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Search results 801 to 900 out of 918 for Fgf21

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Hits by Strain

Type Details Score
Strain
MGI:6438399 | C57BL/6-Tg(APOA1-FGF21)14Mrl/Tac
Attribute String: mutant strain, coisogenic, transgenic
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Strain
MGI:6314746 | B6.129Sv(Cg)-Fgf21<tm1.1Djm>/J
Attribute String: congenic, mutant strain, targeted mutation
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Allele
Fgf21<em1Smoc> | MGI:7289683
Name: fibroblast growth factor 21; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Fgf21<tm1Smoc> | MGI:7289685
Name: fibroblast growth factor 21; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Fgf21/Fgf21
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:6475281 | C57BL/6JSmoc-Fgf21<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6354286 | B6;129S-Fgf21<tm1Smoc>/Smoc
Attribute String: targeted mutation, mutant stock
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Publication
16469704 | J:217996
First Author: Zhang K
Year: 2006
Journal: Cell
Title: Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response.
Volume: 124
Issue: 3
Pages: 587-99
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Protein Domain
IPR029806 | CREBH
Type: Family
Description: cAMP-responsive element-binding protein 3-like protein 3 (also known as CREBH protein) belongs to the OASIS family, which is a group of ER stress transducers, including OASIS, BBF2H7, CREBH, CREB4 and Luman []. Mammalian CREBH protein plays a role in activating expression of inflammatory response in the liver []. This protein also regulates FGF21 transcription [].Members of the OASIS family are transcription factors that transduce signals from the ER to the cytoplasm and nucleus when unfolded proteins are accumulated in the ER. They contains a basic leucine zipper (bZIP) domain that has regulatory function and a transmembrane domain that associates with the ER. Under ER stress the protein is cleaved at the membrane, and their cleaved N-terminal cytoplasmic domain (contains the bZIP domain) translocates into the nucleus where it activates the transcription of target genes that are mediated by ER stress-responsive and cyclic AMP-responsive elements [].
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Genotype
Genotype
Symbol: Fgf21/Fgf21<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Protein Domain
IPR035444 | FGF15/19/21
Type: Family
Description: This entry includes fibroblast growth factor 15/19/21 (FGF15/19/21).Fibroblast growth factor 15 (FGF15) plays a key role in enterohepatic signaling, regulation of liver bile acid biosynthesis, gallbladder motility and metabolic homeostasis [, , ]. Mouse FGF15 has been shown to be stimulated when bile acids bind to farnesoid X receptor (FXR) [], and is therefore thought to a factor in chronic bile acid diarrhoea and in certain metabolic disorders [].FGF15 has been experimentally characterised in mouse, but has not been found in other species. However, there is an orthologous human protein, FGF19, and together they share about 50% amino acid identity and display similar endocrine functions, so are often referred to as FGF15/19 [, ]. FGF15 and FGF19 differ from other FGFs due to subtle changes in their tertiary structure, they have low heparin binding affinity enabling them to diffuse away from their site of secretion and signal to distant cells. FGF signaling through the FGF receptors is also different, as they require klotho protein cofactors rather than heparin sulfate proteoglycan [].Fibroblast growth factor 19 (FGF19) plays a key role in enterohepatic signaling, regulation of liver bile acid biosynthesis, gallbladder motility and metabolic homeostasis [, , ]. Human FGF19 expression has been shown to be stimulated approximately 300-fold by physiological concentrations of bile acids including chenodeoxycholic acid, glycochenodeoxycholic acid and obeticholic acid in explants of ileal mucosa []. The protein is thought to be a factor in chronic bile acid diarrhoea and in certain metabolic disorders [, ]. FGF19 has been experimentally characterised in humans and other species, but has not been found in mouse. However there is an orthologous mouse protein, FGF15, and together they share about 50% amino acid identity and display similar endocrine functions, so are often referred to as FGF15/19 [, ]. FGF15 and FGF19 differ from other FGFs due to subtle changes in their tertiary structure. They have low heparin binding affinity, enabling them to diffuse away from their site of secretion and signal to distant cells. FGF signaling through the FGF receptors is also different, as they require klotho protein cofactors rather than heparin sulfate proteoglycan []. Unlike other members of the family that can bind several FGF receptors, FGF19 is specific for FGFR4 [].FGF21 stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression []. FGF21 has been shown to protect animals from diet-induced obesity when overexpressed in transgenic mice. It also lowers blood glucoseand triglyceride levels when administered to diabetic rodents [], suggesting it may exhibit the therapeutic characteristics necessary for effective treatment of diabetes. Treatment of animals with FGF21 results in increased energy expenditure, fat utilisation and lipid excretion []. FGF21 is most abundantly expressed in the liver, and also expressed in the thymus at lower levels [].
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Publication
17452648 | J:121336
First Author: Ogawa Y
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: BetaKlotho is required for metabolic activity of fibroblast growth factor 21.
Volume: 104
Issue: 18
Pages: 7432-7
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Publication
22958921 | J:189018
First Author: Ding X
Year: 2012
Journal: Cell Metab
Title: βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism.
Volume: 16
Issue: 3
Pages: 387-93
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Publication
30089252 | J:270688
First Author: Restelli LM
Year: 2018
Journal: Cell Rep
Title: Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21.
Volume: 24
Issue: 6
Pages: 1407-1414
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Publication
25931000 | J:228474
First Author: Wu W
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation.
Volume: 461
Issue: 4
Pages: 681-6
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Publication
23217254 | J:194168
First Author: Angelin B
Year: 2012
Journal: Cell Metab
Title: Circulating fibroblast growth factors as metabolic regulators--a critical appraisal.
Volume: 16
Issue: 6
Pages: 693-705
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Publication
29997282 | J:291027
 
First Author: Sawicki KT
Year: 2018
Journal: JCI Insight
Title: Hepatic tristetraprolin promotes insulin resistance through RNA destabilization of FGF21.
Volume: 3
Issue: 13
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Publication
29091029 | J:254998
   
First Author: You D
Year: 2017
Journal: Elife
Title: Dnmt3a is an epigenetic mediator of adipose insulin resistance.
Volume: 6
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Publication
26586424 | J:228947
First Author: Kwon MM
Year: 2015
Journal: Cell Rep
Title: FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1.
Volume: 13
Issue: 8
Pages: 1521-7
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Publication
27367842 | J:235064
   
First Author: Rando G
Year: 2016
Journal: Elife
Title: Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism.
Volume: 5
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Publication
33287957 | J:347526
   
First Author: Crespo M
Year: 2020
Journal: Elife
Title: Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism.
Volume: 9
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Publication
28988823 | J:256754
First Author: Lan T
Year: 2017
Journal: Cell Metab
Title: FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia.
Volume: 26
Issue: 5
Pages: 709-718.e3
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Publication
29157602 | J:263519
First Author: Olivares S
Year: 2017
Journal: Mol Metab
Title: Induction of fibroblast growth factor 21 does not require activation of the hepatic X-box binding protein 1 in mice.
Volume: 6
Issue: 12
Pages: 1616-1624
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Publication
26208451 | J:232523
First Author: Kim B
Year: 2015
Journal: Biochem Biophys Res Commun
Title: B-cell-activating factor deficiency attenuates high-fat diet-induced glucose intolerance by potentiating adipose tissue function.
Volume: 464
Issue: 4
Pages: 1171-7
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Publication
31176759 | J:281998
 
First Author: de Mendonça M
Year: 2019
Journal: Mol Cell Endocrinol
Title: Adiponectin is required for pioglitazone-induced improvements in hepatic steatosis in mice fed a high-fat diet.
Volume: 493
Pages: 110480
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Publication
32160547 | J:287645
First Author: Challa TD
Year: 2020
Journal: Cell Rep
Title: A Genetic Model to Study the Contribution of Brown and Brite Adipocytes to Metabolism.
Volume: 30
Issue: 10
Pages: 3424-3433.e4
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Publication
26233250 | J:226420
First Author: Wang L
Year: 2015
Journal: Diabetologia
Title: Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration.
Volume: 58
Issue: 10
Pages: 2371-80
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Publication
31042465 | J:289596
First Author: Flicker D
Year: 2019
Journal: Cell Rep
Title: Exploring the In Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics.
Volume: 27
Issue: 5
Pages: 1364-1375.e5
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Publication
26797127 | J:263764
First Author: Dunshee DR
Year: 2016
Journal: J Biol Chem
Title: Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21.
Volume: 291
Issue: 11
Pages: 5986-96
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Publication
17623664 | J:124949
First Author: Kurosu H
Year: 2007
Journal: J Biol Chem
Title: Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.
Volume: 282
Issue: 37
Pages: 26687-95
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Publication
22451487 | J:185732
First Author: Goetz R
Year: 2012
Journal: Mol Cell Biol
Title: Klotho coreceptors inhibit signaling by paracrine fibroblast growth factor 8 subfamily ligands.
Volume: 32
Issue: 10
Pages: 1944-54
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Publication
28494871 | J:254349
First Author: Ng R
Year: 2017
Journal: Cell Rep
Title: miRNA-32 Drives Brown Fat Thermogenesis and Trans-activates Subcutaneous White Fat Browning in Mice.
Volume: 19
Issue: 6
Pages: 1229-1246
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Publication
25204652 | J:278698
First Author: Ge H
Year: 2014
Journal: J Biol Chem
Title: Fibroblast growth factor receptor 4 (FGFR4) deficiency improves insulin resistance and glucose metabolism under diet-induced obesity conditions.
Volume: 289
Issue: 44
Pages: 30470-80
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Publication
31882562 | J:285363
First Author: Kusminski CM
Year: 2020
Journal: Diabetes
Title: A Novel Model of Diabetic Complications: Adipocyte Mitochondrial Dysfunction Triggers Massive β-Cell Hyperplasia.
Volume: 69
Issue: 3
Pages: 313-330
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Publication
35771919 | J:326737
First Author: Cangelosi AL
Year: 2022
Journal: Science
Title: Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine.
Volume: 377
Issue: 6601
Pages: 47-56
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Publication
39441934 | J:357580
First Author: Shi X
Year: 2024
Journal: Sci Adv
Title: Compromised macrophages contribute to progression of MASH to hepatocellular carcinoma in FGF21KO mice.
Volume: 10
Issue: 43
Pages: eado9311
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Publication
16213224 | J:129677
First Author: Inagaki T
Year: 2005
Journal: Cell Metab
Title: Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
Volume: 2
Issue: 4
Pages: 217-25
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Publication
22302876 | -
First Author: Potthoff MJ
Year: 2012
Journal: Genes Dev
Title: Endocrine fibroblast growth factors 15/19 and 21: from feast to famine.
Volume: 26
Issue: 4
Pages: 312-24
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Publication
23518683 | -
First Author: Zhang JH
Year: 2013
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Potent stimulation of fibroblast growth factor 19 expression in the human ileum by bile acids.
Volume: 304
Issue: 10
Pages: G940-8
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Publication
22396169 | -
 
First Author: Jones SA
Year: 2012
Journal: Adv Exp Med Biol
Title: Physiology of FGF15/19.
Volume: 728
Pages: 171-82
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Publication
10525310 | -
First Author: Xie MH
Year: 1999
Journal: Cytokine
Title: FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4.
Volume: 11
Issue: 10
Pages: 729-35
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Publication
21436455 | J:169835
First Author: Kir S
Year: 2011
Journal: Science
Title: FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis.
Volume: 331
Issue: 6024
Pages: 1621-4
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Publication
17823457 | J:129925
First Author: Jung D
Year: 2007
Journal: J Lipid Res
Title: FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption.
Volume: 48
Issue: 12
Pages: 2693-700
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Protein
Q91XE9
Organism: Mus musculus/domesticus
Length: 479  
Fragment?: false
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Publication
23825123 | J:202258
First Author: Kim HW
Year: 2013
Journal: Endocrinology
Title: Fibroblast growth factor 21 improves insulin resistance and ameliorates renal injury in db/db mice.
Volume: 154
Issue: 9
Pages: 3366-76
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Publication
29904053 | J:263209
First Author: Yang S
Year: 2018
Journal: Sci Rep
Title: NaoXinTong Capsules inhibit the development of diabetic nephropathy in db/db mice.
Volume: 8
Issue: 1
Pages: 9158
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Publication
30127091 | J:266457
First Author: Hansen AMK
Year: 2018
Journal: Biochem J
Title: Differential receptor selectivity of the FGF15/FGF19 orthologues determines distinct metabolic activities in db/db mice.
Volume: 475
Issue: 18
Pages: 2985-2996
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Publication
22174314 | J:183639
First Author: Wu AL
Year: 2011
Journal: Sci Transl Med
Title: Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1.
Volume: 3
Issue: 113
Pages: 113ra126
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Publication
22087215 | J:180987
First Author: Meissner M
Year: 2011
Journal: PLoS One
Title: Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate.
Volume: 6
Issue: 11
Pages: e24564
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Publication
33277568 | J:299557
First Author: Cho JM
Year: 2020
Journal: Sci Rep
Title: Discovery of a novel fibroblast activation protein (FAP) inhibitor, BR103354, with anti-diabetic and anti-steatotic effects.
Volume: 10
Issue: 1
Pages: 21280
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Publication
19738035 | J:159570
First Author: Badman MK
Year: 2009
Journal: Am J Physiol Endocrinol Metab
Title: A very low carbohydrate ketogenic diet improves glucose tolerance in ob/ob mice independently of weight loss.
Volume: 297
Issue: 5
Pages: E1197-204
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Publication
34040128 | J:306282
First Author: Homer-Bouthiette C
Year: 2021
Journal: Sci Rep
Title: Gait disturbances and muscle dysfunction in fibroblast growth factor 2 knockout mice.
Volume: 11
Issue: 1
Pages: 11005
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Publication
36624945 | J:341436
First Author: Herat LY
Year: 2022
Journal: Front Biosci (Landmark Ed)
Title: Determining the Role of SGLT2 Inhibition with Dapagliflozin in the Development of Diabetic Retinopathy.
Volume: 27
Issue: 12
Pages: 321
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Publication
31351086 | J:283730
First Author: Ueyama T
Year: 2020
Journal: J Invest Dermatol
Title: Rac-Dependent Signaling from Keratinocytes Promotes Differentiation of Intradermal White Adipocytes.
Volume: 140
Issue: 1
Pages: 75-84.e6
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Publication
31208084 | J:289420
 
First Author: Romanello V
Year: 2019
Journal: Cells
Title: Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles.
Volume: 8
Issue: 6
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Publication
34042217 | J:330298
First Author: Nakagawa Y
Year: 2021
Journal: FASEB J
Title: Starvation-induced transcription factor CREBH negatively governs body growth by controlling GH signaling.
Volume: 35
Issue: 6
Pages: e21663
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Publication
36812201 | J:334622
First Author: Yook JS
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: The SLC25A47 locus controls gluconeogenesis and energy expenditure.
Volume: 120
Issue: 9
Pages: e2216810120
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Publication
35409319 | J:324010
 
First Author: Berthou F
Year: 2022
Journal: Int J Mol Sci
Title: Hepatic PTEN Signaling Regulates Systemic Metabolic Homeostasis through Hepatokines-Mediated Liver-to-Peripheral Organs Crosstalk.
Volume: 23
Issue: 7
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Publication
33411693 | J:306932
 
First Author: Nason SR
Year: 2021
Journal: JCI Insight
Title: Glucagon receptor signaling regulates weight loss via central KLB receptor complexes.
Volume: 6
Issue: 4
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Publication
23017736 | J:188996
First Author: Zhang YK
Year: 2012
Journal: Toxicol Appl Pharmacol
Title: Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet.
Volume: 264
Issue: 3
Pages: 305-14
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Publication
30193158 | J:310282
 
First Author: Nelson CN
Year: 2018
Journal: Growth Horm IGF Res
Title: Growth hormone activated STAT5 is required for induction of beige fat in vivo.
Volume: 42-43
Pages: 40-51
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Publication
29866659 | J:265199
First Author: Libby AE
Year: 2018
Journal: J Lipid Res
Title: Perilipin-2 deletion promotes carbohydrate-mediated browning of white adipose tissue at ambient temperature.
Volume: 59
Issue: 8
Pages: 1482-1500
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Publication
32698539 | J:298215
 
First Author: Kim B
Year: 2020
Journal: Int J Mol Sci
Title: B-Cell-Activating Factor Depletion Ameliorates Aging-Dependent Insulin Resistance via Enhancement of Thermogenesis in Adipose Tissues.
Volume: 21
Issue: 14
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Publication
30420558 | J:311799
 
First Author: Rashid T
Year: 2019
Journal: EMBO J
Title: Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy.
Volume: 38
Issue: 1
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Publication
32967428 | J:307410
     
First Author: Myronovych A
Year: 2020
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Assessment of the role of FGF15 in mediating the metabolic outcomes of murine Vertical Sleeve Gastrectomy (VSG).
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Publication
24062250 | J:209046
First Author: Omar BA
Year: 2014
Journal: Diabetes
Title: Fibroblast growth factor 21 (FGF21) and glucagon-like peptide 1 contribute to diabetes resistance in glucagon receptor-deficient mice.
Volume: 63
Issue: 1
Pages: 101-10
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Publication
25491724 | J:219631
First Author: Wilson GJ
Year: 2015
Journal: Am J Physiol Endocrinol Metab
Title: GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment.
Volume: 308
Issue: 4
Pages: E283-93
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Publication
20080590 | J:156868
First Author: Tomiyama K
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Relevant use of Klotho in FGF19 subfamily signaling system in vivo.
Volume: 107
Issue: 4
Pages: 1666-71
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Publication
28754744 | J:262796
First Author: Xu C
Year: 2017
Journal: EMBO Mol Med
Title: KLB, encoding β-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism.
Volume: 9
Issue: 10
Pages: 1379-1397
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Publication
28422755 | J:290882
 
First Author: Somm E
Year: 2017
Journal: JCI Insight
Title: β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue.
Volume: 2
Issue: 8
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Publication
29944388 | J:274393
First Author: Somm E
Year: 2018
Journal: Am J Physiol Endocrinol Metab
Title: β-Klotho deficiency shifts the gut-liver bile acid axis and induces hepatic alterations in mice.
Volume: 315
Issue: 5
Pages: E833-E847
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Publication
28813167 | J:319906
First Author: Minami S
Year: 2017
Journal: Autophagy
Title: Lipophagy maintains energy homeostasis in the kidney proximal tubule during prolonged starvation.
Volume: 13
Issue: 10
Pages: 1629-1647
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Publication
29596655 | J:261403
First Author: Mayer AL
Year: 2018
Journal: Endocrinology
Title: Enhanced Hepatic PPARα Activity Links GLUT8 Deficiency to Augmented Peripheral Fasting Responses in Male Mice.
Volume: 159
Issue: 5
Pages: 2110-2126
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Publication
23690091 | J:320737
First Author: Nagai N
Year: 2013
Journal: Glycobiology
Title: Involvement of heparan sulfate 6-O-sulfation in the regulation of energy metabolism and the alteration of thyroid hormone levels in male mice.
Volume: 23
Issue: 8
Pages: 980-92
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Publication
36429037 | J:332113
 
First Author: Mizumoto T
Year: 2022
Journal: Cells
Title: SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice.
Volume: 11
Issue: 22
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Publication
24949663 | J:217007
First Author: Kinoshita K
Year: 2014
Journal: Endocrinology
Title: Glucagon is essential for adaptive thermogenesis in brown adipose tissue.
Volume: 155
Issue: 9
Pages: 3484-92
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Publication
29378767 | J:258612
First Author: Montgomery MK
Year: 2018
Journal: Diabetes
Title: Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress-Fibroblast Growth Factor 21 Axis in Skeletal Muscle.
Volume: 67
Issue: 4
Pages: 594-606
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Publication
27077115 | J:260429
 
First Author: Sekine S
Year: 2016
Journal: EBioMedicine
Title: The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress.
Volume: 5
Pages: 82-92
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Publication
31470570 | J:293365
 
First Author: Javed K
Year: 2019
Journal: Nutrients
Title: Mice Lacking the Intestinal and Renal Neutral Amino Acid Transporter SLC6A19 Demonstrate the Relationship between Dietary Protein Intake and Amino Acid Malabsorption.
Volume: 11
Issue: 9
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Publication
37044373 | J:340748
 
First Author: Wang H
Year: 2023
Journal: Metabolism
Title: Hepatic IDH2 regulates glycolysis and gluconeogenesis.
Volume: 143
Pages: 155559
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Publication
22378787 | J:184998
First Author: Do HT
Year: 2012
Journal: J Biol Chem
Title: Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap).
Volume: 287
Issue: 16
Pages: 12602-11
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•
•
•
•
Publication
20854792 | J:165845
First Author: Oishi K
Year: 2010
Journal: Biochem Biophys Res Commun
Title: PPARα deficiency augments a ketogenic diet-induced circadian PAI-1 expression possibly through PPARγ activation in the liver.
Volume: 401
Issue: 2
Pages: 313-8
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•
•
•
•
Publication
22012983 | J:179604
First Author: Yatsuga S
Year: 2012
Journal: Hum Mol Genet
Title: Effect of bezafibrate treatment on late-onset mitochondrial myopathy in mice.
Volume: 21
Issue: 3
Pages: 526-35
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•
•
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•
Publication
37191311 | J:354330
First Author: Karnošová A
Year: 2023
Journal: Clin Sci (Lond)
Title: NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose.
Volume: 137
Issue: 10
Pages: 847-862
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•
•
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•
Publication
29550873 | J:261573
First Author: Laeger T
Year: 2018
Journal: Diabetologia
Title: Dietary carbohydrates impair the protective effect of protein restriction against diabetes in NZO mice used as a model of type 2 diabetes.
Volume: 61
Issue: 6
Pages: 1459-1469
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•
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•
Publication
24039848 | J:356995
First Author: Muise ES
Year: 2013
Journal: PLoS One
Title: Downstream signaling pathways in mouse adipose tissues following acute in vivo administration of fibroblast growth factor 21.
Volume: 8
Issue: 9
Pages: e73011
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Publication
30677512 | J:275552
First Author: Li S
Year: 2019
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Fibroblast growth factor 21 protects the heart from angiotensin II-induced cardiac hypertrophy and dysfunction via SIRT1.
Volume: 1865
Issue: 6
Pages: 1241-1252
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•
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•
Publication
37979703 | J:358359
 
First Author: Chen Y
Year: 2023
Journal: Biochem Pharmacol
Title: Berberine protects mice against type 2 diabetes by promoting PPARγ-FGF21-GLUT2-regulated insulin sensitivity and glucose/lipid homeostasis.
Volume: 218
Pages: 115928
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Publication
31676432 | J:294107
 
First Author: Katsu-Jiménez Y
Year: 2019
Journal: Mol Cell Neurosci
Title: Fibroblast growth Factor-21 promotes ketone body utilization in neurons through activation of AMP-dependent kinase.
Volume: 101
Pages: 103415
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•
Publication
30405056 | J:295675
 
First Author: Iizuka K
Year: 2018
Journal: Nutrients
Title: ChREBP Reciprocally Regulates Liver and Plasma Triacylglycerol Levels in Different Manners.
Volume: 10
Issue: 11
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•
Publication
32745530 | J:301000
First Author: Wang L
Year: 2020
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Methionine restriction alleviates high-fat diet-induced obesity: Involvement of diurnal metabolism of lipids and bile acids.
Volume: 1866
Issue: 11
Pages: 165908
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Publication
20236931 | J:313285
First Author: Adams AC
Year: 2010
Journal: J Biol Chem
Title: Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner.
Volume: 285
Issue: 19
Pages: 14078-82
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•
Publication
37941910 | J:342415
 
First Author: Igual Gil C
Year: 2023
Journal: Front Endocrinol (Lausanne)
Title: Temporal dynamics of muscle mitochondrial uncoupling-induced integrated stress response and ferroptosis defense.
Volume: 14
Pages: 1277866
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Publication
35363898 | J:344939
First Author: Ahuja P
Year: 2023
Journal: Hepatology
Title: Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77-FGF21 pathway.
Volume: 77
Issue: 1
Pages: 213-229
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Protein
O35622
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Protein
Q790L8
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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•
Publication
35997288 | J:335401
First Author: Larion S
Year: 2022
Journal: Am J Physiol Gastrointest Liver Physiol
Title: The biological clock enhancer nobiletin ameliorates steatosis in genetically obese mice by restoring aberrant hepatic circadian rhythm.
Volume: 323
Issue: 4
Pages: G387-G400
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Publication
22370560 | J:197702
First Author: Wu X
Year: 2012
Journal: J Mol Biol
Title: A unique FGF23 with the ability to activate FGFR signaling through both αKlotho and βKlotho.
Volume: 418
Issue: 1-2
Pages: 82-9
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Publication
28752049 | J:277948
First Author: Douris N
Year: 2017
Journal: Mol Metab
Title: Beta-adrenergic receptors are critical for weight loss but not for other metabolic adaptations to the consumption of a ketogenic diet in male mice.
Volume: 6
Issue: 8
Pages: 854-862
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Publication
33246135 | J:315747
First Author: Nakagawa Y
Year: 2021
Journal: Cell Mol Gastroenterol Hepatol
Title: Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition.
Volume: 11
Issue: 4
Pages: 949-971
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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