Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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|
|
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
POST-TRANSLATIONAL MODIFICATIONS CONTROL FOXO3 ACTIVITY DURING DENERVATION. |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang F |
Year: |
2012 |
Journal: |
Oncogene |
Title: |
Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation. |
Volume: |
31 |
Issue: |
12 |
Pages: |
1546-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang H |
Year: |
2023 |
Journal: |
COPD |
Title: |
FOXO3 Activation Prevents Cellular Senescence in Emphysema Induced by Cigarette Smoke. |
Volume: |
20 |
Issue: |
1 |
Pages: |
80-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tsuji T |
Year: |
2021 |
Journal: |
Oncogene |
Title: |
FOXO3 is a latent tumor suppressor for FOXO3-positive and cytoplasmic-type gastric cancer cells. |
Volume: |
40 |
Issue: |
17 |
Pages: |
3072-3086 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
RNA-binding protein YTHDF3 suppresses interferon-dependent antiviral responses by promoting FOXO3 translation. |
Volume: |
116 |
Issue: |
3 |
Pages: |
976-981 |
|
•
•
•
•
•
|
Publication |
First Author: |
Franco SS |
Year: |
2014 |
Journal: |
Haematologica |
Title: |
Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice. |
Volume: |
99 |
Issue: |
2 |
Pages: |
267-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sandri M |
Year: |
2006 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. |
Volume: |
103 |
Issue: |
44 |
Pages: |
16260-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Watkins SK |
Year: |
2011 |
Journal: |
J Clin Invest |
Title: |
FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer. |
Volume: |
121 |
Issue: |
4 |
Pages: |
1361-72 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE8249 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
He X |
Year: |
2018 |
Journal: |
Exp Cell Res |
Title: |
MicroRNA-182 inhibits HCMV replication through activation of type I IFN response by targeting FOXO3 in neural cells. |
Volume: |
369 |
Issue: |
2 |
Pages: |
197-207 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bertaggia E |
Year: |
2012 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
Posttranslational modifications control FoxO3 activity during denervation. |
Volume: |
302 |
Issue: |
3 |
Pages: |
C587-96 |
|
•
•
•
•
•
|
Allele |
Name: |
forkhead box O3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents a domain found in the transcription factor forkhead box O (FOXO) that binds to the KIX domain of CREB-binding proteins. Coactivator CBP/p300 is recruited by FOXO3 via the binding of this domain as well as the simultaneous binding of the C-terminal TAD domain []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
373
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
64
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
124
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
TAD is a promiscuous binding domain that mediates the association of the transcription factor FOXO with the coactivator CBP/p300. Both this domain and the KIX-binding domain bind simultaneously the KIX domain of CBP/p300. Coactivator CBP/p300 is recruited by FOXO3 thoughbinding to these two regions. The promiscuity of the TAD is further evidenced by that the finding that they also bind the TAZ1 and TAZ2 domains of CBP/p300 []. |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE35593 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Yuan H |
Year: |
2020 |
Journal: |
Cancer Cell |
Title: |
SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways. |
Volume: |
38 |
Issue: |
3 |
Pages: |
350-365.e7 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
672
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
559
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
652
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
652
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
640
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Castets P |
Year: |
2013 |
Journal: |
Cell Metab |
Title: |
Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy. |
Volume: |
17 |
Issue: |
5 |
Pages: |
731-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yao Y |
Year: |
2022 |
Journal: |
Cell |
Title: |
Mucus sialylation determines intestinal host-commensal homeostasis. |
Volume: |
185 |
Issue: |
7 |
Pages: |
1172-1188.e28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ucar A |
Year: |
2012 |
Journal: |
Nat Commun |
Title: |
The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy. |
Volume: |
3 |
|
Pages: |
1078 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peng XL |
Year: |
2017 |
Journal: |
Nucleic Acids Res |
Title: |
MyoD- and FoxO3-mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation. |
Volume: |
45 |
Issue: |
15 |
Pages: |
8785-8805 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kong DK |
Year: |
2010 |
Journal: |
Mol Biol Cell |
Title: |
Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function. |
Volume: |
21 |
Issue: |
8 |
Pages: |
1335-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Furuyama T |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. |
Volume: |
279 |
Issue: |
33 |
Pages: |
34741-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xiong Z |
Year: |
2020 |
Journal: |
Biochim Biophys Acta Mol Basis Dis |
Title: |
Mst1 knockdown alleviates cardiac lipotoxicity and inhibits the development of diabetic cardiomyopathy in db/db mice. |
Volume: |
1866 |
Issue: |
8 |
Pages: |
165806 |
|
•
•
•
•
•
|
Publication |
First Author: |
John GB |
Year: |
2009 |
Journal: |
Dev Biol |
Title: |
Kit signaling via PI3K promotes ovarian follicle maturation but is dispensable for primordial follicle activation. |
Volume: |
331 |
Issue: |
2 |
Pages: |
292-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Spitali P |
Year: |
2013 |
Journal: |
PLoS Curr |
Title: |
Autophagy is Impaired in the Tibialis Anterior of Dystrophin Null Mice. |
Volume: |
5 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Li XN |
Year: |
2009 |
Journal: |
Diabetes |
Title: |
Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin. |
Volume: |
58 |
Issue: |
10 |
Pages: |
2246-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Santos MA |
Year: |
2014 |
Journal: |
Nature |
Title: |
DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier. |
Volume: |
514 |
Issue: |
7520 |
Pages: |
107-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li N |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
miR-182 Modulates Myocardial Hypertrophic Response Induced by Angiogenesis in Heart. |
Volume: |
6 |
|
Pages: |
21228 |
|
•
•
•
•
•
|
Publication |
First Author: |
Du X |
Year: |
2014 |
Journal: |
J Immunol |
Title: |
Mst1/Mst2 regulate development and function of regulatory T cells through modulation of Foxo1/Foxo3 stability in autoimmune disease. |
Volume: |
192 |
Issue: |
4 |
Pages: |
1525-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chacon-Cabrera A |
Year: |
2015 |
Journal: |
Biochim Biophys Acta |
Title: |
MicroRNA expression and protein acetylation pattern in respiratory and limb muscles of Parp-1(-/-) and Parp-2(-/-) mice with lung cancer cachexia. |
Volume: |
1850 |
Issue: |
12 |
Pages: |
2530-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Puppa MJ |
Year: |
2014 |
Journal: |
FASEB J |
Title: |
Skeletal muscle glycoprotein 130's role in Lewis lung carcinoma-induced cachexia. |
Volume: |
28 |
Issue: |
2 |
Pages: |
998-1009 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miller CH |
Year: |
2016 |
Journal: |
J Immunol |
Title: |
RBP-J-Regulated miR-182 Promotes TNF-α-Induced Osteoclastogenesis. |
Volume: |
196 |
Issue: |
12 |
Pages: |
4977-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ren Y |
Year: |
2015 |
Journal: |
BMC Biol |
Title: |
Lhx8 regulates primordial follicle activation and postnatal folliculogenesis. |
Volume: |
13 |
|
Pages: |
39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu S |
Year: |
2011 |
Journal: |
Blood |
Title: |
GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells. |
Volume: |
117 |
Issue: |
7 |
Pages: |
2166-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang S |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
AMPKalpha1 deletion shortens erythrocyte life span in mice: role of oxidative stress. |
Volume: |
285 |
Issue: |
26 |
Pages: |
19976-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheung K |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
CD31 signals confer immune privilege to the vascular endothelium. |
Volume: |
112 |
Issue: |
43 |
Pages: |
E5815-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
MartÃnez-Moreno M |
Year: |
2012 |
Journal: |
Mol Cell Biol |
Title: |
FoxO-dependent regulation of diacylglycerol kinase α gene expression. |
Volume: |
32 |
Issue: |
20 |
Pages: |
4168-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deng Y |
Year: |
2018 |
Journal: |
Diabetes |
Title: |
SGK1/FOXO3 Signaling in Hypothalamic POMC Neurons Mediates Glucocorticoid-Increased Adiposity. |
Volume: |
67 |
Issue: |
4 |
Pages: |
569-580 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rizzo A |
Year: |
2018 |
Journal: |
Cancer Immunol Res |
Title: |
RORγt-Expressing Tregs Drive the Growth of Colitis-Associated Colorectal Cancer by Controlling IL6 in Dendritic Cells. |
Volume: |
6 |
Issue: |
9 |
Pages: |
1082-1092 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nanda V |
Year: |
2018 |
Journal: |
PLoS Genet |
Title: |
Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus. |
Volume: |
14 |
Issue: |
11 |
Pages: |
e1007755 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu D |
Year: |
2010 |
Journal: |
Genes Dev |
Title: |
miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta. |
Volume: |
24 |
Issue: |
15 |
Pages: |
1620-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hoppstädter J |
Year: |
2020 |
Journal: |
FASEB J |
Title: |
The glucocorticoid-induced leucine zipper mediates statin-induced muscle damage. |
Volume: |
34 |
Issue: |
3 |
Pages: |
4684-4701 |
|
•
•
•
•
•
|
Publication |
First Author: |
Choi S |
Year: |
2019 |
Journal: |
Autophagy |
Title: |
Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis. |
Volume: |
15 |
Issue: |
6 |
Pages: |
1069-1081 |
|
•
•
•
•
•
|
Publication |
First Author: |
González-Soria I |
Year: |
2023 |
Journal: |
Int J Mol Sci |
Title: |
SerpinA3K Deficiency Reduces Oxidative Stress in Acute Kidney Injury. |
Volume: |
24 |
Issue: |
9 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ching JK |
Year: |
2013 |
Journal: |
Hum Mol Genet |
Title: |
mTOR dysfunction contributes to vacuolar pathology and weakness in valosin-containing protein associated inclusion body myopathy. |
Volume: |
22 |
Issue: |
6 |
Pages: |
1167-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gwag T |
Year: |
2013 |
Journal: |
Arch Biochem Biophys |
Title: |
Inhibition of C2C12 myotube atrophy by a novel HSP70 inducer, celastrol, via activation of Akt1 and ERK1/2 pathways. |
Volume: |
537 |
Issue: |
1 |
Pages: |
21-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma W |
Year: |
2015 |
Journal: |
Biochem J |
Title: |
FoxO1 negatively regulates leptin-induced POMC transcription through its direct interaction with STAT3. |
Volume: |
466 |
Issue: |
2 |
Pages: |
291-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bulstrode H |
Year: |
2017 |
Journal: |
Genes Dev |
Title: |
Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators. |
Volume: |
31 |
Issue: |
8 |
Pages: |
757-773 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu G |
Year: |
2019 |
Journal: |
Mol Reprod Dev |
Title: |
Primordial follicle activation is affected by the absence of Sohlh1 in mice. |
Volume: |
86 |
Issue: |
1 |
Pages: |
20-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang P |
Year: |
2014 |
Journal: |
Basic Res Cardiol |
Title: |
The alteration of Hippo/YAP signaling in the development of hypertrophic cardiomyopathy. |
Volume: |
109 |
Issue: |
5 |
Pages: |
435 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
505
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
448
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
505
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim KA |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway. |
Volume: |
7 |
Issue: |
10 |
Pages: |
e47713 |
|
•
•
•
•
•
|
Publication |
First Author: |
Venkatraman A |
Year: |
2013 |
Journal: |
Nature |
Title: |
Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence. |
Volume: |
500 |
Issue: |
7462 |
Pages: |
345-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Das A |
Year: |
2022 |
Journal: |
J Cachexia Sarcopenia Muscle |
Title: |
Systemic ablation of vitamin D receptor leads to skeletal muscle glycogen storage disorder in mice. |
Volume: |
13 |
Issue: |
1 |
Pages: |
467-480 |
|
•
•
•
•
•
|