
Endothelial function of von Hippel-Lindau tumor suppressor gene: control of fibroblast growth factor receptor signaling. |
Volume: |
68 |
Issue: |
12 |
Pages: |
4649-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang D |
Year: |
2013 |
Journal: |
Sci Transl Med |
Title: |
Overexpression of vascular endothelial growth factor in the germinal matrix induces neurovascular proteases and intraventricular hemorrhage. |
Volume: |
5 |
Issue: |
193 |
Pages: |
193ra90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang M |
Year: |
2010 |
Journal: |
Endocrinology |
Title: |
LEFTY, a member of the transforming growth factor-beta superfamily, inhibits uterine stromal cell differentiation: a novel autocrine role. |
Volume: |
151 |
Issue: |
3 |
Pages: |
1320-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Watson DK |
Year: |
1992 |
Journal: |
Cell Growth Differ |
Title: |
The ERGB/Fli-1 gene: isolation and characterization of a new member of the family of human ETS transcription factors. |
Volume: |
3 |
Issue: |
10 |
Pages: |
705-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
McKnight RA |
Year: |
1995 |
Journal: |
Mol Endocrinol |
Title: |
An Ets site in the whey acidic protein gene promoter mediates transcriptional activation in the mammary gland of pregnant mice but is dispensable during lactation. |
Volume: |
9 |
Issue: |
6 |
Pages: |
717-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsuda Y |
Year: |
1996 |
Journal: |
Genomics |
Title: |
Comparative genome mapping of the ataxia-telangiectasia region in mouse, rat, and Syrian hamster. |
Volume: |
34 |
Issue: |
3 |
Pages: |
347-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Imai K |
Year: |
1998 |
Journal: |
Gene |
Title: |
Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes. |
Volume: |
222 |
Issue: |
2 |
Pages: |
287-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Iljin K |
Year: |
1999 |
Journal: |
FASEB J |
Title: |
Role of ets factors in the activity and endothelial cell specificity of the mouse Tie gene promoter. |
Volume: |
13 |
Issue: |
2 |
Pages: |
377-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu MJ |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Systems-level analysis of cell-specific AQP2 gene expression in renal collecting duct. |
Volume: |
106 |
Issue: |
7 |
Pages: |
2441-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okamura K |
Year: |
2009 |
Journal: |
Biochim Biophys Acta |
Title: |
Identification of nuclear localization and nuclear export signals in Ets2, and the transcriptional regulation of Ets2 and CTP:phosphocholine cytidylyltransferase alpha in tetradecanoyl-13-acetate or macrophage-colony stimulating factor stimulated RAW264 cells. |
Volume: |
1791 |
Issue: |
3 |
Pages: |
173-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang H |
Year: |
2015 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Tyrosine kinase receptor B protects against coronary artery disease and promotes adult vasculature integrity by regulating Ets1-mediated VE-cadherin expression. |
Volume: |
35 |
Issue: |
3 |
Pages: |
580-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hirai H |
Year: |
2018 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Direct Reprogramming of Fibroblasts Into Smooth Muscle-Like Cells With Defined Transcription Factors-Brief Report. |
Volume: |
38 |
Issue: |
9 |
Pages: |
2191-2197 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang L |
Year: |
2021 |
Journal: |
Cancer Res |
Title: |
Targeting Pan-ETS Factors Inhibits Melanoma Progression. |
Volume: |
81 |
Issue: |
8 |
Pages: |
2071-2085 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harada Y |
Year: |
2021 |
Journal: |
Genes Cells |
Title: |
ETS-dependent enhancers for endothelial-specific expression of serum/glucocorticoid-regulated kinase 1 during mouse embryo development. |
Volume: |
26 |
Issue: |
8 |
Pages: |
611-626 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kang JH |
Year: |
2023 |
Journal: |
Gastroenterology |
Title: |
The Epigenetic Reader, Bromodomain Containing 2, Mediates Cholangiocyte Senescence via Interaction With ETS Proto-Oncogene 1. |
Volume: |
165 |
Issue: |
1 |
Pages: |
228-243.e2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fleet JC |
Year: |
2016 |
Journal: |
Endocrinology |
Title: |
Gene-by-Diet Interactions Affect Serum 1,25-Dihydroxyvitamin D Levels in Male BXD Recombinant Inbred Mice. |
Volume: |
157 |
Issue: |
2 |
Pages: |
470-81 |
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•
•
•
•
•
|
Publication |
First Author: |
Jheon AH |
Year: |
2003 |
Journal: |
Gene |
Title: |
Characterization of the 5'-flanking region of the rat AJ18 gene. |
Volume: |
310 |
|
Pages: |
203-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cooper S |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
The +37 kb Cebpa Enhancer Is Critical for Cebpa Myeloid Gene Expression and Contains Functional Sites that Bind SCL, GATA2, C/EBPα, PU.1, and Additional Ets Factors. |
Volume: |
10 |
Issue: |
5 |
Pages: |
e0126385 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
314
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
272
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
224
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
440
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
468
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
468
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
468
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
440
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
353
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
468
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
346
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
484
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
468
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
468
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Seth A |
Year: |
1994 |
Journal: |
Oncogene |
Title: |
The EndoA enhancer contains multiple ETS binding site repeats and is regulated by ETS proteins. |
Volume: |
9 |
Issue: |
2 |
Pages: |
469-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1617-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
1999 |
Journal: |
Methods Enzymol |
Title: |
High-efficiency full-length cDNA cloning. |
Volume: |
303 |
|
Pages: |
19-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shibata K |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. |
Volume: |
10 |
Issue: |
11 |
Pages: |
1757-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katayama S |
Year: |
2005 |
Journal: |
Science |
Title: |
Antisense transcription in the mammalian transcriptome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1564-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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•
•
•
•
•
|