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Search results 801 to 900 out of 1071 for Hdac1

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Type Details Score
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment
Series Id: GSE27451
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment
Series Id: GSE47745
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication  
First Author: Meng J
Year: 2016
Journal: J Autoimmun
Title: Rb selectively inhibits innate IFN-β production by enhancing deacetylation of IFN-β promoter through HDAC1 and HDAC8.
Volume: 73
Pages: 42-53
Publication
First Author: Kato T
Year: 2009
Journal: Cancer Res
Title: Characterization of the HDAC1 complex that regulates the sensitivity of cancer cells to oxidative stress.
Volume: 69
Issue: 8
Pages: 3597-604
HT Experiment
Series Id: GSE34786
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
GXD Expression
Probe: MGI:6194047
Assay Type: Immunohistochemistry
Annotation Date: 2018-08-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3102528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6194075
Age: postnatal adult
Image: 2 HDAC2
Note: Expression co-localizes with Hdac1 mainly throughout the nucleoplasm.
Specimen Label: 2 HDAC2
Detected: true
Specimen Num: 1
Publication
First Author: Reichmann J
Year: 2012
Journal: PLoS Comput Biol
Title: Microarray analysis of LTR retrotransposon silencing identifies Hdac1 as a regulator of retrotransposon expression in mouse embryonic stem cells.
Volume: 8
Issue: 4
Pages: e1002486
Publication
First Author: Yang Y
Year: 2020
Journal: Cancer Res
Title: The Deubiquitinase USP38 Promotes NHEJ Repair through Regulation of HDAC1 Activity and Regulates Cancer Cell Response to Genotoxic Insults.
Volume: 80
Issue: 4
Pages: 719-731
Protein
Organism: Mus musculus/domesticus
Length: 482  
Fragment?: false
Publication
First Author: Popova EY
Year: 2021
Journal: J Neurosci
Title: Inhibition of Epigenetic Modifiers LSD1 and HDAC1 Blocks Rod Photoreceptor Death in Mouse Models of Retinitis Pigmentosa.
Volume: 41
Issue: 31
Pages: 6775-6792
Publication
First Author: Wang WY
Year: 2013
Journal: Nat Neurosci
Title: Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons.
Volume: 16
Issue: 10
Pages: 1383-91
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Cartwright TN
Year: 2018
Journal: Biochim Biophys Acta Gene Regul Mech
Title: HDAC1 interacts with the p50 NF-?B subunit via its nuclear localization sequence to constrain inflammatory gene expression.
Volume: 1861
Issue: 10
Pages: 962-970
HT Experiment
Series Id: E-GEOD-36564
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
HT Experiment
Series Id: GSE54785
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
GXD Expression
Probe: MGI:5565505
Assay Type: Immunohistochemistry
Annotation Date: 2014-06-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5567094
Age: postnatal day 7
Image: 3L
Note: Coexpressed with HDAC1 in the white matter surrounding the hippocampal formation.
Specimen Label: 3L
Detected: true
Specimen Num: 1
Interaction Experiment
Description: HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage.
Interaction Experiment
Description: HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction.
Interaction Experiment
Description: STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPbeta.
Interaction Experiment
Description: Interaction of Ets-1 with HDAC1 represses IL-10 expression in Th1 cells.
Interaction Experiment
Description: SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons.
Publication
First Author: Bruno T
Year: 2002
Journal: Cancer Cell
Title: Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb.
Volume: 2
Issue: 5
Pages: 387-99
Interaction Experiment
Description: A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program.
Interaction Experiment
Description: HDAC1 regulates the stability of glutamate carboxypeptidase II protein by modulating acetylation status of lysine 479 residue.
Allele
Name: histone deacetylase 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Publication
First Author: Robertson KD
Year: 2000
Journal: Nat Genet
Title: DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters.
Volume: 25
Issue: 3
Pages: 338-42
Publication
First Author: Unoki M
Year: 2004
Journal: Oncogene
Title: ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain.
Volume: 23
Issue: 46
Pages: 7601-10
Publication
First Author: Laduron S
Year: 2004
Journal: Nucleic Acids Res
Title: MAGE-A1 interacts with adaptor SKIP and the deacetylase HDAC1 to repress transcription.
Volume: 32
Issue: 14
Pages: 4340-50
Publication
First Author: Derwish R
Year: 2017
Journal: PLoS One
Title: Differential HDAC1 and 2 Recruitment by Members of the MIER Family.
Volume: 12
Issue: 1
Pages: e0169338
Publication
First Author: Xu M
Year: 2003
Journal: EMBO J
Title: STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPbeta.
Volume: 22
Issue: 4
Pages: 893-904
Interaction Experiment
Description: The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression.
Interaction Experiment
Description: Activation of CCAAT/enhancer-binding protein (C/EBP) alpha expression by C/EBP beta during adipogenesis requires a peroxisome proliferator-activated receptor-gamma-associated repression of HDAC1 at the C/ebp alpha gene promoter.
Publication
First Author: Saito M
Year: 2002
Journal: J Biol Chem
Title: The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2.
Volume: 277
Issue: 38
Pages: 35434-9
Publication
First Author: Mal A
Year: 2001
Journal: EMBO J
Title: A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program.
Volume: 20
Issue: 7
Pages: 1739-53
Publication
First Author: Choi JY
Year: 2018
Journal: Biochem Biophys Res Commun
Title: HDAC1 regulates the stability of glutamate carboxypeptidase II protein by modulating acetylation status of lysine 479 residue.
Volume: 497
Issue: 1
Pages: 416-423
Publication
First Author: Ashburner BP
Year: 2001
Journal: Mol Cell Biol
Title: The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression.
Volume: 21
Issue: 20
Pages: 7065-77
Publication
First Author: Zuo Y
Year: 2006
Journal: J Biol Chem
Title: Activation of CCAAT/enhancer-binding protein (C/EBP) alpha expression by C/EBP beta during adipogenesis requires a peroxisome proliferator-activated receptor-gamma-associated repression of HDAC1 at the C/ebp alpha gene promoter.
Volume: 281
Issue: 12
Pages: 7960-7
Allele
Name: histone deacetylase 2; targeted mutation 1.2, Ronald DePinho
Allele Type: Targeted
Attribute String: Null/knockout
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Allele
Name: microtubule-associated protein tau; targeted mutation 2, Rudolf Jaenisch
Allele Type: Targeted
Attribute String: Inserted expressed sequence
Strain
Attribute String: mutant stock, targeted mutation
Allele
Name: GATA binding protein 1; targeted mutation 1.1, inGenious Targeting Laboratory
Allele Type: Targeted
Attribute String: Not Specified
Genotype
Symbol: Hdac2/Hdac2
Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Wu H
Year: 2011
Journal: Mol Cancer Res
Title: Pirh2, a ubiquitin E3 ligase, inhibits p73 transcriptional activity by promoting its ubiquitination.
Volume: 9
Issue: 12
Pages: 1780-90
Publication
First Author: Daks A
Year: 2016
Journal: Genes Cancer
Title: E3 ubiquitin ligase Pirh2 enhances tumorigenic properties of human non-small cell lung carcinoma cells.
Volume: 7
Issue: 11-12
Pages: 383-393
Protein Domain
Type: Domain
Description: This entry represents the zinc-ribbon domain found in RCHY1 and related proteins. RCHY1, also known as Pirh2, is a ubiquitin E3 ligase that mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B [, ].
HT Experiment
Series Id: GSE35432
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
Genotype
Symbol: Mapt/Mapt
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Cdkn1a/Cdkn1a Hdac2/Hdac2
Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Protein
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 255  
Fragment?: true
Publication  
First Author: Dias C
Year: 2013
Journal: Case Rep Genet
Title: Trichorhinophalangeal Syndrome Type I: A Patient with Two Novel and Different Mutations in the TRPS1 Gene.
Volume: 2013
Pages: 748057
Publication
First Author: Kaiser FJ
Year: 2004
Journal: Eur J Hum Genet
Title: Novel missense mutations in the TRPS1 transcription factor define the nuclear localization signal.
Volume: 12
Issue: 2
Pages: 121-6
Publication
First Author: Wuelling M
Year: 2013
Journal: Cell Cycle
Title: The multi zinc-finger protein Trps1 acts as a regulator of histone deacetylation during mitosis.
Volume: 12
Issue: 14
Pages: 2219-32
Publication
First Author: Wang L
Year: 2008
Journal: EMBO Rep
Title: Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fates.
Volume: 9
Issue: 6
Pages: 555-62
Publication
First Author: Bantscheff M
Year: 2011
Journal: Nat Biotechnol
Title: Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes.
Volume: 29
Issue: 3
Pages: 255-65
Protein Domain
Type: Family
Description: The TRPS1 gene encodes a multi zinc-finger nuclear regulator of chondrocyte proliferation and differentiation []. Mutations in the gene cause trichorhinophalangeal syndrome (TRPS), an autosomal dominant skeletal dysplasia []. The Trps1 protein also acts as regulator of histone deacetylation, interacting with two histone deacetylases, Hdac1 and Hdac4, thereby increasing their activity [].
Protein Domain
Type: Family
Description: MIER1, MIER2, MIER3 are ELM-SAINT domain-containing proteins that have been purified with HDAC1 and/or HDAC2, and most likely represent components of distinct histone deacetylase (HDAC) complexes formed around ELM-SANT scaffolds [, ].The gene encoding mesoderm induction early response protein 3 (MIER3) has been identified as a candidate cancer susceptibility gene [].
Protein Domain
Type: Domain
Description: This leucine zipper-containing domain is found in apoptosis antagonizing transcription factor (AATF, also known as Che-1) and related proteins. AATF may function as a general inhibitor of the histone deacetylase HDAC1 []. AATF has been shown to inhibit the abberant production of the amyloid beta peptide 1-42 by direct interaction with Par4 []. This interaction occurs via the leucine zipper.
Allele
Name: transgene insertion B22-1, M I Kotlikoff
Allele Type: Transgenic
Attribute String: Reporter
Genotype
Symbol: Cdkn2a/Cdkn2a Hdac2/Hdac2
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Zygosity: cx
Has Mutant Allele: true
HT Experiment
Series Id: GSE18610
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
GO Term
Strain
Attribute String: congenic, mutant strain, transgenic
Publication
First Author: Brandt S
Year: 2010
Journal: Int J Biochem Cell Biol
Title: SLy2 targets the nuclear SAP30/HDAC1 complex.
Volume: 42
Issue: 9
Pages: 1472-81
Publication
First Author: Shiio Y
Year: 2006
Journal: Mol Cell Biol
Title: Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex.
Volume: 26
Issue: 4
Pages: 1386-97
Protein
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: false
Publication
First Author: von Holleben M
Year: 2011
Journal: J Biol Chem
Title: Immunoinhibitory adapter protein Src homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading.
Volume: 286
Issue: 15
Pages: 13489-501
Protein
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Publication
First Author: Dumasia A
Year: 1990
Journal: Leuk Res
Title: Quantitative variations in A, B, Ht1 and Ht2 antigens on erythrocytes in leukemia and lymphoma.
Volume: 14
Issue: 10
Pages: 857-61
Publication  
First Author: Kolos JM
Year: 2018
Journal: Front Pharmacol
Title: FKBP Ligands-Where We Are and Where to Go?
Volume: 9
Pages: 1425
Publication
First Author: Yang WM
Year: 2001
Journal: EMBO J
Title: The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1.
Volume: 20
Issue: 17
Pages: 4814-25
Publication
First Author: Zhu W
Year: 2017
Journal: Theranostics
Title: FKBP3 Promotes Proliferation of Non-Small Cell Lung Cancer Cells through Regulating Sp1/HDAC2/p27.
Volume: 7
Issue: 12
Pages: 3078-3089
Publication
First Author: Dilworth D
Year: 2017
Journal: Nucleic Acids Res
Title: The basic tilted helix bundle domain of the prolyl isomerase FKBP25 is a novel double-stranded RNA binding module.
Volume: 45
Issue: 20
Pages: 11989-12004
Protein Domain
Type: Family
Description: FKBP3, also known as FKBP25, contains the N-terminal basic tilted helix bundle (BTHB) domain and the C-terminal PPIase domain. It is a nuclear prolyl isomerase that interacts directlywith nucleic acids []. It interacts with the histone deacetylases HDAC1 and HDAC2 as well as with their transcriptional regulator Yin Yang 1 (YY1) []. It is also a microtubule-associated protein that shuttles between nucleus and cytoplasm and stabilizes the microtubule network by direct binding of the C-terminal PPIase domain []. It plays a role in the proliferation of non-small cell type lung cancer cells (NSCLC) by modulating Sp1/HDAC2/p27 [].
Protein Domain
Type: Family
Description: Members of the ING (inhibitor of growth protein) family of tumour suppressors regulate cell cycle progression, senescence, apoptosis, and DNA repair as important cofactors of p53. Inhibitorof growth protein 2 (ING2) seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53 []. It is also a component of a chromatin-modifying complex containing the transcriptional co-repressor SIN3A and HDAC1 (histone deacetylase 1), which is involved in deacetylation of nucleosomal histones [, ]. The stability of ING2 is regulated by nuclear phosphatidylinositol-5-phosphate at discrete chromatin targets in response to DNA damage [, ].
Protein Domain
Type: Family
Description: In mammals, SAP25 is involved in the transcriptional repression mediated by the mSIN3 complex, which consists of at least SAP30, SAP45/Sds3, SAP130, SAP180/BCAA, RBP1, HDAC1 (histone deacetylase1), HDAC2, RbAp46, and RbAp48 []. The mSIN3 complex can be recruited by sequence-specific DNA binding transcription factors and chromatin-binding proteins to specific regions of the genome and regulate their transcription []. SAP25 binds to the the PAH1 domain of mSin3A and changes the conformation of the complex that affects its protein-protein interaction []. SAP25 can be actively exported from the nucleus to cytoplasm by a CRM1-dependent nuclear export pathway. Its localisation is regulated by promyelocytic leukemia protein (PML), which induces a nuclear accumulation of SAP25 [].
Protein Domain
Type: Domain
Description: This entry represents the PHD domain of ING2.Members of the ING (inhibitor of growth protein) family of tumour suppressors regulate cell cycle progression, senescence, apoptosis, and DNA repair as important cofactors of p53. Inhibitor of growth protein 2 (ING2) seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53 []. It is also a component of a chromatin-modifying complex containing the transcriptional co-repressor SIN3A and HDAC1 (histone deacetylase 1), which is involved in deacetylation of nucleosomal histones [, ]. The stability of ING2 is regulated by nuclear phosphatidylinositol-5-phosphate at discrete chromatin targets in response to DNA damage [, ].
Protein Domain
Type: Domain
Description: SAMSN1 (also known as HACS1 or NASH1) is a member of the SH3/SAM adapter molecules family. It is strongly up-regulated in primary B cells upon differentiation and proliferation-inducing stimuli and functions as an endogenous immunoinhibitor. It has been found to regulate cell spreading and polarization []. 14-3-3 proteins interact and control nucleo-cytoplasmic shuttling of SAMSN1. In the nucleus, SAMSN1 interacts with the SAP30/HDAC1 complex and regulates the activity of HDAC1 [].This entry represents the SAM domain of SAMSN1. The SAM domain is a predicted protein-protein interaction domain.
Publication
First Author: Ythier D
Year: 2010
Journal: Oncogene
Title: Sumoylation of ING2 regulates the transcription mediated by Sin3A.
Volume: 29
Issue: 44
Pages: 5946-56
Publication
First Author: Nagashima M
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53.
Volume: 98
Issue: 17
Pages: 9671-6
Publication
First Author: Gozani O
Year: 2003
Journal: Cell
Title: The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor.
Volume: 114
Issue: 1
Pages: 99-111
Publication  
First Author: Bua DJ
Year: 2013
Journal: Sci Rep
Title: Nuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage.
Volume: 3
Pages: 2137
Publication
First Author: Jenkins D
Year: 2010
Journal: Nephrol Dial Transplant
Title: Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction.
Volume: 25
Issue: 1
Pages: 54-60
Publication
First Author: Caubit X
Year: 2008
Journal: Development
Title: Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4.
Volume: 135
Issue: 19
Pages: 3301-10
Publication
First Author: Caubit X
Year: 2010
Journal: J Neurosci
Title: Teashirt 3 regulates development of neurons involved in both respiratory rhythm and airflow control.
Volume: 30
Issue: 28
Pages: 9465-76
Protein
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: false