| Type |
Details |
Score |
| Publication |
| First Author: |
Yang S |
| Year: |
2012 |
| Journal: |
Bone |
| Title: |
The intraflagellar transport protein IFT80 is required for cilia formation and osteogenesis. |
| Volume: |
51 |
| Issue: |
3 |
| Pages: |
407-17 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang C |
| Year: |
2013 |
| Journal: |
Exp Cell Res |
| Title: |
IFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathways. |
| Volume: |
319 |
| Issue: |
5 |
| Pages: |
623-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Han W |
| Year: |
2017 |
| Journal: |
J Immunol |
| Title: |
Novel Molecular Mechanism of Regulation of CD40 Ligand by the Transcription Factor GLI2. |
| Volume: |
198 |
| Issue: |
11 |
| Pages: |
4481-4489 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kimura H |
| Year: |
2005 |
| Journal: |
Oncogene |
| Title: |
Gli1 is important for medulloblastoma formation in Ptc1+/- mice. |
| Volume: |
24 |
| Issue: |
25 |
| Pages: |
4026-36 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim PC |
| Year: |
2001 |
| Journal: |
J Pediatr Surg |
| Title: |
Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway. |
| Volume: |
36 |
| Issue: |
2 |
| Pages: |
381-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kimmel SG |
| Year: |
2000 |
| Journal: |
J Pediatr Surg |
| Title: |
New mouse models of congenital anorectal malformations. |
| Volume: |
35 |
| Issue: |
2 |
| Pages: |
227-30; discussion 230-1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wen X |
| Year: |
2010 |
| Journal: |
Mol Cell Biol |
| Title: |
Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation. |
| Volume: |
30 |
| Issue: |
8 |
| Pages: |
1910-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Constantin L |
| Year: |
2015 |
| Journal: |
Cerebellum |
| Title: |
MicroRNAs Promote Granule Cell Expansion in the Cerebellum Through Gli2. |
| Volume: |
14 |
| Issue: |
6 |
| Pages: |
688-98 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guo P |
| Year: |
2022 |
| Journal: |
Oncogene |
| Title: |
Nuclear receptor coactivator SRC-1 promotes colorectal cancer progression through enhancing GLI2-mediated Hedgehog signaling. |
| Volume: |
41 |
| Issue: |
20 |
| Pages: |
2846-2859 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kasaai B |
| Year: |
2013 |
| Journal: |
J Biol Chem |
| Title: |
Regulation of the bone-restricted IFITM-like (Bril) gene transcription by Sp and Gli family members and CpG methylation. |
| Volume: |
288 |
| Issue: |
19 |
| Pages: |
13278-94 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lin YT |
| Year: |
2012 |
| Journal: |
Exp Cell Res |
| Title: |
YAP regulates neuronal differentiation through Sonic hedgehog signaling pathway. |
| Volume: |
318 |
| Issue: |
15 |
| Pages: |
1877-88 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang Q |
| Year: |
2009 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase. |
| Volume: |
106 |
| Issue: |
50 |
| Pages: |
21191-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sasaki H |
| Year: |
1999 |
| Journal: |
Development |
| Title: |
Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. |
| Volume: |
126 |
| Issue: |
17 |
| Pages: |
3915-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ahn S |
| Year: |
2004 |
| Journal: |
Cell |
| Title: |
Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning. |
| Volume: |
118 |
| Issue: |
4 |
| Pages: |
505-16 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Barakat B |
| Year: |
2013 |
| Journal: |
EMBO Rep |
| Title: |
Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling. |
| Volume: |
14 |
| Issue: |
9 |
| Pages: |
837-44 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1277646 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
1999-08-19 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1609215 |
|
| Stage: |
TS15 |
| Assay Id: |
MGI:1342244 |
| Age: |
embryonic day 9.5 |
|
|
| Specimen Label: |
Gli2 KO |
| Detected: |
false |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Persengiev SP |
| Year: |
1997 |
| Journal: |
Oncogene |
| Title: |
Gli family members are differentially expressed during the mitotic phase of spermatogenesis. |
| Volume: |
14 |
| Issue: |
19 |
| Pages: |
2259-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lipinski RJ |
| Year: |
2006 |
| Journal: |
Exp Cell Res |
| Title: |
Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling. |
| Volume: |
312 |
| Issue: |
11 |
| Pages: |
1925-38 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Du J |
| Year: |
2012 |
| Journal: |
Acta Histochem |
| Title: |
Different expression patterns of Gli1-3 in mouse embryonic maxillofacial development. |
| Volume: |
114 |
| Issue: |
6 |
| Pages: |
620-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Büscher D |
| Year: |
1998 |
| Journal: |
Dev Dyn |
| Title: |
Expression profile of Gli family members and Shh in normal and mutant mouse limb development. |
| Volume: |
211 |
| Issue: |
1 |
| Pages: |
88-96 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mo R |
| Year: |
2001 |
| Journal: |
Am J Pathol |
| Title: |
Anorectal malformations caused by defects in sonic hedgehog signaling. |
| Volume: |
159 |
| Issue: |
2 |
| Pages: |
765-74 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McNeill B |
| Year: |
2012 |
| Journal: |
Mol Cell Neurosci |
| Title: |
Comparative genomics identification of a novel set of temporally regulated hedgehog target genes in the retina. |
| Volume: |
49 |
| Issue: |
3 |
| Pages: |
333-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Petrova R |
| Year: |
2013 |
| Journal: |
J Neurosci |
| Title: |
Titration of GLI3 repressor activity by sonic hedgehog signaling is critical for maintaining multiple adult neural stem cell and astrocyte functions. |
| Volume: |
33 |
| Issue: |
44 |
| Pages: |
17490-505 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu M |
| Year: |
2016 |
| Journal: |
J Biol Chem |
| Title: |
Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis. |
| Volume: |
291 |
| Issue: |
49 |
| Pages: |
25749-25760 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chao AS |
| Year: |
2023 |
| Journal: |
Cell Stem Cell |
| Title: |
20-αHydroxycholesterol, an oxysterol in human breast milk, reverses mouse neonatal white matter injury through Gli-dependent oligodendrogenesis. |
| Volume: |
30 |
| Issue: |
8 |
| Pages: |
1054-1071.e8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ermilov AN |
| Year: |
2016 |
| Journal: |
PLoS Genet |
| Title: |
Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling. |
| Volume: |
12 |
| Issue: |
11 |
| Pages: |
e1006442 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
He J |
| Year: |
2006 |
| Journal: |
J Biol Chem |
| Title: |
Suppressing Wnt signaling by the hedgehog pathway through sFRP-1. |
| Volume: |
281 |
| Issue: |
47 |
| Pages: |
35598-602 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sittaramane V |
| Year: |
2013 |
| Journal: |
Dev Biol |
| Title: |
The PCP protein Vangl2 regulates migration of hindbrain motor neurons by acting in floor plate cells, and independently of cilia function. |
| Volume: |
382 |
| Issue: |
2 |
| Pages: |
400-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Eggenschwiler JT |
| Year: |
2006 |
| Journal: |
Dev Biol |
| Title: |
Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins. |
| Volume: |
290 |
| Issue: |
1 |
| Pages: |
1-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Doles J |
| Year: |
2006 |
| Journal: |
Dev Biol |
| Title: |
Functional compensation in Hedgehog signaling during mouse prostate development. |
| Volume: |
295 |
| Issue: |
1 |
| Pages: |
13-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kumari A |
| Year: |
2022 |
| Journal: |
Dev Dyn |
| Title: |
Unique lingual expression of the Hedgehog pathway antagonist Hedgehog-interacting protein in filiform papillae during homeostasis and ectopic expression in fungiform papillae during Hedgehog signaling inhibition. |
| Volume: |
251 |
| Issue: |
7 |
| Pages: |
1175-1195 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fabian SL |
| Year: |
2012 |
| Journal: |
Am J Pathol |
| Title: |
Hedgehog-Gli pathway activation during kidney fibrosis. |
| Volume: |
180 |
| Issue: |
4 |
| Pages: |
1441-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shimoyama A |
| Year: |
2007 |
| Journal: |
Mol Biol Cell |
| Title: |
Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function. |
| Volume: |
18 |
| Issue: |
7 |
| Pages: |
2411-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zülch A |
| Year: |
2001 |
| Journal: |
Mech Dev |
| Title: |
Expression pattern of Irx1 and Irx2 during mouse digit development. |
| Volume: |
106 |
| Issue: |
1-2 |
| Pages: |
159-62 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stone DM |
| Year: |
1999 |
| Journal: |
J Cell Sci |
| Title: |
Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli. |
| Volume: |
112 ( Pt 23) |
|
| Pages: |
4437-48 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
He F |
| Year: |
2016 |
| Journal: |
PLoS One |
| Title: |
Adult Gli2+/-;Gli3Δ699/+ Male and Female Mice Display a Spectrum of Genital Malformation. |
| Volume: |
11 |
| Issue: |
11 |
| Pages: |
e0165958 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bai CB |
| Year: |
2001 |
| Journal: |
Development |
| Title: |
Gli1 can rescue the in vivo function of Gli2. |
| Volume: |
128 |
| Issue: |
24 |
| Pages: |
5161-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bai CB |
| Year: |
2004 |
| Journal: |
Dev Cell |
| Title: |
All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. |
| Volume: |
6 |
| Issue: |
1 |
| Pages: |
103-15 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
538
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sillitoe RV |
| Year: |
2010 |
| Journal: |
J Neurosci |
| Title: |
Engrailed homeobox genes regulate establishment of the cerebellar afferent circuit map. |
| Volume: |
30 |
| Issue: |
30 |
| Pages: |
10015-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen J |
| Year: |
2002 |
| Journal: |
Blood |
| Title: |
Quantitative trait loci regulating relative lymphocyte proportions in mouse peripheral blood. |
| Volume: |
99 |
| Issue: |
2 |
| Pages: |
561-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Agrawal V |
| Year: |
2017 |
| Journal: |
Exp Mol Med |
| Title: |
Hhip regulates tumor-stroma-mediated upregulation of tumor angiogenesis. |
| Volume: |
49 |
| Issue: |
1 |
| Pages: |
e289 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang H |
| Year: |
2021 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic Gli via HDAC6. |
| Volume: |
557 |
|
| Pages: |
323-328 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Friedland-Little JM |
| Year: |
2011 |
| Journal: |
Hum Mol Genet |
| Title: |
A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus. |
| Volume: |
20 |
| Issue: |
19 |
| Pages: |
3725-37 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Corrales JD |
| Year: |
2006 |
| Journal: |
Development |
| Title: |
The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation. |
| Volume: |
133 |
| Issue: |
9 |
| Pages: |
1811-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Saitsu H |
| Year: |
2005 |
| Journal: |
Dev Dyn |
| Title: |
Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain. |
| Volume: |
232 |
| Issue: |
2 |
| Pages: |
282-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee J |
| Year: |
1997 |
| Journal: |
Development |
| Title: |
Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. |
| Volume: |
124 |
| Issue: |
13 |
| Pages: |
2537-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen M |
| Year: |
2003 |
| Journal: |
Am J Pathol |
| Title: |
Hedgehog signaling regulates sebaceous gland development. |
| Volume: |
163 |
| Issue: |
6 |
| Pages: |
2173-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu J |
| Year: |
2012 |
| Journal: |
Dev Biol |
| Title: |
Dual function of suppressor of fused in Hh pathway activation and mouse spinal cord patterning. |
| Volume: |
362 |
| Issue: |
2 |
| Pages: |
141-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Madison BB |
| Year: |
2009 |
| Journal: |
J Biol Chem |
| Title: |
FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine. |
| Volume: |
284 |
| Issue: |
9 |
| Pages: |
5936-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sasaki H |
| Year: |
1997 |
| Journal: |
Development |
| Title: |
A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. |
| Volume: |
124 |
| Issue: |
7 |
| Pages: |
1313-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McNeill B |
| Year: |
2013 |
| Journal: |
Hum Mol Genet |
| Title: |
Hedgehog regulates Norrie disease protein to drive neural progenitor self-renewal. |
| Volume: |
22 |
| Issue: |
5 |
| Pages: |
1005-16 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mau E |
| Year: |
2007 |
| Journal: |
Dev Biol |
| Title: |
PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms. |
| Volume: |
305 |
| Issue: |
1 |
| Pages: |
28-39 |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
1 |
| Description: |
Zinc finger protein GLI2 |
| Type: |
chain |
| End: |
1544 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1277656 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
1999-08-19 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1609215 |
|
| Stage: |
TS15 |
| Assay Id: |
MGI:1342243 |
| Age: |
embryonic day 9.5 |
|
|
| Specimen Label: |
Gli2 KO |
| Detected: |
false |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Matise MP |
| Year: |
1999 |
| Journal: |
Development |
| Title: |
Ventral midline cells are required for the local control of commissural axon guidance in the mouse spinal cord. |
| Volume: |
126 |
| Issue: |
16 |
| Pages: |
3649-59 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Feuerstein M |
| Year: |
2017 |
| Journal: |
Cell Tissue Res |
| Title: |
Expression patterns of key Sonic Hedgehog signaling pathway components in the developing and adult mouse midbrain and in the MN9D cell line. |
| Volume: |
370 |
| Issue: |
2 |
| Pages: |
211-225 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hui CC |
| Year: |
1993 |
| Journal: |
Nat Genet |
| Title: |
A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. |
| Volume: |
3 |
| Issue: |
3 |
| Pages: |
241-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hatsell SJ |
| Year: |
2006 |
| Journal: |
Development |
| Title: |
Gli3-mediated repression of Hedgehog targets is required for normal mammary development. |
| Volume: |
133 |
| Issue: |
18 |
| Pages: |
3661-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lamm ML |
| Year: |
2002 |
| Journal: |
Dev Biol |
| Title: |
Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation. |
| Volume: |
249 |
| Issue: |
2 |
| Pages: |
349-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hussein MT |
| Year: |
2021 |
| Journal: |
Gene Expr Patterns |
| Title: |
Spatiotemporal expression of sonic hedgehog signalling molecules in the embryonic mesencephalic dopaminergic neurons. |
| Volume: |
42 |
|
| Pages: |
119217 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pritchard JE |
| Year: |
2024 |
| Journal: |
Cell Rep |
| Title: |
Non-canonical Hedgehog signaling mediates profibrotic hematopoiesis-stroma crosstalk in myeloproliferative neoplasms. |
| Volume: |
43 |
| Issue: |
1 |
| Pages: |
113608 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu L |
| Year: |
2013 |
| Journal: |
Am J Respir Cell Mol Biol |
| Title: |
Hedgehog signaling in neonatal and adult lung. |
| Volume: |
48 |
| Issue: |
6 |
| Pages: |
703-10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Peng YC |
| Year: |
2013 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Sonic hedgehog signals to multiple prostate stromal stem cells that replenish distinct stromal subtypes during regeneration. |
| Volume: |
110 |
| Issue: |
51 |
| Pages: |
20611-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hui CC |
| Year: |
1994 |
| Journal: |
Dev Biol |
| Title: |
Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development. |
| Volume: |
162 |
| Issue: |
2 |
| Pages: |
402-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wall DS |
| Year: |
2009 |
| Journal: |
J Cell Biol |
| Title: |
Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. |
| Volume: |
184 |
| Issue: |
1 |
| Pages: |
101-12 |
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Kumari A |
| Year: |
2024 |
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PLoS One |
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Distinct expression patterns of Hedgehog signaling components in mouse gustatory system during postnatal tongue development and adult homeostasis. |
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19 |
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6 |
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Liu HX |
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2013 |
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Dev Biol |
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Multiple Shh signaling centers participate in fungiform papilla and taste bud formation and maintenance. |
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Haraguchi R |
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Development |
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Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling. |
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134 |
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Dev Biol |
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Evidence for the involvement of the Gli gene family in embryonic mouse lung development. |
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| First Author: |
Brownell I |
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2011 |
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Cell Stem Cell |
| Title: |
Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells. |
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5 |
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Qiu N |
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2010 |
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PLoS One |
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Kif3a deficiency reverses the skeletal abnormalities in Pkd1 deficient mice by restoring the balance between osteogenesis and adipogenesis. |
| Volume: |
5 |
| Issue: |
12 |
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e15240 |
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Zeng H |
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PLoS One |
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Coordinated translocation of mammalian Gli proteins and suppressor of fused to the primary cilium. |
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5 |
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12 |
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He M |
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2014 |
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Nat Cell Biol |
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The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment. |
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16 |
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Company V |
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2021 |
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Front Cell Dev Biol |
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Tukachinsky H |
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2010 |
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J Cell Biol |
| Title: |
A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes. |
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191 |
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Brooks ER |
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2020 |
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Elife |
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Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure. |
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Gli3 null mice display glandular overgrowth of the developing stomach. |
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Development |
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Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. |
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J Cell Sci |
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The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation. |
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Mech Dev |
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Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear. |
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9 |
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PLoS Genet |
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Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline. |
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| Organism: |
Mus musculus/domesticus |
| Length: |
1540
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| Fragment?: |
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Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1. |
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Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis. |
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Mol Cell Biol |
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Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2. |
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J Neurosci |
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2021 |
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Elife |
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Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in a tissue-specific manner. |
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Elife |
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Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer. |
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8 |
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Cell Rep |
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Ptch1 is essential for cochlear marginal cell differentiation and stria vascularis formation. |
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J Clin Invest |
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Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. |
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